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Article

Human papillomavirus genotype affects metastatic rate following radiotherapy in patients with uterine cervical cancer

  • Authors:
    • Noriyuki Okonogi
    • Daijiro Kobayashi
    • Tomo Suga
    • Takashi Imai
    • Masaru Wakatsuki
    • Tatsuya Ohno
    • Shingo Kato
    • Takashi Nakano
    • Tadashi Kamada
  • View Affiliations / Copyright

    Affiliations: Hospital of the National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263‑8555, Japan, Department of Radiation Effects Research, National Institutes for Quantum and Radiological Science and Technology, Chiba 263‑8555, Japan, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263‑8555, Japan, Department of Radiology, Jichi Medical University, Tochigi 329‑0498, Japan, Department of Radiation Oncology, Gunma University Graduate School of Medicine, Maebashi, Gunma 371‑8511, Japan, Department of Radiation Oncology, Saitama Medical University International Medical Center, Saitama 350‑1241, Japan
  • Pages: 459-466
    |
    Published online on: November 2, 2017
       https://doi.org/10.3892/ol.2017.7327
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Abstract

Human papillomavirus (HPV) infection is well known as a major etiological risk factor associated with carcinogenesis in uterine cervical cancer. However, few reports have investigated the association between HPV genotype and outcome in patients with uterine cervical cancer following radiotherapy (RT). The aim of the present study was to investigate the association between the HPV genotype and clinical outcome following RT in Japanese patients with uterine cervical cancer. Between November 2001 and August 2006, 157 Japanese women with uterine cervical cancer were treated with RT or concurrent chemoradiotherapy with curative intent. Pretreatment, formalin‑fixed, paraffin‑embedded biopsies were obtained from 83 patients. HPV genotypes were determined using the polymerase chain reaction method. Patients were categorized, according to HPV L1 protein sequence homology, into the HPV α‑9 (HPV 16, 31, 33, 52, and 58), HPV α‑7 (HPV 18, 39, 45, 59, and 68) or ‘other’ (HPV 51 and 56) groups. Associations between HPV genotype and clinical outcome following RT were evaluated. A total of 54 (65.1%) tumors were HPV α‑9‑positive, 13 (15.7%) were HPV α‑7‑positive, 2 (2.4%) were categorized under ‘other’ and 14 (16.9%) were HPV‑negative. There were no significant differences in age, FIGO stage, regional lymph node metastases rate at diagnosis, or concurrent chemotherapy administration between the HPV α‑9 and α‑7 groups. The median follow‑up period was 52 months (range, 2‑156 months). The 5‑year disease‑free survival rates were 54.5 and 30.8% in the HPV α‑9 and α‑7 groups, respectively (P=0.034), and the 5‑year distant metastasis rates were 38.0 and 69.2%, respectively (P=0.015). There were no significant differences in the 5‑year local control or overall survival (OS) rates between the two groups. HPV genotype affected the 5‑year distant metastatic rate, however not the 5‑year local control or OS rate in patients with uterine cervical cancer following RT.
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1 

Ferlay J, Shin HR, Bray F, Forman D, Mathers C and Parkin DM: Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 127:2893–2917. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Cervical cancer: Estimated incidence, mortality and prevalence worldwide in 2012. International Agency for Research on Cancer and World Health Organization. 2012, http://globocan.iarc.fr/Pages/fact_sheets_cancer.aspxDecember 25–2016

3 

Bouvard V, Baan R, Straif K, Grosse Y, Secretan B, El Ghissassi F, Benbrahim-Tallaa L, Guha N, Freeman C, Galichet L, et al: A review of human carcinogens-Part B: Biological agents. Lancet Oncol. 10:321–322. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Walboomers JM, Jacobs MV, Manos MM, Bosch FX, Kummer JA, Shah KV, Snijders PJ, Peto J, Meijer CJ and Muñoz N: Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol. 189:12–19. 1999. View Article : Google Scholar : PubMed/NCBI

5 

de Sanjose S, Quint WG, Alemany L, Geraets DT, Klaustermeier JE, Lloveras B, Tous S, Felix A, Bravo LE, Shin HR, et al: Human papillomavirus genotype attribution in invasive cervical cancer: A retrospective cross-sectional worldwide study. Lancet Oncol. 11:1048–1056. 2010. View Article : Google Scholar : PubMed/NCBI

6 

de Villiers EM, Wagner D, Schneider A, Wesch H, Miklaw H, Wahrendorf J, Papendick U and zur Hausen H: Human papillomavirus infections in women with and without abnormal cervical cytology. Lancet. 2:703–706. 1987. View Article : Google Scholar : PubMed/NCBI

7 

Parkin DM and Bray F: Chapter 2: The burden of HPV-related cancers. Vaccine. 3(24 Suppl): S11–S25. 2006. View Article : Google Scholar

8 

American College of Obstetricians and Gynecologists: ACOG practice bulletin. Diagnosis and treatment of cervical carcinomas. Number 35, May 2002. American College of Obstetricians and Gynecologists. Int J Gynaecol Obstet. 78:79–91. 2002.PubMed/NCBI

9 

Gaffney DK, Erickson-Wittmann BA, Jhingran A, Mayr NA, Puthawala AA, Moore D, Rao GG, Small W Jr, Varia MA, Wolfson AH, et al: ACR Appropriateness Criteria® on advanced cervical cancer expert panel on radiation oncology-gynecology. Int J Radiat Oncol Biol Phys. 81:609–614. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Monk BJ, Tewari KS and Koh WJ: Multimodality therapy for locally advanced cervical carcinoma: State of the art and future directions. J Clin Oncol. 25:2952–2965. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Gien LT, Beauchemin MC and Thomas G: Adenocarcinoma: A unique cervical cancer. Gynecol Oncol. 116:140–146. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Lai CH, Chang CJ, Huang HJ, Hsueh S, Chao A, Yang JE, Lin CT, Huang SL, Hong JH, Chou HH, et al: Role of human papillomavirus genotype in prognosis of early-stage cervical cancer undergoing primary surgery. J Clin Oncol. 25:3628–3634. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Rose BR, Thompson CH, Simpson JM, Jarrett CS, Elliott PM, Tattersall MH, Dalrymple C and Cossart YE: Human papillomavirus deoxyribonucleic acid as a prognostic indicator in early-stage cervical cancer: A possible role for type 18. Am J Obstet Gynecol. 173:1461–1468. 1995. View Article : Google Scholar : PubMed/NCBI

14 

Burger RA, Monk BJ, Kurosaki T, Anton-Culver H, Vasilev SA, Berman ML and Wilczynski SP: Human papillomavirus type 18: Association with poor prognosis in early stage cervical cancer. J Natl Cancer Inst. 88:1361–1368. 1996. View Article : Google Scholar : PubMed/NCBI

15 

Lombard I, Vincent-Salomon A, Validire P, Zafrani B, de la Rochefordière A, Clough K, Favre M, Pouillart P and Sastre-Garau X: Human papillomavirus genotype as a major determinant of the course of cervical cancer. J Clin Oncol. 16:2613–2619. 1998. View Article : Google Scholar : PubMed/NCBI

16 

Huang LW, Chao SL and Hwang JL: Human papillomavirus-31-related types predict better survival in cervical carcinoma. Cancer. 100:327–334. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Lai HC, Sun CA, Yu MH, Chen HJ, Liu HS and Chu TY: Favorable clinical outcome of cervical cancers infected with human papilloma virus type 58 and related types. Int J Cancer. 84:553–557. 1999. View Article : Google Scholar : PubMed/NCBI

18 

de Villiers EM, Fauquet C, Broker TR, Bernard HU and zur Hausen H: Classification of papillomaviruses. Virology. 324:17–27. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Doorbar J: Molecular biology of human papillomavirus infection and cervical cancer. Clin Sci (Lond). 110:525–541. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Wang CC, Lai CH, Huang HJ, Chao A, Chang CJ, Chang TC, Chou HH and Hong JH: Clinical effect of human papillomavirus genotypes in patients with cervical cancer undergoing primary radiotherapy. Int J Radiat Oncol Biol Phys. 78:1111–1120. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Hall JS, Iype R, Armenoult LS, Taylor J, Miller CJ, Davidson S, de Sanjose S, Bosch X, Stern PL and West CM: Poor prognosis associated with human papillomavirus α7 genotypes in cervical carcinoma cannot be explained by intrinsic radiosensitivity. Int J Radiat Oncol Biol Phys. 85:e223–e229. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Ishikawa H, Mitsuhashi N, Sakurai H, Maebayashi K and Niibe H: The effects of p53 status and human papillomavirus infection on the clinical outcome of patients with stage IIIB cervical carcinoma treated with radiation therapy alone. Cancer. 91:80–89. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Woo YL, Damay I, Stanley M, Crawford R and Sterling J: The use of HPV linear array assay for multiple HPV typing on archival frozen tissue and DNA specimens. J Virol Methods. 142:226–230. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Nakamura E, Iwakawa M, Furuta R, Ohno T, Satoh T, Nakawatari M, Ishikawa K, Imadome K, Michikawa Y, Tamaki T, et al: Villin1, a novel diagnostic marker for cervical adenocarcinoma. Cancer Biol Ther. 8:1146–1153. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Salehi-Vaziri M, Sadeghi F, Hashemi FS, Haeri H, Bokharaei-Salim F, Monavari SH and Keyvani H: Distribution of human papillomavirus genotypes in iranian women according to the severity of the cervical lesion. Iran Red Crescent Med J. 18:e244582016.PubMed/NCBI

26 

García Muentes GD, García Rodríguez LK, Galarraga RI Burgos, Carpio F Almeida and Cabezas JC Ruiz: Genotypes distribution of human papillomavirus in cervical samples of Ecuadorian women. Rev Bras Epidemiol. 19:160–166. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Wang L, Wu B, Li J and Chen L: Prevalence of human papillomavirus and its genotype among 1336 invasive cervical cancer patients in Hunan province, central south China. J Med Virol. 87:516–521. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Lin QQ, Yu SZ, Qu W, Cruz Y and Burk RD: Humanpapillomavirus types 52 and 58. Int J Cancer. 75:484–485. 1998. View Article : Google Scholar : PubMed/NCBI

29 

Lin H, Ma YY, Moh JS, Ou YC, Shen SY and ChangChien CC: High prevalence of genital human papillomavirus type 52 and 58 infection in women attending gynecologic practitioners in South Taiwan. Gynecol Oncol. 101:40–45. 2006. View Article : Google Scholar : PubMed/NCBI

30 

Lai CH, Huang HJ, Hsueh S, Chao A, Lin CT, Huang SL, Chao FY, Qiu JT, Hong JH, Chou HH, et al: Human papillomavirus genotype in cervical cancer: A population-based study. Int J Cancer. 120:1999–2006. 2007. View Article : Google Scholar : PubMed/NCBI

31 

Kusanagi Y, Kojima A, Mikami Y, Kiyokawa T, Sudo T, Yamaguchi S and Nishimura R: Absence of high-risk human papillomavirus (HPV) detection in endocervical adenocarcinoma with gastric morphology and phenotype. Am J Pathol. 177:2169–2175. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Fyles AW, Pintilie M, Kirkbride P, Levin W, Manchul LA and Rawlings GA: Prognostic factors in patients with cervix cancer treated by radiation therapy: Results of a multiple regression analysis. Radiother Oncol. 35:107–117. 1995. View Article : Google Scholar : PubMed/NCBI

33 

Werness BA, Levine AJ and Howley PM: Association of human papillomavirus types 16 and 18 E6 proteins with p53. Science. 248:76–79. 1990. View Article : Google Scholar : PubMed/NCBI

34 

Villa LL and Schlegel R: Differences in transformation activity between HPV-18 and HPV-16 map to the viral LCR-E6-E7 region. Virology. 181:374–377. 1991. View Article : Google Scholar : PubMed/NCBI

35 

Arends MJ, Wyllie AH and Bird CC: Human papillomavirus type 18 is associated with less apoptosis in fibroblast tumours than human papillomavirus type 16. Br J Cancer. 72:646–649. 1995. View Article : Google Scholar : PubMed/NCBI

36 

Hampson L, El Hady ES, Moore JV, Kitchener H and Hampson IN: The HPV16 E6 and E7 proteins and the radiation resistance of cervical carcinoma. FASEB J. 15:1445–1447. 2001.PubMed/NCBI

37 

Harris BZ and Lim WA: Mechanism and role of PDZ domains in signaling complex assembly. J Cell Sci. 114:3219–3231. 2001.PubMed/NCBI

38 

Izumchenko E, Singh MK, Plotnikova OV, Tikhmyanova N, Little JL, Serebriiskii IG, Seo S, Kurokawa M, Egleston BL, Klein-Szanto A, et al: NEDD9 promotes oncogenic signaling in mammary tumor development. Cancer Res. 69:7198–7206. 2009. View Article : Google Scholar : PubMed/NCBI

39 

Kim M, Gans JD, Nogueira C, Wang A, Paik JH, Feng B, Brennan C, Hahn WC, Cordon-Cardo C, Wagner SN, et al: Comparative oncogenomics identifies NEDD9 as a melanoma metastasis gene. Cell. 125:1269–1281. 2006. View Article : Google Scholar : PubMed/NCBI

40 

Kondo S, Iwata S, Yamada T, Inoue Y, Ichihara H, Kichikawa Y, Katayose T, Souta-Kuribara A, Yamazaki H, Hosono O, et al: Impact of the integrin signaling adaptor protein NEDD9 on prognosis and metastatic behavior of human lung cancer. Clin Cancer Res. 18:6326–6338. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Okonogi N, Kobayashi D, Suga T, Imai T, Wakatsuki M, Ohno T, Kato S, Nakano T and Kamada T: Human papillomavirus genotype affects metastatic rate following radiotherapy in patients with uterine cervical cancer. Oncol Lett 15: 459-466, 2018.
APA
Okonogi, N., Kobayashi, D., Suga, T., Imai, T., Wakatsuki, M., Ohno, T. ... Kamada, T. (2018). Human papillomavirus genotype affects metastatic rate following radiotherapy in patients with uterine cervical cancer. Oncology Letters, 15, 459-466. https://doi.org/10.3892/ol.2017.7327
MLA
Okonogi, N., Kobayashi, D., Suga, T., Imai, T., Wakatsuki, M., Ohno, T., Kato, S., Nakano, T., Kamada, T."Human papillomavirus genotype affects metastatic rate following radiotherapy in patients with uterine cervical cancer". Oncology Letters 15.1 (2018): 459-466.
Chicago
Okonogi, N., Kobayashi, D., Suga, T., Imai, T., Wakatsuki, M., Ohno, T., Kato, S., Nakano, T., Kamada, T."Human papillomavirus genotype affects metastatic rate following radiotherapy in patients with uterine cervical cancer". Oncology Letters 15, no. 1 (2018): 459-466. https://doi.org/10.3892/ol.2017.7327
Copy and paste a formatted citation
x
Spandidos Publications style
Okonogi N, Kobayashi D, Suga T, Imai T, Wakatsuki M, Ohno T, Kato S, Nakano T and Kamada T: Human papillomavirus genotype affects metastatic rate following radiotherapy in patients with uterine cervical cancer. Oncol Lett 15: 459-466, 2018.
APA
Okonogi, N., Kobayashi, D., Suga, T., Imai, T., Wakatsuki, M., Ohno, T. ... Kamada, T. (2018). Human papillomavirus genotype affects metastatic rate following radiotherapy in patients with uterine cervical cancer. Oncology Letters, 15, 459-466. https://doi.org/10.3892/ol.2017.7327
MLA
Okonogi, N., Kobayashi, D., Suga, T., Imai, T., Wakatsuki, M., Ohno, T., Kato, S., Nakano, T., Kamada, T."Human papillomavirus genotype affects metastatic rate following radiotherapy in patients with uterine cervical cancer". Oncology Letters 15.1 (2018): 459-466.
Chicago
Okonogi, N., Kobayashi, D., Suga, T., Imai, T., Wakatsuki, M., Ohno, T., Kato, S., Nakano, T., Kamada, T."Human papillomavirus genotype affects metastatic rate following radiotherapy in patients with uterine cervical cancer". Oncology Letters 15, no. 1 (2018): 459-466. https://doi.org/10.3892/ol.2017.7327
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