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Article Open Access

Increased copy number of mitochondrial DNA predicts poor prognosis of esophageal squamous cell carcinoma

  • Authors:
    • Heng Li
    • Zhufang Tian
    • Yong Zhang
    • Qi Yang
    • Bingyin Shi
    • Peng Hou
    • Meiju Ji
  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China, Department of Endocrinology, Xi'an Central Hospital, Xi'an, Shaanxi 710003, P.R. China, Department of Thoracic Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China, Center for Translational Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1014-1020
    |
    Published online on: November 15, 2017
       https://doi.org/10.3892/ol.2017.7416
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Abstract

Change in mitochondrial DNA (mtDNA) copy number has been reported in esophageal squamous cell carcinoma (ESCC). However, its prognostic implication in ESCC remains largely unknown. Using reverse transcription‑quantitative PCR assay, the mtDNA copy number was assessed in a cohort of patients with ESCC (n=141) and normal esophageal tissues (n=45), and the association between variable mtDNA levels and clinical outcomes of patients with ESCC were studied. Data revealed that ESCC patients exhibited an increased mtDNA content compared to control subjects. Furthermore, increased mtDNA content was associated with a significantly increased risk of cancer‑associated mortality. This molecular event was associated with poorer survival in patients with ESCC, and was an independent predictor of patient survival. Data demonstrated that increased mtDNA content is a common genetic event in ESCC and may be a predictive factor of poor prognosis for ESCC patients.
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1 

Li JY, Liu BQ, Li GY, Chen ZL, Sun XI and Rong SD: Atlas of cancer mortality in the People's Republic of China. An aid for cancer control and research. Int J Epidemiol. 10:127–133. 1981. View Article : Google Scholar : PubMed/NCBI

2 

Li JY: Cancer mapping as an epidemiologic research resource in China. Recent Results Cancer Res. 114:115–136. 1989. View Article : Google Scholar : PubMed/NCBI

3 

Wu IC, Lu CY, Kuo FC, Tsai SM, Lee KW, Kuo WR, Cheng YJ, Kao EL, Yang MS and Ko YC: Interaction between cigarette, alcohol and betel nut use on esophageal cancer risk in Taiwan. Eur J Clin Invest. 36:236–241. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Lin CS, Chang SC, Wei YH, Chou TY, Wu YC, Lin HC, Wang LS and Hsu WH: Prognostic variables in thoracic esophageal squamous cell carcinoma. Ann Thorac Surg. 87:1056–1065. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Lin CS, Chang SC, Wang LS, Chou TY, Hsu WH, Wu YC and Wei YH: The role of mitochondrial DNA alterations in esophageal squamous cell carcinomas. J Thorac Cardiovascular Surg. 139:189–197.e4. 2010. View Article : Google Scholar

6 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global Cancer Statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Iborra FJ, Kimura H and Cook PR: The functional organization of mitochondrial genomes in human cells. BMC Biol. 2:92004. View Article : Google Scholar : PubMed/NCBI

8 

Wallace DC: Mitochondria and cancer. Nat Rev Cancer. 12:685–698. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Shadel GS: Expression and maintenance of mitochondrial DNA: New insights into human disease pathology. Am J Pathol. 172:1445–1456. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Chinnery PF and Hudson G: Mitochondrial genetics. Br Med Bull. 106:135–159. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Lightowlers RN, Chinnery PF, Turnbull DM and Howell N: Mammalian mitochondrial genetics: Heredity, heteroplasty and disease. Trends Genet. 13:450–455. 1997. View Article : Google Scholar : PubMed/NCBI

12 

Copeland WC, Wachsman JT, Johnson FM and Penta JS: Mitochondrial DNA alterations in cancer. Cancer Invest. 20:557–569. 2002. View Article : Google Scholar : PubMed/NCBI

13 

Zhang G, Qu Y, Dang S, Yang Q, Shi B and Hou P: Variable copy number of mitochondrial DNA (mtDNA) predicts worse prognosis in advanced gastric cancer patients. Diagn Pathol. 8:1732013. View Article : Google Scholar : PubMed/NCBI

14 

Dang S, Qu Y, Wei J, Shao Y, Yang Q, Ji M, Shi B and Hou P: Low copy number of mitochondrial DNA (mtDNA) predicts worse prognosis in early-stage laryngeal cancer patients. Diagn Pathol. 9:282014. View Article : Google Scholar : PubMed/NCBI

15 

Zhang Y, Qu Y, Gao K, Yang Q, Shi B, Hou P and Ji M: High copy number of mitochondrial DNA (mtDNA) predicts good prognosis in glioma patients. Am J Cancer Res. 5:1207–1216. 2015.PubMed/NCBI

16 

Reznik E, Miller ML, Şenbabaoğlu Y, Riaz N, Sarungbam J, Tickoo SK, Al-Ahmadie HA, Lee W, Seshan VE, Hakimi AA and Sander C: Mitochondrial DNA copy number variation across human cancers. Elife. 5:pii:e107692016. View Article : Google Scholar

17 

Lan Q, Lim U, Liu CS, Weinstein SJ, Chanock S, Bonner MR, Virtamo J, Albanes D and Rothman N: A prospective study of mitochondrial DNA copy number and risk of non-Hodgkin lymphoma. Blood. 112:4247–4249. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Xing J, Chen M, Wood CG, Lin J, Spitz MR, Ma J, Amos CI, Shields PG, Benowitz NL, Gu J, et al: Mitochondrial DNA content: Its genetic heritability and association with renal cell carcinoma. J Natl Cancer Inst. 100:1104–1112. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Bonner MR, Shen M, Liu CS, Divita M, He X and Lan Q: Mitochondrial DNA content and lung cancer risk in Xuan Wei, China. Lung Cancer. 63:331–334. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Shen J, Platek M, Mahasneh A, Ambrosone CB and Zhao H: Mitochondrial copy number and risk of breast cancer: A pilot study. Mitochondrion. 10:62–68. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Liao LM, Baccarelli A, Shu XO, Gao YT, Ji BT, Yang G, Li HL, Hoxha M, Dioni L, Rothman N, et al: Mitochondrial DNA copy number and risk of gastric cancer: A report from the Shanghai Women's Health Study. Cancer Epidemiol Biomarkers Prev. 20:1944–1949. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Lynch SM, Weinstein SJ, Virtamo J, Lan Q, Liu CS, Cheng WL, Rothman N, Albanes D and Stolzenberg-Solomon RZ: Mitochondrial DNA copy number and pancreatic cancer in the alpha-tocopherol beta-carotene cancer prevention study. Cancer Prev Res (Phila). 4:1912–1919. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Shen L, Wei J, Chen T, He J, Qu J, He X, Jiang L, Qu Y, Fang H, Chen G, et al: Evaluating mitochondrial DNA in patients with breast cancer and benign breast disease. J Cancer Res Clin Oncol. 4:669–675. 2011. View Article : Google Scholar

24 

Hosgood HD III, Liu CS, Rothman N, Weinstein SJ, Bonner MR, Shen M, Lim U, Virtamo J, Cheng WL, Albanes D and Lan Q: Mitochondrial DNA copy number and lung cancer risk in a prospective cohort study. Carcinogenesis. 31:847–849. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Hamiltion SR and Aaltonen LA: Pathology and genetics of tumours of the digestive system. Lyon: IARCPress; pp. 11–36. 2000

26 

Shi J, Yao D, Liu W, Wang N, Lv H, Zhang G, Ji M, Xu L, He N, Shi B and Hou P: Highly frequent PIK3CA amplification is associated with poor prognosis in gastric cancer. BMC Cancer. 12:502012. View Article : Google Scholar : PubMed/NCBI

27 

Stahl M, Mariette C, Haustermans K, Cervantes A and Arnold D; ESMO Guidelines Working Group, : Oesophageal cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 24 Suppl 6:vi51–vi56. 2013. View Article : Google Scholar : PubMed/NCBI

28 

McBride HM, Neuspiel M and Wasiak S: Mitochondria: More than just a powerhouse. Curr Biol. 16:R551–R560. 2006. View Article : Google Scholar : PubMed/NCBI

29 

Gasparre G, Romeo G, Rugolo M and Porcelli AM: Learning from oncocytic tumors: Why choose inefficient mitochondria? Biochim Biophys Acta. 1807:633–642. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Iommarini L, Calvaruso MA, Kurelac I, Gasparre G and Porcelli AM: Complex impairment in mitochondrial diseases and cancer: Parallel roads leading to different outcomes. Int J Biochem Cell Biol. 45:47–63. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Campbell CL and Thorsness PE: Escape of mitochondrial DNA to the nucleus in yme1 yeast is mediated by vacuolar-dependent turnover of abnormal mitochondrial compartments. J Cell Sci. 111:2455–2564. 1998.PubMed/NCBI

32 

Thorsness PE and Weber ER: Escape and migration of nucleic acids between chloroplasts, mitochondria, and the nucleus. Int Rev Cytol. 165:207–234. 1996. View Article : Google Scholar : PubMed/NCBI

33 

Liang BC and Hays L: Mitochondrial DNA copy number changes in human gliomas. Cancer Lett. 2:167–173. 1996. View Article : Google Scholar

34 

Netter P and Robineau S: The differential over amplification of short sequences in the mitochondrial DNA of rho-petites in Saccharomyces cerevisiae stimulates recombination. Gene. 83:25–38. 1989. View Article : Google Scholar : PubMed/NCBI

35 

Eppert K, Scherer SW, Ozcelik H, Pirone R, Hoodless P, Kim H, Tsui LC, Bapat B, Gallinger S, Andrulis IL, et al: MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma. Cell. 86:543–552. 1996. View Article : Google Scholar : PubMed/NCBI

36 

Borensztajn K, Chafa O, Alhenc-Gelas M, Salha S, Reghis A, Fischer AM and Tapon-Bretaudière J: Characterization of two novel splice site mutations in human factor VII gene causing severe plasma factor VII deficiency and bleeding diathesis. Br J Haematol. 117:168–171. 2002. View Article : Google Scholar : PubMed/NCBI

37 

Turner C, Killoran C, Thomas NS, Rosenberg M, Chuzhanova NA, Johnston J, Kemel Y, Cooper DN and Biesecker LG: Human genetic disease caused by de novo mitochondrial-nuclear DNA transfer. Hum Genet. 112:303–309. 2003.PubMed/NCBI

38 

Zhang G, Qu Y, Dang S, Yang Q, Shi B and Hou P: Variable copy number of mitochondrial DNA (mtDNA) predicts worse prognosis in advanced gastric cancer patients. Diagn Pathol. 8:1732013. View Article : Google Scholar : PubMed/NCBI

39 

Dang S, Qu Y, Wei J, Shao Y, Yang Q, Ji M, Shi B and Hou P: Low copy number of mitochondrial DNA (mtDNA) predicts worse prognosis in early-stage laryngeal cancer patients. Diagn Pathol. 9:282014. View Article : Google Scholar : PubMed/NCBI

40 

Liu M, Hu P, Zhang G, Zeng Y, Yang H, Fan J, Jin L, Liu H, Deng Y, Li S, et al: Copy number variation analysis by ligation-dependent PCR based on magnetic nanoparticles and chemiluminescence. Theranostics. 4:71–85. 2015. View Article : Google Scholar

41 

Yang H, Liu M, Zhou B, Deng Y, He N, Jiang H, Guo Y, Lan G, Jiang Q, Yang X and Li Z: Chemiluminescent detection for estimating relative copy numbers of porcine endogenous retrovirus proviruses from Chinese Minipigs based on magnetic nanoparticles. J Nanosci Nanotechnol. 16:6505–6510. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li H, Tian Z, Zhang Y, Yang Q, Shi B, Hou P and Ji M: Increased copy number of mitochondrial DNA predicts poor prognosis of esophageal squamous cell carcinoma. Oncol Lett 15: 1014-1020, 2018.
APA
Li, H., Tian, Z., Zhang, Y., Yang, Q., Shi, B., Hou, P., & Ji, M. (2018). Increased copy number of mitochondrial DNA predicts poor prognosis of esophageal squamous cell carcinoma. Oncology Letters, 15, 1014-1020. https://doi.org/10.3892/ol.2017.7416
MLA
Li, H., Tian, Z., Zhang, Y., Yang, Q., Shi, B., Hou, P., Ji, M."Increased copy number of mitochondrial DNA predicts poor prognosis of esophageal squamous cell carcinoma". Oncology Letters 15.1 (2018): 1014-1020.
Chicago
Li, H., Tian, Z., Zhang, Y., Yang, Q., Shi, B., Hou, P., Ji, M."Increased copy number of mitochondrial DNA predicts poor prognosis of esophageal squamous cell carcinoma". Oncology Letters 15, no. 1 (2018): 1014-1020. https://doi.org/10.3892/ol.2017.7416
Copy and paste a formatted citation
x
Spandidos Publications style
Li H, Tian Z, Zhang Y, Yang Q, Shi B, Hou P and Ji M: Increased copy number of mitochondrial DNA predicts poor prognosis of esophageal squamous cell carcinoma. Oncol Lett 15: 1014-1020, 2018.
APA
Li, H., Tian, Z., Zhang, Y., Yang, Q., Shi, B., Hou, P., & Ji, M. (2018). Increased copy number of mitochondrial DNA predicts poor prognosis of esophageal squamous cell carcinoma. Oncology Letters, 15, 1014-1020. https://doi.org/10.3892/ol.2017.7416
MLA
Li, H., Tian, Z., Zhang, Y., Yang, Q., Shi, B., Hou, P., Ji, M."Increased copy number of mitochondrial DNA predicts poor prognosis of esophageal squamous cell carcinoma". Oncology Letters 15.1 (2018): 1014-1020.
Chicago
Li, H., Tian, Z., Zhang, Y., Yang, Q., Shi, B., Hou, P., Ji, M."Increased copy number of mitochondrial DNA predicts poor prognosis of esophageal squamous cell carcinoma". Oncology Letters 15, no. 1 (2018): 1014-1020. https://doi.org/10.3892/ol.2017.7416
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