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Case Report

A patient with chronic myeloid leukemia and situs inversus totalis: A case report

  • Authors:
    • Yunxia Sun
    • Xiaoli Li
    • Lijun Li
    • Huan Liu
    • Qian Xu
    • Bei Liu
  • View Affiliations / Copyright

    Affiliations: Medical Department, The First Clinical Medical College, Lanzhou University, Lanzhou, Gansu 730000, P.R. China, Department of Hematology, The First Affiliated Hospital, Lanzhou University, Lanzhou, Gansu 730000, P.R. China
  • Pages: 7425-7430
    |
    Published online on: October 10, 2017
       https://doi.org/10.3892/ol.2017.7166
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Abstract

In the present study, a case of chronic myeloid leukemia (CML) with complete situs inversus in a 68‑year‑old female patient was reported. The patient presented with general weakness, abdominal distension and tenderness in the right hypochondrium. A chest X‑ray revealed a right‑sided heart. Ultrasonography revealed situs inversus totalis. A bone marrow smear demonstrated CML in the accelerated phase. Imatinib mesylate was subsequently administered; the patient stopped taking imatinib mesylate following discharge from the hospital. The patient presented with dizziness, fatigue, and abdominal distention and pain 1 year subsequently. A bone marrow smear demonstrated CML in the blast crisis phase; CML had progressed to acute myeloid leukemia (AML) M2a. The patient was treated with imatinib mesylate and cytarabine. After 5 days, the white blood cell count had decreased compared with that measured at the time of admission, and the previous relevant symptoms had disappeared. The patient succumbed to AML 3 months after discharge from the hospital. Situs inversus totalis is an uncommon congenital anomaly that often occurs concomitantly with other disorders. The present study documented, to the best of our knowledge, the second recorded case of CML in a patient with situs inversus totalis. Previous studies on the pathogenesis of situs inversus have suggested it is caused by embryonic cells failing to rotate normally during early embryonic development. Although there are case reports of situs inversus totalis in patients with cancer, there are few reports on the association between situs inversus totalis and cancer. The present study examined a case of CML with situs inversus totalis and assessed whether the latter may be associated with cancer.
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1 

Aylsworth AS: Clinical aspects of defects in the determination of laterality. Am J Med Genet. 101:345–355. 2001. View Article : Google Scholar : PubMed/NCBI

2 

Murakami S, Terakado M, Misumi M, Tsuji Y, Okubo K, Hirayama R, Inoue K and Arai E: Situs inversus totalis with malignant lymphoma of the stomach: Report of a case. Surg Today. 33:533–536. 2003.PubMed/NCBI

3 

Schmutzer KJ and Linde LM: Situs inversus totalis associated with complex cardiovascular anomalies. Am Heart J. 56:761–768. 1958. View Article : Google Scholar : PubMed/NCBI

4 

Katsuhara K, Kawamoto S, Wakabayashi T and Belsky JL: Situs inversus totalis and Kartagener's syndrome in a Japanese population. Chest. 61:56–61. 1972. View Article : Google Scholar : PubMed/NCBI

5 

Park SS, Min BW, Kim WB, Han HJ, Yong HS, Kim SJ, Kim CS and Mok YJ: Double cancer of the stomach and oesophagus with situs ambiguus with polysplenia: The importance of preoperative evaluation. Dig Liver Dis. 37:799–802. 2005. View Article : Google Scholar : PubMed/NCBI

6 

National Comprehensive Cancer Network: NCCN clinical practice guideline in oncology: Chronic myelogenous leukemia. V.2.2008. NCCN Web Site. 8-28-2007. https://www.nccn.org/professionals/physician_gls/f_guidelines.asp#cllJuly 26–2017

7 

Bennett JM, Dsouza KG, Patel M and O'Dwyer K: ‘Preleukemic or smoldering’ chronic myelogenous leukemia (CML):BCR-ABL1 positive: A brief case report. Leukemia Res Rep. 4:12–14. 2014. View Article : Google Scholar

8 

Druker BJ and Lee SJ: Chapter 43: Chronic leukemias: Section 1: Chronic myelogenous leukemia. DeVitaVincent T..Lawrence, Theodore S..Rosenberg and Steven A: Devita, Hellman & Rosenberg's Cancer: Principles and Practice of Oncology. Wolters Kluwer - Lippincott Williams & Wilkins; Philadelphia, PA, USA: 8th Edition. pp. 2268–2277. 2008

9 

Yang CL and Zhang XB: An epidemiological ivvestigation of leukemia and aplastic anemia. Investigation on incidence of leukemia in China. J China Acad Med Sci. 14:12–18. 1992.

10 

Kalmanti L, Saussele S, Lauseker M, Müller MC, Dietz CT, Heinrich L, Hanfstein B, Proetel U, Fabarius A, Krause SW, et al: Safety and efficacy of imatinib in CML over a period of 10 years: Data from the randomized CML-study IV. Leukemia. 29:1123–1132. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Kasili EG and Gaya Z: A case of chronic granulocytic leukemia with a right sided splenomegaly: Case-report. East Afr Med J. 65:140–143. 1988.PubMed/NCBI

12 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

13 

Kim YW, Ryu H, Kim DS and Kim IY: Double primary malignancies associated with colon cancer in patients with situs inversus totalis: Two case reports. World J Surg Oncol. 9:1092011. View Article : Google Scholar : PubMed/NCBI

14 

Varano NR and Merklin RJ: Situs inversus: Review of the literature, report of four cases and analysis of the clinical implications. J Int Coll Surg. 33:131–148. 1960.PubMed/NCBI

15 

RS CVK and SL R: Robbins Pathologic Basis of Disease. (4th edition). Asia-Pac J Clin onco. 777:1989.

16 

Galiatsatos P, Kasprzak L, Chong G, Jass JR and Foulkes WD: Multiple primary malignancies in a patient with situs ambiguus. Clin Genet. 69:528–531. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Haruki T, Maeta Y, Nakamura S, Sawata T, Shimizu T, Kishi K, Miyasaka S, Maeta H, Morimoto K and Taniguchi I: Advanced cancer with situs inversus totalis associated with KIF3 complex deficiency: Report of two case. Surg Today. 40:162–166. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Teng J, Rai T, Tanaka Y, Takei Y, Nakata T, Hirasawa M, Kulkarni AB and Hirokawa N: The KIF3 motor transports N-cadherin and organizes the developing neuroepithelium. Nat Cell Biol. 7:474–482. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Worley KE, Shieh D and Wan LQ: Inhibition of cell-cell adhesion impairs directional epithelial migration on micropatterned surfaces. Integr Biol (Camb). 7:580–590. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Bamford RN, Roessler E, Burdine RD, Saplakoğlu U, dela Cruz J, Splitt M, Goodship JA, Towbin J, Bowers P, Ferrero GB, et al: Loss-of-function mutations in the EGF-CFC gene CFC1 are associated with human left-right laterality defects. Nat Genet. 26:365–369. 2000. View Article : Google Scholar : PubMed/NCBI

21 

Peeters H, Debeer P, Bairoch A, Wilquet V, Huysmans C, Parthoens E, Fryns JP, Gewillig M, Nakamura Y, Niikawa N, et al: PA26 is a candidate gene for heterotaxia in humans: Identification of a novel PA26-related gene family in human and mouse. Hum Genet. 112:573–580. 2003.PubMed/NCBI

22 

Hirokawa N: Determination of left-right asymmetry: Role of cilia and KIF3 motor proteins. News Physiol Sci. 15:562000.PubMed/NCBI

23 

Hirokawa N, Tanaka Y, Okada Y and Takeda S: Nodal flow and the generation of left-right asymmetry. Cell. 125:33–45. 2006. View Article : Google Scholar : PubMed/NCBI

24 

Teng J, Rai T, Tanaka Y, Takei Y, Nakata T, Hirasawa M, Kulkarni AB and Hirokawa N: The KIF3 motor transports N-cadherin and organizes the developing neuroepithelium. Nat Cell Biol. 7:474–482. 2005. View Article : Google Scholar : PubMed/NCBI

25 

Worley KE, Shieh D and Wan LQ: Inhibition of cell-cell adhesion impairs directional epithelial migration on micropatterned surfaces. Integr Biol (Camb). 7:580–590. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Kamiike W, Itakura T, Tanaka H, Hatanaka N, Nakamuro M, Miyata M and Izumi H: Hepatic segmentectomy on primary liver cancer with situs inversus totalis. HPB Surg. 9:169–173. 1996. View Article : Google Scholar : PubMed/NCBI

27 

Horie M, Arai H, Noguchi S, Suzuki M, Sakamoto Y and Oka T: Kartagener syndrome with lung cancer and mediastinal tumor. Nihon Kokyuki Gakkai Zasshi. 48:375–378. 2010.(In Japanese). PubMed/NCBI

28 

Iwamura T, Shibata N, Haraguchi Y, Hisashi Y, Nishikawa T, Yamada H, Hayashi T and Toyoda K: Synchronous double cancer of the stomach and rectum with situs inversus totalis and polysplenia syndrome. J Clin Gastroenterol. 33:148–153. 2001. View Article : Google Scholar : PubMed/NCBI

29 

Dulganov KP and Nelip VE: Synchronous early cancer of the esophagus and larynx in a patient with complete situs viscerum inversus. Vopr Onkol. 36:1125–1126. 1990.(In Russian). PubMed/NCBI

30 

Rosseau Guerra R, Amat Daumy O, De Armas Haramboure L and Andial A: Case of multiple cancer and situs inversus. Arch Cuba Cancerol. 11:61–65. 1952.(In Undetermined Language). PubMed/NCBI

31 

Kim YI, Tada I, Kuwabara A and Kobayashi M: Double cancer of the liver and stomach with situs inversus totalis-a case report. Jpn J Surg. 19:756–759. 1989. View Article : Google Scholar : PubMed/NCBI

32 

Vijayakumar V and Brandt T: Prolonged survival with isolated levocardia and situs inversus. Clev Clin J Med. 58:243–247. 1991. View Article : Google Scholar

33 

Pathak P, Zilberman V, Avezbakiyev B and Gotlieb V: Hairy cell leukemia in a patient with situs inversus totalis: An extremely rare combination. Future Oncol. 9:753–756. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Yun S, Vincelette ND, Phan T and Anwer F: Spontaneous tumour lysis syndrome associated with contrast dye iohexol use in mantle cell lymphoma. BMJ Case Rep. 2014:pii: bcr2014204113. 2014. View Article : Google Scholar

35 

Trautner M, Szyszko T, Gnanasegaran G and Nunan T: Interesting image. Situs inversus totalis in newly diagnosed lymphoma: Additional value of hybrid imaging. Clin Nucl Med. 35:26–28. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Patel RV, Mehta MH, Bhoot NH, Gondalia JS and Ghodadra JK: Ileocecal lymphoma presenting as an epigastric mass. Indian Pediatr. 29:519–521. 1992.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Sun Y, Li X, Li L, Liu H, Xu Q and Liu B: A patient with chronic myeloid leukemia and situs inversus totalis: A case report. Oncol Lett 14: 7425-7430, 2017.
APA
Sun, Y., Li, X., Li, L., Liu, H., Xu, Q., & Liu, B. (2017). A patient with chronic myeloid leukemia and situs inversus totalis: A case report. Oncology Letters, 14, 7425-7430. https://doi.org/10.3892/ol.2017.7166
MLA
Sun, Y., Li, X., Li, L., Liu, H., Xu, Q., Liu, B."A patient with chronic myeloid leukemia and situs inversus totalis: A case report". Oncology Letters 14.6 (2017): 7425-7430.
Chicago
Sun, Y., Li, X., Li, L., Liu, H., Xu, Q., Liu, B."A patient with chronic myeloid leukemia and situs inversus totalis: A case report". Oncology Letters 14, no. 6 (2017): 7425-7430. https://doi.org/10.3892/ol.2017.7166
Copy and paste a formatted citation
x
Spandidos Publications style
Sun Y, Li X, Li L, Liu H, Xu Q and Liu B: A patient with chronic myeloid leukemia and situs inversus totalis: A case report. Oncol Lett 14: 7425-7430, 2017.
APA
Sun, Y., Li, X., Li, L., Liu, H., Xu, Q., & Liu, B. (2017). A patient with chronic myeloid leukemia and situs inversus totalis: A case report. Oncology Letters, 14, 7425-7430. https://doi.org/10.3892/ol.2017.7166
MLA
Sun, Y., Li, X., Li, L., Liu, H., Xu, Q., Liu, B."A patient with chronic myeloid leukemia and situs inversus totalis: A case report". Oncology Letters 14.6 (2017): 7425-7430.
Chicago
Sun, Y., Li, X., Li, L., Liu, H., Xu, Q., Liu, B."A patient with chronic myeloid leukemia and situs inversus totalis: A case report". Oncology Letters 14, no. 6 (2017): 7425-7430. https://doi.org/10.3892/ol.2017.7166
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