Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
February-2018 Volume 15 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2018 Volume 15 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Effects of flurbiprofen on serum level of interleukin-6, prostacyclin and corticosteroid A2 in patients with bone metastases of cancer

  • Authors:
    • Yanwei Yin
    • Yusheng Yi
    • Junmin Yu
    • Xiuming Sun
    • Chuansheng Liu
    • Fenghe Xu
  • View Affiliations / Copyright

    Affiliations: Department of Pain Treatment, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China
    Copyright: © Yin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1545-1548
    |
    Published online on: November 23, 2017
       https://doi.org/10.3892/ol.2017.7482
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study aimed to investigate the effects of flurbiprofen on serum level of interleukin-6 (IL-6), prostacyclin (PGI2) and corticosteroid A2 (TXA2) in patients with bone metastases of cancer. A total of 210 patients with bone metastasis of cancer were randomly divided into two groups: Flurbiprofen axetil analgesia group (group A) and dezocine analgesia group (group B), 105 cases in each group. The analgesic effect was evaluated using visual analogue scale (VAS) scoring system at 1, 12, 24 and 48 h after treatment. Serum levels of IL-6, PGI2 and TXA2 at 12 and 24 h after treatment were detected using double-antibody sandwich enzyme-linked immunosorbent assay. No significant differences in VAS scores were found between the two groups at 1, 12, 24 and 48 h after treatment, and no gastrointestinal adverse events and abnormal bleeding were observed. No significant differences in the serum levels of IL-6 were found between the two groups at 12 and 24 h after treatment. Significantly lower serum levels of TXA2 and PGI2 were found in group A compared to group B at 12 and 24 h after treatment (P<0.05). Serum level of PGI2 was positively correlated with serum level of TXA2 (r=0.7212, P<0.05) and VAS score (r=0.7159, P<0.05). Serum level of IL-6 was positively correlated with VAS score (r=0.7997, P<0.05). The results show that flurbiprofen axetil can effectively relieve pain in patients with bone metastases of cancer, can inhibit platelet activation, adhesion and aggregation, and reduce the formation of deep vein thrombosis, and can inhibit stress response and inflammatory response in the body.
View Figures
View References

1 

Yang L and Du S: Efficasy and safety of zoledronic acid and pamidronate disodium in the treatment of malignant skeletal metastasis: A meta-analysis. Medicine (Baltimore). 94:e18222015. View Article : Google Scholar : PubMed/NCBI

2 

Silva SC, Wilson C and Woll PJ: Bone-targeted agents in the treatment of lung cancer. Ther Adv Med Oncol. 7:219–228. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Winter MC and Coleman RE: Bisphosphonates in the adjuvant treatment of breast cancer. Clin Oncol. 25:135–145. 2013. View Article : Google Scholar

4 

McCormick Z, Chang-Chien G, Marshall B, Huang M and Harden RN: Phantom limb pain: A systematic neuroanatomical-based review of pharmacologic treatment. Pain Med. 15:292–305. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Kushwaha N, Sahu S and Tyagi RK: Flurbiprofen axetil loaded coaxial electrospun poly(vinyl pyrrolidone)-nanopoly(lactic-co-glycolic acid) core-shell composite nanofibers: Preparation, characterization, and anti-adhesion activity. J Appl Polym Sci. 132:899–907. 2015.

6 

Lin X, Zhang R, Xing J, Gao X, Chang P and Li W: Flurbiprofen axetil reduces postoperative sufentanil consumption and enhances postoperative analgesic effects in patients with colorectal cancer surgery. Int J Clin Exp Med. 7:4887–4896. 2014.PubMed/NCBI

7 

Wen Y, Wang M, Yang J, Wang Y, Sun H, Zhao J, Liu W, Zhou Z, Deng H, Castillo-Pedraza C, et al: A comparison of fentanyl and flurbiprofen axetil on serum VEGF-C, TNF-α, and IL-1β concentrations in women undergoing surgery for breast cancer. Pain Pract. 15:530–537. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Baid M, Kar M, De U and Mukhopadhyay M: Conventional laparoscopic appendicectomy and laparoscope-assisted appendicectomy: A comparative study. Indian J Surg. 77:330–334. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Schiavone S and Trabace L: Redox dysregulation biomarkers: Clinical outcomes and pharmacological implications for psychosis. Front Psychiatry. 8:2032017. View Article : Google Scholar : PubMed/NCBI

10 

Antoun M, Edwards KM, Sweeting J and Ding D: The acute physiological stress response to driving: A systematic review. PLoS One. 12:e01855172017. View Article : Google Scholar : PubMed/NCBI

11 

Tabellini G, Borsani E, Benassi M, Patrizi O, Ricotta D, Caimi L, Lanzi R, Micheli F, Iorno V, Bettaglio R, et al: Effects of opioid therapy on human natural killer cells. Int Immunopharmacol. 18:169–174. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Pillai AK, Kovoor JM, Reis SP, Kho K, Sutphin PD and Lucas E: Expulsion of a uterine fibroid into the small bowel through uteroenteric fistula presenting with bowel obstruction after uterine fibroid embolization: Case report with histopathologic correlation. J Vasc Interv Radiol. 27:762–764. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Shen JC, Sun HL, Zhang MQ, Liu XY, Wang Z and Yang JJ: Flurbiprofen improves dysfunction of T-lymphocyte subsets and natural killer cells in cancer patients receiving post-operative morphine analgesia. Int J Clin Pharmacol Ther. 52:669–675. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Zhang L, Zhu J, Xu L, Zhang X, Wang H, Luo Z, Zhao Y, Yu Y, Zhang Y, Shi H, et al: Efficacy and safety of flurbiprofen axetil in the prevention of pain on propofol injection: A systematic review and meta-analysis. Med Sci Monit. 20:995–1002. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Geng W, Hong W, Wang J, Dai Q, Mo Y, Shi K, Sun J, Qin J, Li M and Tang H: Flurbiprofen axetil enhances analgesic effects of sufentanil and attenuates postoperative emergence agitation and systemic proinflammation in patients undergoing tangential excision surgery. Mediators Inflamm. 2015:6010832015. View Article : Google Scholar : PubMed/NCBI

16 

Wu TT, Wang ZG, Ou WL, Wang J, Yao GQ, Yang B, Rao ZG, Gao JF and Zhang BC: Intravenous flurbiprofen axetil enhances analgesic effect of opioids in patients with refractory cancer pain by increasing plasma β-endorphin. Asian Pac J Cancer Prev. 15:10855–10860. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Clancy NT, Arya S, Stoyanov D, Singh M, Hanna GB and Elson DS: Intraoperative measurement of bowel oxygen saturation using a multispectral imaging laparoscope. Biomed Opt Express. 6:4179–4190. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Shen JC, Sun HL, Zhang MQ, Liu XY, Wang Z and Yang JJ: Flurbiprofen improves dysfunction of T-lymphocyte subsets and natural killer cells in cancer patients receiving post-operative morphine analgesia. Int J Clin Pharmacol Ther. 52:669–675. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Zhou M, Li B and Kong M: Effects of flurbiprofen axetil on postoperative analgesia and cytokines in peripheral blood of thoracotomy patients. Cell Biochem Biophys. 72:429–432. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Celik IH, Demirel G, Uras N, Oguz ES, Erdeve O and Dilmen U: The role of serum interleukin-6 and C-reactive protein levels for differentiating aetiology of neonatal sepsis. Arch Argent Pediatr. 113:534–537. 2015.(In Spanish). PubMed/NCBI

21 

Patricio JP, Barbosa JP, Ramos RM, Antunes NF and de Melo PC: Relative cardiovascular and gastrointestinal safety of non-selective non-steroidal anti-inflammatory drugs versus cyclo-oxygenase-2 inhibitors: Implications for clinical practice. Clin Drug Investig. 33:167–183. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Zhang L, Shu R, Zhao Q, Li Y, Wang C, Wang H, Yu Y and Wang G: Preoperative but not postoperative flurbiprofen axetil alleviates remifentanil-induced hyperalgesia after laparoscopic gynecological surgery: A prospective, randomized, double-blinded, trial. Clin J Pain. 33:435–442. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Jiang WW, Wang QH, Peng P, Liao YJ, Duan HX, Xu M, Li Y and Zhang PB: Effects of flurbiprofen axetil on postoperative serum IL-2 and IL-6 levels in patients with colorectal cancer. Genet Mol Res. 14:16469–16475. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Zhang L and Gong Z: Clinical characteristics and prognostic factors in bone metastases from lung cancer. Med Sci Monit. 23:4087–4094. 2017. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yin Y, Yi Y, Yu J, Sun X, Liu C and Xu F: Effects of flurbiprofen on serum level of interleukin-6, prostacyclin and corticosteroid A2 in patients with bone metastases of cancer. Oncol Lett 15: 1545-1548, 2018.
APA
Yin, Y., Yi, Y., Yu, J., Sun, X., Liu, C., & Xu, F. (2018). Effects of flurbiprofen on serum level of interleukin-6, prostacyclin and corticosteroid A2 in patients with bone metastases of cancer. Oncology Letters, 15, 1545-1548. https://doi.org/10.3892/ol.2017.7482
MLA
Yin, Y., Yi, Y., Yu, J., Sun, X., Liu, C., Xu, F."Effects of flurbiprofen on serum level of interleukin-6, prostacyclin and corticosteroid A2 in patients with bone metastases of cancer". Oncology Letters 15.2 (2018): 1545-1548.
Chicago
Yin, Y., Yi, Y., Yu, J., Sun, X., Liu, C., Xu, F."Effects of flurbiprofen on serum level of interleukin-6, prostacyclin and corticosteroid A2 in patients with bone metastases of cancer". Oncology Letters 15, no. 2 (2018): 1545-1548. https://doi.org/10.3892/ol.2017.7482
Copy and paste a formatted citation
x
Spandidos Publications style
Yin Y, Yi Y, Yu J, Sun X, Liu C and Xu F: Effects of flurbiprofen on serum level of interleukin-6, prostacyclin and corticosteroid A2 in patients with bone metastases of cancer. Oncol Lett 15: 1545-1548, 2018.
APA
Yin, Y., Yi, Y., Yu, J., Sun, X., Liu, C., & Xu, F. (2018). Effects of flurbiprofen on serum level of interleukin-6, prostacyclin and corticosteroid A2 in patients with bone metastases of cancer. Oncology Letters, 15, 1545-1548. https://doi.org/10.3892/ol.2017.7482
MLA
Yin, Y., Yi, Y., Yu, J., Sun, X., Liu, C., Xu, F."Effects of flurbiprofen on serum level of interleukin-6, prostacyclin and corticosteroid A2 in patients with bone metastases of cancer". Oncology Letters 15.2 (2018): 1545-1548.
Chicago
Yin, Y., Yi, Y., Yu, J., Sun, X., Liu, C., Xu, F."Effects of flurbiprofen on serum level of interleukin-6, prostacyclin and corticosteroid A2 in patients with bone metastases of cancer". Oncology Letters 15, no. 2 (2018): 1545-1548. https://doi.org/10.3892/ol.2017.7482
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team