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Article Open Access

Vernodalol mediates antitumor effects in acute promyelocytic leukemia cells

  • Authors:
    • Wenjun Wu
    • Xiaoyan Han
    • Cai Wu
    • Guoqing Wei
    • Gaofeng Zheng
    • Yi Li
    • Yang Yang
    • Li Yang
    • Donghua He
    • Yi Zhao
    • Zhen Cai
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Bone Marrow Transplantation Center and Multiple Myeloma Treatment Center, The First Affiliated Hospital of Zhejiang Medical College, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China, Department of Hematology, The Fourth Affiliated Hospital of Zhejiang University School of Medicine, Yiwu, Zhejiang 322000, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2227-2235
    |
    Published online on: December 7, 2017
       https://doi.org/10.3892/ol.2017.7544
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Abstract

Acute promyelocytic leukemia (APL) remains a challenge to cure due to the side effects of cytotoxic chemotherapy and drug resistance. The present study demonstrated that vernodalol, an active compound isolated from Centratherum anthelminticum, suppresses APL cell proliferation and induces cell cycle arrest in the G2/M phase through the upregulation of p21 and cell division cycle 25. In addition, vernodalol induced cellular apoptosis via the mitochondrial pathway as observed by the cleavage of caspase‑9 as well as the release of cytochrome c and Smac/DIABLO into the cytosol. A mechanistic study revealed that vernodalol may exert its antitumor activity through the suppression of phosphoinositide 3‑kinase/protein kinase B/mechanistic target of rapamycin signaling. In conclusion, vernodalol may be developed as a potential therapeutic compound for the treatment of APL.
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Copy and paste a formatted citation
Spandidos Publications style
Wu W, Han X, Wu C, Wei G, Zheng G, Li Y, Yang Y, Yang L, He D, Zhao Y, Zhao Y, et al: Vernodalol mediates antitumor effects in acute promyelocytic leukemia cells. Oncol Lett 15: 2227-2235, 2018.
APA
Wu, W., Han, X., Wu, C., Wei, G., Zheng, G., Li, Y. ... Cai, Z. (2018). Vernodalol mediates antitumor effects in acute promyelocytic leukemia cells. Oncology Letters, 15, 2227-2235. https://doi.org/10.3892/ol.2017.7544
MLA
Wu, W., Han, X., Wu, C., Wei, G., Zheng, G., Li, Y., Yang, Y., Yang, L., He, D., Zhao, Y., Cai, Z."Vernodalol mediates antitumor effects in acute promyelocytic leukemia cells". Oncology Letters 15.2 (2018): 2227-2235.
Chicago
Wu, W., Han, X., Wu, C., Wei, G., Zheng, G., Li, Y., Yang, Y., Yang, L., He, D., Zhao, Y., Cai, Z."Vernodalol mediates antitumor effects in acute promyelocytic leukemia cells". Oncology Letters 15, no. 2 (2018): 2227-2235. https://doi.org/10.3892/ol.2017.7544
Copy and paste a formatted citation
x
Spandidos Publications style
Wu W, Han X, Wu C, Wei G, Zheng G, Li Y, Yang Y, Yang L, He D, Zhao Y, Zhao Y, et al: Vernodalol mediates antitumor effects in acute promyelocytic leukemia cells. Oncol Lett 15: 2227-2235, 2018.
APA
Wu, W., Han, X., Wu, C., Wei, G., Zheng, G., Li, Y. ... Cai, Z. (2018). Vernodalol mediates antitumor effects in acute promyelocytic leukemia cells. Oncology Letters, 15, 2227-2235. https://doi.org/10.3892/ol.2017.7544
MLA
Wu, W., Han, X., Wu, C., Wei, G., Zheng, G., Li, Y., Yang, Y., Yang, L., He, D., Zhao, Y., Cai, Z."Vernodalol mediates antitumor effects in acute promyelocytic leukemia cells". Oncology Letters 15.2 (2018): 2227-2235.
Chicago
Wu, W., Han, X., Wu, C., Wei, G., Zheng, G., Li, Y., Yang, Y., Yang, L., He, D., Zhao, Y., Cai, Z."Vernodalol mediates antitumor effects in acute promyelocytic leukemia cells". Oncology Letters 15, no. 2 (2018): 2227-2235. https://doi.org/10.3892/ol.2017.7544
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