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Article

Artesunate inhibits proliferation and invasion of mouse hemangioendothelioma cells in vitro and of tumor growth in vivo

  • Authors:
    • Ning Wang
    • Hongxia Chen
    • Yinping Teng
    • Xionghui Ding
    • Huan Wu
    • Xianqing Jin
  • View Affiliations / Copyright

    Affiliations: Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Medical University, Yuzhong, Chongqing 400014, P.R. China
  • Pages: 6170-6176
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    Published online on: September 18, 2017
       https://doi.org/10.3892/ol.2017.6986
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Abstract

Artesunate has been demonstrated to be a novel potential antitumor agent in numerous studies. However, its efficacy in infantile hemangioma is unknown. The aim of the present study was to investigate the role of artesunate in the control of vascular tumor biological behavior and molecular mechanism using mouse hemangioendothelioma endothelial (EOMA) cells and a nude mouse model. Cell viability, apoptosis and invasion were determined by an MTT assay, flow cytometric analysis and Transwell invasion assay, respectively. Reverse transcription‑quantitative polymerase chain reaction and western blotting were utilized to examine the expression of genes and proteins. Inoculated EOMA cells were injected into the subcutaneous tissues of nude mice to observe the effect of artesunate therapy on the vascular tumor, an effect that was similar to that of pingyangmycin (PYM). It was identified that artesunate treatment (0‑600 µg/ml) inhibited cell growth in a time‑ and dose‑dependent manner. Artesunate at 300 µg/ml significantly reduced the proliferation and invasion of EOMA cells, and significantly decreased the expression of vascular endothelial growth factor (VEGF)‑A, VEGFR‑1, VEGFR‑2 and hypoxia inducible factor‑1α over time; caspase‑3 was simultaneously upregulated in vitro. Artesunate significantly inhibited tumor growth, and the curative effect was similar to that observed with PYM in vivo. It was concluded that artesunate could effectively inhibit the growth of vascular tumors, and thus could be a novel drug candidate for the treatment of infantile hemangioma.
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1 

Bruckner AL and VFrieden IJ: Hemangiomas of infancy. J Am Acad Dennatol. 48:477–496. 2003. View Article : Google Scholar

2 

Xu D, O TM, Shartava A, Fowles TC, Yang J, Fink LM, Ward DC, Mihm MC, Waner M and Ma Y: Isolation, characterization, and in vitro propagation of infantile hemangioma stem cells and an in vivo mouse model. J Hematol Oncol. 4:542011. View Article : Google Scholar : PubMed/NCBI

3 

Yasui N, Koh K, Kato M, Park MJ, Tomizawa D, Oshima K, Uchisaka N, Gocho Y, Arakawa A, Seki M, et al: Kasabach-Merritt phenomenon: A report of 11 cases from a single institution. J Pediatr Hematol Oncol. 35:554–558. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Fernandez-Pineda I, Lopez-Gutierrez JC, Chocarro G, Bernabeu-Wittel J and Ramirez-Villar GL: Long-term outcome of vincristine-aspirin-ticlopidine (VAT) therapy for vascular tumors associated with Kasabach-Merritt phenomenon. Pediatr Blood Cancer. 60:1478–1481. 2013. View Article : Google Scholar : PubMed/NCBI

5 

O'Regan GM, Irvine AD, Yao N, O'Marcaigh A, Sheridan-Pereira M, Phelan E, McDermott MB, Twomey A, Russell J and Watson R: Mediastinal and neck kaposiform hemangioendothelioma: Report of three cases. Pediatr Dermatol. 26:331–337. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Sarkar M, Mulliken JB, Kozakewich HP, Robertson RL and Burrows PE: Thrombocytopenic coagulopathy (Kasabach-Merritt phenomenon) is associated with kaposiform hemangioendothelioma and not with common infantile hemangioma. Plast Reconstr Surg. 100:1377–1386. 1997. View Article : Google Scholar : PubMed/NCBI

7 

Wang Z, Li K, Yao W, Dong K, Xiao X and Zheng S: Steroid-resistant kaposiform hemangioendothelioma: A retrospective study of 37 patients treated with vincristine and long-term follow-up. Pediatr Blood Cancer. 62:577–580. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Enjolras O, Wassef M, Mazoyer E, Frieden IJ, Rieu PN, Drouet L, Taïeb A, Stalder JF and Escande JP: Infants with Kasabach-Merritt syndrome do not have ‘true’ hemangiomas. J Pediatr. 130:631–640. 1997. View Article : Google Scholar : PubMed/NCBI

9 

Cooper JG, Edwards SL and Holmes JD: Kaposiform haemangioendothelioma: Case report and review of the literature. Br J Plast Surg. 55:163–165. 2002. View Article : Google Scholar : PubMed/NCBI

10 

Enjolras O, Mulliken JB, Wassef M, Frieden IJ, Rieu PN, Burrows PE, Salhi A, Léauté-Labreze C and Kozakewich HP: Residual lesions after Kasabach-Merritt phenomenon in 41 patients. J Am Acad Dermatol. 42:225–235. 2000. View Article : Google Scholar : PubMed/NCBI

11 

Hervella M and Iqlesias ME: Vascular tumors as syndromic indicators. An Sist Sanit Navar. 27(Suppl 1): S33–S44. 2004.(In Spanish).

12 

Haisley-Royster C, Enjolras O, Frieden IJ, Garzon M, Lee M, Oranje A, de Laat PC, Madern GC, Gonzalez F, Frangoul H, et al: Kasabach-Merritt phenomenon: A retrospective study of treatment with vincristine. J Pediatr Hematol/Oncol. 24:459–462. 2002. View Article : Google Scholar

13 

Greenberger S and Bisehoff J: Pathogenesis of infantile haemangioma. Br J Dermatol. 169:12–19. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Przewratil P, Sitkiewicz A and Andrzejewska E: Local serum levels of vascular endothelial growth factor in infantile hemangioma: Intriguing mechanism of endothelial growth. Cytokine. 49:141–147. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Koh GY: Orchestral actions of angiopoietin-1 in vascular regeneration. Trends Mol Med. 19:31–39. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Phng LK and Gerhardt H: Angiogenesis: A team effort coordinated by notch. Dev Cell. 16:196–208. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Laplante M and Sabatini DM: mTOR signaling in growth control and disease. Cell. 149:274–293. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Léauté-Labrèze C, Dumas de la Roque E, Hubiche T, Boralevi F, Thambo JB and Taïeb A: Propranolol for severe hemangiomas of infancy. N Engl J Med. 358:2649–2651. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Sagara I, Beavogui AH, Zongo I, Soulama I, Borghini-Fuhrer I, Fofana B, Camara D, Somé AF, Coulibaly AS, Traore OB, et al: Safety and efficacy of re-treatments with pyronaridine-artesunate in African patients with malaria: A sub study of the WANECAM randomised trial. Lancet Infect Dis. 16:189–198. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Efferth T, Li PC, Konkimalla VS and Kaina B: From traditional Chinese medicine to rational cancer therapy. Trends Mol Med. 13:353–361. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Zhang LX, Liu ZN, Ye J, Sha M, Qian H, Bu XH, Luan ZY, Xu XL, Huang AH, Yuan DL, et al: Artesunate exerts an anti-immunosuppressive effect on cervical cancer by inhibiting PGE2 production and Foxp3 expression. Cell Biol Int. 38:639–646. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Jeong DE, Song HJ, Lim S, Lee SJ, Lim JE, Nam DH, Joo KM, Jeong BC, Jeon SS, Choi HY and Lee HW: Repurposing the anti-malarial drug artesunate as a novel therapeutic agent for metastatic renal cell carcinoma due to its attenuation of tumor growth, metastasis, and angiogenesis. Oncotarget. 6:33046–33064. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Mukanganyama S, Naik YS, Widersten M, Mannervik B and Hasler JA: Proposed reductive metabolism of artemisinin by glutathione transferases in vitro. Free Radic Res. 35:427–434. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Wang C, Quevedo ME, Lannutti BJ, Gordon KB, Guo D, Sun W and Paller AS: In vivo gene therapy with interleukin-12 inhibits primary vascular tumor growth and induces apoptosis in a mouse model. J Invest Dermatol. 112:775–781. 1999. View Article : Google Scholar : PubMed/NCBI

25 

Sidbury R, Neuschler N, Neuschler E, Sun P, Wang XQ, Miller R, Tomai M, Puscasiu E, Gugneja S and Paller AS: Topically applied imiquimod inhibits vascular tumor growth in vivo. J Invest Dermatol. 121:1205–1209. 2003. View Article : Google Scholar : PubMed/NCBI

26 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

27 

Alvarez-Mendoza A, Lourdes TS, Ridaura-Sanz C and Ruiz-Maldonado R: Histopathology of vascular lesions found in Kasahach-Merritt syndrome: Review based on 13 cases. Pediatr Dev Pathol. 3:556–560. 2000. View Article : Google Scholar : PubMed/NCBI

28 

Hammill AM, Wentzel M, Gupta A, Nelson S, Lucky A, Elluru R, Dasgupta R, Azizkhan RG and Adams DM: Sirolimus for the treatment of complicated vascular anomalies in children. Pediatr Blood Cancer. 57:1018–1024. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Gordillo GM, Atalay M, Roy S and Sen CK: Hemangioma model for in vivo angiogenesis: Inducible oxidative stress and MCP-1 expression in EOMA cells. Methods Enzymol. 352:422–432. 2002. View Article : Google Scholar : PubMed/NCBI

30 

Lannutti BJ, Gately ST, Quevedo ME, Soff GA and Paller AS: Human angiostatin inhibits murine hemangioendothelioma tumor growth in vivo. Cancer Res. 57:5277–5280. 1997.PubMed/NCBI

31 

O'Reilly MS, Brem H and Folkman J: Treatment of murine hemangioendotheliomas with the angiogenesis inhibitor AGM-1470. J Pediatr Surg. 30:325–330. 1995. View Article : Google Scholar : PubMed/NCBI

32 

Breier G, Albrecht U, Sterrer S and Risau W: Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation. Development. 114:521–532. 1992.PubMed/NCBI

33 

O'Reilly MS, Holmgren L, Shing Y, Chen C, Rosenthal RA, Moses M, Lane WS, Cao Y, Sage EH and Folkman J: Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell. 79:315–328. 1994. View Article : Google Scholar : PubMed/NCBI

34 

O'Reilly MS, Boehm T, Shing Y, Fukai N, Vasios G, Lane WS, Flynn E, Birkhead JR, Olsen BR and Folkman J: Endostatin: An endogenous inhibitor of angiogenesis and tumor growth. Cell. 88:277–285. 1997. View Article : Google Scholar : PubMed/NCBI

35 

Dvorak HF, Brown LF, Detmar M and Dvorak AM: Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am J Pathol. 146:1029–1039. 1995.PubMed/NCBI

36 

Olsson AK, Dimberg A, Kreuger J and Claesson-Welsh L: VEGF receptor signalling-in control of vascular function. Nat Rev Mol Cell Biol. 7:359–371. 2006. View Article : Google Scholar : PubMed/NCBI

37 

Manalo DJ, Rowan A, Lavoie T, Natarajan L, Kelly BD, Ye SQ, Garcia JG and Semenza GL: Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1. Blood. 105:659–669. 2005. View Article : Google Scholar : PubMed/NCBI

38 

Ferrara N, Gerber HP and LeCouter J: The biology of VEGF and its receptors. Nat Med. 9:669–676. 2003. View Article : Google Scholar : PubMed/NCBI

39 

Jain RK: Molecular regulation of vessel maturation. Nat Med. 9:685–693. 2003. View Article : Google Scholar : PubMed/NCBI

40 

Iruela-Arispe ML and Dvorak HF: Angiogenesis: A dynamic balance of stimulators and inhibitors. Thromb Haemost. 78:672–677. 1997.PubMed/NCBI

41 

Chowdri NA, Darzi MA, Fazili Z and Iqbal S: Intralesional corticosteroid therapy for childhood cutaneous hemangiomas. Ann Plast Surg. 33:46–51. 1994. View Article : Google Scholar : PubMed/NCBI

42 

Cao X, He N, Sun J, Wang S, Ji X, Wang J, Zhang C, Yang J, Lu T, Li J and Zhang G: Interventional treatment of huge hepatic cavernous hemangioma. Chin Med J (Engl). 113:927–929. 2000.PubMed/NCBI

43 

Medici D and Olsen BR: Rapamycin inhibits proliferation of hemangioma endothelial cells by reducing HIF-1-dependent expression of VEGF. PLoS One. 7:e429132012. View Article : Google Scholar : PubMed/NCBI

44 

Chim H, Armijo BS, Miller E, Gliniak C, Serret MA and Gosain AK: Propranolol induces regression of hemangioma cells through HIF-1α-mediated inhibition of VEGF-A. Ann Surg. 256:146–156. 2012. View Article : Google Scholar : PubMed/NCBI

45 

Yang ND, Tan SH, Ng S, Shi Y, Zhou J, Tan KS, Wong WS and Shen HM: Artesunate induces cell death in human cancer cells via enhancing lysosomal function and lysosomal degradation of ferritin. J Biol Chem. 289:33425–33441. 2014. View Article : Google Scholar : PubMed/NCBI

46 

Efferth T, Dunstan H, Sauerbrey A, Miyachi H and Chitambar CR: The anti-malarial artesunate is also active against cancer. Int J Oncol. 18:767–773. 2001.PubMed/NCBI

47 

Chemical studies on qinghaosu (artemisinine), . China cooperative research group on qinghaosu and its derivatives as antimalarials. J Tradit Chin Med. 2:3–8. 1982.PubMed/NCBI

48 

Douglas NM, Anstey NM, Angus BJ, Nosten F and Price RN: Artemisinin combination therapy for vivax malaria. Lancet Infect Dis. 10:405–416. 2010. View Article : Google Scholar : PubMed/NCBI

49 

Chan K: Chinese medicinal materials and their interface with Western medical concepts. J Ethnopharmacol. 96:1–18. 2005. View Article : Google Scholar : PubMed/NCBI

50 

Hanahan D and Weinberg RA: Hallmarks of cancer: The next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI

51 

Aggarwal C, Somaiah N and Simon G: Antiangiogenic agents in the management of non-small cell lung cancer: Where do we stand now and where are we headed? Cancer Biol Ther. 13:247–263. 2012. View Article : Google Scholar : PubMed/NCBI

52 

Imai K and Takaoka A: Comparing antibody and small-molecule therapies for cancer. Nat Rev Cancer. 6:714–727. 2006. View Article : Google Scholar : PubMed/NCBI

53 

Zhou HJ, Wang WQ, Wu GD, Lee J and Li A: Artesunate inhibits angiogenesis and downregulates vascular endothelial growth factor expression in chronic myeloid leukemia K562 cells. Vascul Pharmacol. 47:131–138. 2007. View Article : Google Scholar : PubMed/NCBI

54 

Liao K, Li J and Wang Z: Dihydroartemisinin inhibits cell proliferation via AKT/GSK3β/cyclinD1 pathway and induces apoptosis in A549 lung cancer cells. Int J Clin Exp Pathol. 7:8684–8691. 2014.PubMed/NCBI

55 

Tong Y, Liu Y, Zheng H, Zheng L, Liu W, Wu J, Ou R, Zhang G, Li F, Hu M, et al: Artemisinin and its derivatives can significantly inhibit lung tumorigenesis and tumor metastasis through Wnt/β-catenin signaling. Oncotarget. 7:31413–31428. 2016. View Article : Google Scholar : PubMed/NCBI

56 

Ma H, Yao Q, Zhang AM, Lin S, Wang XX, Wu L, Sun JG and Chen ZT: The effects of artesunate on the expression of EGFR and ABCG2 in A549 human lung cancer cells and a xenograft model. Molecules. 16:10556–10569. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang N, Chen H, Teng Y, Ding X, Wu H and Jin X: Artesunate inhibits proliferation and invasion of mouse hemangioendothelioma cells in vitro and of tumor growth in vivo. Oncol Lett 14: 6170-6176, 2017.
APA
Wang, N., Chen, H., Teng, Y., Ding, X., Wu, H., & Jin, X. (2017). Artesunate inhibits proliferation and invasion of mouse hemangioendothelioma cells in vitro and of tumor growth in vivo. Oncology Letters, 14, 6170-6176. https://doi.org/10.3892/ol.2017.6986
MLA
Wang, N., Chen, H., Teng, Y., Ding, X., Wu, H., Jin, X."Artesunate inhibits proliferation and invasion of mouse hemangioendothelioma cells in vitro and of tumor growth in vivo". Oncology Letters 14.5 (2017): 6170-6176.
Chicago
Wang, N., Chen, H., Teng, Y., Ding, X., Wu, H., Jin, X."Artesunate inhibits proliferation and invasion of mouse hemangioendothelioma cells in vitro and of tumor growth in vivo". Oncology Letters 14, no. 5 (2017): 6170-6176. https://doi.org/10.3892/ol.2017.6986
Copy and paste a formatted citation
x
Spandidos Publications style
Wang N, Chen H, Teng Y, Ding X, Wu H and Jin X: Artesunate inhibits proliferation and invasion of mouse hemangioendothelioma cells in vitro and of tumor growth in vivo. Oncol Lett 14: 6170-6176, 2017.
APA
Wang, N., Chen, H., Teng, Y., Ding, X., Wu, H., & Jin, X. (2017). Artesunate inhibits proliferation and invasion of mouse hemangioendothelioma cells in vitro and of tumor growth in vivo. Oncology Letters, 14, 6170-6176. https://doi.org/10.3892/ol.2017.6986
MLA
Wang, N., Chen, H., Teng, Y., Ding, X., Wu, H., Jin, X."Artesunate inhibits proliferation and invasion of mouse hemangioendothelioma cells in vitro and of tumor growth in vivo". Oncology Letters 14.5 (2017): 6170-6176.
Chicago
Wang, N., Chen, H., Teng, Y., Ding, X., Wu, H., Jin, X."Artesunate inhibits proliferation and invasion of mouse hemangioendothelioma cells in vitro and of tumor growth in vivo". Oncology Letters 14, no. 5 (2017): 6170-6176. https://doi.org/10.3892/ol.2017.6986
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