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Review

Advances in targeting the transforming growth factor β1 signaling pathway in lung cancer radiotherapy (Review)

  • Authors:
    • Zhonghua Lu
    • Yiting Tang
    • Judong Luo
    • Shuyu Zhang
    • Xifa Zhou
    • Lei Fu
  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, Changzhou Cancer Hospital, Soochow University, Changzhou, Jiangsu 213001, P.R. China, Department of Radiation Biology, School of Radiation Medicine and Protection and Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou, Jiangsu 215123, P.R. China, Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan, Shandong 250117, P.R. China
  • Pages: 5681-5687
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    Published online on: September 18, 2017
       https://doi.org/10.3892/ol.2017.6991
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Abstract

Lung cancer was demonstrated to be the most lethal type of malignant tumor amongst humans in the global cancer statistics of 2012. As one of the primary treatments, radiotherapy has been reported to induce remission in, and even cure, patients with lung cancer. However, the side effects of radiotherapy may prove lethal in certain patients. In past decades, the transforming growth factor β1 (TGFB1) signaling pathway has been revealed to serve multiple functions in the control of lung cancer progression and the radiotherapy response. In mammals, this signaling pathway is initiated through activation of the TGFB1 receptor complex, which signals via cytoplasmic SMAD proteins or other downstream signaling pathways. Multiple studies have demonstrated that TGFB1 serves important functions in lung cancer radiotherapy. The present study summarized and reviewed recent progress in elucidating the function of the TGFB1 signaling pathway in predicting radiation pneumonitis, as well as current strategies for targeting the TGFB1 signaling pathway in lung cancer radiotherapy, which may provide potential targets for lung cancer therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Lu Z, Tang Y, Luo J, Zhang S, Zhou X and Fu L: Advances in targeting the transforming growth factor β1 signaling pathway in lung cancer radiotherapy (Review). Oncol Lett 14: 5681-5687, 2017.
APA
Lu, Z., Tang, Y., Luo, J., Zhang, S., Zhou, X., & Fu, L. (2017). Advances in targeting the transforming growth factor β1 signaling pathway in lung cancer radiotherapy (Review). Oncology Letters, 14, 5681-5687. https://doi.org/10.3892/ol.2017.6991
MLA
Lu, Z., Tang, Y., Luo, J., Zhang, S., Zhou, X., Fu, L."Advances in targeting the transforming growth factor β1 signaling pathway in lung cancer radiotherapy (Review)". Oncology Letters 14.5 (2017): 5681-5687.
Chicago
Lu, Z., Tang, Y., Luo, J., Zhang, S., Zhou, X., Fu, L."Advances in targeting the transforming growth factor β1 signaling pathway in lung cancer radiotherapy (Review)". Oncology Letters 14, no. 5 (2017): 5681-5687. https://doi.org/10.3892/ol.2017.6991
Copy and paste a formatted citation
x
Spandidos Publications style
Lu Z, Tang Y, Luo J, Zhang S, Zhou X and Fu L: Advances in targeting the transforming growth factor β1 signaling pathway in lung cancer radiotherapy (Review). Oncol Lett 14: 5681-5687, 2017.
APA
Lu, Z., Tang, Y., Luo, J., Zhang, S., Zhou, X., & Fu, L. (2017). Advances in targeting the transforming growth factor β1 signaling pathway in lung cancer radiotherapy (Review). Oncology Letters, 14, 5681-5687. https://doi.org/10.3892/ol.2017.6991
MLA
Lu, Z., Tang, Y., Luo, J., Zhang, S., Zhou, X., Fu, L."Advances in targeting the transforming growth factor β1 signaling pathway in lung cancer radiotherapy (Review)". Oncology Letters 14.5 (2017): 5681-5687.
Chicago
Lu, Z., Tang, Y., Luo, J., Zhang, S., Zhou, X., Fu, L."Advances in targeting the transforming growth factor β1 signaling pathway in lung cancer radiotherapy (Review)". Oncology Letters 14, no. 5 (2017): 5681-5687. https://doi.org/10.3892/ol.2017.6991
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