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Intracellular IL‑4 and IFN‑γ expression in iNKT cells from patients with chronic lymphocytic leukemia

  • Authors:
    • Agnieszka Bojarska‑Junak
    • Małgorzata Waldowska
    • Justyna Woś
    • Sylwia Chocholska
    • Iwona Hus
    • Waldemar Tomczak
    • Michał Dzik
    • Marek Hus
    • Jacek Roliński
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Immunology, Medical University of Lublin, 20‑093 Lublin, Poland, Department of Haematooncology and Bone Marrow Transplantation, Medical University of Lublin, 20‑093 Lublin, Poland, Department of Clinical Transplantology, Medical University of Lublin, 20‑093 Lublin, Poland
    Copyright: © Bojarska‑Junak et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1580-1590
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    Published online on: November 24, 2017
       https://doi.org/10.3892/ol.2017.7484
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Abstract

Malignant B cells in chronic lymphocytic leukemia serve an essential role in the whole immune response, so their interactions with other immune cells are more complex than observed in solid tumors. The latest study results indicate that the immune dysregulation in chronic lymphocytic leukemia (CLL) also affects a small population of invariant natural killer T cells (iNKT). Using peripheral blood iNKT cells obtained from patients with CLL, the objective of the present study was to assess the intracellular expression of typical cytokines involved in the Th1 (IFN‑γ) and Th2 (IL‑4) response pathways following stimulation with the iNKT‑specific ligand α‑galactosylceramide. iNKT cells from patients with CLL exhibited upregulated IL‑4 and IFN‑γ expression in comparison to those from HVs. No significant association between the ability of iNKT cells to produce IL‑4 or IFN‑γ and the expression of CD1d on leukemic B lymphocytes or monocytes was identified. However, the function of iNKT cells was compromised in patients with CLL by a strong Th2 bias (high IL‑4 and low IFN‑γ expression). The ratio of iNKT+IFN‑γ+:iNKT+IL‑4+ was significantly decreased in the CLL group when compared with HVs, and this decreased further as the disease progressed. This change may result in the promotion of leukemic B lymphocyte survival. Therefore, in the pathogenesis of CLL, Th2 bias may delay the antitumor response that relies on stimulation of the Th1 immune response.
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View References

1 

Joyce JA: Therapeutic targeting of the tumor microenvironment. Cancer Cell. 7:513–520. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Burger JA and Gribben JG: The microenvironment in chronic lymphocytic leukemia (CLL) and other B cell malignancies: Insight into disease biology and new targeted therapies. Semin Cancer Biol. 24:71–81. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Tinhofer I, Rubenzer G, Holler C, Hofstaetter E, Stoecher M, Egle A, Steurer M and Greil R: Expression levels of CD38 in T cells predict course of disease in male patients with B-chronic lymphocytic leukemia. Blood. 108:2950–2956. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Mainou-Fowler T and Prentice AG: Modulation of apoptosis with cytokines in B-cell chronic lymphocytic leukaemia. Leuk Lymphoma. 21:369–377. 1996. View Article : Google Scholar : PubMed/NCBI

5 

Terabe M, Swann J, Ambrosino E, Sinha P, Takaku S, Hayakawa Y, Godfrey DI, Ostrand-Rosenberg S, Smyth MJ and Berzofsky JA: A nonclassical non-Valpha14Jalpha18 CD1d-restricted (type II) NKT cell is sufficient for down-regulation of tumor immunosurveillance. J Exp Med. 202:1627–1633. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Gapin L: Development of invariant natural killer T cells. Curr Opin Immunol. 39:68–74. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Dellabona P, Abrignani S and Casorati G: iNKT-cell help to B cells: A cooperative job between innate and adaptive immune responses. Eur J Immunol. 44:2230–2237. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Exley M, Porcelli S, Furman M, Garcia J and Balk S: CD161 (NKR-P1A) costimulation of CD1d-dependent activation of human T cells expressing invariant V alpha 24 J alpha Q T cell receptor alpha chains. J Exp Med. 188:867–876. 1998. View Article : Google Scholar : PubMed/NCBI

9 

Seino K and Taniguchi M: Functionally distinct NKT cell subsets and subtypes. J Exp Med. 202:1623–1626. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Godfrey DI, MacDonald HR, Kronenberg M, Smyth MJ and Van Kaer L: NKT cells: What's in a name? Nat Rev Immunol. 4:231–237. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Kawano T, Cui J, Koezuka Y, Toura I, Kaneko Y, Motoki K, Ueno H, Nakagawa R, Sato H, Kondo E, et al: CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides. Science. 278:1626–1629. 1997. View Article : Google Scholar : PubMed/NCBI

12 

Spada FM, Koezuka Y and Porcelli SA: CD1d-restricted recognition of synthetic glycolipid antigens by human natural killer T cells. J Exp Med. 188:1529–1534. 1998. View Article : Google Scholar : PubMed/NCBI

13 

Hayakawa Y, Godfrey DI and Smyth MJ: Alpha-galactosylceramide: Potential immunomodulatory activity and future application. Curr Med Chem. 11:241–252. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Matsuda JL, Naidenko OV, Gapin L, Nakayama T, Taniguchi M, Wang CR, Koezuka Y and Kronenberg M: Tracking the response of natural killer T cells to a glycolipid antigen using CD1d tetramers. J Exp Med. 192:741–754. 2000. View Article : Google Scholar : PubMed/NCBI

15 

Matsuda JL, Mallevaey T, Scott-Browne J and Gapin L: CD1d-restricted iNKT cells, the ‘Swiss-Army knife’ of the immune system. Curr Opin Immunol. 20:358–368. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Gumperz JE, Miyake S, Yamamura T and Brenner MB: Functionally distinct subsets of CD1d-restricted natural killer T cells revealed by CD1d tetramer staining. J Exp Med. 195:625–636. 2002. View Article : Google Scholar : PubMed/NCBI

17 

Brennan PJ, Brigl M and Brenner MB: Invariant natural killer T cells: An innate activation scheme linked to diverse effector functions. Nat Rev Immunol. 13:101–117. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Godfrey DI and Kronenberg M: Going both ways: Immune regulation via CD1d-dependent NKT cells. J Clin Inves. 114:1379–1388. 2004. View Article : Google Scholar

19 

Fujii S, Shimizu K, Smith C, Bonifaz L and Steinman RM: Activation of natural killer T cells by alpha-galactosylceramide rapidly induces the full maturation of dendritic cells in vivo and thereby acts as an adjuvant for combined CD4 and CD8 T cell immunity to a coadministered protein. J Exp Med. 198:267–279. 2003. View Article : Google Scholar : PubMed/NCBI

20 

Smyth MJ and Godfrey DI: NKT cells and tumor immunity-a double-edged sword. Nat Immunol. 1:459–460. 2000. View Article : Google Scholar : PubMed/NCBI

21 

Tahir SM, Cheng O, Shaulov A, Koezuka Y, Bubley GJ, Wilson SB, Balk SP and Exley MA: Loss of IFN-gamma production by invariant NK T cells in advanced cancer. J Immunol. 167:4046–4050. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Hallek M, Cheson BD, Catovsky D, Caligaris-Cappio F, Dighiero G, Döhner H, Hillmen P, Keating MJ, Montserrat E, Rai KR, et al: Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: A report from the international workshop on chronic lymphocytic leukemia updating the national cancer institute-working group 1996 guidelines. Blood. 111:5446–5456. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Rai KR, Sawitsky A, Cronkite EP, Chanana AD, Levy RN and Pasternack BS: Clinical staging of chronic lymphocytic leukemia. Blood. 46:219–234. 1975.PubMed/NCBI

24 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Bojarska-Junak A, Hus I, Chocholska S, Tomczak W, Woś J, Czubak P, Putowski L and Roliński J: CD1d expression is higher in chronic lymphocytic leukemia patients with unfavorable prognosis. Leuk Res. 38:435–442. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Bojarska-Junak A, Hus I, Chocholska S, Wasik-Szczepanek E, Sieklucka M, Dmoszyńska A and Roliński J: BAFF and APRIL expression in B-cell chronic lymphocytic leukemia: Correlation with biological and clinical features. Leuk Res. 33:1319–1327. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Sieklucka M, Pozarowski P, Bojarska-Junak A, Hus I, Dmoszynska A and Rolinski J: Apoptosis in B-CLL: The relationship between higher ex vivo spontaneous apoptosis before treatment in III–IV Rai stage patients and poor outcome. Oncol Rep. 19:1611–1620. 2008.PubMed/NCBI

28 

Bojarska-Junak A, Hus I, Olszewska-Bożek K, Chocholska S, Wąsik-Szczepanek E, Tomczak W, Miłczak J, Dmoszyńska A and Roliński J: Analysis of ex vivo apoptosis of B and T cells from peripheral blood and bone marrow of patients with chronic lymphocytic leukemia. Acta Haematol Pol. 43:336–341. 2012. View Article : Google Scholar

29 

Christopoulos P, Pfeifer D, Bartholomé K, Follo M, Timmer J, Fisch P and Veelken H: Definition and characterization of the systemic T-cell dysregulation in untreated indolent B-cell lymphoma and very early CLL. Blood. 117:3836–3846. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Rossmann ED, Lewin N, Jeddi-Tehrani M, Osterborg A and Mellstedt H: Intracellular T cell cytokines in patients with B cell chronic lymphocytic leukaemia (B-CLL). Eur J Haematol. 68:299–306. 2002. View Article : Google Scholar : PubMed/NCBI

31 

Weinkove R, Brooks CR, Carter JM, Hermans IF and Ronchese F: Functional invariant natural killer T-cell and CD1d axis in chronic lymphocytic leukemia: Implications for immunotherapy. Haematologica. 98:376–384. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Borg NA, Wun KS, Kjer-Nielsen L, Wilce MC, Pellicci DG, Koh R, Besra GS, Bharadwaj M, Godfrey DI, McCluskey J and Rossjohn J: CD1d-lipid-antigen recognition by the semi-invariant NKT T-cell receptor. Nature. 448:44–49. 2007. View Article : Google Scholar : PubMed/NCBI

33 

Fernandez CS, Cameron G, Godfrey DI and Kent SJ: Ex-vivo α-galactosylceramide activation of NKT cells in humans and macaques. J Immunol Methods. 382:150–159. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Ai W, Li H, Song N, Li L and Chen H: Optimal method to stimulate cytokine production and its use in immunotoxicity assessment. Int J Environ Res Public Health. 10:3834–3842. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Liu Z, Yuan X, Luo Y, He Y, Jiang Y, Chen ZK and Sun E: Evaluating the effects of immunosuppressants on human immunity using cytokine profiles of whole blood. Cytokine. 45:141–147. 2009. View Article : Google Scholar : PubMed/NCBI

36 

Hill SJ, Peters SH, Ayliffe MJ, Merceica J and Bansal AS: Reduced IL-4 and interferon-gamma (IFN-gamma) expression by CD4 T cells in patients with chronic lymphocytic leukaemia. Clin Exp Immunol. 117:8–117. 1999. View Article : Google Scholar : PubMed/NCBI

37 

Dhodapkar MV, Geller MD, Chang DH, Shimizu K, Fujii S, Dhodapkar KM and Krasovsky J: A reversible defect in natural killer T cell function characterizes the progression of premalignant to malignantmultiple myeloma. J Exp Med. 197:1667–1676. 2003. View Article : Google Scholar : PubMed/NCBI

38 

Singh N, Hong S, Scherer DC, Serizawa I, Burdin N, Kronenberg M, Koezuka Y and Van Kaer L: Cutting edge: Activation of NK T cells by CD1d and alpha-galactosylceramide directs conventional T cells to the acquisition of a Th2 phenotype. J Immunol. 163:2373–2377. 1999.PubMed/NCBI

39 

Burdin N, Brossay L and Kronenberg M: Immunization with alpha-galactosylceramide polarizes CD1-reactive NK T cells towards Th2 cytokine synthesis. Eur J Immunol. 29:2014–2025. 1999. View Article : Google Scholar : PubMed/NCBI

40 

Dancescu M, Rubio-Trujillo M, Biron G, Bron D, Delespesse G and Sarfati M: Interleukin 4 protects chronic lymphocytic leukemic B cells from death by apoptosis and upregulates Bcl-2 expression. J Exp Med. 176:1319–1326. 1992. View Article : Google Scholar : PubMed/NCBI

41 

Smyth MJ, Crowe NY, Pellicci DG, Kyparissoudis K, Kelly JM, Takeda K, Yagita H and Godfrey DI: Sequential production of interferon-gamma by NK1.1(+) T cells and natural killer cells is essential for the antimetastatic effect of alpha-galactosylceramide. Blood. 99:1259–1266. 2002. View Article : Google Scholar : PubMed/NCBI

42 

Palmer VL, Nganga VK, Rothermund ME, Perry GA and Swanson PC: Cd1d regulates B cell development but not B cell accumulation and IL10 production in mice with pathologic CD5(+) B cell expansion. BMC Immunol. 16:662015. View Article : Google Scholar : PubMed/NCBI

43 

Molling JW, Kölgen W, van der Vliet HJ, Boomsma MF, Kruizenga H, Smorenburg CH, Molenkamp BG, Langendijk JA, Leemans CR, von Blomberg BM, et al: Peripheral blood IFN-gamma-secreting Valpha24+Vbeta11+ NKT cell numbers are decreased in cancer patients independent of tumor type or tumor load. Int J Cancer. 116:87–93. 2005. View Article : Google Scholar : PubMed/NCBI

44 

Giaccone G, Punt CJ, Ando Y, Ruijter R, Nishi N, Peters M, von Blomberg BM, Scheper RJ, van der Vliet HJ, van den Eertwegh AJ, et al: A phase I study of the natural killer T-cell ligand alpha-galactosylceramide (KRN7000) in patients with solid tumors. Clin Cancer Res. 8:3702–3709. 2002.PubMed/NCBI

45 

Yoneda K, Morii T, Nieda M, Tsukaguchi N, Amano I, Tanaka H, Yagi H, Narita N and Kimura H: The peripheral blood Valpha24+ NKT cell numbers decrease in patients with haematopoietic malignancy. Leuk Res. 29:147–152. 2005. View Article : Google Scholar : PubMed/NCBI

46 

Hus I, Bojarska-Junak A, Gonet-Sebastianka J, Glazer M, Drab E, Woś J and Roliński J: iNKT cell percentage is decreased in patients with chronic lymphocytic leukemia and correlates inversely with the clinical stage and negative prognostic factors. Centr Eur J Immunol. 36:79–84. 2011.

47 

Singh AK, Shukla NK and Das SN: Altered invariant natural killer T cell subsets and its functions in patients with oral squamous cell carcinoma. Scand J Immunol. 78:468–477. 2013. View Article : Google Scholar : PubMed/NCBI

48 

Fujii S, Shimizu K, Klimek V, Geller MD, Nimer SD and Dhodapkar MV: Severe and selective deficiency of interferon-gamma-producing invariant natural killer T cells in patients with myelodysplastic syndromes. Br J Haematol. 122:617–622. 2003. View Article : Google Scholar : PubMed/NCBI

49 

Fais F, Morabito F, Stelitano C, Callea V, Zanardi S, Scudeletti M, Varese P, Ciccone E and Grossi CE: CD1d is expressed on B-chronic lymphocytic leukemia cells and mediates alpha-galactosylceramide presentation to natural killer T lymphocytes. Int J Cancer. 109:402–411. 2004. View Article : Google Scholar : PubMed/NCBI

50 

Fujii S, Shimizu K, Okamoto Y, Kunii N, Nakayama T, Motohashi S and Taniguchi M: NKT cells as an ideal anti-tumor immunotherapeutic. Front Immunol. 4:4092013. View Article : Google Scholar : PubMed/NCBI

51 

Mendiratta SK, Martin WD, Hong S, Boesteanu A, Joyce S and Van Kaer L: CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4. Immunity. 6:469–477. 1997. View Article : Google Scholar : PubMed/NCBI

52 

Wang X, Bishop KA, Hegde S, Rodenkirch LA, Pike JW and Gumperz JE: Human invariant natural killer T cells acquire transient innate responsiveness via histone H4 acetylation induced by weak TCR stimulation. J Exp Med. 209:987–1000. 2012. View Article : Google Scholar : PubMed/NCBI

53 

Lanasa MC: Novel insights into the biology of CLL. Hematology Am Soc Hematol Educ Program. 2010:70–76. 2010.PubMed/NCBI

54 

Bojarska-Junak A, Hus I, Sieklucka M, Wasik-Szczepanek E, Mazurkiewicz T, Polak P, Dmoszynska A and Rolinski J: Natural killer-like T CD3+/CD16+CD56+ cells in chronic lymphocytic leukemia: Intracellular cytokine expression and relationship with clinical outcome. Oncol Rep. 24:803–810. 2010. View Article : Google Scholar : PubMed/NCBI

55 

Robertson FC, Berzofsky JA and Terabe M: NKT cell networks in the regulation of tumor immunity. Front Immunol. 5:5432014. View Article : Google Scholar : PubMed/NCBI

56 

Wang Y, Hu X, Guo C, Zhang Q, Peng J, Zhang J, Li L, Zhang T and Xu C: Polarization of natural killer T cells towards an NKT2 subpopulation occurs after stimulation with alpha-galactosylceramide and rhG-CSF in aplastic anemia. Acta Haematol. 119:178–186. 2008. View Article : Google Scholar : PubMed/NCBI

57 

Mattarollo SR and Smyth MJ: NKT cell adjuvants in therapeutic vaccines against hematological cancers. Oncoimmunology. 2:e226152013. View Article : Google Scholar : PubMed/NCBI

58 

McEwen-Smith RM, Salio M and Cerundolo V: The regulatory role of invariant NKT cells in tumor immunity. Cancer Immunol Res. 3:425–435. 2015. View Article : Google Scholar : PubMed/NCBI

59 

La Cava A, Van Kaer L and Fu-Dong-Shi: CD4+CD25+ Tregs and NKT cells: Regulators regulating regulators. Trends Immunol. 27:322–327. 2006. View Article : Google Scholar : PubMed/NCBI

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Spandidos Publications style
Bojarska‑Junak A, Waldowska M, Woś J, Chocholska S, Hus I, Tomczak W, Dzik M, Hus M and Roliński J: Intracellular IL‑4 and IFN‑γ expression in iNKT cells from patients with chronic lymphocytic leukemia. Oncol Lett 15: 1580-1590, 2018.
APA
Bojarska‑Junak, A., Waldowska, M., Woś, J., Chocholska, S., Hus, I., Tomczak, W. ... Roliński, J. (2018). Intracellular IL‑4 and IFN‑γ expression in iNKT cells from patients with chronic lymphocytic leukemia. Oncology Letters, 15, 1580-1590. https://doi.org/10.3892/ol.2017.7484
MLA
Bojarska‑Junak, A., Waldowska, M., Woś, J., Chocholska, S., Hus, I., Tomczak, W., Dzik, M., Hus, M., Roliński, J."Intracellular IL‑4 and IFN‑γ expression in iNKT cells from patients with chronic lymphocytic leukemia". Oncology Letters 15.2 (2018): 1580-1590.
Chicago
Bojarska‑Junak, A., Waldowska, M., Woś, J., Chocholska, S., Hus, I., Tomczak, W., Dzik, M., Hus, M., Roliński, J."Intracellular IL‑4 and IFN‑γ expression in iNKT cells from patients with chronic lymphocytic leukemia". Oncology Letters 15, no. 2 (2018): 1580-1590. https://doi.org/10.3892/ol.2017.7484
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Spandidos Publications style
Bojarska‑Junak A, Waldowska M, Woś J, Chocholska S, Hus I, Tomczak W, Dzik M, Hus M and Roliński J: Intracellular IL‑4 and IFN‑γ expression in iNKT cells from patients with chronic lymphocytic leukemia. Oncol Lett 15: 1580-1590, 2018.
APA
Bojarska‑Junak, A., Waldowska, M., Woś, J., Chocholska, S., Hus, I., Tomczak, W. ... Roliński, J. (2018). Intracellular IL‑4 and IFN‑γ expression in iNKT cells from patients with chronic lymphocytic leukemia. Oncology Letters, 15, 1580-1590. https://doi.org/10.3892/ol.2017.7484
MLA
Bojarska‑Junak, A., Waldowska, M., Woś, J., Chocholska, S., Hus, I., Tomczak, W., Dzik, M., Hus, M., Roliński, J."Intracellular IL‑4 and IFN‑γ expression in iNKT cells from patients with chronic lymphocytic leukemia". Oncology Letters 15.2 (2018): 1580-1590.
Chicago
Bojarska‑Junak, A., Waldowska, M., Woś, J., Chocholska, S., Hus, I., Tomczak, W., Dzik, M., Hus, M., Roliński, J."Intracellular IL‑4 and IFN‑γ expression in iNKT cells from patients with chronic lymphocytic leukemia". Oncology Letters 15, no. 2 (2018): 1580-1590. https://doi.org/10.3892/ol.2017.7484
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