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Clinical, histological, immunohistochemical and genetic factors associated with measurable response of high‑risk canine mast cell tumours to tyrosine kinase inhibitors

  • Authors:
    • Rodrigo dos Santos Horta
    • Antonio Giuliano
    • Gleidice Eunice Lavalle
    • Mariana de Pádua Costa
    • Roberto Baracat de Araújo
    • Fernando Constantino‑Casas
    • Jane Margaret Dobson
  • View Affiliations / Copyright

    Affiliations: Department of Veterinary Medicine, Universidade Vila Velha (UVV), Vila Velha, ES 29120‑920, Brazil, Department of Veterinary Medicine, The Queen's Veterinary School Hospital, University of Cambridge, Cambridge CB3 0ES, UK, Department of Veterinary Clinic and Surgery, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG 31270‑901, Brazil
    Copyright: © Horta et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 129-136
    |
    Published online on: November 1, 2017
       https://doi.org/10.3892/ol.2017.7323
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Abstract

The aim of the present prospective-retrospective study was to evaluate the response of high‑risk canine mast cell tumours (MCTs) to tyrosine kinase inhibitors (TKIs) and to correlate this with prognostic factors. A total of 24 dogs presented with macroscopic cutaneous MCTs at disease stage II or III, and therefore, at high‑risk of associated mortality, were included in the study and treated with masitinib (n=20) or toceranib (n=4). A total of 12/24 dogs achieved an objective response and the overall survival (OS) for all subjects was 113 days. Dogs responding to treatment had a significant increase in OS compared to non‑responders (146.5 days vs. 47 days, P=0.02). Internal tandem duplications in exon 11 of the c‑kit gene were identified in 6/24 cases. Ki67, KIT immunolabelling and c‑kit mutation did not provide information regarding prognosis or prediction of response to TKIs in this population. Initial response to TKIs appears to be the most reliable prognostic factor for survival duration.
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Copy and paste a formatted citation
Spandidos Publications style
Horta Rd, Giuliano A, Lavalle GE, Costa Md, de Araújo RB, Constantino‑Casas F and Dobson JM: Clinical, histological, immunohistochemical and genetic factors associated with measurable response of high‑risk canine mast cell tumours to tyrosine kinase inhibitors. Oncol Lett 15: 129-136, 2018.
APA
Horta, R.d., Giuliano, A., Lavalle, G.E., Costa, M.d., de Araújo, R.B., Constantino‑Casas, F., & Dobson, J.M. (2018). Clinical, histological, immunohistochemical and genetic factors associated with measurable response of high‑risk canine mast cell tumours to tyrosine kinase inhibitors. Oncology Letters, 15, 129-136. https://doi.org/10.3892/ol.2017.7323
MLA
Horta, R. d., Giuliano, A., Lavalle, G. E., Costa, M. d., de Araújo, R. B., Constantino‑Casas, F., Dobson, J. M."Clinical, histological, immunohistochemical and genetic factors associated with measurable response of high‑risk canine mast cell tumours to tyrosine kinase inhibitors". Oncology Letters 15.1 (2018): 129-136.
Chicago
Horta, R. d., Giuliano, A., Lavalle, G. E., Costa, M. d., de Araújo, R. B., Constantino‑Casas, F., Dobson, J. M."Clinical, histological, immunohistochemical and genetic factors associated with measurable response of high‑risk canine mast cell tumours to tyrosine kinase inhibitors". Oncology Letters 15, no. 1 (2018): 129-136. https://doi.org/10.3892/ol.2017.7323
Copy and paste a formatted citation
x
Spandidos Publications style
Horta Rd, Giuliano A, Lavalle GE, Costa Md, de Araújo RB, Constantino‑Casas F and Dobson JM: Clinical, histological, immunohistochemical and genetic factors associated with measurable response of high‑risk canine mast cell tumours to tyrosine kinase inhibitors. Oncol Lett 15: 129-136, 2018.
APA
Horta, R.d., Giuliano, A., Lavalle, G.E., Costa, M.d., de Araújo, R.B., Constantino‑Casas, F., & Dobson, J.M. (2018). Clinical, histological, immunohistochemical and genetic factors associated with measurable response of high‑risk canine mast cell tumours to tyrosine kinase inhibitors. Oncology Letters, 15, 129-136. https://doi.org/10.3892/ol.2017.7323
MLA
Horta, R. d., Giuliano, A., Lavalle, G. E., Costa, M. d., de Araújo, R. B., Constantino‑Casas, F., Dobson, J. M."Clinical, histological, immunohistochemical and genetic factors associated with measurable response of high‑risk canine mast cell tumours to tyrosine kinase inhibitors". Oncology Letters 15.1 (2018): 129-136.
Chicago
Horta, R. d., Giuliano, A., Lavalle, G. E., Costa, M. d., de Araújo, R. B., Constantino‑Casas, F., Dobson, J. M."Clinical, histological, immunohistochemical and genetic factors associated with measurable response of high‑risk canine mast cell tumours to tyrosine kinase inhibitors". Oncology Letters 15, no. 1 (2018): 129-136. https://doi.org/10.3892/ol.2017.7323
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