Potato freeze‑thaw solution enhances immune function and antitumor activity in vivo

Xu,Guihua; Shen,Jie; Sun,Peng; Niu,Yan; Zhao,Pengwei; Tang,Pingping; Zhang,Jiayi; Fei,Chunxue; Bu,Leinan; Yue,Zhiyi; Liu,Honghao; Wang,Zhiqiang; Yang,Limin; Sun,Dejun

doi:10.3892/ol.2017.6970

Potato freeze‑thaw solution enhances immune function and antitumor activity in vivo

Authors:
- Guihua Xu
- Jie Shen
- Peng Sun
- Yan Niu
- Pengwei Zhao
- Pingping Tang
- Jiayi Zhang
- Chunxue Fei
- Leinan Bu
- Zhiyi Yue
- Honghao Liu
- Zhiqiang Wang
- Limin Yang
- Dejun Sun
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Affiliations: Department of Clinical Medical Research Center, Inner Mongolia Autonomous Region People's Hospital, Hohhot, Inner Mongolia 010017, P.R. China, Department of Neurology, Inner Mongolia Autonomous Region People's Hospital, Hohhot, Inner Mongolia 010017, P.R. China, Institute of Microbiology and Immunology, School of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot, Inner Mongolia 010110, P.R. China, Department of Forensic Medicine, School of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot, Inner Mongolia 010110, P.R. China, Department of Anatomy, School of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot, Inner Mongolia 010110, P.R. China, Departments of Respiratory and Critical Diseases, Inner Mongolia Autonomous Region People's Hospital, Hohhot, Inner Mongolia 010017, P.R. China
Published online on: September 15, 2017 https://doi.org/10.3892/ol.2017.6970
Pages: 6129-6134

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Abstract

Although potato extract, derived from various methods, exhibits anticancer, antiviral and anti‑parasite activities in vitro and in vivo, the bioactivity of potato solution remains unclear using the freeze‑thaw extraction method granted by the State Intellectual Property Office of China. In the present study, a potato freeze‑thaw solution (PFTS) was fed to mice with ascites tumor that were pre‑treated with cyclophosphamide. The numbers of peripheral white blood cells (WBCs), macrophage phagocytosis, lymphocyte transformation and survival of mice were measured. While mice injected with cyclophosphamide exhibited decreased counts of peripheral WBCs, treatment of the cyclophosphamide‑injected mice with PFTS for 10 days significantly increased the number of peripheral WBCs and reversed WBC counts to the normal level, a comparable effect to that of Ganoderma lucidum. In addition, treatment with PFTS for 20 days significantly enhanced peritoneal macrophage phagocytosis and lymphocyte transformation. Lastly, PFTS was noticed to prolong the survival of tumor‑bearing mice when compared with that of control mice. Collectively, these data suggested that PFTS, at least in part, enhances immune function and possesses antitumor activity.

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