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Article

PI3K/AKT/Afadin signaling pathway contributes to pathological vascularization in glioblastomas

  • Authors:
    • Xuan Zhai
    • Yingliang Li
    • Ping Liang
    • Lusheng Li
    • Yudong Zhou
    • Weidan Zhang
    • Difei Wang
    • Guanghui Wei
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Children's Hospital of Chongqing Medical University, Chongqing 400014, P.R. China, Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, P.R. China
  • Pages: 1893-1899
    |
    Published online on: November 21, 2017
       https://doi.org/10.3892/ol.2017.7461
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Abstract

Glioblastomas are brain tumors with extensive vascularization that are associated with tumor malignancy. The phosphoinositide 3‑kinase (PI3K)/protein kinase B (AKT) signaling pathway is activated in endothelial cell tumors, although its exact function in glioblastoma neovascularization is poorly characterized. The present study identified that endothelial cells derived from human glioblastomas exhibit increased permeability and motility compared with normal brain vascular endothelial cells. Furthermore, the phosphorylation of AKT was significantly induced in glioblastoma‑derived endothelial cells and glioblastoma vessels. To the best of our knowledge, the present study demonstrated for the first time that the cell‑cell adhesion junction protein Afadin is phosphorylated and re‑localized in glioblastoma‑derived endothelial cells, and the phosphorylation and re‑localization of Afadin is PI3K/AKT pathway‑dependent. AKT‑mediated phosphorylation and re‑localization of Afadin may be critically involved in the modulation of brain endothelial permeability and migration. Therapies targeting the PI3K/AKT/Afadin pathway may therefore be beneficial for reducing the angiogenic potential of glioblastoma.
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Copy and paste a formatted citation
Spandidos Publications style
Zhai X, Li Y, Liang P, Li L, Zhou Y, Zhang W, Wang D and Wei G: PI3K/AKT/Afadin signaling pathway contributes to pathological vascularization in glioblastomas. Oncol Lett 15: 1893-1899, 2018.
APA
Zhai, X., Li, Y., Liang, P., Li, L., Zhou, Y., Zhang, W. ... Wei, G. (2018). PI3K/AKT/Afadin signaling pathway contributes to pathological vascularization in glioblastomas. Oncology Letters, 15, 1893-1899. https://doi.org/10.3892/ol.2017.7461
MLA
Zhai, X., Li, Y., Liang, P., Li, L., Zhou, Y., Zhang, W., Wang, D., Wei, G."PI3K/AKT/Afadin signaling pathway contributes to pathological vascularization in glioblastomas". Oncology Letters 15.2 (2018): 1893-1899.
Chicago
Zhai, X., Li, Y., Liang, P., Li, L., Zhou, Y., Zhang, W., Wang, D., Wei, G."PI3K/AKT/Afadin signaling pathway contributes to pathological vascularization in glioblastomas". Oncology Letters 15, no. 2 (2018): 1893-1899. https://doi.org/10.3892/ol.2017.7461
Copy and paste a formatted citation
x
Spandidos Publications style
Zhai X, Li Y, Liang P, Li L, Zhou Y, Zhang W, Wang D and Wei G: PI3K/AKT/Afadin signaling pathway contributes to pathological vascularization in glioblastomas. Oncol Lett 15: 1893-1899, 2018.
APA
Zhai, X., Li, Y., Liang, P., Li, L., Zhou, Y., Zhang, W. ... Wei, G. (2018). PI3K/AKT/Afadin signaling pathway contributes to pathological vascularization in glioblastomas. Oncology Letters, 15, 1893-1899. https://doi.org/10.3892/ol.2017.7461
MLA
Zhai, X., Li, Y., Liang, P., Li, L., Zhou, Y., Zhang, W., Wang, D., Wei, G."PI3K/AKT/Afadin signaling pathway contributes to pathological vascularization in glioblastomas". Oncology Letters 15.2 (2018): 1893-1899.
Chicago
Zhai, X., Li, Y., Liang, P., Li, L., Zhou, Y., Zhang, W., Wang, D., Wei, G."PI3K/AKT/Afadin signaling pathway contributes to pathological vascularization in glioblastomas". Oncology Letters 15, no. 2 (2018): 1893-1899. https://doi.org/10.3892/ol.2017.7461
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