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Autophagy activation promotes bevacizumab resistance in glioblastoma by suppressing Akt/mTOR signaling pathway

  • Authors:
    • He Huang
    • Jian Song
    • Zheng Liu
    • Li Pan
    • Guozheng Xu
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China, Department of Neurosurgery, Wuhan General Hospital of PLA, Wuhan, Hubei 430070, P.R. China
    Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1487-1494
    |
    Published online on: November 20, 2017
       https://doi.org/10.3892/ol.2017.7446
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Abstract

Glioblastomas are the most common primary and malignant brain tumors. The standard therapy includes surgery and radiotherapy plus chemotherapy, with additional bevacizumab to block the angiogenesis in tumors. However, the ever‑growing tolerance of glioblastomas to chemotherapeutic drugs impairs the clinical outputs of tumor treatment. The present study investigated the tolerance of glioblastomas to bevacizumab. Although bevacizumab resulted in direct anti‑proliferation and pro‑apoptosis effects on glioblastoma cells via downregulating the anti‑apoptotic proteins and upregulating the pro‑apoptotic proteins, tolerance was also encountered that was mainly caused by autophagy induction in tumor cells. The suppressed Akt‑mTOR signaling pathway led to the upregulated autophagy process. Blockade of the autophagy process significantly increased the tumor‑suppressive effect of bevacizumab on glioblastoma cells. To our knowledge, the present study is the first to report the involvement of autophagy in the tolerance of glioblastomas to bevacizumab. Therefore, autophagy inhibition may be considered a novel way to overcome the tolerance of glioblastomas to anti‑angiogenic agents.
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Copy and paste a formatted citation
Spandidos Publications style
Huang H, Song J, Liu Z, Pan L and Xu G: Autophagy activation promotes bevacizumab resistance in glioblastoma by suppressing Akt/mTOR signaling pathway. Oncol Lett 15: 1487-1494, 2018.
APA
Huang, H., Song, J., Liu, Z., Pan, L., & Xu, G. (2018). Autophagy activation promotes bevacizumab resistance in glioblastoma by suppressing Akt/mTOR signaling pathway. Oncology Letters, 15, 1487-1494. https://doi.org/10.3892/ol.2017.7446
MLA
Huang, H., Song, J., Liu, Z., Pan, L., Xu, G."Autophagy activation promotes bevacizumab resistance in glioblastoma by suppressing Akt/mTOR signaling pathway". Oncology Letters 15.2 (2018): 1487-1494.
Chicago
Huang, H., Song, J., Liu, Z., Pan, L., Xu, G."Autophagy activation promotes bevacizumab resistance in glioblastoma by suppressing Akt/mTOR signaling pathway". Oncology Letters 15, no. 2 (2018): 1487-1494. https://doi.org/10.3892/ol.2017.7446
Copy and paste a formatted citation
x
Spandidos Publications style
Huang H, Song J, Liu Z, Pan L and Xu G: Autophagy activation promotes bevacizumab resistance in glioblastoma by suppressing Akt/mTOR signaling pathway. Oncol Lett 15: 1487-1494, 2018.
APA
Huang, H., Song, J., Liu, Z., Pan, L., & Xu, G. (2018). Autophagy activation promotes bevacizumab resistance in glioblastoma by suppressing Akt/mTOR signaling pathway. Oncology Letters, 15, 1487-1494. https://doi.org/10.3892/ol.2017.7446
MLA
Huang, H., Song, J., Liu, Z., Pan, L., Xu, G."Autophagy activation promotes bevacizumab resistance in glioblastoma by suppressing Akt/mTOR signaling pathway". Oncology Letters 15.2 (2018): 1487-1494.
Chicago
Huang, H., Song, J., Liu, Z., Pan, L., Xu, G."Autophagy activation promotes bevacizumab resistance in glioblastoma by suppressing Akt/mTOR signaling pathway". Oncology Letters 15, no. 2 (2018): 1487-1494. https://doi.org/10.3892/ol.2017.7446
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