Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
December-2017 Volume 14 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2017 Volume 14 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Upregulation of the checkpoint protein CHFR is associated with tumor suppression in pancreatic cancers

  • Authors:
    • Di Zhang
    • Xiao‑Lan Xu
    • Fei Li
    • Hai‑Chen Sun
    • Ye‑Qing Cui
    • Shuang Liu
    • Ping‑Yong Xu
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, P.R. China, National Key Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 8042-8050
    |
    Published online on: October 20, 2017
       https://doi.org/10.3892/ol.2017.7239
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The checkpoint with forkhead‑associated (FHA) domain and RING‑finger (CHFR) protein was identified as a cell cycle checkpoint protein and E3 ubiquitin ligase. In the present study, the potential functions of CHFR in pancreatic cancer were investigated. CHFR expression was measured in five pancreatic cancer cell lines by reverse transcription‑ quantitative polymerase chain reaction and western blotting. Capan‑1 cells stably expressing CHFR were established by lentiviral vector transfection. Cell proliferation was assessed using Cell Counting Kit‑8, and cell migration/invasion assay was determined using Transwell assays. Cell cycle and apoptosis induced by gemcitabine or docetaxel were evaluated using flow cytometry. CHFR expression levels were also evaluated in pancreatic ductal adenocarcinoma (PDAC) tumor samples as well as adjacent non‑tumor tissues by immunohistochemistry. The significance of CHFR expression was determined, with respect to clinicopathological features and overall survival. Overexpression of CHFR in Capan‑1 cells led to a decreased proliferative rate and reduced cell migration and invasion abilities. Results also indicated an increase in G1 phase cells in Capan‑1 cells overexpressing CHFR. Docetaxel‑induced apoptosis was inhibited in Capan‑1 cells with CHFR‑overexpression. A reduction in CHFR expression was detected in 51.9% of patients with PDAC, which significantly correlated with later T‑stage. The results show CHFR functions as a tumor suppressor in pancreatic cancer, suggests its potential role in controlling the cell cycle of pancreatic cancer cells; however, CHFR overexpression is not a favorable factor in apoptosis induced by docetaxel.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Ilic M and Ilic I: Epidemiology of pancreatic cancer: World. J Gastroenterol. 22:9694–9705. 2016.

2 

Pannala R, Leirness JB, Bamlet WR, Basu A, Petersen GM and Chari ST: Prevalence and clinical profile of pancreatic cancer-associated diabetes mellitus. Gastroenterology. 134:981–987. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Greenhalf W, Grocock C, Harcus M and Neoptolemos J: Screening of high-risk families for pancreatic cancer. Pancreatology. 9:215–222. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Shin EJ and Canto MI: Pancreatic cancer screening. Gastroenterol Clin North Am. 41:143–157. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Scolnick DM and Halazonetis TD: Chfr defines a mitotic stress checkpoint that delays entry into metaphase. Nature. 406:430–435. 2000. View Article : Google Scholar : PubMed/NCBI

6 

Hofmann K and Bucher P: The FHA domain: A putative nuclear signalling domain found in protein kinases and transcription factors. Trends Biochem Sci. 20:347–349. 1995. View Article : Google Scholar : PubMed/NCBI

7 

Lovering R, Hanson IM, Borden KL, Martin S, O'Reilly NJ, Evan GI, Rahman D, Pappin DJ, Trowsdale J and Freemont PS: Identification and preliminary characterization of a protein motif related to the zinc finger. Proc Natl Acad Sci USA. 90:pp. 2112–2116. 1993, View Article : Google Scholar : PubMed/NCBI

8 

Borden KL, Boddy MN, Lally J, O'Reilly NJ, Martin S, Howe K, Solomon E and Freemont PS: The solution structure of the RING finger domain from the acute promyelocytic leukaemia proto-oncoprotein PML. EMBO J. 14:1532–1541. 1995.PubMed/NCBI

9 

Durocher D and Jackson SP: The FHA domain. FEBS Lett. 513:58–66. 2002. View Article : Google Scholar : PubMed/NCBI

10 

Yu X, Minter-Dykhouse K, Malureanu L, Zhao WM, Zhang D, Merkle CJ, Ward IM, Saya H, Fang G, van Deursen J and Chen J: Chfr is required for tumor suppression and aurora a regulation. Nat Genet. 37:401–406. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Oh YM, Kwon YE, Kim JM, Bae SJ, Lee BK, Yoo SJ, Chung CH, Deshaies RJ and Seol JH: Chfr is linked to tumour metastasis through the downregulation of HDAC1. Nat Cell Biol. 11:295–302. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Bertholon J, Wang Q, Falette N, Verny C, Auclair J, Chassot C, Navarro C, Saurin JC and Puisieux A: Chfr inactivation is not associated to chromosomal instability in colon cancers. Oncogene. 22:8956–8960. 2003. View Article : Google Scholar : PubMed/NCBI

13 

Yoshida K, Hamai Y, Suzuki T, Sanada Y, Oue N and Yasui W: DNA methylation of CHFR is not a predictor of the response to docetaxel and paclitaxel in advanced and recurrent gastric cancer. Anticancer Res. 26:49–54. 2006.PubMed/NCBI

14 

Yanokura M, Banno K, Kawaguchi M, Hirao N, Hirasawa A, Susumu N, Tsukazaki K and Aoki D: Relationship of aberrant DNA hypermethylation of CHFR with sensitivity to taxanes in endometrial cancer. Oncol Rep. 17:41–48. 2007.PubMed/NCBI

15 

Pillai RN, Brodie SA, Sica GL, Shaojin Y, Li G, Nickleach DC, Yuan L, Varma VA, Bonta D, Herman JG, et al: CHFR protein expression predicts outcomes to taxane-based first line therapy in metastatic NSCLC. Clin Cancer Res. 19:1603–1611. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

17 

Ketefian S: Ethical considerations in research. Focus on vulnerable groups. Invest Educ Enferm. 33:164–172. 2015.PubMed/NCBI

18 

Kobayashi C, Oda Y, Takahira T, Izumi T, Kawaguchi K, Yamamoto H, Tamiya S, Yamada T, Iwamoto Y and Tsuneyoshi M: Aberrant expression of CHFR in malignant peripheral nerve sheath tumors. Mod Pathol. 19:524–532. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Chin CF and Yeong FM: Safeguarding entry into mitosis: The antephase checkpoint. Mol Cell Biol. 30:22–32. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Bothos J, Summers MK, Venere M, Scolnick DM and Halazonetis TD: The Chfr mitotic checkpoint protein functions with Ubc13-Mms2 to form Lys63-linked polyubiquitin chains. Oncogene. 22:7101–7107. 2003. View Article : Google Scholar : PubMed/NCBI

21 

Chaturvedi P, Sudakin V, Bobiak ML, Fisher PW, Mattern MR, Jablonski SA, Hurle MR, Zhu Y, Yen TJ and Zhou BB: Chfr regulates a mitotic stress pathway through its RING-finger domain with ubiquitin ligase activity. Cancer Res. 62:1797–1801. 2002.PubMed/NCBI

22 

Brooks L III, Heimsath EG Jr, Loring GL and Brenner C: FHA-RING ubiquitin ligases in cell division cycle control. Cell Mol Life Sci. 65:3458–3466. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Summers MK, Bothos J and Halazonetis TD: The CHFR mitotic checkpoint protein delays cell cycle progression by excluding Cyclin B1 from the nucleus. Oncogene. 24:2589–2598. 2005. View Article : Google Scholar : PubMed/NCBI

24 

Ogi K, Toyota M, Mita H, Satoh A, Kashima L, Sasaki Y, Suzuki H, Akino K, Nishikawa N, Noguchi M, et al: Small interfering RNA-induced CHFR silencing sensitizes oral squamous cell cancer cells to microtubule inhibitors. Cancer Biol Ther. 4:773–780. 2005. View Article : Google Scholar : PubMed/NCBI

25 

Bieganowski P, Shilinski K, Tsichlis PN and Brenner C: Cdc123 and checkpoint forkhead associated with RING proteins control the cell cycle by controlling eIF2gamma abundance. J Biol Chem. 279:44656–44666. 2004. View Article : Google Scholar : PubMed/NCBI

26 

Kashima L, Toyota M, Mita H, Suzuki H, Idogawa M, Ogi K, Sasaki Y and Tokino T: CHFR, a potential tumor suppressor, downregulates interleukin-8 through the inhibition of NF-kappaB. Oncogene. 28:2643–2653. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Lee KH, Bae SH, Lee JL, Hyun MS, Kim SH, Song SK and Kim HS: Relationship between urokinase-type plasminogen receptor, interleukin-8 gene expression and clinicopathological features in gastric cancer. Oncology. 66:210–217. 2004. View Article : Google Scholar : PubMed/NCBI

28 

Kang D, Chen J, Wong J and Fang G: The checkpoint protein Chfr is a ligase that ubiquitinates Plk1 and inhibits Cdc2 at the G2 to M transition. J Cell Biol. 156:249–259. 2002. View Article : Google Scholar : PubMed/NCBI

29 

Hagting A, Jackman M, Simpson K and Pines J: Translocation of cyclin B1 to the nucleus at prophase requires a phosphorylation-dependent nuclear import signal. Curr Biol. 9:680–689. 1999. View Article : Google Scholar : PubMed/NCBI

30 

Hirota T, Kunitoku N, Sasayama T, Marumoto T, Zhang D, Nitta M, Hatakeyama K and Saya H: Aurora A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells. Cell. 114:585–598. 2003. View Article : Google Scholar : PubMed/NCBI

31 

Matsusaka T and Pines J: Chfr acts with the p38 stress kinases to block entry to mitosis in mammalian cells. J Cell Biol. 166:507–516. 2004. View Article : Google Scholar : PubMed/NCBI

32 

Erson AE and Petty EM: CHFR-associated early G2/M checkpoint defects in breast cancer cells. Mol Carcinog. 39:26–33. 2004. View Article : Google Scholar : PubMed/NCBI

33 

Awasthi N, Zhang C, Schwarz AM, Hinz S, Schwarz MA and Schwarz RE: Enhancement of nab-paclitaxel antitumor activity through addition of multitargeting antiangiogenic agents in experimental pancreatic cancer. Mol Cancer Ther. 13:1032–1043. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Toyota M, Sasaki Y, Satoh A, Ogi K, Kikuchi T, Suzuki H, Mita H, Tanaka N, Itoh F, Issa JP, et al: Epigenetic inactivation of CHFR in human tumors. Proc Natl Acad Sci USA. 100:pp. 7818–7823. 2003, View Article : Google Scholar : PubMed/NCBI

35 

Gebauer F, Wicklein D, Horst J, Sundermann P, Maar H, Streichert T, Tachezy M, Izbicki JR, Bockhorn M and Schumacher U: Carcinoembryonic antigen-related cell adhesion molecules (CEACAM) 1, 5 and 6 as biomarkers in pancreatic cancer. PLoS One. 9:e1130232014. View Article : Google Scholar : PubMed/NCBI

36 

Privette LM, González ME, Ding L, Kleer CG and Petty EM: Altered expression of the early mitotic checkpoint protein, CHFR, in breast cancers: Implications for tumor suppression. Cancer Res. 67:6064–6074. 2007. View Article : Google Scholar : PubMed/NCBI

37 

Soutto M, Peng D, Razvi M, Ruemmele P, Hartmann A, Roessner A, Schneider-Stock R and El-Rifai W: Epigenetic and genetic silencing of CHFR in esophageal adenocarcinomas. Cancer. 116:4033–4042. 2010. View Article : Google Scholar : PubMed/NCBI

38 

Mariatos G, Bothos J, Zacharatos P, Summers MK, Scolnick DM, Kittas C, Halazonetis TD and Gorgoulis VG: Inactivating mutations targeting the chfr mitotic checkpoint gene in human lung cancer. Cancer Res. 63:7185–7189. 2003.PubMed/NCBI

39 

Cleven AH, Derks S, Draht MX, Smits KM, Melotte V, Van Neste L, Tournier B, Jooste V, Chapusot C, Weijenberg MP, et al: CHFR promoter methylation indicates poor prognosis in stage II microsatellite stable colorectal cancer. Clin Cancer Res. 20:3261–3271. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Gao L, Liu F, Zhang H, Sun J and Ma Y: CHFR hypermethylation, a frequent event in acute myeloid leukemia, is independently associated with an adverse outcome. Genes Chromosomes Cancer. 55:158–168. 2016. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhang D, Xu XL, Li F, Sun HC, Cui YQ, Liu S and Xu PY: Upregulation of the checkpoint protein CHFR is associated with tumor suppression in pancreatic cancers. Oncol Lett 14: 8042-8050, 2017.
APA
Zhang, D., Xu, X., Li, F., Sun, H., Cui, Y., Liu, S., & Xu, P. (2017). Upregulation of the checkpoint protein CHFR is associated with tumor suppression in pancreatic cancers. Oncology Letters, 14, 8042-8050. https://doi.org/10.3892/ol.2017.7239
MLA
Zhang, D., Xu, X., Li, F., Sun, H., Cui, Y., Liu, S., Xu, P."Upregulation of the checkpoint protein CHFR is associated with tumor suppression in pancreatic cancers". Oncology Letters 14.6 (2017): 8042-8050.
Chicago
Zhang, D., Xu, X., Li, F., Sun, H., Cui, Y., Liu, S., Xu, P."Upregulation of the checkpoint protein CHFR is associated with tumor suppression in pancreatic cancers". Oncology Letters 14, no. 6 (2017): 8042-8050. https://doi.org/10.3892/ol.2017.7239
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang D, Xu XL, Li F, Sun HC, Cui YQ, Liu S and Xu PY: Upregulation of the checkpoint protein CHFR is associated with tumor suppression in pancreatic cancers. Oncol Lett 14: 8042-8050, 2017.
APA
Zhang, D., Xu, X., Li, F., Sun, H., Cui, Y., Liu, S., & Xu, P. (2017). Upregulation of the checkpoint protein CHFR is associated with tumor suppression in pancreatic cancers. Oncology Letters, 14, 8042-8050. https://doi.org/10.3892/ol.2017.7239
MLA
Zhang, D., Xu, X., Li, F., Sun, H., Cui, Y., Liu, S., Xu, P."Upregulation of the checkpoint protein CHFR is associated with tumor suppression in pancreatic cancers". Oncology Letters 14.6 (2017): 8042-8050.
Chicago
Zhang, D., Xu, X., Li, F., Sun, H., Cui, Y., Liu, S., Xu, P."Upregulation of the checkpoint protein CHFR is associated with tumor suppression in pancreatic cancers". Oncology Letters 14, no. 6 (2017): 8042-8050. https://doi.org/10.3892/ol.2017.7239
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team