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Article

Granulocyte-colony stimulating factor producing mucinous cystic neoplasm with an associated invasive carcinoma of the pancreas

  • Authors:
    • Kazuhide Shimamatsu
    • Yoshiki Naito
    • Yutaro Mihara
    • Masamichi Nakayama
    • Masahiko Tanigawa
    • Yushi Abe
    • Ken Nakamura
    • Toshihiro Araki
    • Kenji Sakata
    • Kazunori Noguchi
    • Jun Akiba
    • Hirohisa Yano
    • Osamu Nakashima
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Omuta City Hospital, Omuta, Fukuoka 836‑8567, Japan, Department of Diagnostic Pathology, Kurume University Hospital, Kurume, Fukuoka 830‑0011, Japan, Department of Pathology, Kurume University School of Medicine, Kurume, Fukuoka 830‑0011, Japan, Department of Medicine, Omuta City Hospital, Omuta, Fukuoka 836‑8567, Japan, Department of Clinical Laboratory, Kurume University Hospital, Kurume, Fukuoka 830‑0011, Japan
  • Pages: 2387-2392
    |
    Published online on: December 8, 2017
       https://doi.org/10.3892/ol.2017.7572
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Abstract

The present case study documents an autopsy case of granulocyte‑colony stimulating factor (G‑CSF)‑producing mucinous cystic neoplasm (MCN), with an associated invasive carcinoma of the pancreas. A 65‑year‑old woman presented to Omuta City Hospital (Omuta Japan) with a primary complaint of abdominal pain. Multiple liver nodules and a pancreatic cyst were detected upon abdominal computed tomography. Initially, liver abscess was suspected as the patient exhibited leukocytosis and elevated C‑reactive protein level. However, the serum concentration of G‑CSF was 98.8 pg/ml (normal, <39.0 pg/ml). At 6 weeks after admission, the patient succumbed to liver failure. At autopsy, a cystic lesion was identified in the pancreatic tail that contained bloody necrotic fluid. Microscopically, the cystic lesion was composed of columnar and mucin‑producing epithelium associated with ovarian‑type subepithelial stroma. The stroma exhibited positive immunostaining for vimentin, estrogen receptor and progesterone receptor. Calcification on the cystic wall was observed. The tumor invaded the pancreatic parenchyma and metastasized to the liver and lungs. The lesion was diagnosed as invasive adenocarcinoma arising in MCN. By contrast, liver nodules predominantly consisted of pleomorphic cancer cells with small foci of adenocarcinoma. Pancreatic and hepatic cancer cells were confirmed to be positive for G‑CSF staining. The present case report indicates that G‑CSF‑producing MCNs may be associated with an aggressive clinical course, particularly when anaplastic changes are observed.
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Copy and paste a formatted citation
Spandidos Publications style
Shimamatsu K, Naito Y, Mihara Y, Nakayama M, Tanigawa M, Abe Y, Nakamura K, Araki T, Sakata K, Noguchi K, Noguchi K, et al: Granulocyte-colony stimulating factor producing mucinous cystic neoplasm with an associated invasive carcinoma of the pancreas. Oncol Lett 15: 2387-2392, 2018.
APA
Shimamatsu, K., Naito, Y., Mihara, Y., Nakayama, M., Tanigawa, M., Abe, Y. ... Nakashima, O. (2018). Granulocyte-colony stimulating factor producing mucinous cystic neoplasm with an associated invasive carcinoma of the pancreas. Oncology Letters, 15, 2387-2392. https://doi.org/10.3892/ol.2017.7572
MLA
Shimamatsu, K., Naito, Y., Mihara, Y., Nakayama, M., Tanigawa, M., Abe, Y., Nakamura, K., Araki, T., Sakata, K., Noguchi, K., Akiba, J., Yano, H., Nakashima, O."Granulocyte-colony stimulating factor producing mucinous cystic neoplasm with an associated invasive carcinoma of the pancreas". Oncology Letters 15.2 (2018): 2387-2392.
Chicago
Shimamatsu, K., Naito, Y., Mihara, Y., Nakayama, M., Tanigawa, M., Abe, Y., Nakamura, K., Araki, T., Sakata, K., Noguchi, K., Akiba, J., Yano, H., Nakashima, O."Granulocyte-colony stimulating factor producing mucinous cystic neoplasm with an associated invasive carcinoma of the pancreas". Oncology Letters 15, no. 2 (2018): 2387-2392. https://doi.org/10.3892/ol.2017.7572
Copy and paste a formatted citation
x
Spandidos Publications style
Shimamatsu K, Naito Y, Mihara Y, Nakayama M, Tanigawa M, Abe Y, Nakamura K, Araki T, Sakata K, Noguchi K, Noguchi K, et al: Granulocyte-colony stimulating factor producing mucinous cystic neoplasm with an associated invasive carcinoma of the pancreas. Oncol Lett 15: 2387-2392, 2018.
APA
Shimamatsu, K., Naito, Y., Mihara, Y., Nakayama, M., Tanigawa, M., Abe, Y. ... Nakashima, O. (2018). Granulocyte-colony stimulating factor producing mucinous cystic neoplasm with an associated invasive carcinoma of the pancreas. Oncology Letters, 15, 2387-2392. https://doi.org/10.3892/ol.2017.7572
MLA
Shimamatsu, K., Naito, Y., Mihara, Y., Nakayama, M., Tanigawa, M., Abe, Y., Nakamura, K., Araki, T., Sakata, K., Noguchi, K., Akiba, J., Yano, H., Nakashima, O."Granulocyte-colony stimulating factor producing mucinous cystic neoplasm with an associated invasive carcinoma of the pancreas". Oncology Letters 15.2 (2018): 2387-2392.
Chicago
Shimamatsu, K., Naito, Y., Mihara, Y., Nakayama, M., Tanigawa, M., Abe, Y., Nakamura, K., Araki, T., Sakata, K., Noguchi, K., Akiba, J., Yano, H., Nakashima, O."Granulocyte-colony stimulating factor producing mucinous cystic neoplasm with an associated invasive carcinoma of the pancreas". Oncology Letters 15, no. 2 (2018): 2387-2392. https://doi.org/10.3892/ol.2017.7572
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