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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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Article

Soluble HER3 predicts survival in bladder cancer patients

  • Authors:
    • Ashfaque A. Memon
    • Stephen C. Gilliver
    • Michael Borre
    • Jan Sundquist
    • Kristina Sundquist
    • Ebba Nexo
    • Boe S. Sorensen
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus DK‑8200, Denmark, Center for Primary Health Care Research, Lund University, 205 02 Malmö, Sweden, Department of Urology, Aarhus University Hospital, Aarhus DK‑8200, Denmark
  • Pages: 1783-1788
    |
    Published online on: November 22, 2017
       https://doi.org/10.3892/ol.2017.7470
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Abstract

The role of soluble human epidermal growth factor receptor (sHER3) in bladder cancer remains unclear. In the present study, an ELISA was developed for the quantification of sHER3 and its role was investigated in patients with bladder cancer (n=82) followed for 10 years. Furthermore, the effects of sHER3 on bladder cancer cell growth and migration were also investigated. The results demonstrated that plasma sHER3 levels were significantly higher in non‑invasive tumours (Ta) compared with muscle‑invasive tumours (T2‑T4). Higher sHER3 levels were associated with a more improved survival rate. However multivariate Cox regression analysis, adjusted for clinical stage, grade, type and size of the tumour, demonstrated that sHER3 was not an independent biomarker of survival. Exogenous sHER3 significantly inhibited bladder cancer cell growth and migration. These results suggest that high sHER3 levels are associated with improved survival rates in patients with bladder cancer, and that sHER3 inhibits bladder cancer cell growth and migration.
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Copy and paste a formatted citation
Spandidos Publications style
Memon AA, Gilliver SC, Borre M, Sundquist J, Sundquist K, Nexo E and Sorensen BS: Soluble HER3 predicts survival in bladder cancer patients. Oncol Lett 15: 1783-1788, 2018.
APA
Memon, A.A., Gilliver, S.C., Borre, M., Sundquist, J., Sundquist, K., Nexo, E., & Sorensen, B.S. (2018). Soluble HER3 predicts survival in bladder cancer patients. Oncology Letters, 15, 1783-1788. https://doi.org/10.3892/ol.2017.7470
MLA
Memon, A. A., Gilliver, S. C., Borre, M., Sundquist, J., Sundquist, K., Nexo, E., Sorensen, B. S."Soluble HER3 predicts survival in bladder cancer patients". Oncology Letters 15.2 (2018): 1783-1788.
Chicago
Memon, A. A., Gilliver, S. C., Borre, M., Sundquist, J., Sundquist, K., Nexo, E., Sorensen, B. S."Soluble HER3 predicts survival in bladder cancer patients". Oncology Letters 15, no. 2 (2018): 1783-1788. https://doi.org/10.3892/ol.2017.7470
Copy and paste a formatted citation
x
Spandidos Publications style
Memon AA, Gilliver SC, Borre M, Sundquist J, Sundquist K, Nexo E and Sorensen BS: Soluble HER3 predicts survival in bladder cancer patients. Oncol Lett 15: 1783-1788, 2018.
APA
Memon, A.A., Gilliver, S.C., Borre, M., Sundquist, J., Sundquist, K., Nexo, E., & Sorensen, B.S. (2018). Soluble HER3 predicts survival in bladder cancer patients. Oncology Letters, 15, 1783-1788. https://doi.org/10.3892/ol.2017.7470
MLA
Memon, A. A., Gilliver, S. C., Borre, M., Sundquist, J., Sundquist, K., Nexo, E., Sorensen, B. S."Soluble HER3 predicts survival in bladder cancer patients". Oncology Letters 15.2 (2018): 1783-1788.
Chicago
Memon, A. A., Gilliver, S. C., Borre, M., Sundquist, J., Sundquist, K., Nexo, E., Sorensen, B. S."Soluble HER3 predicts survival in bladder cancer patients". Oncology Letters 15, no. 2 (2018): 1783-1788. https://doi.org/10.3892/ol.2017.7470
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