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Increased expression of mitochondrial transcription factor A and nuclear respiratory factor‑1 predicts a poor clinical outcome of breast cancer

  • Authors:
    • Wei Gao
    • Meihong Wu
    • Ning Wang
    • Yingyi Zhang
    • Jing Hua
    • Gusheng Tang
    • Yajie Wang
  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, Shanghai 9th People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200433, P.R. China, Department of Oncology, Changhai Hospital, The Second Military Medical University, Shanghai 200433, P.R. China, Department of Hematology, Changhai Hospital, The Second Military Medical University, Shanghai 200433, P.R. China
    Copyright: © Gao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1449-1458
    |
    Published online on: November 24, 2017
       https://doi.org/10.3892/ol.2017.7487
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Abstract

Nuclear respiratory factor‑1 (Nrf1) and mitochondrial transcription factor A (TFAM) are involved in the regulation of a variety of mitochondrial functional genes, which are associated with decreased sensitivity of tumor cells to chemotherapy. However, the expression status of Nrf1 and TFAM, as well as their clinical significance in breast cancer, is unknown. In the present study, tumor tissues and corresponding adjacent normal tissues were collected from 336 patients with breast cancer, and Nrf1 and TFAM expression was analyzed by immunohistochemistry using a tissue microarray. Expression of Nrf1 and TFAM was significantly increased in breast cancer tissue compared with adjacent normal tissues. In addition, patients positive for Nrf1 or TFAM had a poorer clinical prognosis than patients who were negative, and those positive for Nrf1 and TFAM had the shortest survival time. These results suggest that Nrf1 and TFAM are potential biomarkers for the determination of individualized therapy and the prognosis of breast cancer, and molecular targeting of Nrf1 and TFAM is a promising strategy for the sensitization of breast cancer cells to chemotherapeutics.
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Copy and paste a formatted citation
Spandidos Publications style
Gao W, Wu M, Wang N, Zhang Y, Hua J, Tang G and Wang Y: Increased expression of mitochondrial transcription factor A and nuclear respiratory factor‑1 predicts a poor clinical outcome of breast cancer. Oncol Lett 15: 1449-1458, 2018.
APA
Gao, W., Wu, M., Wang, N., Zhang, Y., Hua, J., Tang, G., & Wang, Y. (2018). Increased expression of mitochondrial transcription factor A and nuclear respiratory factor‑1 predicts a poor clinical outcome of breast cancer. Oncology Letters, 15, 1449-1458. https://doi.org/10.3892/ol.2017.7487
MLA
Gao, W., Wu, M., Wang, N., Zhang, Y., Hua, J., Tang, G., Wang, Y."Increased expression of mitochondrial transcription factor A and nuclear respiratory factor‑1 predicts a poor clinical outcome of breast cancer". Oncology Letters 15.2 (2018): 1449-1458.
Chicago
Gao, W., Wu, M., Wang, N., Zhang, Y., Hua, J., Tang, G., Wang, Y."Increased expression of mitochondrial transcription factor A and nuclear respiratory factor‑1 predicts a poor clinical outcome of breast cancer". Oncology Letters 15, no. 2 (2018): 1449-1458. https://doi.org/10.3892/ol.2017.7487
Copy and paste a formatted citation
x
Spandidos Publications style
Gao W, Wu M, Wang N, Zhang Y, Hua J, Tang G and Wang Y: Increased expression of mitochondrial transcription factor A and nuclear respiratory factor‑1 predicts a poor clinical outcome of breast cancer. Oncol Lett 15: 1449-1458, 2018.
APA
Gao, W., Wu, M., Wang, N., Zhang, Y., Hua, J., Tang, G., & Wang, Y. (2018). Increased expression of mitochondrial transcription factor A and nuclear respiratory factor‑1 predicts a poor clinical outcome of breast cancer. Oncology Letters, 15, 1449-1458. https://doi.org/10.3892/ol.2017.7487
MLA
Gao, W., Wu, M., Wang, N., Zhang, Y., Hua, J., Tang, G., Wang, Y."Increased expression of mitochondrial transcription factor A and nuclear respiratory factor‑1 predicts a poor clinical outcome of breast cancer". Oncology Letters 15.2 (2018): 1449-1458.
Chicago
Gao, W., Wu, M., Wang, N., Zhang, Y., Hua, J., Tang, G., Wang, Y."Increased expression of mitochondrial transcription factor A and nuclear respiratory factor‑1 predicts a poor clinical outcome of breast cancer". Oncology Letters 15, no. 2 (2018): 1449-1458. https://doi.org/10.3892/ol.2017.7487
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