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Article

Dietary flavonoid tangeretin induces reprogramming of epithelial to mesenchymal transition in prostate cancer cells by targeting the PI3K/Akt/mTOR signaling pathway

  • Authors:
    • Wen‑Bin Zhu
    • Ning Xiao
    • Xing‑Jie Liu
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Linyi People's Hospital, Linyi, Shandong 276003, P.R. China, Department of Obstetrics and Gynecology, Linyi People's Hospital, Linyi, Shandong 276003, P.R. China
  • Pages: 433-440
    |
    Published online on: October 31, 2017
       https://doi.org/10.3892/ol.2017.7307
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Abstract

Tangeretin, a natural polymethoxyflavone present in the peel of citrus fruits is known to exhibit anticancer properties against a variety of carcinomas. Previous experimental evidence suggests that lifestyle and dietary habits affect the risk of prostate cancer to a certain extent. As the effect of tangeretin on prostate cancer is unexplored, the present study investigated the effect of tangeretin on androgen‑insensitive PC‑3 cells and androgen‑sensitive LNCaP cells. Tangeretin reduced the cell viability of PC‑3 cells in a dose‑ and time‑dependent manner, with the half‑maximal inhibitory concentration (IC50) observed at 75 µM dose following 72 h of incubation, while in LNCaP cells, the IC50 was identified to be ~65 µM. Expression levels of the mesenchymal proteins including vimentin, cluster of differentiation 44 and Neural cadherin in PC‑3 cells were reduced by tangeretin treatment, whereas those of the epithelial proteins, including Epithelial cadherin and cytokeratin‑19 were upregulated. Treatment of PC‑3 cells also resulted in the downregulation of the phosphoinositide 3‑kinase/protein kinase B/mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathway. Therefore, it may be concluded that tangeretin induces reprogramming of epithelial‑mesenchymal transition in PC‑3 cells by targeting the PI3K/Akt/mTOR signaling pathway.
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Copy and paste a formatted citation
Spandidos Publications style
Zhu WB, Xiao N and Liu XJ: Dietary flavonoid tangeretin induces reprogramming of epithelial to mesenchymal transition in prostate cancer cells by targeting the PI3K/Akt/mTOR signaling pathway. Oncol Lett 15: 433-440, 2018.
APA
Zhu, W., Xiao, N., & Liu, X. (2018). Dietary flavonoid tangeretin induces reprogramming of epithelial to mesenchymal transition in prostate cancer cells by targeting the PI3K/Akt/mTOR signaling pathway. Oncology Letters, 15, 433-440. https://doi.org/10.3892/ol.2017.7307
MLA
Zhu, W., Xiao, N., Liu, X."Dietary flavonoid tangeretin induces reprogramming of epithelial to mesenchymal transition in prostate cancer cells by targeting the PI3K/Akt/mTOR signaling pathway". Oncology Letters 15.1 (2018): 433-440.
Chicago
Zhu, W., Xiao, N., Liu, X."Dietary flavonoid tangeretin induces reprogramming of epithelial to mesenchymal transition in prostate cancer cells by targeting the PI3K/Akt/mTOR signaling pathway". Oncology Letters 15, no. 1 (2018): 433-440. https://doi.org/10.3892/ol.2017.7307
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu WB, Xiao N and Liu XJ: Dietary flavonoid tangeretin induces reprogramming of epithelial to mesenchymal transition in prostate cancer cells by targeting the PI3K/Akt/mTOR signaling pathway. Oncol Lett 15: 433-440, 2018.
APA
Zhu, W., Xiao, N., & Liu, X. (2018). Dietary flavonoid tangeretin induces reprogramming of epithelial to mesenchymal transition in prostate cancer cells by targeting the PI3K/Akt/mTOR signaling pathway. Oncology Letters, 15, 433-440. https://doi.org/10.3892/ol.2017.7307
MLA
Zhu, W., Xiao, N., Liu, X."Dietary flavonoid tangeretin induces reprogramming of epithelial to mesenchymal transition in prostate cancer cells by targeting the PI3K/Akt/mTOR signaling pathway". Oncology Letters 15.1 (2018): 433-440.
Chicago
Zhu, W., Xiao, N., Liu, X."Dietary flavonoid tangeretin induces reprogramming of epithelial to mesenchymal transition in prostate cancer cells by targeting the PI3K/Akt/mTOR signaling pathway". Oncology Letters 15, no. 1 (2018): 433-440. https://doi.org/10.3892/ol.2017.7307
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