Open Access

CD109 expression is upregulated in penile squamous cell carcinoma

  • Authors:
    • Fengyun Dong
    • Jin Wang
    • Yinghua Xu
    • Zuowang Cheng
    • Xiaocui Chen
    • Yifan Wang
    • Ju Liu
  • View Affiliations

  • Published online on: September 15, 2017     https://doi.org/10.3892/ol.2017.6975
  • Pages: 6012-6016
  • Copyright: © Dong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cluster of differentiation (CD) 109 is a glycosylphosphatidylinositol‑anchored cell surface glycoprotein and a co‑receptor for transforming growth factor β. The expression of CD109 has been detected in squamous cell carcinoma of the lung, esophagus, skin and gallbladder. The aim of the present study was to evaluate CD109 expression in penile squamous cell carcinoma (PSCC). CD109 expression in PSCC tumor and adjacent tissues from 45 specimens in tissue microarrays was examined by immunohistochemical analyses. In addition, 3 fresh surgical samples of PSCC were collected and examined for their CD109 mRNA and protein levels by reverse transcription‑quantitative polymerase chain reaction, western blotting and immunofluorescence staining. CD109 transcription and expression were significantly higher in the PSCC tissues compared with adjacent normal penile tissues, and its expression was restricted to squamous cells. However, CD109 expression level was not associated with the PSCC differentiation grade. These results suggest that CD109 may be associated with the pathogenesis of PSCC, and may therefore be a potential therapeutic target.
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November-2017
Volume 14 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Dong F, Wang J, Xu Y, Cheng Z, Chen X, Wang Y and Liu J: CD109 expression is upregulated in penile squamous cell carcinoma. Oncol Lett 14: 6012-6016, 2017
APA
Dong, F., Wang, J., Xu, Y., Cheng, Z., Chen, X., Wang, Y., & Liu, J. (2017). CD109 expression is upregulated in penile squamous cell carcinoma. Oncology Letters, 14, 6012-6016. https://doi.org/10.3892/ol.2017.6975
MLA
Dong, F., Wang, J., Xu, Y., Cheng, Z., Chen, X., Wang, Y., Liu, J."CD109 expression is upregulated in penile squamous cell carcinoma". Oncology Letters 14.5 (2017): 6012-6016.
Chicago
Dong, F., Wang, J., Xu, Y., Cheng, Z., Chen, X., Wang, Y., Liu, J."CD109 expression is upregulated in penile squamous cell carcinoma". Oncology Letters 14, no. 5 (2017): 6012-6016. https://doi.org/10.3892/ol.2017.6975