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Article

Immunohistochemical CD73 expression status in gastrointestinal neuroendocrine neoplasms: A retrospective study of 136 patients

  • Authors:
    • Kohei Ono
    • Eisuke Shiozawa
    • Nobuyuki Ohike
    • Tomonori Fujii
    • Hideki Shibata
    • Tetsuya Kitajima
    • Koichiro Fujimasa
    • Naoko Okamoto
    • Yukiko Kawaguchi
    • Tasuku Nagumo
    • Sakiko Tazawa
    • Mayumi Homma
    • Toshiko Yamochi‑Onizuka
    • Tomoko Norose
    • Hitoshi Yoshida
    • Masahiko Murakami
    • Gensyu Tate
    • Masafumi Takimoto
  • View Affiliations / Copyright

    Affiliations: Department of Pathology and Laboratory Medicine, Showa University School of Medicine, Shinagawa‑ku, Tokyo 142‑8666, Japan, Department of Pathology and Laboratory Medicine, Showa University Fujigaoka Hospital, Aoba‑ku, Yokohama 227‑8501, Japan, Department of Gastroenterology, Showa University School of Medicine, Shinagawa‑ku, Tokyo 142‑8666, Japan, Department of Gastroenterological and General Surgery, Showa University School of Medicine, Shinagawa‑ku, Tokyo 142‑8666, Japan
  • Pages: 2123-2130
    |
    Published online on: December 8, 2017
       https://doi.org/10.3892/ol.2017.7569
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Abstract

The WHO 2010 classification divides gastrointestinal neuroendocrine neoplasms (GI‑NENs) into neuroendocrine tumor (NET) G1, NET G2, neuroendocrine carcinoma (NEC) and mixed adenoendocrine carcinoma (MANEC) groups. A total of 136 cases of GI‑NENs diagnosed at our hospitals as gastrointestinal carcinoids, endocrine cell carcinomas and NENs over the last 11 years, using the WHO 2010 classification were assessed. Among the 136 cases, 88.2% (120/136) were classified into the NET group (NET G1/G2) and 11.8% (16/136) were classified into the NEC group (NEC/MANEC). The incidences of lymphatic and venous invasions were higher in the NEC group compared with in the NET group (P<0.0001 and P=0.0021, respectively). The immunohistochemical staining of cluster of differentiation 73 (CD73) was evaluated in GI‑NENs. CD73 is a potentially useful molecule in tumor immunity. In general, CD73 on the tumor cell membrane converts adenosine monophosphate to adenosine, which restrains the production of interferon‑γ and cytocidal activity. Although the association between stem cells of pancreatic NENs and CD73 has been reported, few studies have reported on CD73 expression in GI‑NENs. Immunohistochemical CD73 expression on the cytomembrane of neuroendocrine cells was detected in 27.2% (37/136) of the GI‑NENs. The positive ratio of CD73 was significantly higher in the NEC group compared with in the NET group (P=0.0015). CD73 is also considered as a potential biomarker of anti‑programmed death‑1 (PD‑1) therapy. The expression of programmed death‑ligand 1 (PD‑L1) on the cytomembrane of GI‑NENs was assessed. The positive ratio of PD‑L1 was higher in the NEC group compared with in the NET group (P=0.0011). Furthermore, CD73 expression status was significantly correlated with PD‑L1 expression (P<0.0001). These results indicate that CD73 may be an interesting candidate for a biomarker for certain prognostic factors and therapeutics concerning PD‑1 therapy.
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View References

1 

Langhans TH: Ueber einen Drüsenpolyp im ileum. Virchows Arch Euro J Pathol. 38:pp559–560. 1867. View Article : Google Scholar

2 

Oberndorfer S: Karzinoide tumoren des dunndarms. Frankf Z Pathol. 1:426–432. 1907.

3 

Modlin IM, Shapiro MD, Kidd M and Eick G: Siegfried Oberndorfer and the evolution of carcinoid disease. Arch Surg. 142:187–197. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Modlin IM, Oberg K, Chung DC, Jensen RT, de Herder WW, Thakker RV, Caplin M, Delle Fave G, Kaltsas GA, Krenning EP, et al: Gastroenteropancreatic neuroendocrine tumours. Lancet Oncol. 9:61–72. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Klimstra DS, Modlin IR, Adsay NV, Chetty R, Deshpande V, Gönen M, Jensen RT, Kidd M, Kulke MH, Lloyd RV, et al: Pathology reporting of neuroendocrine tumors: Application of the Delphic consensus process to the development of a minimum pathology data set. Am J Surg Pathol. 34:300–313. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Japanese society for cancer of the colon and rectum: General rules for clinical and pathological studies on cancer of the colon, rectum and anus. 8th edn. Tokyo: Japanese society for cancer of the colon and rectum; 2013

7 

Yegutkin GG: Nucleotide- and nucleoside converting ectoenzymes: Important modulators of purinergic signalling cascade. Biochim Biophys Acta. 1783:673–694. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Jin D, Fan J, Wang L, Thompson LF, Liu A, Daniel BJ, Shin T, Curiel TJ and Zhang B: CD73 on tumor cells impairs antitumor T-cell responses: A novel mechanism of tumor-induced immune suppression. Cancer Res. 70:2245–2255. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Beavis PA, Divisekera U, Paget C, Chow MT, John LB, Devaud C, Dwyer K, Stagg J, Smyth MJ and Darcy PK: Blockade of A2A receptors potently suppresses the metastasis of CD73+ tumors. Proc Natl Acad Sci USA. 110:14711–14716. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Stagg J, Divisekera U, McLaughlin N, Sharkey J, Pommey S, Denoyer D, Dwyer KM and Smyth MJ: Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis. Proc Natl Acad Sci USA. 107:1547–1552. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Ohta A, Gorelik E, Prasad SJ, Ronchese F, Lukashev D, Wong MK, Huang X, Caldwell S, Liu K, Smith P, et al: A2A adenosine receptor protects tumors from antitumor T cells. Proc Natl Acad Sci USA. 103:13132–13137. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Stagg J, Divisekera U, Duret H, Sparwasser T, Teng MW, Darcy PK and Smyth MJ: CD73-deficient mice have increased antitumor immunity and are resistant to experimental metastasis. Cancer Res. 71:2892–2900. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Wang L, Fan J, Thompson LF, Zhang Y, Shin T, Curiel TJ and Zhang B: CD73 has distinct roles in nonhematopoietic and hematopoietic cells to promote tumor growth in mice. J Clin Invest. 121:2371–2382. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Katsuta E, Tanaka S, Mogushi K, Shimada S, Akiyama Y, Aihara A, Matsumura S, Mitsunori Y, Ban D, Ochiai T, et al: CD73 as a therapeutic target for pancreatic neuroendocrine tumor stem cells. Int J Oncol. 48:657–669. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Beavis PA, Slaney CY, Milenkovski N, Henderson MA, Loi S, Stagg J, Kershaw MH and Darcy PK: CD73: A potential biomarker for anti-PD-1 therapy. Oncoimmunology. 4:e10466752015. View Article : Google Scholar : PubMed/NCBI

16 

Rindi G, Arnold R and Bosman FT: Nomenclature and classification of neuroendocrine neoplasms of the digestive systemWHO Classification of Tumors of the Digestive System. IARC; Lyon: pp. 13–14. 2010

17 

Oh HK, Sin JI, Choi J, Park SH, Lee TS and Choi YS: Overexpression of CD73 in epithelial ovarian carcinoma is associated with better prognosis, lower stage, better differentiation and lower regulatory T cell infiltration. J Gynecol Oncol. 23:174–281. 2012. View Article : Google Scholar

18 

Ito T, Igarashi H, Nakamura K, Sasano H, Okusaka T, Takano K, Komoto I, Tanaka M, Imamura M, Jensen RT, et al: Epidemiological trends of pancreatic and gastrointestinal neuroendocrine tumors in Japan: A nationwide survey analysis. J Gastroenterol. 50:58–64. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Mocellin S and Nitti D: Gastrointestinal carcinoid: Epidemiological and survival evidence from a large population-based study (n=25 531). Ann Oncol. 24:3040–3044. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Yao JC, Hassan M, Phan A, Dagohoy C, Leary C, Mares JE, Abdalla EK, Fleming JB, Vauthey JN, Rashid A and Evans DB: One hundred years after ‘carcinoid’: Epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. J Clin Oncol. 26:3063–3072. 2008. View Article : Google Scholar : PubMed/NCBI

21 

Pavel M, Baudin E, Couvelard A, Krenning E, Öberg K, Steinmüller T, Anlauf M, Wiedenmann B and Salazar R: Barcelona Consensus Conference participants: ENETS consensus guidelines for the management of patients with liver and other distant metastases from neuroendocrine neoplasms of foregut, midgut, hindgut, and unknown primary. Neuroendocrinology. 95:157–176. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Oberg K: Diagnosis and treatment of carcinoid tumors. Expert Rev Anticancer Ther. 3:863–877. 2003. View Article : Google Scholar : PubMed/NCBI

23 

Ikeda K, Kojima M, Saito N, Sakuyama N, Koushi K, Watanabe T, Sugihara K, Akimoto T, Ito M and Ochiai A: Current status of the histopathological assessment, diagnosis, and reporting of colorectal neuroendocrine tumors: A web survey from the Japanese society for cancer of colon and rectum. Pathol Int. 66:94–101. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Bosman FT, Carneiro F, Hruban RH and Theise ND: WHO classification of tumors of the digestive system, 4th edition. Lyon. Int Agency Res Cancer. 3:pp4172010.

25 

Soga J: The term ‘carcinoid’ is a misnomer: The evidence based on local invasion. J Exp Clin Cancer Res. 28:152009. View Article : Google Scholar : PubMed/NCBI

26 

Parkins CS, Darling JL, Gill SS, Revesz T and Thomas DG: Cell proliferation in serial biopsies through human malignant brain tumours: Measurement using Ki67 antibody labelling. Br J Neurosurg. 5:289–298. 1991. View Article : Google Scholar : PubMed/NCBI

27 

Torp SH and Alsaker M: Ki-67 immunoreactivity, basic fibroblastic growth factor (bFGF) expression, and microvessel density as supplementary prognostic tools in low-grade astrocytomas. An immunohistochemical study with special reference to the reliability of different Ki-67 antibodies. Pathol Res Pract. 198:261–265. 2002. View Article : Google Scholar : PubMed/NCBI

28 

Voss SM, Riley MP, Lokhandwala PM, Wang M and Yang Z: Mitotic count by phosphohistone H3 immunohistochemical staining predicts survival and improves interobserver reproducibility in well-differentiated neuroendocrine tumors of the pancreas. Am J Surg Pathol. 39:13–24. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Reid MD, Balci S, Saka B and Adsay NV: Neuroendocrine tumors of the pancreas: Current concepts and controversies. Endocr Pathol. 25:65–79. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Cross SS, Start RD and Smith JH: Does delay in fixation affect the number of mitotic figures in processed tissue? J Clin Pathol. 43:597–599. 1990. View Article : Google Scholar : PubMed/NCBI

31 

Inoue Y, Yoshimura K, Kurabe N, Kahyo T, Kawase A, Tanahashi M, Ogawa H, Inui N, Funai K, Shinmura K, et al: Prognostic impact of CD73 and A2A adenosine receptor expression in non-small-cell lung cancer. Oncotarget. 8:8738–8751. 2017.PubMed/NCBI

32 

Wu XR, He XS, Chen YF, Yuan RX, Zeng Y, Lian L, Zou YF, Lan N, Wu XJ and Lan P: High expression of CD73 as a poor prognostic biomarker in human colorectal cancer. J Surg Oncol. 106:130–137. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Lu XX, Chen YT, Feng B, Mao XB, Yu B and Chu XY: Expression and clinical significance of CD73 and hypoxia-inducible factor-1α in gastric carcinoma. World J Gastroenterol. 19:1912–1918. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Xiong L, Wen Y, Miao X and Yang Z: NT5E and FcGBP as key regulators of TGF-1-induced epithelial-mesenchymal transition (EMT) are associated with tumor progression and survival of patients with gallbladder cancer. Cell Tissue Res. 355:365–374. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Turcotte M, Spring K, Pommey S, Chouinard G, Cousineau I, George J, Chen GM, Gendoo DM, Haibe-Kains B, Karn T, et al: CD73 is associated with poor prognosis in high-grade serous ovarian cancer. Cancer Res. 75:4494–4503. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Loi S, Pommey S, Haibe-Kains B, Beavis PA, Darcy PK, Smyth MJ and Stagg J: CD73 promotes anthracycline resistance and poor prognosis in triple negative breast cancer. Proc Natl Acad Sci USA. 110:11091–11096. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Arozarena I, Sanchez-Laorden B, Packer L, Hidalgo-Carcedo C, Hayward R, Viros A, Sahai E and Marais R: Oncogenic BRAF induces melanoma cell invasion by downregulating the cGMP-specific phosphodiesterase PDE5A. Cancer Cell. 19:45–57. 2011. View Article : Google Scholar : PubMed/NCBI

38 

Aliagas E, Vidal A, Texidó L, Ponce J, Condom E and Martín-Satué M: High expression of ecto-nucleotidases CD39 and CD73 in human endometrial tumors. Mediators Inflamm. 2014:5090272014. View Article : Google Scholar : PubMed/NCBI

39 

Kojima M, Ikeda K, Saito N, Sakuyama N, Koushi K, Kawano S, Watanabe T, Sugihara K, Ito M and Ochiai A: Neuroendocrine tumors of the large intestine: Clinicopathological features and predictive factors of lymph node metastasis. Front Oncol. 6:1732016. View Article : Google Scholar : PubMed/NCBI

40 

Allard B, Pommey S, Smyth MJ and Stagg J: Targeting CD73 enhances the antitumor activity of anti-PD-1 and anti-CTLA-4 mAbs. Clin Cancer Res. 19:5626–5635. 2013. View Article : Google Scholar : PubMed/NCBI

41 

Balar AV and Weber JS: PD-1 and PD-L1 antibodies in cancer: Current status and future directions. Cancer Immunol Immunother. 66:551–564. 2017. View Article : Google Scholar : PubMed/NCBI

42 

Phillips T, Simmons P, Inzunza HD, Cogswell J, Novotny J Jr, Taylor C and Zhang X: Development of an automated PD-L1 immunohistochemistry (IHC) assay for non-small cell lung cancer. Appl Immunohistochem Mol Morphol. 23:541–549. 2015. View Article : Google Scholar : PubMed/NCBI

43 

Rangachari D, VanderLaan PA, Shea M, Le X, Huberman MS, Kobayashi SS and Costa DB: Correlation between classic driver oncogene mutations in EGFR, ALK, or ROS1 and 22C3-PD-L1 ≥50% expression in lung adenocarcinoma. J Thorac Oncol. 12:878–883. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ono K, Shiozawa E, Ohike N, Fujii T, Shibata H, Kitajima T, Fujimasa K, Okamoto N, Kawaguchi Y, Nagumo T, Nagumo T, et al: Immunohistochemical CD73 expression status in gastrointestinal neuroendocrine neoplasms: A retrospective study of 136 patients. Oncol Lett 15: 2123-2130, 2018.
APA
Ono, K., Shiozawa, E., Ohike, N., Fujii, T., Shibata, H., Kitajima, T. ... Takimoto, M. (2018). Immunohistochemical CD73 expression status in gastrointestinal neuroendocrine neoplasms: A retrospective study of 136 patients. Oncology Letters, 15, 2123-2130. https://doi.org/10.3892/ol.2017.7569
MLA
Ono, K., Shiozawa, E., Ohike, N., Fujii, T., Shibata, H., Kitajima, T., Fujimasa, K., Okamoto, N., Kawaguchi, Y., Nagumo, T., Tazawa, S., Homma, M., Yamochi‑Onizuka, T., Norose, T., Yoshida, H., Murakami, M., Tate, G., Takimoto, M."Immunohistochemical CD73 expression status in gastrointestinal neuroendocrine neoplasms: A retrospective study of 136 patients". Oncology Letters 15.2 (2018): 2123-2130.
Chicago
Ono, K., Shiozawa, E., Ohike, N., Fujii, T., Shibata, H., Kitajima, T., Fujimasa, K., Okamoto, N., Kawaguchi, Y., Nagumo, T., Tazawa, S., Homma, M., Yamochi‑Onizuka, T., Norose, T., Yoshida, H., Murakami, M., Tate, G., Takimoto, M."Immunohistochemical CD73 expression status in gastrointestinal neuroendocrine neoplasms: A retrospective study of 136 patients". Oncology Letters 15, no. 2 (2018): 2123-2130. https://doi.org/10.3892/ol.2017.7569
Copy and paste a formatted citation
x
Spandidos Publications style
Ono K, Shiozawa E, Ohike N, Fujii T, Shibata H, Kitajima T, Fujimasa K, Okamoto N, Kawaguchi Y, Nagumo T, Nagumo T, et al: Immunohistochemical CD73 expression status in gastrointestinal neuroendocrine neoplasms: A retrospective study of 136 patients. Oncol Lett 15: 2123-2130, 2018.
APA
Ono, K., Shiozawa, E., Ohike, N., Fujii, T., Shibata, H., Kitajima, T. ... Takimoto, M. (2018). Immunohistochemical CD73 expression status in gastrointestinal neuroendocrine neoplasms: A retrospective study of 136 patients. Oncology Letters, 15, 2123-2130. https://doi.org/10.3892/ol.2017.7569
MLA
Ono, K., Shiozawa, E., Ohike, N., Fujii, T., Shibata, H., Kitajima, T., Fujimasa, K., Okamoto, N., Kawaguchi, Y., Nagumo, T., Tazawa, S., Homma, M., Yamochi‑Onizuka, T., Norose, T., Yoshida, H., Murakami, M., Tate, G., Takimoto, M."Immunohistochemical CD73 expression status in gastrointestinal neuroendocrine neoplasms: A retrospective study of 136 patients". Oncology Letters 15.2 (2018): 2123-2130.
Chicago
Ono, K., Shiozawa, E., Ohike, N., Fujii, T., Shibata, H., Kitajima, T., Fujimasa, K., Okamoto, N., Kawaguchi, Y., Nagumo, T., Tazawa, S., Homma, M., Yamochi‑Onizuka, T., Norose, T., Yoshida, H., Murakami, M., Tate, G., Takimoto, M."Immunohistochemical CD73 expression status in gastrointestinal neuroendocrine neoplasms: A retrospective study of 136 patients". Oncology Letters 15, no. 2 (2018): 2123-2130. https://doi.org/10.3892/ol.2017.7569
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