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Article

Expression of CXC-motif-chemokine 12 and the receptor C‑X‑C receptor 4 in glioma and theeffect on peritumoral brain edema

  • Authors:
    • Wenlong Tang
    • Yupeng Chen
    • Xingfu Wang
    • Yao Chen
    • Jiandong Zhang
    • Zhixiong Lin
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, P.R. China, Department of Pathology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, P.R. China
  • Pages: 2501-2507
    |
    Published online on: December 8, 2017
       https://doi.org/10.3892/ol.2017.7547
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Abstract

The present study aimed to evaluate the association between CXC‑motif‑chemokine 12 (CXCL12)/C‑X‑C receptor 4 (CXCR4) expression and peritumoral brain edema (PTBE) in glioma patients. Immunohistochemical techniques were used to detect the expression of CXCR4 and CXCL12 in 58 glioma tissues. Magnetic resonance imaging was used to evaluate the extent and type of brain edema in preoperative glioma patients. The association between edema and CXCL12/CXCR4 expression was examined by χ2 analysis. The prognostic significance of CXCL12 or CXCR4 was determined by log‑rank tests and Cox's proportional hazards model. Expression of CXCL12 and CXCR4 was observed in vascular endothelial cells and tumor cells. The degree (P=0.033) and morphology (P=0.033) of PTBE were significantly associated with the level of CXCL12 expression in vascular endothelial cells. The degree (P=0.001) and morphology (P=0.001) of PTBE were associated with the level of CXCR4 expression in tumor cells. CXCR4‑positive vascular endothelial cells were significantly associated only with the degree of edema (P=0.030). Therefore, the present study indicated that levels of CXCL12 expression in vascular endothelial cells and CXCR4 expression in tumor cells are associated with PTBE.
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Copy and paste a formatted citation
Spandidos Publications style
Tang W, Chen Y, Wang X, Chen Y, Zhang J and Lin Z: Expression of CXC-motif-chemokine 12 and the receptor C‑X‑C receptor 4 in glioma and theeffect on peritumoral brain edema. Oncol Lett 15: 2501-2507, 2018.
APA
Tang, W., Chen, Y., Wang, X., Chen, Y., Zhang, J., & Lin, Z. (2018). Expression of CXC-motif-chemokine 12 and the receptor C‑X‑C receptor 4 in glioma and theeffect on peritumoral brain edema. Oncology Letters, 15, 2501-2507. https://doi.org/10.3892/ol.2017.7547
MLA
Tang, W., Chen, Y., Wang, X., Chen, Y., Zhang, J., Lin, Z."Expression of CXC-motif-chemokine 12 and the receptor C‑X‑C receptor 4 in glioma and theeffect on peritumoral brain edema". Oncology Letters 15.2 (2018): 2501-2507.
Chicago
Tang, W., Chen, Y., Wang, X., Chen, Y., Zhang, J., Lin, Z."Expression of CXC-motif-chemokine 12 and the receptor C‑X‑C receptor 4 in glioma and theeffect on peritumoral brain edema". Oncology Letters 15, no. 2 (2018): 2501-2507. https://doi.org/10.3892/ol.2017.7547
Copy and paste a formatted citation
x
Spandidos Publications style
Tang W, Chen Y, Wang X, Chen Y, Zhang J and Lin Z: Expression of CXC-motif-chemokine 12 and the receptor C‑X‑C receptor 4 in glioma and theeffect on peritumoral brain edema. Oncol Lett 15: 2501-2507, 2018.
APA
Tang, W., Chen, Y., Wang, X., Chen, Y., Zhang, J., & Lin, Z. (2018). Expression of CXC-motif-chemokine 12 and the receptor C‑X‑C receptor 4 in glioma and theeffect on peritumoral brain edema. Oncology Letters, 15, 2501-2507. https://doi.org/10.3892/ol.2017.7547
MLA
Tang, W., Chen, Y., Wang, X., Chen, Y., Zhang, J., Lin, Z."Expression of CXC-motif-chemokine 12 and the receptor C‑X‑C receptor 4 in glioma and theeffect on peritumoral brain edema". Oncology Letters 15.2 (2018): 2501-2507.
Chicago
Tang, W., Chen, Y., Wang, X., Chen, Y., Zhang, J., Lin, Z."Expression of CXC-motif-chemokine 12 and the receptor C‑X‑C receptor 4 in glioma and theeffect on peritumoral brain edema". Oncology Letters 15, no. 2 (2018): 2501-2507. https://doi.org/10.3892/ol.2017.7547
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