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Article

Peripheral lung adenocarcinomas harboring epithelial growth factor receptor mutations with microRNA‑135b overexpression are more likely to invade visceral pleura

  • Authors:
    • Hanbo Le
    • Xiaoling Wang
    • Yao Zha
    • Jie Wang
    • Wangyu Zhu
    • Zhinan Ye
    • Xiaoguang Liu
    • Haijie Ma
    • Yongkui Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Cardio‑Thoracic Surgery, Lung Cancer Research Center, The Affiliated Zhoushan Hospital of Wenzhou Medical University, Zhoushan, Zhejiang 316004, P.R. China, Laboratory of Cytobiology and Molecular Biology, The Affiliated Zhoushan Hospital of Wenzhou Medical University, Zhoushan, Zhejiang 316004, P.R. China
  • Pages: 7931-7940
    |
    Published online on: October 16, 2017
       https://doi.org/10.3892/ol.2017.7195
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Abstract

Lung adenocarcinoma, characterized by its early and aggressive local invasion and high metastatic potential, is the most frequently observed histological type of non‑small‑cell lung cancer (NSCLC). Visceral pleural invasion (VPI) caused by peripheral lung adenocarcinomas is closely associated with the poor prognosis of patients with NSCLC. The association between VPI and some clinicopathological characteristics has been observed in the past few decades. However, the molecular mechanism of VPI in lung adenocarcinomas is unknown. In the present, the expression level of microRNA (miR‑)135b and epidermal growth factor receptor (EGFR) mutations using the reverse transcription‑quantitative polymerase chain reaction and DNA sequencing, respectively. In addition, the present study aimed at exploring the association between the miR‑135b level, EGFR mutations and VPI in peripheral lung adenocarcinoma. The results of the present study demonstrated that miR‑135b was significantly upregulated in lung adenocarcinoma compared with adjacent normal tissue and positively associated EGFR mutations in peripheral lung adenocarcinoma. Furthermore, it was identified that lung adenocarcinomas with EGFR mutations and miR‑135b overexpression were more likely to invade visceral pleura. Taken together, these findings indicate that miR‑135b overexpression is positively associated with mutations to EGFR, which may promote the development of peripheral lung adenocarcinomas by the formation of VPI. This indicates that the two factors may serve as prognostic markers and molecular targets for the treatment of peripheral lung adenocarcinomas.
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Spandidos Publications style
Le H, Wang X, Zha Y, Wang J, Zhu W, Ye Z, Liu X, Ma H and Zhang Y: Peripheral lung adenocarcinomas harboring epithelial growth factor receptor mutations with microRNA‑135b overexpression are more likely to invade visceral pleura. Oncol Lett 14: 7931-7940, 2017.
APA
Le, H., Wang, X., Zha, Y., Wang, J., Zhu, W., Ye, Z. ... Zhang, Y. (2017). Peripheral lung adenocarcinomas harboring epithelial growth factor receptor mutations with microRNA‑135b overexpression are more likely to invade visceral pleura. Oncology Letters, 14, 7931-7940. https://doi.org/10.3892/ol.2017.7195
MLA
Le, H., Wang, X., Zha, Y., Wang, J., Zhu, W., Ye, Z., Liu, X., Ma, H., Zhang, Y."Peripheral lung adenocarcinomas harboring epithelial growth factor receptor mutations with microRNA‑135b overexpression are more likely to invade visceral pleura". Oncology Letters 14.6 (2017): 7931-7940.
Chicago
Le, H., Wang, X., Zha, Y., Wang, J., Zhu, W., Ye, Z., Liu, X., Ma, H., Zhang, Y."Peripheral lung adenocarcinomas harboring epithelial growth factor receptor mutations with microRNA‑135b overexpression are more likely to invade visceral pleura". Oncology Letters 14, no. 6 (2017): 7931-7940. https://doi.org/10.3892/ol.2017.7195
Copy and paste a formatted citation
x
Spandidos Publications style
Le H, Wang X, Zha Y, Wang J, Zhu W, Ye Z, Liu X, Ma H and Zhang Y: Peripheral lung adenocarcinomas harboring epithelial growth factor receptor mutations with microRNA‑135b overexpression are more likely to invade visceral pleura. Oncol Lett 14: 7931-7940, 2017.
APA
Le, H., Wang, X., Zha, Y., Wang, J., Zhu, W., Ye, Z. ... Zhang, Y. (2017). Peripheral lung adenocarcinomas harboring epithelial growth factor receptor mutations with microRNA‑135b overexpression are more likely to invade visceral pleura. Oncology Letters, 14, 7931-7940. https://doi.org/10.3892/ol.2017.7195
MLA
Le, H., Wang, X., Zha, Y., Wang, J., Zhu, W., Ye, Z., Liu, X., Ma, H., Zhang, Y."Peripheral lung adenocarcinomas harboring epithelial growth factor receptor mutations with microRNA‑135b overexpression are more likely to invade visceral pleura". Oncology Letters 14.6 (2017): 7931-7940.
Chicago
Le, H., Wang, X., Zha, Y., Wang, J., Zhu, W., Ye, Z., Liu, X., Ma, H., Zhang, Y."Peripheral lung adenocarcinomas harboring epithelial growth factor receptor mutations with microRNA‑135b overexpression are more likely to invade visceral pleura". Oncology Letters 14, no. 6 (2017): 7931-7940. https://doi.org/10.3892/ol.2017.7195
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