Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
November-2017 Volume 14 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2017 Volume 14 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Overexpression of CD164 in oral cavity squamous cell carcinoma predicts a favourable prognosis

  • Authors:
    • Jia‑Hong Chen
    • Wei‑Liang Chen
    • James Yi‑Hsin Chan
    • Yuan‑Wu Chen
    • Yi‑Jen Peng
    • Ming‑Fang Cheng
    • Chun‑Shu Lin
  • View Affiliations / Copyright

    Affiliations: Division of Medical Oncology and Haematology, Tri‑Service General Hospital, National Defense Medical Centre, Taipei 11490, Taiwan, R.O.C., Division of Family Medicine, Tri‑Service General Hospital, National Defense Medical Centre, Taipei 11490, Taiwan, R.O.C., Department of Oral and Maxillofacial Surgery, Tri‑Service General Hospital, National Defense Medical Centre, Taipei 11490, Taiwan, R.O.C., Department of Pathology, Tri‑Service General Hospital, National Defense Medical Centre, Taipei 11490, Taiwan, R.O.C., Division of Histological and Clinical Pathology, Hualien Armed Forces General Hospital, Hualien 97144, Taiwan, R.O.C., Department of Radiation Oncology, Tri‑Service General Hospital, National Defense Medical Centre, Taipei 11490, Taiwan, R.O.C.
  • Pages: 6103-6108
    |
    Published online on: September 15, 2017
       https://doi.org/10.3892/ol.2017.6966
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to investigate the association between cluster of differentiation (CD) 164 expression with clinicopathological parameters and prognosis among patients with oral cavity squamous cell carcinoma (OSCC). The present study retrospectively reviewed 70 patients with OSCC who underwent curative primary surgery. A number of patients subsequently received postoperative chemoradiotherapy although the specimens were not exposed to radiation or chemotherapy prior to anti‑CD164 antibody immunohistochemical staining. CD164 overexpression was arbitrarily defined as exhibiting an H‑score of ≥120. Univariate and multivariate analyses were performed for sex, age, American Joint Committee on Cancer stage, tumour location, histological grade, surgical margin and H‑score. The 5‑year overall survival rate was 54.4% and the median follow‑up time was 46 months for surviving patients. Univariate analyses revealed that a low overall survival rate was associated with advanced‑stage disease (P<0.001), buccogingival tumour location (P=0.038) and a CD164 H‑score of <120 (P=0.016). Multivariate Cox's regression analyses revealed that poor overall survival rate was associated with advanced‑stage disease (P=0.001) and a CD164 H‑score of <120 (P=0.04). CD164 overexpression in OSCC was associated with favourable survival rate. Thus, CD164 expression may be a clinically useful predictor of prognosis in patients with OSCC.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Ferlay J, Shin HR, Bray F, Forman D, Mathers C and Parkin DM: Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 127:2893–2917. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Lin CS, Lin YC, Adebayo BO, Wu A, Chen JH, Peng YJ, Cheng MF, Lee WH, Hsiao M, Chao TY and Yeh CT: Silencing JARID1B suppresses oncogenicity, stemness and increases radiation sensitivity in human oral carcinoma. Cancer Lett. 368:36–45. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Cooper JS, Pajak TF, Forastiere AA, Jacobs J, Campbell BH, Saxman SB, Kish JA, Kim HE, Cmelak AJ, Rotman M, et al: Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck. N Engl J Med. 350:1937–1944. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Blanchard P, Baujat B, Holostenco V, Bourredjem A, Baey C, Bourhis J and Pignon JP; and MACH-CH Collaborative group, . Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): A comprehensive analysis by tumour site. Radiother Oncol. 100:33–40. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Lin CS, Jen YM, Cheng MF, Lin YS, Su WF, Hwang JM, Chang LP, Chao HL, Liu DW, Lin HY and Shum WY: Squamous cell carcinoma of the buccal mucosa: An aggressive cancer requiring multimodality treatment. Head Neck. 28:150–157. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Lin CS, Jen YM, Kao WY, Ho CL, Dai MS, Shih CL, Cheng JC, Chang PY, Huang WY and Su YF: Improved outcomes in buccal squamous cell carcinoma. Head Neck. 35:65–71. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Machtay M, Moughan J, Trotti A, Garden AS, Weber RS, Cooper JS, Forastiere A and Ang KK: Factors associated with severe late toxicity after concurrent chemoradiation for locally advanced head and neck cancer: An RTOG analysis. J Clin Oncol. 26:3582–3589. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Bjordal K, Hammerlid E, Ahlner-Elmqvist M, de Graeff A, Boysen M, Evensen JF, Biörklund A, de Leeuw JR, Fayers PM, Jannert M, et al: Quality of life in head and neck cancer patients: Validation of the european organization for research and treatment of cancer quality of life questionnaire-H&N35. J Clin Oncol. 17:1008–1019. 1999. View Article : Google Scholar : PubMed/NCBI

9 

Westra WH, Taube JM, Poeta ML, Begum S, Sidransky D and Koch WM: Inverse relationship between human papillomavirus-16 infection and disruptive p53 gene mutations in squamous cell carcinoma of the head and neck. Clin Cancer Res. 14:366–369. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Chera BS, Amdur RJ, Tepper J, Qaqish B, Green R, Aumer SL, Hayes N, Weiss J, Grilley-Olson J, Zanation A, et al: Phase 2 trial of De-intensified chemoradiation therapy for favorable-risk human papillomavirus-associated oropharyngeal squamous cell carcinoma. Int J Radiat Oncol Biol Phys. 93:976–985. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Watt SM, Buhring HJ, Rappold I, Chan JY, Lee-Prudhoe J, Jones T, Zannettino AC, Simmons PJ, Doyonnas R, Sheer D and Butler LH: CD164, a novel sialomucin on CD34(+) and erythroid subsets, is located on human chromosome 6q21. Blood. 92:849–866. 1998.PubMed/NCBI

12 

Doyonnas R, Chan Yi-Hsin J, Butler LH, Rappold I, Lee-Prudhoe JE, Zannettino AC, Simmons PJ, Bühring HJ, Levesque JP and Watt SM: CD164 monoclonal antibodies that block hemopoietic progenitor cell adhesion and proliferation interact with the first mucin domain of the CD164 receptor. J Immunol. 165:840–851. 2000. View Article : Google Scholar : PubMed/NCBI

13 

Kurosawa N, Kanemitsu Y, Matsui T, Shimada K, Ishihama H and Muramatsu T: Genomic analysis of a murine cell-surface sialomucin, MGC-24/CD164. Eur J Biochem. 265:466–472. 1999. View Article : Google Scholar : PubMed/NCBI

14 

Watt SM, Butler LH, Tavian M, Bühring HJ, Rappold I, Simmons PJ, Zannettino AC, Buck D, Fuchs A, Doyonnas R, et al: Functionally defined CD164 epitopes are expressed on CD34(+) cells throughout ontogeny but display distinct distribution patterns in adult hematopoietic and nonhematopoietic tissues. Blood. 95:3113–3124. 2000.PubMed/NCBI

15 

Zannettino AC, Bühring HJ, Niutta S, Watt SM, Benton MA and Simmons PJ: The sialomucin CD164 (MGC-24v) is an adhesive glycoprotein expressed by human hematopoietic progenitors and bone marrow stromal cells that serves as a potent negative regulator of hematopoiesis. Blood. 92:2613–2628. 1998.PubMed/NCBI

16 

Shi JA, Lu DL, Huang X and Tan W: miR-219 inhibits the proliferation, migration and invasion of medulloblastoma cells by targeting CD164. Int J Mol Med. 34:237–243. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Tang J, Zhang L, She X, Zhou G, Yu F, Xiang J and Li G: Inhibiting CD164 expression in colon cancer cell line HCT116 leads to reduced cancer cell proliferation, mobility and metastasis in vitro and in vivo. Cancer Invest. 30:380–389. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Havens AM, Jung Y, Sun YX, Wang J, Shah RB, Bühring HJ, Pienta KJ and Taichman RS: The role of sialomucin CD164 (MGC-24v or endolyn) in prostate cancer metastasis. BMC Cancer. 6:1952006. View Article : Google Scholar : PubMed/NCBI

19 

Guenova E, Ignatova D, Chang YT, Contassot E, Mehra T, Saulite I, Navarini AA, Mitev V, Dummer R and Kazakov DV: Expression of CD164 on malignant T cells in Sézary syndrome. Acta Derm Venereol. 96:464–467. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Wysocka M, Kossenkov AV, Benoit BM, Troxel AB, Singer E, Schaffer A, Kim B, Dentchev T, Nagata S, Ise T, et al: CD164 and FCRL3 are highly expressed on CD4+CD26- T cells in Sézary syndrome patients. J Invest Dermatol. 134:229–236. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Huang AF, Chen MW, Huang SM, Kao CL, Lai HC and Chan JY: CD164 regulates the tumorigenesis of ovarian surface epithelial cells through the SDF-1α/CXCR4 axis. Mol Cancer. 12:1152013. View Article : Google Scholar : PubMed/NCBI

22 

Matsui T, Kurosawa N, Hibi K, Akiyama S, Kasai Y, Sakamoto J, Ito K, Nakao A and Muramatsu T: The ratio of splicing variants of MGC-24/CD164, a sialomucin, correlates with the metastatic potential of colorectal carcinomas. J Biochem. 127:1103–1107. 2000. View Article : Google Scholar : PubMed/NCBI

23 

Edge SB and Compton CC: The american joint committee on cancer: The 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol. 17:1471–1474. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Marcial VA, Pajak TF, Mohiuddin M, Cooper JS, al Sarraf M, Mowry PA, Curran W, Crissman J, Rodríguez M and Vélez-García E: Concomitant cisplatin chemotherapy and radiotherapy in advanced mucosal squamous cell carcinoma of the head and neck. Long-term results of the radiation therapy oncology group study 81–17. Cancer. 66:1861–1868. 1990. View Article : Google Scholar : PubMed/NCBI

25 

van den Bent MJ, van Putten WL, Hilkens PH, de Wit R and van der Burg ME: Retreatment with dose-dense weekly cisplatin after previous cisplatin chemotherapy is not complicated by significant neuro-toxicity. Eur J Cancer. 38:387–391. 2002. View Article : Google Scholar : PubMed/NCBI

26 

Mazieres J, Brugger W, Cappuzzo F, Middel P, Frosch A, Bara I, Klingelschmitt G and Klughammer B: Evaluation of EGFR protein expression by immunohistochemistry using H-score and the magnification rule: Re-analysis of the SATURN study. Lung Cancer. 82:231–237. 2013. View Article : Google Scholar : PubMed/NCBI

27 

McGuckin CP, Forraz N, Baradez MO, Lojo-Rial C, Wertheim D, Whiting K, Watt SM and Pettengell R: Colocalization analysis of sialomucins CD34 and CD164. Stem Cells. 21:162–170. 2003. View Article : Google Scholar : PubMed/NCBI

28 

Jorgensen-Tye B, Levesque JP, Royle L, Doyonnas R, Chan JY, Dwek RA, Rudd PM, Harvey DJ, Simmons PJ and Watt SM: Epitope recognition of antibodies that define the sialomucin, endolyn (CD164), a negative regulator of haematopoiesis. Tissue Antigens. 65:220–239. 2005. View Article : Google Scholar : PubMed/NCBI

29 

Chen AY and Myers JN: Cancer of the oral cavity. Dis Mon. 47:275–361. 2001. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Chen JH, Chen WL, Chan JY, Chen YW, Peng YJ, Cheng MF and Lin CS: Overexpression of CD164 in oral cavity squamous cell carcinoma predicts a favourable prognosis. Oncol Lett 14: 6103-6108, 2017.
APA
Chen, J., Chen, W., Chan, J.Y., Chen, Y., Peng, Y., Cheng, M., & Lin, C. (2017). Overexpression of CD164 in oral cavity squamous cell carcinoma predicts a favourable prognosis. Oncology Letters, 14, 6103-6108. https://doi.org/10.3892/ol.2017.6966
MLA
Chen, J., Chen, W., Chan, J. Y., Chen, Y., Peng, Y., Cheng, M., Lin, C."Overexpression of CD164 in oral cavity squamous cell carcinoma predicts a favourable prognosis". Oncology Letters 14.5 (2017): 6103-6108.
Chicago
Chen, J., Chen, W., Chan, J. Y., Chen, Y., Peng, Y., Cheng, M., Lin, C."Overexpression of CD164 in oral cavity squamous cell carcinoma predicts a favourable prognosis". Oncology Letters 14, no. 5 (2017): 6103-6108. https://doi.org/10.3892/ol.2017.6966
Copy and paste a formatted citation
x
Spandidos Publications style
Chen JH, Chen WL, Chan JY, Chen YW, Peng YJ, Cheng MF and Lin CS: Overexpression of CD164 in oral cavity squamous cell carcinoma predicts a favourable prognosis. Oncol Lett 14: 6103-6108, 2017.
APA
Chen, J., Chen, W., Chan, J.Y., Chen, Y., Peng, Y., Cheng, M., & Lin, C. (2017). Overexpression of CD164 in oral cavity squamous cell carcinoma predicts a favourable prognosis. Oncology Letters, 14, 6103-6108. https://doi.org/10.3892/ol.2017.6966
MLA
Chen, J., Chen, W., Chan, J. Y., Chen, Y., Peng, Y., Cheng, M., Lin, C."Overexpression of CD164 in oral cavity squamous cell carcinoma predicts a favourable prognosis". Oncology Letters 14.5 (2017): 6103-6108.
Chicago
Chen, J., Chen, W., Chan, J. Y., Chen, Y., Peng, Y., Cheng, M., Lin, C."Overexpression of CD164 in oral cavity squamous cell carcinoma predicts a favourable prognosis". Oncology Letters 14, no. 5 (2017): 6103-6108. https://doi.org/10.3892/ol.2017.6966
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team