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Article

Decreased expression of CADM1 and CADM4 are associated with advanced stage breast cancer

  • Authors:
    • Motonobu Saito
    • Akiteru Goto
    • Noriko Abe
    • Katsuharu Saito
    • Daichi Maeda
    • Tohru Ohtake
    • Yoshinori Murakami
    • Seiichi Takenoshita
  • View Affiliations / Copyright

    Affiliations: Department of Organ Regulatory Surgery, Fukushima Medical University School of Medicine, Fukushima 960‑1295, Japan, Department of Cellular and Organ Pathology, Akita University Graduate School of Medicine, Akita 010‑8543, Japan, Division of Molecular Pathology, Institute of Medical Science, The University of Tokyo, Tokyo 108‑8639, Japan
  • Pages: 2401-2406
    |
    Published online on: December 6, 2017
       https://doi.org/10.3892/ol.2017.7536
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Abstract

Cell adhesion molecule (CADM) genes encode immunoglobulin superfamily molecules, which are involved in cell‑cell adhesion in a number of human epithelia. Through the maintenance of epithelia, CADM genes protect against malignant conversion and metastasis. Whilst numerous in vitro studies have investigated the molecular characteristics of CADM1 and CADM4 and in vivo studies have investigated CADM1 and CADM4 expression in a number of tumor types, the roles of CADM1 and CADM4 have yet to be elucidated. Therefore, in the present study, CADM1 and CADM4 expression levels were evaluated using immunohistochemistry staining in 208 patients with breast cancer and compared with clinicopathological factors. CADM1 and CADM4 expression levels were negative in 160 (76.9%) and 166 (79.8%) of the 208 cases, respectively. The lack of expression in these cases was associated with advanced tumor stage, suggesting that inactivation of CADM1 and CADM4 promotes breast cancer development. The prognostic role of CADM1 and CADM4 in breast cancer was also evaluated and the expression of CADM1 and CADM4 were not associated with cancer‑specific survival or overall survival rate in the cohort of patients in the present study. Whilst these results suggested that CADM1 and CADM4 possess tumor suppressive roles, further functional experiments are required to address the important mechanisms involving CADM1 and CADM4.
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1 

Katanoda K, Hori M, Matsuda T, Shibata A, Nishino Y, Hattori M, Soda M, Ioka A, Sobue T and Nishimoto H: An updated report on the trends in cancer incidence and mortality in Japan, 1958-2013. Jpn J Clin Oncol. 45:390–401. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2016. CA Cancer J Clin. 66:7–30. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Chia SK, Speers CH, Bryce CJ, Hayes MM and Olivotto IA: Ten-year outcomes in a population-based cohort of node-negative, lymphatic, and vascular invasion-negative early breast cancers without adjuvant systemic therapies. J Clin Oncol. 22:1630–1637. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Cianfrocca M and Goldstein LJ: Prognostic and predictive factors in early-stage breast cancer. Oncologist. 9:606–616. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Hanrahan EO, Valero V, Gonzalez-Angulo AM and Hortobagyi GN: Prognosis and management of patients with node-negative invasive breast carcinoma that is 1 cm or smaller in size (stage 1; T1a, bN0M0): A review of the literature. J Clin Oncol. 24:2113–2122. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Murakami Y: Involvement of a cell adhesion molecule, TSLC1/IGSF4, in human oncogenesis. Cancer Sci. 96:543–552. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Murakami Y: Functional cloning of a tumor suppressor gene, TSLC1, in human non-small cell lung cancer. Oncogene. 21:6936–6948. 2002. View Article : Google Scholar : PubMed/NCBI

8 

Kuramochi M, Fukuhara H, Nobukuni T, Kanbe T, Maruyama T, Ghosh HP, Pletcher M, Isomura M, Onizuka M, Kitamura T, et al: TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer. Nat Genet. 27:427–430. 2001. View Article : Google Scholar : PubMed/NCBI

9 

Goto A, Niki T, Chi-Pin L, Matsubara D, Murakami Y, Funata N and Fukayama M: Loss of TSLC1 expression in lung adenocarcinoma: Relationships with histological subtypes, sex and prognostic significance. Cancer Sci. 96:480–486. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Hui AB, Lo KW, Kwong J, Lam EC, Chan SY, Chow LS, Chan AS, Teo PM and Huang DP: Epigenetic inactivation of TSLC1 gene in nasopharyngeal carcinoma. Mol Carcinog. 38:170–178. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Honda T, Tamura G, Waki T, Jin Z, Sato K, Motoyama T, Kawata S, Kimura W, Nishizuka S and Murakami Y: Hypermethylation of the TSLC1 gene promoter in primary gastric cancers and gastric cancer cell lines. Jpn J Cancer Res. 93:857–860. 2002. View Article : Google Scholar : PubMed/NCBI

12 

Jansen M, Fukushima N, Rosty C, Walter K, Altink R, Heek TV, Hruban R, Offerhaus JG and Goggins M: Aberrant methylation of the 5′ CpG island of TSLC1 is common in pancreatic ductal adenocarcinoma and is first manifest in high-grade PanlNs. Cancer Biol Ther. 1:293–296. 2002. View Article : Google Scholar : PubMed/NCBI

13 

Fukuhara H, Kuramochi M, Fukami T, Kasahara K, Furuhata M, Nobukuni T, Maruyama T, Isogai K, Sekiya T, Shuin T, et al: Promoter methylation of TSLC1 and tumor suppression by its gene product in human prostate cancer. Jpn J Cancer Res. 93:605–609. 2002. View Article : Google Scholar : PubMed/NCBI

14 

Steenbergen RD, Kramer D, Braakhuis BJ, Stern PL, Verheijen RH, Meijer CJ and Snijders PJ: TSLC1 gene silencing in cervical cancer cell lines and cervical neoplasia. J Natl Cancer Inst. 96:294–305. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Takahashi Y, Iwai M, Kawai T, Arakawa A, Ito T, Sakurai-Yageta M, Ito A, Goto A, Saito M, Kasumi F and Murakami Y: Aberrant expression of tumor suppressors CADM1 and 4.1B in invasive lesions of primary breast cancer. Breast Cancer. 19:242–252. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Jang SM, Han H, Jun YJ, Jang SH, Min KW, Sim J, Ahn HI, Lee KH, Jang KS and Paik SS: Clinicopathological significance of CADM4 expression, and its correlation with expression of E-cadherin and Ki-67 in colorectal adenocarcinomas. J Clin Pathol. 65:902–906. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Jang SM, Sim J, Han H, Ahn HI, Kim H, Yi K, Jun YJ, Rehman A, Chung MS, Jang K and Paik SS: Clinicopathological significance of CADM4 expression in invasive ductal carcinoma of the breast. J Clin Pathol. 66:681–686. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Sobin LH and Compton CC: TNM seventh edition: What's new, what's changed: communication from the international union against cancer and the American joint committee on cancer. Cancer. 116:5336–5339. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Sobin LH, Gospodarowicz MK and Wittekind Ch: International Union Against Cancer (UICC) TNM Classification of Malignant Tumors. 7th. Wiley-Blackwell; Oxford, UK: 2009

20 

Nagata M, Sakurai-Yageta M, Yamada D, Goto A, Ito A, Fukuhara H, Kume H, Morikawa T, Fukayama M, Homma Y and Murakami Y: Aberrations of a cell adhesion molecule CADM4 in renal clear cell carcinoma. Int J Cancer. 130:1329–1337. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Saito M, Matsuzaki M, Sakuma T, Katagata N, Watanabe F, Yamaguchi Y, Schetter AJ, Takenoshita S and Nomizu T: Clinicopathological study of non-palpable familial breast cancer detected by screening mammography and diagnosed as DCIS. Breast Cancer. 21:140–145. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Wikman H, Westphal L, Schmid F, Pollari S, Kropidlowski J, Sielaff-Frimpong B, Glatzel M, Matschke J, Westphal M, Iljin K, et al: Loss of CADM1 expression is associated with poor prognosis and brain metastasis in breast cancer patients. Oncotarget. 5:3076–3087. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Masuda M, Kikuchi S, Maruyama T, Sakurai-Yageta M, Williams YN, Ghosh HP and Murakami Y: Tumor suppressor in lung cancer (TSLC)1 suppresses epithelial cell scattering and tubulogenesis. J Biol Chem. 280:42164–42171. 2005. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Saito M, Goto A, Abe N, Saito K, Maeda D, Ohtake T, Murakami Y and Takenoshita S: Decreased expression of CADM1 and CADM4 are associated with advanced stage breast cancer. Oncol Lett 15: 2401-2406, 2018.
APA
Saito, M., Goto, A., Abe, N., Saito, K., Maeda, D., Ohtake, T. ... Takenoshita, S. (2018). Decreased expression of CADM1 and CADM4 are associated with advanced stage breast cancer. Oncology Letters, 15, 2401-2406. https://doi.org/10.3892/ol.2017.7536
MLA
Saito, M., Goto, A., Abe, N., Saito, K., Maeda, D., Ohtake, T., Murakami, Y., Takenoshita, S."Decreased expression of CADM1 and CADM4 are associated with advanced stage breast cancer". Oncology Letters 15.2 (2018): 2401-2406.
Chicago
Saito, M., Goto, A., Abe, N., Saito, K., Maeda, D., Ohtake, T., Murakami, Y., Takenoshita, S."Decreased expression of CADM1 and CADM4 are associated with advanced stage breast cancer". Oncology Letters 15, no. 2 (2018): 2401-2406. https://doi.org/10.3892/ol.2017.7536
Copy and paste a formatted citation
x
Spandidos Publications style
Saito M, Goto A, Abe N, Saito K, Maeda D, Ohtake T, Murakami Y and Takenoshita S: Decreased expression of CADM1 and CADM4 are associated with advanced stage breast cancer. Oncol Lett 15: 2401-2406, 2018.
APA
Saito, M., Goto, A., Abe, N., Saito, K., Maeda, D., Ohtake, T. ... Takenoshita, S. (2018). Decreased expression of CADM1 and CADM4 are associated with advanced stage breast cancer. Oncology Letters, 15, 2401-2406. https://doi.org/10.3892/ol.2017.7536
MLA
Saito, M., Goto, A., Abe, N., Saito, K., Maeda, D., Ohtake, T., Murakami, Y., Takenoshita, S."Decreased expression of CADM1 and CADM4 are associated with advanced stage breast cancer". Oncology Letters 15.2 (2018): 2401-2406.
Chicago
Saito, M., Goto, A., Abe, N., Saito, K., Maeda, D., Ohtake, T., Murakami, Y., Takenoshita, S."Decreased expression of CADM1 and CADM4 are associated with advanced stage breast cancer". Oncology Letters 15, no. 2 (2018): 2401-2406. https://doi.org/10.3892/ol.2017.7536
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