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Article

NUDT expression is predictive of prognosis in patients with clear cell renal cell carcinoma

  • Authors:
    • Yue Wang
    • Fangning Wan
    • Kun Chang
    • Xiaolin Lu
    • Bo Dai
    • Dingwei Ye
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Fudan University Shanghai Cancer Center, Shanghai 20032, P.R. China
  • Pages: 6121-6128
    |
    Published online on: September 18, 2017
       https://doi.org/10.3892/ol.2017.6997
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Abstract

The nudix hydroxylase (NUDT) family of genes may have notable roles in cancer growth and metastasis. The present study aimed to determine the prognostic ability of NUDT genes in clear cell renal cell carcinoma (ccRCC). Data from 509 patients with ccRCC was obtained from The Cancer Genome Atlas (TCGA) database and 192 patient samples from Fudan University Shanghai Cancer Center (FUSCC) were analyzed in the present study. The expression profile of NUDT gene family members in the TCGA cohort was obtained from the TCGA RNA sequencing database. Pathological characteristics, including age, sex, tumor size, tumor grade, stage, laterality and overall survival were collected. Cox proportional hazards regression model and Kaplan‑Meier survival analysis were performed to assess the associations between pathological characteristics and expression levels of NUDT family genes. NUDT family genes that exhibited associations with overall survival (OS) were further validated in the FUSCC cohort. In the TCGA cohort, Cox proportional hazards analysis found that NUDT5 [hazards ratio (HR)=1.676; 95% confidence interval (CI), 1.097‑2.559] and NUDT17 (HR=1.375; 95% CI, 1.092‑1.732) were predictive of ccRCC prognosis. Further analysis revealed that low NUDT5 (P<0.0001) and NUDT17 (P<0.0001) expression were associated with poorer OS rates in the TCGA cohort. In the FUSCC cohort, low NUDT5 expression was also associated with poor OS rates (P=0.0116), and tumor grade was a factor that influenced the expression level of NUDT5 (P=0.016).
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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Wan F, Chang K, Lu X, Dai B and Ye D: NUDT expression is predictive of prognosis in patients with clear cell renal cell carcinoma. Oncol Lett 14: 6121-6128, 2017.
APA
Wang, Y., Wan, F., Chang, K., Lu, X., Dai, B., & Ye, D. (2017). NUDT expression is predictive of prognosis in patients with clear cell renal cell carcinoma. Oncology Letters, 14, 6121-6128. https://doi.org/10.3892/ol.2017.6997
MLA
Wang, Y., Wan, F., Chang, K., Lu, X., Dai, B., Ye, D."NUDT expression is predictive of prognosis in patients with clear cell renal cell carcinoma". Oncology Letters 14.5 (2017): 6121-6128.
Chicago
Wang, Y., Wan, F., Chang, K., Lu, X., Dai, B., Ye, D."NUDT expression is predictive of prognosis in patients with clear cell renal cell carcinoma". Oncology Letters 14, no. 5 (2017): 6121-6128. https://doi.org/10.3892/ol.2017.6997
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Wan F, Chang K, Lu X, Dai B and Ye D: NUDT expression is predictive of prognosis in patients with clear cell renal cell carcinoma. Oncol Lett 14: 6121-6128, 2017.
APA
Wang, Y., Wan, F., Chang, K., Lu, X., Dai, B., & Ye, D. (2017). NUDT expression is predictive of prognosis in patients with clear cell renal cell carcinoma. Oncology Letters, 14, 6121-6128. https://doi.org/10.3892/ol.2017.6997
MLA
Wang, Y., Wan, F., Chang, K., Lu, X., Dai, B., Ye, D."NUDT expression is predictive of prognosis in patients with clear cell renal cell carcinoma". Oncology Letters 14.5 (2017): 6121-6128.
Chicago
Wang, Y., Wan, F., Chang, K., Lu, X., Dai, B., Ye, D."NUDT expression is predictive of prognosis in patients with clear cell renal cell carcinoma". Oncology Letters 14, no. 5 (2017): 6121-6128. https://doi.org/10.3892/ol.2017.6997
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