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Article Open Access

A five‑gene based risk score with high prognostic value in colorectal cancer

  • Authors:
    • Yida Pan
    • Hongyang Zhang
    • Mingming Zhang
    • Jie Zhu
    • Jianghong Yu
    • Bangting Wang
    • Jigang Qiu
    • Jun Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Digestive Diseases, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China, Department of Gastroenterology, Nanjing Drum Tower Hospital, Nanjing University, Nanjing 210008, P.R. China, Department of General Surgery, Huadong Hospital, Fudan University, Shanghai 200040, P.R. China
    Copyright: © Pan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 6724-6734
    |
    Published online on: September 28, 2017
       https://doi.org/10.3892/ol.2017.7097
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Abstract

Colorectal cancer (CRC) is one of the most frequently occurring malignancies worldwide. The outcomes of patients with similar clinical symptoms or at similar pathological stages remain unpredictable. This inherent clinical diversity is most likely due to the genetic heterogeneity. The present study aimed to create a predicting tool to evaluate patient survival based on genetic profile. Firstly, three Gene Expression Omnibus (GEO) datasets (GSE9348, GSE44076 and GSE44861) were utilized to identify and validate differentially expressed genes (DEGs) in CRC. The GSE14333 dataset containing survival information was then introduced in order to screen and verify prognosis‑associated genes. Of the 66 DEGs, the present study screened out 46 biomarkers closely associated to patient overall survival. By Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analysis, it was demonstrated that these genes participated in multiple biological processes which were highly associated with cancer proliferation, drug‑resistance and metastasis, thus further affecting patient survival. The five most important genes, MET proto‑oncogene, receptor tyrosine kinase, carboxypeptidase M, serine hydroxymethyltransferase 2, guanylate cyclase activator 2B and sodium voltage‑gated channel a subunit 9 were selected by a random survival forests algorithm, and were further made up to a linear risk score formula by multivariable cox regression. Finally, the present study tested and verified this risk score within three independent GEO datasets (GSE14333, GSE17536 and GSE29621), and observed that patients with a high risk score had a lower overall survival (P<0.05). Furthermore, this risk score was the most significant compared with other predicting factors including age and American Joint Committee on Cancer stage, in the model, and was able to predict patient survival independently and directly. The findings suggest that this survival associated DEGs‑based risk score is a powerful and accurate prognostic tool and is promisingly implemented in a clinical setting.
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1 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Siegel RL, Miller KD and Jemal A: Cancer Statistics, 2017. CA Cancer J Clin. 67:7–30. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Frampton M and Houlston RS: Modeling the prevention of colorectal cancer from the combined impact of host and behavioral risk factors. Genet Med. 19:314–321. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Inadomi JM: Screening for colorectal neoplasia. N Engl J Med. 376:149–156. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Chang W, Gao X, Han Y, Du Y, Liu Q, Wang L, Tan X, Zhang Q, Liu Y, Zhu Y, et al: Gene expression profiling-derived immunohistochemistry signature with high prognostic value in colorectal carcinoma. Gut. 63:1457–1467. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Shahid M, Choi TG, Nguyen MN, Matondo A, Jo YH, Yoo JY, Nguyen NN, Yun HR, Kim J, Akter S, et al: An 8-gene signature for prediction of prognosis and chemoresponse in non-small cell lung cancer. Oncotarget. 7:86561–86572. 2016.PubMed/NCBI

7 

Francois-Vaughan H, Adebayo AO, Brilliant KE, Parry NMA, Gruppuso PA and Sanders JA: Persistent effect of mTOR inhibition on preneoplastic foci progression and gene expression in a rat model of hepatocellular carcinoma. Carcinogenesis. 37:408–419. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Baek SJ, Sato K, Nishida N, Koseki J, Azuma R, Kawamoto K, Konno M, Hayashi K, Satoh T, Doki Y, et al: MicroRNA miR-374, a potential radiosensitizer for carbon ion beam radiotherapy. Oncol Rep. 36:2946–2950. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Paula LM, De Moraes LH, Do Canto AL, Dos Santos L, Martin AA, Rogatto SR and De Azevedo Canevari R: Analysis of molecular markers as predictive factors of lymph node involvement in breast carcinoma. Oncol Lett. 13:488–496. 2017.PubMed/NCBI

10 

Li G, Li X, Yang M, Xu L, Deng S and Ran L: Prediction of biomarkers of oral squamous cell carcinoma using microarray technology. Sci Rep. 7:421052017. View Article : Google Scholar : PubMed/NCBI

11 

Viziteu E, Klein B, Basbous J, Lin YL, Hirtz C, Gourzones C, Tiers L, Bruyer A, Vincent L, Grandmougin C, et al: RECQ1 helicase is involved in replication stress survival and drug resistance in multiple myeloma. Leukemia. Mar 10–2017.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

12 

Wu J, Wang J and Shen W: Identification of MAGEA12 as a prognostic outlier gene in gastric cancers. Neoplasma. 64:238–243. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Jo J, Nam CM, Sull JW, Yun JE, Kim SY, Lee SJ, Kim YN, Park EJ, Kimm H and Jee SH: Prediction of colorectal cancer risk using a genetic risk score: The Korean cancer prevention study-II (KCPS-II). Genomics Inform. 10:175–183. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Ito H, Mo Q, Qin LX, Viale A, Maithel SK, Maker AV, Shia J, Kingham P, Allen P, DeMatteo RP, et al: Gene expression profiles accurately predict outcome following liver resection in patients with metastatic colorectal cancer. PLoS One. 8:e816802013. View Article : Google Scholar : PubMed/NCBI

15 

Mármol I, Sánchez-de-Diego C, Dieste Pradilla A, Cerrada E and Yoldi Rodriguez MJ: Colorectal carcinoma: A general overview and future perspectives in colorectal cancer. Int J Mol Sci. 18:pii:E1972017. View Article : Google Scholar

16 

Zhu Q, Izumchenko E, Aliper AM, Makarev E, Paz K, Buzdin AA, Zhavoronkov AA and Sidransky D: Pathway activation strength is a novel independent prognostic biomarker for cetuximab sensitivity in colorectal cancer patients. Hum Genome Var. 2:150092015. View Article : Google Scholar : PubMed/NCBI

17 

Zhu T, Gao YF, Chen YX, Wang ZB, Yin JY, Mao XY, Li X, Zhang W, Zhou HH and Liu ZQ: Genome-scale analysis identifies GJB2 and ERO1LB as prognosis markers in patients with pancreatic cancer. Oncotarget. 8:21281–21289. 2017.PubMed/NCBI

18 

Tabas-Madrid D, Nogales-Cadenas R and Pascual-Montano A: GeneCodis3: A non-redundant and modular enrichment analysis tool for functional genomics. Nucleic Acids Res. 40:W478–W483. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Gruber-Rouh T, Marko C, Thalhammer A, Nour-Eldin NE, Langenbach M, Beeres M, Naguib NN, Zangos S and Vogl TJ: Current strategies in interventional oncology of colorectal liver metastases. Br J Radiol. May 26–2016.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

20 

Song N, Shin A, Park JW, Kim J and Oh JH: Common risk variants for colorectal cancer: An evaluation of associations with age at cancer onset. Sci Rep. 7:406442017. View Article : Google Scholar : PubMed/NCBI

21 

Slattery ML, Herrick JS, Mullany LE, Gertz J and Wolff RK: Improved survival among colon cancer patients with increased differentially expressed pathways. BMC Med. 13:752015. View Article : Google Scholar : PubMed/NCBI

22 

Dong G, Mao Q, Yu D, Zhang Y, Qiu M, Dong G, Chen Q, Xia W, Wang J, Xu L and Jiang F: Integrative analysis of copy number and transcriptional expression profiles in esophageal cancer to identify a novel driver gene for therapy. Sci Rep. 7:420602017. View Article : Google Scholar : PubMed/NCBI

23 

Gao B, Shao Q, Choudhry H, Marcus V, Dong K, Ragoussis J and Gao ZH: Weighted gene co-expression network analysis of colorectal cancer liver metastasis genome sequencing data and screening of anti-metastasis drugs. Int J Oncol. 49:1108–1118. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Xiong W, Gao D, Li Y, Liu X, Dai P, Qin J, Wang G, Li K, Bai H and Li W: Genome-wide profiling of chemoradiation-induced changes in alternative splicing in colon cancer cells. Oncol Rep. 36:2142–2150. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Huang H, Jiang X, Wang J, Li Y, Song CX, Chen P, Li S, Gurbuxani S, Arnovitz S, Wang Y, et al: Identification of MLL-fusion/MYC-miR-26-TET1 signaling circuit in MLL-rearranged leukemia. Cancer Lett. 372:157–165. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Zhu XL, Ai ZH, Wang J, Xu YL and Teng YC: Weighted gene co-expression network analysis in identification of endometrial cancer prognosis markers. Asian Pac J Cancer Prev. 13:4607–4611. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Bradley CA, Dunne PD, Bingham V, McQuaid S, Khawaja H, Craig S, James J, Moore WL, McArt DG, Lawler M, et al: Transcriptional upregulation of c-MET is associated with invasion and tumor budding in colorectal cancer. Oncotarget. 7:78932–78945. 2016.PubMed/NCBI

28 

Gayyed MF, Abd El-Maqsoud NM, El-Heeny El-Hameed AA and Mohammed MF: c-MET expression in colorectal adenomas and primary carcinomas with its corresponding metastases. J Gastrointest Oncol. 6:618–627. 2015.PubMed/NCBI

29 

Raghav K, Morris V, Tang C, Morelli P, Amin HM, Chen K, Manyam GC, Broom B, Overman MJ, Shaw K, et al: MET amplification in metastatic colorectal cancer: An acquired response to EGFR inhibition, not a de novo phenomenon. Oncotarget. 7:54627–54631. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Al-Maghrabi J, Emam E, Gomaa W, Saggaf M, Buhmeida A, Al-Qahtani M and Al-Ahwal M: c-MET immunostaining in colorectal carcinoma is associated with local disease recurrence. BMC Cancer. 15:6762015. View Article : Google Scholar : PubMed/NCBI

31 

Takahashi N, Iwasa S, Taniguchi H, Sasaki Y, Shoji H, Honma Y, Takashima A, Okita N, Kato K, Hamaguchi T, et al: Prognostic role of ERBB2, MET and VEGFA expression in metastatic colorectal cancer patients treated with anti-EGFR antibodies. Br J Cancer. 114:1003–1011. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Jia Y, Dai G, Wang J, Gao X, Zhao Z, Duan Z, Gu B, Yang W, Wu J, Ju Y, et al: c-MET inhibition enhances the response of the colorectal cancer cells to irradiation in vitro and in vivo. Oncol Lett. 11:2879–2885. 2016.PubMed/NCBI

33 

Sun Y, Sun L, An Y and Shen X: Cabozantinib, a Novel c-Met Inhibitor, inhibits colorectal cancer development in a Xenograft model. Med Sci Monit. 21:2316–2321. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Lu D, Yao Q, Zhan C, Le-Meng Z, Liu H, Cai Y, Tu C, Li X, Zou Y and Zhang S: MicroRNA-146a promote cell migration and invasion in human colorectal cancer via carboxypeptidase M/src-FAK pathway. Oncotarget. 8:22674–22684. 2017.PubMed/NCBI

35 

Denis CJ and Lambeir AM: The potential of carboxypeptidase M as a therapeutic target in cancer. Expert Opin Ther Targets. 17:265–279. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Wang B, Wang W, Zhu Z, Zhang X, Tang F, Wang D, Liu X, Yan X and Zhuang H: Mitochondrial serine hydroxymethyltransferase 2 is a potential diagnostic and prognostic biomarker for human glioma. Clin Neurol Neurosurg. 154:28–33. 2017. View Article : Google Scholar : PubMed/NCBI

37 

Zhang L, Chen Z, Xue D, Zhang Q, Liu X, Luh F, Hong L, Zhang H, Pan F, Liu Y, et al: Prognostic and therapeutic value of mitochondrial serine hydroxyl-methyltransferase 2 as a breast cancer biomarker. Oncol Rep. 36:2489–2500. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Kim D, Fiske BP, Birsoy K, Freinkman E, Kami K, Possemato RL, Chudnovsky Y, Pacold ME, Chen WW, Cantor JR, et al: SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance. Nature. 520:363–367. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Pan Y, Zhang H, Zhang M, Zhu J, Yu J, Wang B, Qiu J and Zhang J: A five‑gene based risk score with high prognostic value in colorectal cancer. Oncol Lett 14: 6724-6734, 2017.
APA
Pan, Y., Zhang, H., Zhang, M., Zhu, J., Yu, J., Wang, B. ... Zhang, J. (2017). A five‑gene based risk score with high prognostic value in colorectal cancer. Oncology Letters, 14, 6724-6734. https://doi.org/10.3892/ol.2017.7097
MLA
Pan, Y., Zhang, H., Zhang, M., Zhu, J., Yu, J., Wang, B., Qiu, J., Zhang, J."A five‑gene based risk score with high prognostic value in colorectal cancer". Oncology Letters 14.6 (2017): 6724-6734.
Chicago
Pan, Y., Zhang, H., Zhang, M., Zhu, J., Yu, J., Wang, B., Qiu, J., Zhang, J."A five‑gene based risk score with high prognostic value in colorectal cancer". Oncology Letters 14, no. 6 (2017): 6724-6734. https://doi.org/10.3892/ol.2017.7097
Copy and paste a formatted citation
x
Spandidos Publications style
Pan Y, Zhang H, Zhang M, Zhu J, Yu J, Wang B, Qiu J and Zhang J: A five‑gene based risk score with high prognostic value in colorectal cancer. Oncol Lett 14: 6724-6734, 2017.
APA
Pan, Y., Zhang, H., Zhang, M., Zhu, J., Yu, J., Wang, B. ... Zhang, J. (2017). A five‑gene based risk score with high prognostic value in colorectal cancer. Oncology Letters, 14, 6724-6734. https://doi.org/10.3892/ol.2017.7097
MLA
Pan, Y., Zhang, H., Zhang, M., Zhu, J., Yu, J., Wang, B., Qiu, J., Zhang, J."A five‑gene based risk score with high prognostic value in colorectal cancer". Oncology Letters 14.6 (2017): 6724-6734.
Chicago
Pan, Y., Zhang, H., Zhang, M., Zhu, J., Yu, J., Wang, B., Qiu, J., Zhang, J."A five‑gene based risk score with high prognostic value in colorectal cancer". Oncology Letters 14, no. 6 (2017): 6724-6734. https://doi.org/10.3892/ol.2017.7097
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