Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
January-2018 Volume 15 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2018 Volume 15 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Antitumor and immunostimulatory activities of a genotype V recombinant attenuated veterinary Newcastle disease virus vaccine

  • Authors:
    • Oscar Antonio Ortega‑Rivera
    • J Luis Quintanar
    • Susana Del Toro‑Arreola
    • Ángel G Alpuche‑Solis
    • Mayra J Esparza‑Araiza
    • Eva Salinas
  • View Affiliations / Copyright

    Affiliations: Laboratory of Immunology, Department of Microbiology, Basic Science Center, Autonomous University of Aguascalientes, Aguascalientes 20131, Aguascalientes, Mexico, Laboratory of Neurophysiology, Department of Physiology and Pharmacology, Basic Science Center, Autonomous University of Aguascalientes, Aguascalientes 20131, Aguascalientes, Mexico, Laboratory of Immunology, Department of Physiology, CUCS, University of Guadalajara, Guadalajara 44340, Jalisco, Mexico, Division of Molecular Biology, Potosinian Institute of Scientific and Technological Research, San Luis Potosí 78216, San Luis Potosí, Mexico
  • Pages: 1246-1254
    |
    Published online on: November 9, 2017
       https://doi.org/10.3892/ol.2017.7387
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Antitumor conventional treatments including chemo/radiotherapy result in several side effects and non‑specificity. Therapies including the use of oncolytic viruses, particularly the Newcastle disease virus (NDV), have emerged as an attractive alternative due to their capacity to kill cancer cells directly or through stimulation of the immune system. In the present study, a commercial vaccine composed of a recombinant attenuated NDV strain P05 (rNDV‑P05) was assessed for antitumor and immunostimulatory activity. Firstly, hemagglutination activity was evaluated at different pH and temperature conditions. Then, cancer cell lines and peripheral blood mononuclear cells (PBMC) were co‑cultured with or without rNDV‑P05 and cytoplasmic nucleosomes were measured by enzyme‑linked immunosorbent assay (ELISA) as an apoptosis indicator. Antitumor cytokines produced by PBMC in response to the virus were analyzed by ELISA and reverse transcription quantitative polymerase chain reaction. Characterization of rNDV‑P05 indicates that the virus is slightly sensible to acid and basic pH, and stable at temperatures no greater than 42˚C. The majority of cell lines developed apoptosis in co‑culture with rNDV‑P05 in a dose‑time dependent manner. The highest level of HeLa, HCC1954 and HepG2 cell apoptosis was at 48 h/50 hemagglutination units (HU), and HL‑60 was 24 h/50 HU. A549 cell line and PBMC did not show sensitivity to apoptosis by the virus. PBMC from healthy donors stimulated with the rNDV‑P05 increased significantly the levels of interferon (IFN)‑α, IFN‑γ, tumor necrosis factor (TNF)‑α and soluble TNF‑related apoptosis‑inducing ligand in culture supernatants, as well as their mRNA expression. These results demonstrate that the pro‑apoptotic effect of rNDV‑P05 and its magnitude is specific to particular tumor cell lines and is not induced on PBMC; and the virus stimulates the expression of several key antitumor cytokines. This study promotes the use of rNDV‑P05 in an alternate application of different viral strains during virotherapy with NDV.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

World Health Organization (WHO), . 2017, https://www.who.int/cancer/en/April 10–2017

2 

Schirrmacher V: Fifty years of clinical application of Newcastle disease virus: Time to celebrate! Biomedicines. 4:E162016. View Article : Google Scholar : PubMed/NCBI

3 

Russell SJ, Peng KW and Bell JC: Oncolytic virotherapy. Nat Biotechnol. 30:658–670. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Kroemer G, Galluzzi L, Kepp O and Zitvogel L: Immunogenic cell death in cancer therapy. Annu Rev Immunol. 31:51–72. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Guo ZS, Liu Z and Bartlett DL: Oncolytic immunotherapy: Dying the right way is a key to eliciting potent antitumor immunity. Front Oncol. 4:742014. View Article : Google Scholar : PubMed/NCBI

6 

Mayo MA: Virus taxonomy-Houston 2002. Arch Virol. 147:1071–1076. 2002.PubMed/NCBI

7 

Alexander DJ: Newcastle disease and other avian paramyxoviruses. Rev Sci Tech. 19:443–462. 2000. View Article : Google Scholar : PubMed/NCBI

8 

Czeglédi A, Ujvári D, Somogyi E, Wehmann E, Werner O and Lomniczi B: Third genome size category of avian paramyxovirus serotype 1 (Newcastle disease virus) and evolutionary implications. Virus Res. 120:36–48. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Morrison T, McQuain C, Sergel T, McGinnes L and Reitter J: The role of the amino terminus of F1 of the Newcastle disease virus fusion protein in cleavage and fusion. Virology. 193:997–1000. 1993. View Article : Google Scholar : PubMed/NCBI

10 

Panda A, Huang Z, Elankumaran S, Rockemann DD and Samal SK: Role of fusion protein cleavage site in the virulence of Newcastle disease virus. Microb Pathog. 36:1–10. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Ahlert T and Schirrmacher V: Isolation of a human melanoma adapted Newcastle disease virus mutant with highly selective replication patterns. Cancer Res. 50:5962–5968. 1990.PubMed/NCBI

12 

Elankumaran S, Rockemann D and Samal SK: Newcastle disease virus exerts oncolysis by both intrinsic and extrinsic caspase-dependent pathways of cell death. J Virol. 80:7522–7534. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Kumar R, Tiwari AK, Chaturvedi U, Kumar GR, Sahoo AP, Rajmani RS, Saxena L, Saxena S, Tiwari S and Kumar S: Velogenic Newcastle disease virus as an oncolytic virotherapeutics: In vitro characterization. Appl Biochem Biotechnol. 167:2005–2022. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Gallucci S and Matzinger P: Danger signals: SOS to the immune system. Curr Opin Immunol. 13:114–119. 2001. View Article : Google Scholar : PubMed/NCBI

15 

Zeng J, Fournier P and Schirrmacher V: Induction of interferon-alpha and tumor necrosis factor-related apoptosis-inducing ligand in human blood mononuclear cells by hemagglutinin-neuraminidase but not F protein of Newcastle disease virus. Virology. 297:19–30. 2002. View Article : Google Scholar : PubMed/NCBI

16 

Fournier P, Zeng J and Schirrmacher V: Two ways to induce innate immune responses in human PBMCs: Paracrine stimulation of IFN-α responses by viral protein or dsRNA. Int J Oncol. 23:673–680. 2003.PubMed/NCBI

17 

Lam HY, Yusoff K, Yeap SK, Subramani T, Abd-Aziz S, Omar AR and Alitheen NB: Immunomodulatory effects of Newcastle disease virus AF2240 strain on human peripheral blood mononuclear cells. Int J Med Sci. 11:1240–1247. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Zorn U, Dallmann I, Grosse J, Kirchner H, Poliwoda H and Atzpodien J: Induction of cytokines and cytotoxicity against tumor cells by Νewcastle disease virus. Cancer Biother. 9:225–235. 1994. View Article : Google Scholar : PubMed/NCBI

19 

Schirrmacher V, Bai L, Umansky V, Yu L, Xing Y and Qian Z: Newcastle disease virus activates macrophages for anti-tumor activity. Int J Oncol. 16:363–373. 2000.PubMed/NCBI

20 

Janke M, Peeters B, de Leeuw O, Moorman R, Arnold A, Fournier P and Schirrmacher V: Recombinant Newcastle disease virus (NDV) with inserted gene coding for GM-CSF as a new vector for cancer immunogene therapy. Gene Ther. 14:1639–1649. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Janke M, Peeters B, Zhao H, de Leeuw O, Moorman R, Arnold A, Ziouta Y, Fournier P and Schirrmacher V: Activation of human T cells by a tumor vaccine infected with recombinant Newcastle disease virus producing IL-2. Int J Oncol. 33:823–832. 2008.PubMed/NCBI

22 

Absalón AE, Mariano-Matías A, Vásquez-Márquez A, Morales-Garzón A, Cortés-Espinosa DV, Ortega-García R and Lucio-Decanini E: Complete genome sequence of a velogenic Newcastle disease virus isolated in Mexico. Virus Genes. 45:304–310. 2012. View Article : Google Scholar : PubMed/NCBI

23 

López-Terrada D, Cheung SW, Finegold MJ and Knowles BB: Hep G2 is a hepatoblastoma-derived cell line. Hum Pathol. 40:1512–1515. 2009. View Article : Google Scholar

24 

Garzón-Morales JA, Lucio-Decanini E, Cortes-Espinosa DV and Absalón-Constantino AE: Newcastle disease virus and the use thereof as a vaccine US Patent 2013/0315956 A1. Filing date: November 18, 2011. Publication date. November 28–2013

25 

Gallagher SR: Unit 7.3. SDS-polyacrylamide gel electrophoresis (SDS-PAGE). Curr Protoc Essent Lab Tech. 2012:1–28. 2011.

26 

Schmittgen TD and Livak KJ: Analyzing real-time PCR data by the comparative CT method. Nat Protoc. 3:1101–1108. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Zamarin D and Palese P: Oncolytic Newcastle disease virus for cancer therapy: Old challenges and new directions. Future Microbiol. 7:347–367. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Rani S, Gogoi P and Kumar S: Spectrum of Newcastle disease virus stability in gradients of temperature and pH. Biologicals. 42:351–354. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Alabsi AM, Bakar SA, Ali R, Omar AR, Bejo MH, Ideris A and Ali AM: Effects of Newcastle disease virus strains AF2240 and V4-UPM on cytolysis and apoptosis of leukemia cell lines. Int J Mol Sci. 12:8645–8660. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Lv Z, Zhang TY, Yin JC, Wang H, Sun T, Chen LQ, Bai FL, Wu W, Ren GP and Li DS: Enhancement of anti-tumor activity of Newcastle disease virus by the synergistic effect of cytosine deaminase. Asian Pac J Cancer Prev. 14:7489–7496. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Jiang K, Li Y, Zhu Q, Xu J, Wang Y, Deng W, Liu Q, Zhang G and Meng S: Pharmacological modulation of autophagy enhances Newcastle disease virus-mediated oncolysis in drug-resistant lung cancer cells. BMC Cancer. 14:5512014. View Article : Google Scholar : PubMed/NCBI

32 

Rajmani RS, Gupta SK, Singh PK, Gandham RK, Sahoo AP, Chaturvedi U and Tiwari AK: HN protein of Newcastle disease virus sensitizes HeLa cells to TNF-α-induced apoptosis by downregulating NF-κB expression. Arch Virol. 161:2395–2405. 2016. View Article : Google Scholar : PubMed/NCBI

33 

Ni J, Galani IE, Cerwenka A, Schirrmacher V and Fournier P: Antitumor vaccination by Newcastle disease virus hemagglutinin-neuraminidase plasmid DNA application: Changes in tumor microenvironment and activation of innate anti-tumor immunity. Vaccine. 29:1185–1193. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Donnelly OG, Errington-mais F, Steele L, Hadac E, Scott K, Peach H, Phillips RM, Bond J, Harrington K, Vile R, et al: Measles virus causes immunogenic cell death in human melanoma. Gene Ther. 20:7–15. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Zamarin D, Holmgaard RB, Subudhi SK, Park JS, Mansour M, Palese P, Merghoub T, Wolchok JD and Allison JP: Localized oncolytic virotherapy overcomes systemic tumor resistance to immune checkpoint blockade immunotherapy. Sci Transl Med. 6:226–232. 2014. View Article : Google Scholar

36 

Seal BS, King DJ and Sellers HS: The avian response to Newcastle disease virus. Dev Comp Immunol. 24:257–268. 2000. View Article : Google Scholar : PubMed/NCBI

37 

Miller PJ, King DJ, Afonso CL and Suarez DL: Antigenic differences among Newcastle disease virus strains of different genotypes used in vaccine formulation affect viral shedding after a virulent challenge. Vaccine. 25:7238–7246. 2007. View Article : Google Scholar : PubMed/NCBI

38 

Balkwill FR, Lee A, Aldam G, Moodie E, Thomas JA, Tavernier J and Fiers W: Human tumor xenografts treated with recombinant human tumor necrosis factor alone or in combination with interferons. Cancer Res. 46:3990–3993. 1986.PubMed/NCBI

39 

Talmadge JE, Phillips H, Schneider M, Rowe T, Pennington R, Bowersox O and Lenz B: Immunomodulatory properties of recombinant murine and human tumor necrosis factor. Cancer Res. 48:544–550. 1988.PubMed/NCBI

40 

van der Veen AH, de Wilt JH, Eggermont AM, van Tiel ST, Seynhaeve ALB and ten Hagen TL: TNF-alpha augments intratumoural concentrations of doxorubicin in TNF-alpha-based isolated limb perfusion in rat sarcoma models and enhances anti-tumour effects. Br J Cancer. 82:973–980. 2000. View Article : Google Scholar : PubMed/NCBI

41 

Seynhaeve AL, Hoving S, Schipper D, Vermeulen CE, De Wiel-Ambagtsheer GA, VanTiel ST, Eggermont AM and Ten Hagen TL: Tumor necrosis factor-alpha mediates homogeneous distribution of liposomes in murine melanoma that contributes to a better tumor response. Cancer Res. 67:9455–9462. 2007. View Article : Google Scholar : PubMed/NCBI

42 

Lorence RM, Rood PA and Kelley KW: Newcastle disease virus as an antineoplastic agent: Induction of tumor necrosis factor-alpha and augmentation of its cytotoxicity. J Natl Cancer Inst. 80:1305–1312. 1988. View Article : Google Scholar : PubMed/NCBI

43 

Ahmed I, Ahmad U, Keong YY, Manna NA and Othman F: Induction of nitric oxide and TNF-α in Newcastle disease virus (NDV) AF2240 infected RAW 264.7 macrophages and their cytotoxic activity on MDA-MB-231 breast cancer cell line. J Cancer Sci Ther. 6:478–482. 2014. View Article : Google Scholar

44 

Pecora AL, Rizvi N, Cohen GI, Meropol NJ, Sterman D, Marshall JL, Goldberg S, Gross P, O'Neil JD, Groene WS, et al: Phase I trial of intravenous administration of PV701, an oncolytic virus, in patients with advanced solid cancers. J Clin Oncol. 20:2251–2266. 2002. View Article : Google Scholar : PubMed/NCBI

45 

Ashkenazi A, Pai RC, Fong S, Leung S, Lawrence DA, Marsters SA, Blackie C, Chang L, McMurtrey AE, Hebert A, et al: Safety and antitumor activity of recombinant soluble Apo2 ligand. J Clin Invest. 104:155–162. 1999. View Article : Google Scholar : PubMed/NCBI

46 

Walczak H, Miller RE, Ariail K, Gliniak B, Griffith TS, Kubin M, Chin W, Jones J, Woodward A, Le T, et al: Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo. Nat Med. 5:157–163. 1999. View Article : Google Scholar : PubMed/NCBI

47 

Washburn B, Weigand MA, Grosse-Wilde A, Janke M, Stahl H, Rieser E, Sprick MR, Schirrmacher V and Walczak H: TNF-related apoptosis-inducing ligand mediates tumoricidal activity of human monocytes stimulated by Newcastle disease virus. J Immunol. 170:1814–1821. 2003. View Article : Google Scholar : PubMed/NCBI

48 

Song DZ, Liang Y, Xiao Q, Yin J, Gong JL, Lai ZP, Zhang ZF, Gao LX and Fan XH: TRAIL is involved in the tumoricidal activity of mouse natural killer cells stimulated by Newcastle disease virus in vitro. Anat Rec (Hoboken). 296:1552–1560. 2013. View Article : Google Scholar : PubMed/NCBI

49 

Vidalain PO, Azocar O, Lamouille B, Astier A, Rabourdin-Combe C and Servet-Delprat C: Measles virus induces functional TRAIL production by human dendritic cells. J Virol. 74:556–559. 2000. View Article : Google Scholar : PubMed/NCBI

50 

Chaperot L, Blum A, Manches O, Lui G, Angel J, Molens JP and Plumas J: Virus or TLR agonists induce TRAIL-mediated cytotoxic activity of plasmacytoid dendritic cells. J Immunol. 176:248–255. 2005. View Article : Google Scholar

51 

Ehrlich S, Infante-Duarte C, Seeger B and Zipp F: Regulation of soluble and surface-bound TRAIL in human T cells, B cells and monocytes. Cytokine. 24:244–253. 2003. View Article : Google Scholar : PubMed/NCBI

52 

Griffith TS, Wiley SR, Kubin MZ, Sedger LM, Maliszewski CR and Fanger NA: Monocyte-mediated tumoricidal activity via the tumor necrosis factor-related cytokine, TRAIL. J Exp Med. 189:1343–1354. 1999. View Article : Google Scholar : PubMed/NCBI

53 

Fanger NA, Maliszewski CR, Schooley K and Griffith TS: Human dendritic cells mediate cellular apoptosis via tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). J Exp Med. 190:1155–1164. 1999. View Article : Google Scholar : PubMed/NCBI

54 

Löseke S, Grage-Griebenow E, Wagner A, Gehlhar K and Bufe A: Differential expression of IFN-alpha subtypes in human PBMC: Evaluation of novel real-time PCR assays. J Immunol Methods. 276:207–222. 2003. View Article : Google Scholar : PubMed/NCBI

55 

Goodbourn S, Didcock L and Randall RE: Interferons: Cell signalling, immune modulation, antiviral response and virus countermeasure. J Gen Virol. 81:2341–2364. 2000. View Article : Google Scholar : PubMed/NCBI

56 

Onoguchi K, Yoneyama M, Takemura A, Akira S, Taniguchi T, Namiki H and Fujita T: Viral infections activate types I and III interferon genes through a common mechanism. J Biol Chem. 282:7576–7581. 2007. View Article : Google Scholar : PubMed/NCBI

57 

Ivashkiv LB and Donlin LT: Regulation of type I interferon responses. Nat Rev Immunol. 14:36–49. 2014. View Article : Google Scholar : PubMed/NCBI

58 

Schroder K, Hertzog PJ, Ravasi T and Hume DA: Interferon-gamma: An overview of signals, mechanisms and functions. J Leukoc Biol. 75:163–189. 2004. View Article : Google Scholar : PubMed/NCBI

59 

Parker BS, Rautela J and Hertzog PJ: Antitumour actions of interferons: Implications for cancer therapy. Nat Rev Cancer. 16:131–144. 2016. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ortega‑Rivera OA, Quintanar J, Del Toro‑Arreola S, Alpuche‑Solis ÁG, Esparza‑Araiza MJ and Salinas E: Antitumor and immunostimulatory activities of a genotype V recombinant attenuated veterinary Newcastle disease virus vaccine. Oncol Lett 15: 1246-1254, 2018.
APA
Ortega‑Rivera, O.A., Quintanar, J., Del Toro‑Arreola, S., Alpuche‑Solis, Á.G., Esparza‑Araiza, M.J., & Salinas, E. (2018). Antitumor and immunostimulatory activities of a genotype V recombinant attenuated veterinary Newcastle disease virus vaccine. Oncology Letters, 15, 1246-1254. https://doi.org/10.3892/ol.2017.7387
MLA
Ortega‑Rivera, O. A., Quintanar, J., Del Toro‑Arreola, S., Alpuche‑Solis, Á. G., Esparza‑Araiza, M. J., Salinas, E."Antitumor and immunostimulatory activities of a genotype V recombinant attenuated veterinary Newcastle disease virus vaccine". Oncology Letters 15.1 (2018): 1246-1254.
Chicago
Ortega‑Rivera, O. A., Quintanar, J., Del Toro‑Arreola, S., Alpuche‑Solis, Á. G., Esparza‑Araiza, M. J., Salinas, E."Antitumor and immunostimulatory activities of a genotype V recombinant attenuated veterinary Newcastle disease virus vaccine". Oncology Letters 15, no. 1 (2018): 1246-1254. https://doi.org/10.3892/ol.2017.7387
Copy and paste a formatted citation
x
Spandidos Publications style
Ortega‑Rivera OA, Quintanar J, Del Toro‑Arreola S, Alpuche‑Solis ÁG, Esparza‑Araiza MJ and Salinas E: Antitumor and immunostimulatory activities of a genotype V recombinant attenuated veterinary Newcastle disease virus vaccine. Oncol Lett 15: 1246-1254, 2018.
APA
Ortega‑Rivera, O.A., Quintanar, J., Del Toro‑Arreola, S., Alpuche‑Solis, Á.G., Esparza‑Araiza, M.J., & Salinas, E. (2018). Antitumor and immunostimulatory activities of a genotype V recombinant attenuated veterinary Newcastle disease virus vaccine. Oncology Letters, 15, 1246-1254. https://doi.org/10.3892/ol.2017.7387
MLA
Ortega‑Rivera, O. A., Quintanar, J., Del Toro‑Arreola, S., Alpuche‑Solis, Á. G., Esparza‑Araiza, M. J., Salinas, E."Antitumor and immunostimulatory activities of a genotype V recombinant attenuated veterinary Newcastle disease virus vaccine". Oncology Letters 15.1 (2018): 1246-1254.
Chicago
Ortega‑Rivera, O. A., Quintanar, J., Del Toro‑Arreola, S., Alpuche‑Solis, Á. G., Esparza‑Araiza, M. J., Salinas, E."Antitumor and immunostimulatory activities of a genotype V recombinant attenuated veterinary Newcastle disease virus vaccine". Oncology Letters 15, no. 1 (2018): 1246-1254. https://doi.org/10.3892/ol.2017.7387
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team