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Article Open Access

High expression of RACK1 is associated with poor prognosis in patients with pancreatic ductal adenocarcinoma

  • Authors:
    • Hailin Han
    • Dongmei Wang
    • Maowu Yang
    • Shenhao Wang
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, The Second People's Hospital of Liaocheng Affiliated to Taishan Medical College, Liaocheng, Shandong 252600, P.R. China, Department of Gastroenterology, The Second People's Hospital of Liaocheng Affiliated to Taishan Medical College, Liaocheng, Shandong 252600, P.R. China, Department of Gastroenterology, The Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China
    Copyright: © Han et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2073-2078
    |
    Published online on: December 6, 2017
       https://doi.org/10.3892/ol.2017.7539
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Abstract

Receptor for activated C kinase 1 (RACK1) is associated with certain aspects of cancer biology and signaling pathways, but its function in pancreatic ductal adenocarcinoma (PDAC) remains unknown. In the present study, 157 patients with PDAC were enrolled. RACK1 mRNA and protein expression levels were analyzed in PDAC tissues and matched adjacent noncancerous tissues by reverse transcription‑quantitative polymerase chain reaction and western blotting. RACK1 expression levels in paraffin‑embedded PDAC tissues were determined by immunohistochemistry. The associations between RACK1 expression and clinical data were evaluated using χ2 analysis. The relationship between RACK1 expression and the survival data of patients was analyzed using Kaplan‑Meier and log rank tests. RACK1 mRNA and protein were revealed to be overexpressed in PDAC tumor tissues compared with adjacent noncancerous tissues. RACK1 expression was associated with clinical stage (P=0.001), lymph node invasion (P=0.003) and liver metastasis (P=0.001). Furthermore, patients with PDAC and high RACK1 expression demonstrated shorter overall survival times compared with patients with low RACK1 expression (P=0.002). Multivariate analysis indicated that RACK1 overexpression was an independent prognostic factor for patients with PDAC. Overexpression of RACK1 may contribute to tumor progression, and may be a potential prognostic biomarker for patients with PDAC.
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Copy and paste a formatted citation
Spandidos Publications style
Han H, Wang D, Yang M and Wang S: High expression of RACK1 is associated with poor prognosis in patients with pancreatic ductal adenocarcinoma. Oncol Lett 15: 2073-2078, 2018.
APA
Han, H., Wang, D., Yang, M., & Wang, S. (2018). High expression of RACK1 is associated with poor prognosis in patients with pancreatic ductal adenocarcinoma. Oncology Letters, 15, 2073-2078. https://doi.org/10.3892/ol.2017.7539
MLA
Han, H., Wang, D., Yang, M., Wang, S."High expression of RACK1 is associated with poor prognosis in patients with pancreatic ductal adenocarcinoma". Oncology Letters 15.2 (2018): 2073-2078.
Chicago
Han, H., Wang, D., Yang, M., Wang, S."High expression of RACK1 is associated with poor prognosis in patients with pancreatic ductal adenocarcinoma". Oncology Letters 15, no. 2 (2018): 2073-2078. https://doi.org/10.3892/ol.2017.7539
Copy and paste a formatted citation
x
Spandidos Publications style
Han H, Wang D, Yang M and Wang S: High expression of RACK1 is associated with poor prognosis in patients with pancreatic ductal adenocarcinoma. Oncol Lett 15: 2073-2078, 2018.
APA
Han, H., Wang, D., Yang, M., & Wang, S. (2018). High expression of RACK1 is associated with poor prognosis in patients with pancreatic ductal adenocarcinoma. Oncology Letters, 15, 2073-2078. https://doi.org/10.3892/ol.2017.7539
MLA
Han, H., Wang, D., Yang, M., Wang, S."High expression of RACK1 is associated with poor prognosis in patients with pancreatic ductal adenocarcinoma". Oncology Letters 15.2 (2018): 2073-2078.
Chicago
Han, H., Wang, D., Yang, M., Wang, S."High expression of RACK1 is associated with poor prognosis in patients with pancreatic ductal adenocarcinoma". Oncology Letters 15, no. 2 (2018): 2073-2078. https://doi.org/10.3892/ol.2017.7539
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