Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
February-2018 Volume 15 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2018 Volume 15 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

The role of cadherin-11 in microcystin-LR-induced migration and invasion in colorectal carcinoma cells

  • Authors:
    • Qiangqiang Zhu
    • Zhen Wang
    • Lihua Zhou
    • Yan Ren
    • Ying Gong
    • Wei Qin
    • Lin Bai
    • Jun Hu
    • Ting Wang
  • View Affiliations / Copyright

    Affiliations: Department of Cell Biology, Nanjing Medical University, Nanjing, Jiangsu 211166, P.R. China, Department of Pathology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China, Clinical Medicine School, Nanjing Medical University, Nanjing, Jiangsu 211166, P.R. China, Department of Pharmacy, The Fourth People's Hospital of Jinan City, Jinan, Shandong 250000, P.R. China, School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu 211166, P.R. China
    Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1417-1422
    |
    Published online on: November 21, 2017
       https://doi.org/10.3892/ol.2017.7458
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study aimed to explore whether microcystin‑LR (MC‑LR; a well‑known cyanobacterial toxin produced in eutrophic lakes or reservoirs) induced tumor progression by activating cadherin‑11(CDH11). A previous tumor metastasis PCR array demonstrated that MC‑LR exposure resulted in a significant increase in the expression of CDH11. In the present study, to confirm the effect of the MC‑LR treatment on CDH11 expression, HT‑29 cell migration and invasion following MC‑LR treatment were tested by Transwell assays, and protein levels of CDH11 were tested by immunofluorescence and western blot analysis. The results demonstrated that MC‑LR activated CDH11 expression in addition to cell migration and invasion in HT‑29 cells. To further investigate the association between MC‑LR‑induced CDH11 upregulation, and higher motility and invasiveness in HT‑29 cells, knockdown of CDH11 using small interfering RNA (siRNA) in HT‑29 cells was performed. Subsequent Transwell assays confirmed that MC‑LR‑induced enhancement of migration and invasion was significantly decreased following CDH11 knockdown by CDH11‑siRNA in HT‑29 cells. The results from the present study indicate that MC‑LR may act as a CDH11 activator to promote HT‑29 cell migration and invasion.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Chakrabarti SK, Bai C and Subramanian KS: DNA-Protein crosslinks induced by nickel compounds in isolated rat renal cortical cells and its antagonism by specific amino acids and magnesium ion. Toxicol Appl Pharmacol. 154:245–255. 1999. View Article : Google Scholar : PubMed/NCBI

2 

Ueno Y, Nagata S, Tsutsumi T, Hasegawa A, Watanabe MF, Park HD, Chen GC, Chen G and Yu SZ: Detection of microcystins, a blue-green algal hepatotoxin, in drinking water sampled in Haimen and Fusui, endemic areas of primary liver cancer in China, by highly sensitive immunoassay. Carcinogenesis. 17:1317–1321. 1996. View Article : Google Scholar : PubMed/NCBI

3 

Zhou L, Yu H and Chen K: Relationship between microcystin in drinking water and colorectal cancer. Biomed Environ Sci. 15:166–171. 2002.PubMed/NCBI

4 

Choi P, Jordan CD, Mendez E, Houck J, Yueh B, Farwell DG, Futran N and Chen C: Examination of oral cancer biomarkers by tissue microarray analysis. Arch Otolaryngol Head Neck Surg. 134:539–546. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Zhang H, Cai C, Fang W, Wang J, Zhang Y, Liu J and Jia X: Oxidative damage and apoptosis induced by microcystin-LR in the liver of Rana nigromaculata in vivo. Aquat Toxicol. 140–141, 1 18. 2013.PubMed/NCBI

6 

Zegura B, Volcic M, Lah TT and Filipic M: Different sensitivities of human colon adenocarcinoma (CaCo-2), astrocytoma (IPDDC-A2) and lymphoblastoid (NCNC) cell lines to microcystin-LR induced reactive oxygen species and DNA damage. Toxicon. 52:518–525. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Gaudin J, Huet S, Jarry G and Fessard V: In vivo DNA damage induced by the cyanotoxin microcystin-LR: Comparison of intra-peritoneal and oral administrations by use of the comet assay. Mutat Res. 652:65–71. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Puerto M, Pichardo S, Jos A, Prieto AI, Sevilla E, Frías JE and Cameán AM: Differential oxidative stress responses to pure Microcystin-LR and Microcystin-containing and non-containing cyanobacterial crude extracts on Caco-2 cells. Toxicon. 55:514–522. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Yoon SS and Tanabe KK: Surgical treatment and other regional treatments for colorectal cancer liver metastases. Oncologist. 4:197–208. 1999.PubMed/NCBI

10 

Wheelock MJ and Johnson KR: Cadherins as modulators of cellular phenotype. Annu Rev Cell Dev Biol. 19:207–235. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Berx G and van Roy F: Involvement of members of the cadherin superfamily in cancer. Cold Spring Harb Perspect Biol. 1:a0031292009. View Article : Google Scholar : PubMed/NCBI

12 

Margulis A, Zhang W, Alt-Holland A, Crawford HC, Fusenig NE and Garlick JA: E-cadherin suppression accelerates squamous cell carcinoma progression in three-dimensional, human tissue constructs. Cancer Res. 65:1783–1791. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Andreeva AV and Kutuzov MA: Cadherin 13 in cancer. Gene Chromosome Cancer. 49:775–790. 2010.

14 

Van Roy F: Beyond E-cadherin: Roles of other cadherin superfamily members in cancer. Nat Rev Cancer. 14:121–134. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Huang CF, Lira C, Chu K, Bilen MA, Lee YC, Ye X, Kim SM, Ortiz A, Wu FL, Logothetis CJ, et al: Cadherin-11 increases migration and invasion of prostate cancer cells and enhances their interaction with osteoblasts. Cancer Res. 70:4580–4589. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Pishvaian MJ, Feltes CM, Thompson P, Bussemakers MJ, Schalken JA and Byers SW: Cadherin-11 is expressed in invasive breast cancer cell lines. Cancer Res. 59:947–952. 1999.PubMed/NCBI

17 

Kaur H, Phillips-Mason PJ, Burden-Gulley SM, Kerstetter-Fogle AE, Basilion JP, Sloan AE and Brady-Kalnay SM: Cadherin-11, a marker of the mesenchymal phenotype, regulates glioblastoma cell migration and survival in vivo. Mol Cancer Res. 10:293–304. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Miao C, Ren Y, Chen M, Wang Z and Wang T: Microcystin-LR promotes migration and invasion of colorectal cancer through matrix metalloproteinase-13 up-regulation. Mol Carcinog. 55:514–524. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Xu PF, Zhang XX, Miao C, Fu Z, Li Z, Zhang G, Zheng M, Liu Y, Yang L and Wang T: Promotion of melanoma cell invasion and tumor metastasis by microcystin-LR via phosphatidylinositol 3-Kinase/AKT pathway. Environ Sci Technol. 47:8801–8808. 2013.PubMed/NCBI

20 

Zhang XX, Fu Z, Zhang Z, Miao C, Xu P, Wang T, Yang L and Cheng S: Microcystin-LR promotes melanoma cell invasion and enhances matrix metalloproteinase-2/−9 expression mediated by NF-kappaB activation. Environ Sci Technol. 46:11319–11326. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Yao H, Miura Y, Yoshioka S, Miura M, Hayashi Y, Tamura A, Iwasa M, Sato A, Hishita T, Higashi Y, et al: Parathyroid hormone enhances hematopoietic expansion via upregulation of cadherin-11 in bone marrow mesenchymal stromal cells. Stem Cells. 32:2245–2255. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Sun Y, Liu JH, Huang P, Guo ZL and Xu LH: Alterations of tau and VASP during microcystin-LR-induced cytoskeletal reorganization in a human liver cell line. Environ Toxicol. 30:92–100. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Brasch J, Harrison OJ, Honig B and Shapiro L: Thinking outside the cell: How cadherins drive adhesion. Trends Cell Biol. 22:299–310. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Cavallaro U and Dejana E: Adhesion molecule signalling: Not always a sticky business. Nat Rev Mol Cell Biol. 12:189–197. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Harris TJ and Tepass U: Adherens junctions: From molecules to morphogenesis. Nat Rev Mol Cell Biol. 11:502–514. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Li Y, Guo Z, Chen H, Dong Z, Pan ZK, Ding H, Su SB and Huang S: HOXC8-dependent cadherin 11 expression facilitates breast cancer cell migration through Trio and Rac. Genes Cancer. 2:880–888. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Ridley AJ: Rho GTPases and cell migration. J Cell Sci. 114:2713–2722. 2001.PubMed/NCBI

28 

Li Y, Chao F, Huang B, Liu D, Kim J and Huang S: HOXC8 promotes breast tumorigenesis by transcriptionally facilitating cadherin-11 expression. Oncotarget. 5:2596–2607. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Ortiz A, Lee YC, Yu G, Liu HC, Lin SC, Bilen MA, Cho H, Yu-Lee LY and Lin SH: Angiomotin is a novel component of cadherin-11/β-catenin/p120 complex and is critical for cadherin-11-mediated cell migration. FASEB J. 29:1080–1091. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Noss EH, Chang SK, Watts GF and Brenner MB: Modulation of matrix metalloproteinase production by rheumatoid arthritis synovial fibroblasts after cadherin 11 engagement. Arthritis Rheum. 63:3768–3778. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Roeb E, Arndt M, Jansen B, Schumpelick V and Matern S: Simultaneous determination of matrix metalloproteinase (MMP)-7, MMP-1, −3, and −13 gene expression by multiplex PCR in colorectal carcinomas. Int J Colorectal Dis. 19:518–524. 2004. View Article : Google Scholar : PubMed/NCBI

32 

Monahan TS, Andersen ND, Panossian H, Kalish JA, Daniel S, Shrikhande GV, Ferran C and Logerfo FW: A novel function for cadherin 11/osteoblast-cadherin in vascular smooth muscle cells: Modulation of cell migration and proliferation. J Vasc Surg. 45:581–589. 2007. View Article : Google Scholar : PubMed/NCBI

33 

Locksley RM, Killeen N and Lenardo MJ: The TNF and TNF receptor superfamilies: Integrating mammalian biology. Cell. 104:487–501. 2001. View Article : Google Scholar : PubMed/NCBI

34 

Akira S, Uematsu S and Takeuchi O: Pathogen recognition and innate immunity. Cell. 124:783–801. 2006. View Article : Google Scholar : PubMed/NCBI

35 

Fujiki H and Suganuma M: Tumor promoters-microcystin-LR, nodularin and TNF-alpha and human cancer development. Anticancer Agents Med Chem. 11:4–18. 2011. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhu Q, Wang Z, Zhou L, Ren Y, Gong Y, Qin W, Bai L, Hu J and Wang T: The role of cadherin-11 in microcystin-LR-induced migration and invasion in colorectal carcinoma cells. Oncol Lett 15: 1417-1422, 2018.
APA
Zhu, Q., Wang, Z., Zhou, L., Ren, Y., Gong, Y., Qin, W. ... Wang, T. (2018). The role of cadherin-11 in microcystin-LR-induced migration and invasion in colorectal carcinoma cells. Oncology Letters, 15, 1417-1422. https://doi.org/10.3892/ol.2017.7458
MLA
Zhu, Q., Wang, Z., Zhou, L., Ren, Y., Gong, Y., Qin, W., Bai, L., Hu, J., Wang, T."The role of cadherin-11 in microcystin-LR-induced migration and invasion in colorectal carcinoma cells". Oncology Letters 15.2 (2018): 1417-1422.
Chicago
Zhu, Q., Wang, Z., Zhou, L., Ren, Y., Gong, Y., Qin, W., Bai, L., Hu, J., Wang, T."The role of cadherin-11 in microcystin-LR-induced migration and invasion in colorectal carcinoma cells". Oncology Letters 15, no. 2 (2018): 1417-1422. https://doi.org/10.3892/ol.2017.7458
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu Q, Wang Z, Zhou L, Ren Y, Gong Y, Qin W, Bai L, Hu J and Wang T: The role of cadherin-11 in microcystin-LR-induced migration and invasion in colorectal carcinoma cells. Oncol Lett 15: 1417-1422, 2018.
APA
Zhu, Q., Wang, Z., Zhou, L., Ren, Y., Gong, Y., Qin, W. ... Wang, T. (2018). The role of cadherin-11 in microcystin-LR-induced migration and invasion in colorectal carcinoma cells. Oncology Letters, 15, 1417-1422. https://doi.org/10.3892/ol.2017.7458
MLA
Zhu, Q., Wang, Z., Zhou, L., Ren, Y., Gong, Y., Qin, W., Bai, L., Hu, J., Wang, T."The role of cadherin-11 in microcystin-LR-induced migration and invasion in colorectal carcinoma cells". Oncology Letters 15.2 (2018): 1417-1422.
Chicago
Zhu, Q., Wang, Z., Zhou, L., Ren, Y., Gong, Y., Qin, W., Bai, L., Hu, J., Wang, T."The role of cadherin-11 in microcystin-LR-induced migration and invasion in colorectal carcinoma cells". Oncology Letters 15, no. 2 (2018): 1417-1422. https://doi.org/10.3892/ol.2017.7458
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team