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Aberrant expression of CD133 and CD82 in patients with pediatric acute lymphoblastic leukemia and the clinical significance

  • Authors:
    • Hongyan Ji
    • Li Chen
    • Yunpeng Dai
    • Xiaojun Sun
    • Xiuli Li
    • Qi Wang
    • Daoxin Ma
    • Dongdong Du
    • Ping Zhao
    • Yulin Wang
  • View Affiliations / Copyright

    Affiliations: Department of Pediatrics, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China, Department of Pediatrics, Anhui Provincial Cancer Hospital, Hefei, Anhui 230000, P.R. China, Department of Hematology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, P.R. China
    Copyright: © Ji et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5811-5818
    |
    Published online on: September 18, 2017
       https://doi.org/10.3892/ol.2017.6981
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Abstract

Cluster of differentiation (CD)133 is considered to be a marker of leukemia stem cells (LSCs), which are one of the primary causes of occurrence, drug resistance and relapse of acute lymphoblastic leukemia (ALL). CD82, an adhesion molecule, performs an important role in the interaction between LSCs and their niche. The purpose of the present study was to assess CD133 and CD82 expression in patients with pediatric ALL, and to evaluate the association with the clinical data. Using flow cytometric assessment and reverse transcription‑polymerase chain reaction, CD133 and CD82 expression levels were measured in the bone marrow (BM) of 37 patients with newly diagnosed (ND) pediatric ALL [ALL‑ND; 30 B‑cell‑ALL (B‑ALL) and 7 T‑cell‑ALL (T‑ALL)], in 22 patients with complete remission pediatric ALL (ALL‑CR) and in 16 age‑matched children without BM disease. BM plasma CD82 concentrations were measured by ELISA. The CD82 mRNA expression level in the patients with ALL‑ND was significantly higher compared with that in the controls. CD82 mRNA expression levels in pediatric patients with B cell‑ALL (B‑ALL) were higher than those in ALL‑CR patients and controls. For T‑ALL, CD82 expression in ND patients was higher than in controls. CD133 mRNA expression levels in patients with pediatric B‑ALL‑ND were higher than that of controls and patients with ALL‑CR. The frequency of CD34+ cells in pediatric ALL was significantly higher than that in controls. Frequencies of CD34+CD133+ or CD34+CD82+ cells in pediatric ALL were higher than those in controls. A positive association was observed between CD133 and CD82 mRNA expression in patients with B‑ALL. A significant association was observed between CD133 mRNA expression and the hyperdiploid karyotype. Therefore, it was considered that CD133 and CD82 may serve an important role in the evolution of pediatric ALL. CD133 and CD82 should be considered as potential markers for the prognosis of patients with ALL.
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1 

Pui CH, Robison LL and Look AT: Acute lymphoblastic leukaemia. Lancet. 371:1030–1043. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Pui CH, Carroll WL, Meshinchi S and Arceci RJ: Biology, risk stratification, and therapy of pediatric acute leukemias: An update. J Clin Oncol. 29:551–565. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Möricke A, Zimmermann M, Reiter A, Henze G, Schrauder A, Gadner H, Ludwig WD, Ritter J, Harbott J, Mann G, et al: Long-term results of five consecutive trials in childhood acute lymphoblastic leukemia performed by the ALL-BFM study group from 1981 to 2000. Leukemia. 24:265–284. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Hunger SP, Lu X, Devidas M, Camitta BM, Gaynon PS, Winick NJ, Reaman GH and Carroll WL: Improved survival for children and adolescents with acute lymphoblastic leukemia between 1990 and 2005: A report from the children's oncology group. J Clin Oncol. 30:1663–1669. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Conter V, Aricò M, Basso G, Biondi A, Barisone E, Messina C, Parasole R, De Rossi G, Locatelli F, Pession A, et al: Long-term results of the Italian Association of Pediatric Hematology and Oncology (AIEOP) Studies 82, 87, 88, 91 and 95 for childhood acute lymphoblastic leukemia. Leukemia. 24:255–264. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Pui CH, Campana D, Pei D, Bowman WP, Sandlund JT, Kaste SC, Ribeiro RC, Rubnitz JE, Raimondi SC, Onciu M, et al: Treating childhood acute lymphoblastic leukemia without cranial irradiation. N Engl J Med. 360:2730–2741. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Bhojwani D and Pui CH: Relapsed childhood acute lymphoblastic leukaemia. Lancet Oncol. 14:e205–e217. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Styczynski J and Drewa T: Leukemic stem cells: From metabolic pathways and signaling to a new concept of drug resistance targeting. Acta Biochim Pol. 54:717–726. 2007.PubMed/NCBI

9 

O'Brien CA, Pollett A, Gallinger S and Dick JE: A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature. 445:106–110. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Makino S: The role of tumor stem-cells in regrowth of the tumor following drastic applications. Acta Unio Int Contra Cancrum. 15 Suppl 1:S196–S198. 1959.

11 

Chávez-González A, Dorantes-Acosta E, Moreno-Lorenzana D, Alvarado-Moreno A, Arriaga-Pizano L and Mayani H: Expression of CD90, CD96, CD117, and CD123 on different hematopoietic cell populations from pediatric patients with acute myeloid leukemia. Arch Med Res. 45:343–350. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Hong D, Gupta R, Ancliff P, Atzberger A, Brown J, Soneji S, Green J, Colman S, Piacibello W, Buckle V, et al: Initiating and cancer-propagating cells in TEL-AML1-associated childhood leukemia. Science. 319:336–339. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Toren A, Bielorai B, Jacob-Hirsch J, Fisher T, Kreiser D, Moran O, Zeligson S, Givol D, Yitzhaky A, Itskovitz-Eldor J, et al: CD133-positive hematopoietic stem cell ‘stemness’ genes contain many genes mutated or abnormally expressed in leukemia. Stem cells. 23:1142–1153. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Wuchter C, Ratei R, Spahn G, Schoch C, Harbott J, Schnittger S, Haferlach T, Creutzig U, Sperling C, Karawajew L and Ludwig WD: Impact of CD133 (AC133) and CD90 expression analysis for acute leukemia immunophenotyping. Haematologica. 86:154–161. 2001.PubMed/NCBI

15 

Miraglia S, Godfrey W, Yin AH, Atkins K, Warnke R, Holden JT, Bray RA, Waller EK and Buck DW: A novel five-transmembrane hematopoietic stem cell antigen: Isolation, characterization, and molecular cloning. Blood. 90:5013–5021. 1997.PubMed/NCBI

16 

Horn PA, Tesch H, Staib P, Kube D, Diehl V and Voliotis D: Expression of AC133, a novel hematopoietic precursor antigen, on acute myeloid leukemia cells. Blood. 93:1435–1437. 1999.PubMed/NCBI

17 

Morrison SJ and Scadden DT: The bone marrow niche for haematopoietic stem cells. Nature. 505:327–334. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Sheppard D: In vivo functions of integrins: Lessons from null mutations in mice. Matrix Biol. 19:203–209. 2000. View Article : Google Scholar : PubMed/NCBI

19 

Möhle R, Murea S, Kirsch M and Haas R: Differential expression of L-selectin, VLA-4, and LFA-1 on CD34+ progenitor cells from bone marrow and peripheral blood during G-CSF-enhanced recovery. Exp Hematol. 23:1535–1542. 1995.PubMed/NCBI

20 

Baer MR, Stewart CC, Lawrence D, Arthur DC, Byrd JC, Davey FR, Schiffer CA and Bloomfield CD: Expression of the neural cell adhesion molecule CD56 is associated with short remission duration and survival in acute myeloid leukemia with t(8;21)(q22;q22). Blood. 90:1643–1648. 1997.PubMed/NCBI

21 

Gil ML, Vita N, Lebel-Binay S, Miloux B, Chalon P, Kaghad M, Marchiol-Fournigault C, Conjeaud H, Caput D, Ferrara P, et al: A member of the tetra spans transmembrane protein superfamily is recognized by a monoclonal antibody raised against an HLA class I-deficient, lymphokine-activated killer-susceptible, B lymphocyte line. Cloning and preliminary functional studies. J Immunol. 148:2826–2833. 1992.PubMed/NCBI

22 

Miranti CK: Controlling cell surface dynamics and signaling: How CD82/KAI1 suppresses metastasis. Cell Signal. 21:196–211. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Liu W, Iiizumi-Gairani M, Okuda H, Kobayashi A, Watabe M, Pai SK, Pandey PR, Xing F, Fukuda K, Modur V, et al: KAI1 gene is engaged in NDRG1 gene-mediated metastasis suppression through the ATF3-NFkappaB complex in human prostate cancer. J Biol Chem. 286:18949–18959. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Wu DH, Liu L, Chen LH and Ding YQ: KAI1 gene expression in colonic carcinoma and its clinical significances. World J Gastroenterol. 10:2245–2249. 2004.PubMed/NCBI

25 

Goncharuk VN, del-Rosario A, Kren L, Anwar S, Sheehan CE, Carlson JA and Ross JS: Co-downregulation of PTEN, KAI-1, and nm23-H1 tumor/metastasis suppressor proteins in non-small cell lung cancer. Ann Diagn Pathol. 8:6–16. 2004. View Article : Google Scholar : PubMed/NCBI

26 

Mooez S, Malik FA, Kayani MA, Rashid R, Zahid A and Khan A: Expressional alterations and transcript isoforms of metastasis suppressor genes (KAI1 and KiSS1) in breast cancer patients. Asian Pac J Cancer Prev. 12:2785–2791. 2011.PubMed/NCBI

27 

Burchert A, Notter M, Dietrich Menssen H, Schwartz S, Knauf W, Neubauer A and Thiel E: CD82 (KAI1), a member of the tetraspan family, is expressed on early haemopoietic progenitor cells and up-regulated in distinct human leukaemias. Br J Haematol. 107:494–504. 1999. View Article : Google Scholar : PubMed/NCBI

28 

Nishioka C, Ikezoe T, Furihata M, Yang J, Serada S, Naka T, Nobumoto A, Kataoka S, Tsuda M, Udaka K and Yokoyama A: CD34+/CD38− acute myelogenous leukemia cells aberrantly express CD82 which regulates adhesion and survival of leukemia stem cells. Int J Cancer. 132:2006–2019. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Vardiman JW: The World Health Organization (WHO) classification of tumors of the hematopoietic and lymphoid tissues: An overview with emphasis on the myeloid neoplasms. Chem Biol Interact. 184:16–20. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Liu X, Zou Y, Wang H, Chen X, Ruan M, Chen Y, Yang W, Guo Y, Liu T, Zhang L, et al: Treatment outcome of childhood standard-risk and median-risk acute lymphoblastic leukemia with CCLG-2008 protocol. Zhonghua Er Ke Za Zhi. 52:449–454. 2014.(In Chinese). PubMed/NCBI

31 

Jordan CT, Guzman ML and Noble M: Cancer stem cells. N Engl J Med. 355:1253–1261. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Dick JE: Stem cell concepts renew cancer research. Blood. 112:4793–4807. 2008. View Article : Google Scholar : PubMed/NCBI

33 

Guenova M and Balatzenko G: CD133-2 (AC141) expression analysis in acute leukemia immunophenotyping in correlation to CD34 and P-glycoprotein. Hematology. 13:137–141. 2008. View Article : Google Scholar : PubMed/NCBI

34 

Bene MC, Castoldi G, Knapp W, Ludwig WD, Matutes E, Orfao A and van't Veer MB: Proposals for the immunological classification of acute leukemias. European Group for the Immunological Characterization of Leukemias (EGIL). Leukemia. 9:1783–1786. 1995.PubMed/NCBI

35 

Gallacher L, Murdoch B, Wu DM, Karanu FN, Keeney M and Bhatia M: Isolation and characterization of human CD34(−)Lin(−) and CD34(+)Lin(−) hematopoietic stem cells using cell surface markers AC133 and CD7. Blood. 95:2813–2820. 2000.PubMed/NCBI

36 

Yamamuro S, Okamoto Y, Sano E, Ochiai Y, Ogino A, Ohta T, Hara H, Ueda T, Nakayama T, Yoshino A and Katayama Y: Characterization of glioma stem-like cells from human glioblastomas. Int J Oncol. 47:91–96. 2015.PubMed/NCBI

37 

Welte Y, Davies C, Schäfer R and Regenbrecht CR: Patient derived cell culture and isolation of CD133+ putative cancer stem cells from melanoma. J Vis Exp. e502002013.PubMed/NCBI

38 

Bahnassy AA, Fawzy M, El-Wakil M, Zekri AR, Abdel-Sayed A and Sheta M: Aberrant expression of cancer stem cell markers (CD44, CD90 and CD133) contributes to disease progression and reduced survival in hepatoblastoma patients: 4-year survival data. Transl Res. 165:396–406. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Li J, Zhong XY, Li ZY, Cai JF, Zou L, Li JM, Yang T and Liu W: CD133 expression in osteosarcoma and derivation of CD133+ cells. Mol Med Rep. 7:577–584. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Wang C, Xie J, Guo J, Manning HC, Gore JC and Guo N: Evaluation of CD44 and CD133 as cancer stem cell markers for colorectal cancer. Oncol Rep. 28:1301–1308. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Mak AB, Nixon AM and Moffat J: The mixed lineage leukemia (MLL) fusion-associated gene AF4 promotes CD133 transcription. Cancer Res. 72:1929–1934. 2012. View Article : Google Scholar : PubMed/NCBI

42 

Pellacani D, Packer RJ, Frame FM, Oldridge EE, Berry PA, Labarthe MC, Stower MJ, Simms MS, Collins AT and Maitland NJ: Regulation of the stem cell marker CD133 is independent of promoter hypermethylation in human epithelial differentiation and cancer. Mol Cancer. 10:942011. View Article : Google Scholar : PubMed/NCBI

43 

Nishioka C, Ikezoe T, Yang J, Nobumoto A, Kataoka S, Tsuda M, Udaka K and Yokoyama A: CD82 regulates STAT5/IL-10 and supports survival of acute myelogenous leukemia cells. Int J Cancer. 134:55–64. 2014. View Article : Google Scholar : PubMed/NCBI

44 

Nishioka C, Ikezoe T, Yang J and Yokoyama A: Tetraspanin family member, CD82, regulates expression of EZH2 via inactivation of p38 MAPK signaling in leukemia cells. PLoS One. 10:e01250172015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ji H, Chen L, Dai Y, Sun X, Li X, Wang Q, Ma D, Du D, Zhao P, Wang Y, Wang Y, et al: Aberrant expression of CD133 and CD82 in patients with pediatric acute lymphoblastic leukemia and the clinical significance. Oncol Lett 14: 5811-5818, 2017.
APA
Ji, H., Chen, L., Dai, Y., Sun, X., Li, X., Wang, Q. ... Wang, Y. (2017). Aberrant expression of CD133 and CD82 in patients with pediatric acute lymphoblastic leukemia and the clinical significance. Oncology Letters, 14, 5811-5818. https://doi.org/10.3892/ol.2017.6981
MLA
Ji, H., Chen, L., Dai, Y., Sun, X., Li, X., Wang, Q., Ma, D., Du, D., Zhao, P., Wang, Y."Aberrant expression of CD133 and CD82 in patients with pediatric acute lymphoblastic leukemia and the clinical significance". Oncology Letters 14.5 (2017): 5811-5818.
Chicago
Ji, H., Chen, L., Dai, Y., Sun, X., Li, X., Wang, Q., Ma, D., Du, D., Zhao, P., Wang, Y."Aberrant expression of CD133 and CD82 in patients with pediatric acute lymphoblastic leukemia and the clinical significance". Oncology Letters 14, no. 5 (2017): 5811-5818. https://doi.org/10.3892/ol.2017.6981
Copy and paste a formatted citation
x
Spandidos Publications style
Ji H, Chen L, Dai Y, Sun X, Li X, Wang Q, Ma D, Du D, Zhao P, Wang Y, Wang Y, et al: Aberrant expression of CD133 and CD82 in patients with pediatric acute lymphoblastic leukemia and the clinical significance. Oncol Lett 14: 5811-5818, 2017.
APA
Ji, H., Chen, L., Dai, Y., Sun, X., Li, X., Wang, Q. ... Wang, Y. (2017). Aberrant expression of CD133 and CD82 in patients with pediatric acute lymphoblastic leukemia and the clinical significance. Oncology Letters, 14, 5811-5818. https://doi.org/10.3892/ol.2017.6981
MLA
Ji, H., Chen, L., Dai, Y., Sun, X., Li, X., Wang, Q., Ma, D., Du, D., Zhao, P., Wang, Y."Aberrant expression of CD133 and CD82 in patients with pediatric acute lymphoblastic leukemia and the clinical significance". Oncology Letters 14.5 (2017): 5811-5818.
Chicago
Ji, H., Chen, L., Dai, Y., Sun, X., Li, X., Wang, Q., Ma, D., Du, D., Zhao, P., Wang, Y."Aberrant expression of CD133 and CD82 in patients with pediatric acute lymphoblastic leukemia and the clinical significance". Oncology Letters 14, no. 5 (2017): 5811-5818. https://doi.org/10.3892/ol.2017.6981
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