Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
December-2017 Volume 14 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2017 Volume 14 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Elevation of serum CEA and CA15‑3 levels during antitumor therapy predicts poor therapeutic response in advanced breast cancer patients

  • Authors:
    • Yue Yang
    • Huijuan Zhang
    • Mingyan Zhang
    • Qingwei Meng
    • Li Cai
    • Qingyuan Zhang
  • View Affiliations / Copyright

    Affiliations: Institute of Cancer Prevention and Treatment, Harbin Medical University, Harbin, Heilongjiang 150081, P.R. China, Fourth Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang 150040, P.R. China, Laboratory Department, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang 150040, P.R. China, Institute of Cancer Prevention and Treatment, Harbin Medical University, Harbin, Heilongjiang 150040, P.R. China
  • Pages: 7549-7556
    |
    Published online on: October 10, 2017
       https://doi.org/10.3892/ol.2017.7164
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to assess the correlation between therapeutic response and carcinoembryonic antigen (CEA) and carbohydrate antigen 15‑3 (CA15‑3) levels in advanced breast cancer patients with non‑assessable lesions or stable disease (SD) according to the Response Evaluation Criteria in Solid Tumors. A total of 232 female patients with recurrent tumors following radical mastectomy were recruited, including 76 patients with non‑assessable lesions and 60 patients with SD. The correlation between CEA and CA15‑3 changes, progression‑free survival (PFS) and therapeutic response were analyzed in the non‑assessable and SD patient groups. For all subjects, the association between the patients' serum tumor markers levels and the clinical presentation of the tumor, as well as the correlation between initial tumor marker levels and PFS, were analyzed. An increase in CEA (an increment of >2 ng/ml) or CA15‑3 levels (an increase of >15 U/ml) following the second cycle of treatment correlated with shorter PFS in both non‑assessable and SD patients, and with poor clinical outcome in SD patients. High CA15‑3 levels correlated with hormone receptor‑positive tumors, multiple metastases and liver metastases. Bone metastases correlated with high levels of both CEA and CA15‑3. Relatively low CEA and CA15‑3 concentrations were associated with triple‑negative and locally invasive tumors. High CEA and CA15‑3 levels at the beginning of relapse correlated with shorter PFS. The present study illustrates that CEA and CA15‑3 levels correlate with several factors in recurrent breast cancer patients. Elevated levels of CEA and CA15‑3 at the beginning of relapse may predict shorter PFS. Furthermore, elevation of CEA and CA15‑3 levels following the second therapeutic cycle predict poor therapeutic response in patients with non‑assessable lesions and SD. Our findings suggest that alterations in CEA and CA15‑3 levels can predict therapeutic response in advanced breast cancer patients.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Siegel R, DeSantis C, Virgo K, Stein K, Mariotto A, Smith T, Cooper D, Gansler T, Lerro C, Fedewa S, et al: Cancer treatment and survivorship statistics, 2012. CA Cancer J Clin. 62:220–241. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Esteva FJ, Valero V, Pusztai L, Boehnke-Michaud L, Buzdar AU and Hortobagyi GN: Chemotherapy of metastatic breast cancer: What to expect in 2001 and beyond. Oncologist. 6:133–146. 2001. View Article : Google Scholar : PubMed/NCBI

3 

Robertson JF, Jaeger W, Syzmendera JJ, Selby C, Coleman R, Howell A, Winstanley J, Jonssen PE, Bombardieri E, Sainsbury JR, et al: European Group for Serum Tumour Markers in Breast Cancer: The objective measurement of remission and progression in metastatic breast cancer by use of serum tumour markers. Eur J Cancer. 35:47–53. 1999. View Article : Google Scholar : PubMed/NCBI

4 

Watanabe H, Okada M, Kaji Y, Satouchi M, Sato Y, Yamabe Y, Onaya H, Endo M, Sone M and Arai Y: New response evaluation criteria in solid tumours-revised RECIST guideline (version 1.1). Gan To Kagaku Ryoho. 36:2495–2501. 2009.(In Japanese). PubMed/NCBI

5 

Clamp A, Danson S, Nguyen H, Cole D and Clemons M: Assessment of therapeutic response in patients with metastatic bone disease. Lancet Oncol. 5:607–616. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Stafford SE, Gralow JR, Schubert EK, Rinn KJ, Dunnwald LK, Livingston RB and Mankoff DA: Use of serial FDG PET to measure the response of bone-dominant breast cancer to therapy. Acad Radiol. 9:913–921. 2002. View Article : Google Scholar : PubMed/NCBI

7 

Costa L, Demers LM, Gouveia-Oliveira A, Schaller J, Costa EB, de Moura MC and Lipton A: Prospective evaluation of the peptide-bound collagen type I cross-links N-telopeptide and C-telopeptide in predicting bone metastases status. J Clin Oncol. 20:850–856. 2002. View Article : Google Scholar : PubMed/NCBI

8 

Lipton A, Demers L, Curley E, Chinchilli V, Gaydos L, Hortobagyi G, Theriault R, Clemens D, Costa L, Seaman J, et al: Markers of bone resorption in patients treated with pamidronate. Eur J Cancer. 34:2021–2026. 1998. View Article : Google Scholar : PubMed/NCBI

9 

Massacesi C, Rocchi MB, Marcucci F, Pilone A, Galeazzi M and Bonsignori M: Serum tumor markers may precede instrumental response to chemotherapy in patients with metastatic cancer. Int J Biol Markers. 18:295–300. 2003. View Article : Google Scholar : PubMed/NCBI

10 

Molina R, Auge JM, Farrus B, Zanón G, Pahisa J, Muñoz M, Torne A, Filella X, Escudero JM, Fernandez P, et al: Prospective evaluation of carcinoembryonic antigen (CEA) and carbohydrate antigen 15.3 (CA 15.3) in patients with primary locoregional breast cancer. Clin Chem. 56:1148–1157. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Duffy MJ: Serum tumor markers in breast cancer: Are they of clinical value? Clin Chem. 52:345–351. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Zheng H and Luo RC: Diagnostic value of combined detection of TPS, CA153 and CEA in breast cancer. Di Yi Jun Yi Da Xue Xue Bao. 25(1293–1294): 12982005.(In Chinese).

13 

Ebeling FG, Stieber P, Untch M, Nagel D, Konecny GE, Schmitt UM, Fateh-Moghadam A and Seidel D: Serum CEA and CA 15-3 as prognostic factors in primary breast cancer. Br J Cancer. 86:1217–1222. 2002. View Article : Google Scholar : PubMed/NCBI

14 

Marić P, Ozretić P, Levanat S, Oresković S, Antunac K and Beketić-Oreskovic L: Tumor markers in breast cancer - evaluation of their clinical usefulness. Coll Antropol. 35:241–247. 2011.

15 

Agrawal AK, Jelen M, Rudnicki J, Grzebieniak Z, Zyśko D, Kielan W, Słonina J and Marek G: The importance of preoperative elevated serum levels of CEA and CA15-3 in patients with breast cancer in predicting its histological type. Folia Histochem Cytobiol. 48:26–29. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Parker C: Active surveillance: Towards a new paradigm in the management of early prostate cancer. Lancet Oncol. 5:101–106. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Di Gioia D, Heinemann V, Nagel D, Untch M, Kahlert S, Bauerfeind I, Koehnke T and Stieber P: Kinetics of CEA and CA15-3 correlate with treatment response in patients undergoing chemotherapy for metastatic breast cancer (MBC). Tumour Biol. 32:777–785. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Mariani L, Miceli R, Michilin S and Gion M: Serial determination of CEA and CA 15.3 in breast cancer follow-up: An assessment of their diagnostic accuracy for the detection of tumour recurrences. Biomarkers. 14:130–136. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Harris L, Fritsche H, Mennel R, Norton L, Ravdin P, Taube S, Somerfield MR, Hayes DF and Bast RC Jr: American Society of Clinical Oncology: American Society of Clinical Oncology 2007 update of recommendations for the use of tumor markers in breast cancer. J Clin Oncol. 25:5287–5312. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Williams MR, Turkes A, Pearson D, Griffiths K and Blamey RW: An objective biochemical assessment of therapeutic response in metastatic breast cancer: A study with external review of clinical data. Br J Cancer. 61:126–132. 1990. View Article : Google Scholar : PubMed/NCBI

21 

Robertson JF, Pearson D, Price MR, Selby C, Blamey RW and Howell A: Objective measurement of therapeutic response in breast cancer using tumour markers. Br J Cancer. 64:757–763. 1991. View Article : Google Scholar : PubMed/NCBI

22 

Dixon AR, Jackson L, Chan SY, Badley RA and Blamey RW: Continuous chemotherapy in responsive metastatic breast cancer: A role for tumour markers? Br J Cancer. 68:181–185. 1993. View Article : Google Scholar : PubMed/NCBI

23 

Kurebayashi J, Nishimura R, Tanaka K, Kohno N, Kurosumi M, Moriya T, Ogawa Y and Taguchi T: Significance of serum tumor markers in monitoring advanced breast cancer patients treated with systemic therapy: A prospective study. Breast Cancer. 11:389–395. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Hashimoto K, Yonemori K, Katsumata N, Shimizu C, Hirakawa A, Hirata T, Kouno T, Tamura K, Ando M and Fujiwara Y: Prediction of progressive disease using tumor markers in metastatic breast cancer patients without target lesions in first-line chemotherapy. Ann Oncol. 21:2195–2200. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Sölétormos G, Nielsen D, Schiøler V, Mouridsen H and Dombernowsky P: Monitoring different stages of breast cancer using tumour markers CA 15-3, CEA and TPA. Eur J Cancer. 40:481–486. 2004. View Article : Google Scholar : PubMed/NCBI

26 

Schroeder JA, Thompson MC, Gardner MM and Gendler SJ: Transgenic MUC1 interacts with epidermal growth factor receptor and correlates with mitogen-activated protein kinase activation in the mouse mammary gland. J Biol Chem. 276:13057–13064. 2001. View Article : Google Scholar : PubMed/NCBI

27 

Tanaka M, Kitajima Y, Sato S and Miyazaki K: Combined evaluation of mucin antigen and E-cadherin expression may help select patients with gastric cancer suitable for minimally invasive therapy. Br J Surg. 90:95–101. 2003. View Article : Google Scholar : PubMed/NCBI

28 

Rahn JJ, Dabbagh L, Pasdar M and Hugh JC: The importance of MUC1 cellular localization in patients with breast carcinoma: An immunohistologic study of 71 patients and review of the literature. Cancer. 91:1973–1982. 2001. View Article : Google Scholar : PubMed/NCBI

29 

Cheng JP, Yan Y, Wang XY, Lu YL, Yuan YH, Jia J and Ren J: MUC1-positive circulating tumor cells and MUC1 protein predict chemotherapeutic efficacy in the treatment of metastatic breast cancer. Chin J Cancer. 30:54–61. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Sölétormos G, Nielsen D, Schiøler V, Skovsgaard T and Dombernowsky P: Tumor markers cancer antigen 15.3, carcinoembryonic antigen, and tissue polypeptide antigen for monitoring metastatic breast cancer during first-line chemotherapy and follow-up. Clin Chem. 42:564–575. 1996.PubMed/NCBI

31 

Cheung KL, Graves CR and Robertson JF: Tumour marker measurements in the diagnosis and monitoring of breast cancer. Cancer Treat Rev. 26:91–102. 2000. View Article : Google Scholar : PubMed/NCBI

32 

Tondini C, Hayes DF, Gelman R, Henderson IC and Kufe DW: Comparison of CA15-3 and carcinoembryonic antigen in monitoring the clinical course of patients with metastatic breast cancer. Cancer Res. 48:4107–4112. 1988.PubMed/NCBI

33 

Lee JS, Park S, Park JM, Cho JH, Kim SI and Park BW: Elevated levels of serum tumor markers CA 15-3 and CEA are prognostic factors for diagnosis of metastatic breast cancers. Breast Cancer Res Treat. 141:477–484. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Yerushalmi R, Tyldesley S, Kennecke H, Speers C, Woods R, Knight B and Gelmon KA: Tumor markers in metastatic breast cancer subtypes: Frequency of elevation and correlation with outcome. Ann Oncol. 23:338–345. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Bidard FC, Hajage D, Bachelot T, Delaloge S, Brain E, Campone M, Cottu P, Beuzeboc P, Rolland E, Mathiot C, et al: Assessment of circulating tumor cells and serum markers for progression-free survival prediction in metastatic breast cancer: A prospective observational study. Breast Cancer Res. 14:R292012. View Article : Google Scholar : PubMed/NCBI

36 

Nishimura R, Nagao K, Miyayama H, Matsuda M, Baba K, Matsuoka Y and Yamashita H: Elevated serum CA15-3 levels correlate with positive estrogen receptor and initial favorable outcome in patients who died from recurrent breast cancer. Breast Cancer. 10:220–227. 2003. View Article : Google Scholar : PubMed/NCBI

37 

Sørlie T, Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H, Hastie T, Eisen MB, van de Rijn M, Jeffrey SS, et al: Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci USA. 98:pp. 10869–10874. 2001, View Article : Google Scholar : PubMed/NCBI

38 

Nakshatri H, Srour EF and Badve S: Breast cancer stem cells and intrinsic subtypes: Controversies rage on. Curr Stem Cell Res Ther. 4:50–60. 2009. View Article : Google Scholar : PubMed/NCBI

39 

Molina R, Augé JM, Escudero JM, Filella X, Zanon G, Pahisa J, Farrus B, Muñoz M and Velasco M: Evaluation of tumor markers (HER-2/neu oncoprotein, CEA, and CA 15.3) in patients with locoregional breast cancer: Prognostic value. Tumour Biol. 31:171–180. 2010. View Article : Google Scholar : PubMed/NCBI

40 

Pedersen AC, Sorensen PD, Jacobsen EH, Madsen JS and Brandslund I: Sensitivity of CA 15-3, CEA and serum HER2 in the early detection of recurrence of breast cancer. Clin Chem Lab Med. 51:1511–1519. 2013. View Article : Google Scholar : PubMed/NCBI

41 

Bao H, Yu D, Wang J, Qiu T, Yang J and Wang L: Predictive value of serum anti-p53 antibodies, carcino-embryonic antigen, carbohydrate antigen 15-3, estrogen receptor, progesterone receptor and human epidermal growth factor receptor-2 in taxane-based and anthracycline-based neoadjuvant chemotherapy in locally advanced breast cancer patients. Anticancer Drugs. 19:317–323. 2008. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yang Y, Zhang H, Zhang M, Meng Q, Cai L and Zhang Q: Elevation of serum CEA and CA15‑3 levels during antitumor therapy predicts poor therapeutic response in advanced breast cancer patients. Oncol Lett 14: 7549-7556, 2017.
APA
Yang, Y., Zhang, H., Zhang, M., Meng, Q., Cai, L., & Zhang, Q. (2017). Elevation of serum CEA and CA15‑3 levels during antitumor therapy predicts poor therapeutic response in advanced breast cancer patients. Oncology Letters, 14, 7549-7556. https://doi.org/10.3892/ol.2017.7164
MLA
Yang, Y., Zhang, H., Zhang, M., Meng, Q., Cai, L., Zhang, Q."Elevation of serum CEA and CA15‑3 levels during antitumor therapy predicts poor therapeutic response in advanced breast cancer patients". Oncology Letters 14.6 (2017): 7549-7556.
Chicago
Yang, Y., Zhang, H., Zhang, M., Meng, Q., Cai, L., Zhang, Q."Elevation of serum CEA and CA15‑3 levels during antitumor therapy predicts poor therapeutic response in advanced breast cancer patients". Oncology Letters 14, no. 6 (2017): 7549-7556. https://doi.org/10.3892/ol.2017.7164
Copy and paste a formatted citation
x
Spandidos Publications style
Yang Y, Zhang H, Zhang M, Meng Q, Cai L and Zhang Q: Elevation of serum CEA and CA15‑3 levels during antitumor therapy predicts poor therapeutic response in advanced breast cancer patients. Oncol Lett 14: 7549-7556, 2017.
APA
Yang, Y., Zhang, H., Zhang, M., Meng, Q., Cai, L., & Zhang, Q. (2017). Elevation of serum CEA and CA15‑3 levels during antitumor therapy predicts poor therapeutic response in advanced breast cancer patients. Oncology Letters, 14, 7549-7556. https://doi.org/10.3892/ol.2017.7164
MLA
Yang, Y., Zhang, H., Zhang, M., Meng, Q., Cai, L., Zhang, Q."Elevation of serum CEA and CA15‑3 levels during antitumor therapy predicts poor therapeutic response in advanced breast cancer patients". Oncology Letters 14.6 (2017): 7549-7556.
Chicago
Yang, Y., Zhang, H., Zhang, M., Meng, Q., Cai, L., Zhang, Q."Elevation of serum CEA and CA15‑3 levels during antitumor therapy predicts poor therapeutic response in advanced breast cancer patients". Oncology Letters 14, no. 6 (2017): 7549-7556. https://doi.org/10.3892/ol.2017.7164
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team