Advances in targeting the transforming growth factor β1 signaling pathway in lung cancer radiotherapy (Review)

  • Authors:
    • Zhonghua Lu
    • Yiting Tang
    • Judong Luo
    • Shuyu Zhang
    • Xifa Zhou
    • Lei Fu
  • View Affiliations

  • Published online on: September 18, 2017     https://doi.org/10.3892/ol.2017.6991
  • Pages: 5681-5687
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Lung cancer was demonstrated to be the most lethal type of malignant tumor amongst humans in the global cancer statistics of 2012. As one of the primary treatments, radiotherapy has been reported to induce remission in, and even cure, patients with lung cancer. However, the side effects of radiotherapy may prove lethal in certain patients. In past decades, the transforming growth factor β1 (TGFB1) signaling pathway has been revealed to serve multiple functions in the control of lung cancer progression and the radiotherapy response. In mammals, this signaling pathway is initiated through activation of the TGFB1 receptor complex, which signals via cytoplasmic SMAD proteins or other downstream signaling pathways. Multiple studies have demonstrated that TGFB1 serves important functions in lung cancer radiotherapy. The present study summarized and reviewed recent progress in elucidating the function of the TGFB1 signaling pathway in predicting radiation pneumonitis, as well as current strategies for targeting the TGFB1 signaling pathway in lung cancer radiotherapy, which may provide potential targets for lung cancer therapy.
View Figures
View References

Related Articles

Journal Cover

November-2017
Volume 14 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Lu Z, Tang Y, Luo J, Zhang S, Zhou X and Fu L: Advances in targeting the transforming growth factor β1 signaling pathway in lung cancer radiotherapy (Review). Oncol Lett 14: 5681-5687, 2017
APA
Lu, Z., Tang, Y., Luo, J., Zhang, S., Zhou, X., & Fu, L. (2017). Advances in targeting the transforming growth factor β1 signaling pathway in lung cancer radiotherapy (Review). Oncology Letters, 14, 5681-5687. https://doi.org/10.3892/ol.2017.6991
MLA
Lu, Z., Tang, Y., Luo, J., Zhang, S., Zhou, X., Fu, L."Advances in targeting the transforming growth factor β1 signaling pathway in lung cancer radiotherapy (Review)". Oncology Letters 14.5 (2017): 5681-5687.
Chicago
Lu, Z., Tang, Y., Luo, J., Zhang, S., Zhou, X., Fu, L."Advances in targeting the transforming growth factor β1 signaling pathway in lung cancer radiotherapy (Review)". Oncology Letters 14, no. 5 (2017): 5681-5687. https://doi.org/10.3892/ol.2017.6991