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Article

Tanshinone II is a potent candidate for treatment of lipopolysaccharide-induced acute lung injury in rat model

  • Authors:
    • Ling Li
    • Yong‑Gang Zhang
    • Yu‑Fei Tan
    • Jing‑Jing Zhao
    • Hua‑Ru Zhang
    • Bing Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory and Critical Care, Zhumadian Central Hospital, Zhumadian, Henan 463000, P.R. China
  • Pages: 2550-2554
    |
    Published online on: December 11, 2017
       https://doi.org/10.3892/ol.2017.7581
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Abstract

The present study aimed to investigate the effect of tanshinone II, isolated from Salvia miltiorrhiza Bunge, on lipopolysaccharide (LPS)‑induced acute lung injury (ALI) in rats. Male Sprague‑Dawley rats were divided into three groups: Control, LPS and tanshinone II. Animals in the tanshinone II and LPS groups were administered 10 mg/kg LPS, whereas those in the control group received an equal volume of normal saline. Tanshinone II treatment group were injected with 30 nm/kg tanshinone II at 1 h after LPS administration. The results revealed that LPS administration increased the bronchoalveolar lavage fluid protein concentration significantly compared with the control group. However, tanshinone II treatment significantly inhibited the LPS‑induced increase in protein level. Treatment of the LPS‑administered rats with tanshinone II prevented the formation of pulmonary edema, which was evidenced by low values for wet to dry lung weight ratio. The activity of myeloperoxidase and expression of malondialdehyde were significantly lower in lung homogenates from the tanshinone II group compared with the LPS group. Furthermore, tanshinone II treatment inhibited the expression of tumor necrosis factor‑α and interleukin‑6 in the blood plasma. Tissue sections of the tanshinone II group exhibited normal morphology and absence of neutrophil accumulation. However, in the LPS group, neutrophils accumulated and penetrated into the pulmonary tissues. These results suggested that tanshinone II protects the rats from LPS‑induced ALI. Therefore tanshinone II may have clinical applications in the treatment of ALI.
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1 

Herridge MS, Cheung AM, Tansey CM, Matte-Martyn A, Diaz-Granados N, Al-Saidi F, Cooper AB, Guest CB, Mazer CD, Mehta S, et al: One-year outcomes in survivors of the acute respiratory distress syndrome. N Engl J Med. 348:683–693. 2003. View Article : Google Scholar : PubMed/NCBI

2 

Chung YJ, Jarvis B and Pestka J: Modulation of lipopolysaccharide-induced proinflammatory cytokine production by satratoxins and other macrocyclic trichothecenes in the murine macrophage. J Toxicol Environ Health A. 66:379–391. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Brandolini L, Asti C, Ruggieri V, Intilangelo A, Pellegrini L, Chiusaroli R, Caselli GF and Bertini R: Lipopolysaccharide-induced lung injury in mice. II. Evaluation of functional damage in isolated parenchyma strips. Pulm Pharmacol Ther. 13:71–78. 2000. View Article : Google Scholar : PubMed/NCBI

4 

Bucher M and Taeger K: Endothelin-receptor gene-expression in rat endotoxemia. Intensive Care Med. 28:642–647. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Emery DA, Nagaraja KV, Sivanandan V, Lee BW, Zhang CL and Newman JA: Endotoxin lipopolysaccharide from Escherichia coli and its effects on the phagocytic function of systemic and pulmonary macrophages in turkeys. Avian Dis. 35:901–909. 1991. View Article : Google Scholar : PubMed/NCBI

6 

Esbenshade AM, Newman JH, Lams PM, Jolles H and Brigham KL: Respiratory failure after endotoxin infusion in sheep: Lung mechanics and lung fluid balance. J Appl Physiol Respir Environ Exerc Physiol. 53:967–976. 1982.PubMed/NCBI

7 

Rojas M, Woods CR, Mora AL, Xu J and Brigham KL: Endotoxin-induced lung injury in mice: Structural, functional and biochemical responses. Am J Physiol Lung Cell Mol Physiol. 288:L333–L341. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Matuschak GM and Lechner AJ: Acute lung injury and the acute respiratory distress syndrome: Pathophysiology and treatment. Mo Med. 107:252–258. 2010.PubMed/NCBI

9 

Cross CE, Forte T, Stocker R, Louie S, Yamamoto Y, Ames BN and Frei B: Oxidative stress and abnormal cholesterol metabolism in patients with adult respiratory distress syndrome. J Lab Clin Med. 115:396–404. 1990.PubMed/NCBI

10 

Sabarirajan J, Vijayaraj P and Nachiappan V: Induction of acute respiratory distress syndrome in rats by lipopolysaccharide and its effect on oxidative stress and antioxidant status in lung. Indian J Biochem Biophys. 47:278–284. 2010.PubMed/NCBI

11 

Blackwell TS, Blackwell TR, Holden EP, Christman BW and Christman JW: In vivo antioxidant treatment suppresses nuclear factor-kappa B activation and neutrophilic lung inflammation. J Immunol. 157:1630–1637. 1996.PubMed/NCBI

12 

Gordaliza M: Natural products as leads to anticancer drugs. Clin Transl Oncol. 9:767–776. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Sheen WS, Tsai IL, Teng CM and Chen IS: Nor-neolignan and phenyl propanoid from Zanthoxylum ailanthoides. Phytochemistry. 36:213–215. 1994. View Article : Google Scholar

14 

Yang Z, Hon MH, Chui KY, Xu HM, Lee CM, Cui YX, Wong HNC, Poon CD and Fung BM: Naturally occurring benzofuran: Isolation, structure elucidation and total synthesis of 5-(3-hydroxypropyl)-7-methoxy-2-(3′-methoxy-4′hydroxyphenyl)-3-benzo [b]furancarbaldehyde, a novel adenosine A1 receptor ligand isolated from salvia miltiorrhiza bunge (danshen). Tetrahedron Lett. 32:2061–2064. 1991. View Article : Google Scholar

15 

Zhou L, Zuo Z and Chow MS: Danshen: An overview of its chemistry, pharmacology, pharmacokinetics, and clinical use. J Clin Pharmacol. 45:1345–1359. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Yuan SL, Wei YQ, Wang XJ, Xiao F, Li SF and Zhang J: Growth inhibition and apoptosis induction of tanshinone II-A on human hepatocellular carcinoma cells. World J Gastroenterol. 10:2024–2028. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Sung HJ, Choi SM, Yoon Y and An KS: Tanshinone IIA, an ingredient of Salvia miltiorrhiza BUNGE, induces apoptosis in human leukemia cell lines through the activation of caspase-3. Exp Mol Med. 31:174–178. 1999. View Article : Google Scholar : PubMed/NCBI

18 

Hua Y, Li W, Wan-Liang S, Lei W, Zai-Liang Y, Yuan L, Ke Z, Ying W and Wei-Jing Z: The green tea extract epigallocatechin-3-gallate inhibits irradiation-induced pulmonary fibrosis in adult rats. Int J Mol Med. 34:92–102. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Ford J, Jiang M and Milner J: Cancer-specific functions of SIRT1 enable human epithelial cancer cell growth and survival. Cancer Res. 65:10457–10463. 2005. View Article : Google Scholar : PubMed/NCBI

20 

Dushianthan A, Grocott MP, Postle AD and Cusack R: Acute respiratory distress syndrome and acute lung injury. Postgrad Med J. 87:612–622. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Gattinoni L, Bombino M, Pelosi P, Lissoni A, Pesenti A, Fumagalli R and Tagliabue M: Lung structure and function in different stages of severe adult respiratory distress syndrome. JAMA. 271:1772–1779. 1994. View Article : Google Scholar : PubMed/NCBI

22 

Mu E, Ding R, An X, Li X, Chen S and Ma X: Heparin attenuates lipopolysaccharide-induced acute lung injury by inhibiting nitric oxide synthase and TGF-β/Smad signaling pathway. Thromb Res. 129:479–485. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Ni YF, Tian F, Lu ZF, Yang GD, Fu HY, Wang J, Yan XL, Zhao YC, Wang YJ and Jiang T: Protective effect of nicotine on lipopolysaccharide-induced acute lung injury in mice. Respiration. 81:39–46. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Ma Z, Ji W, Fu Q and Ma S: Formononetin inhibited the inflam-mation of LPS-induced acute lung injury in mice associated with induction of PPAR gamma expression. Inflammation. 36:1560–1566. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Torun AN, Kulaksizoglu S, Kulaksizoglu M, Pamuk BO, Isbilen E and Tutuncu NB: Serum total antioxidant status and lipid peroxidation marker malondialdehyde levels in overt and subclinical hypothyroidism. Clin Endocrinol (Oxf). 70:469–474. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Van Lent PL, van de Loo FA, Holthuysen AE, van den Bersselaar LA and Vermeer H: Major role for interleukin-1 but not tumor necrosis factor in early cartilage damage in immune complex arthritis in mice. J Rheumatol. 22:2250–2058. 1995.PubMed/NCBI

27 

Lee SJ and Kim MM: Resveratrol with antioxidant activity inhibits matrix metalloproteinase via modulation of SIRT1 in human fibrosarcoma cells. Life Sci. 88:465–472. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Niederer F, Ospelt C, Brentano F, Hottiger MO, Gay RE, Gay S, Detmar M and Kyburz D: SIRT1 overexpression in the rheumatoid arthritis synovium contributes to proinflammatory cytokine production and apoptosis resistance. Ann Rheum Dis. 70:1866–1873. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li L, Zhang YG, Tan YF, Zhao JJ, Zhang HR and Zhao B: Tanshinone II is a potent candidate for treatment of lipopolysaccharide-induced acute lung injury in rat model. Oncol Lett 15: 2550-2554, 2018.
APA
Li, L., Zhang, Y., Tan, Y., Zhao, J., Zhang, H., & Zhao, B. (2018). Tanshinone II is a potent candidate for treatment of lipopolysaccharide-induced acute lung injury in rat model. Oncology Letters, 15, 2550-2554. https://doi.org/10.3892/ol.2017.7581
MLA
Li, L., Zhang, Y., Tan, Y., Zhao, J., Zhang, H., Zhao, B."Tanshinone II is a potent candidate for treatment of lipopolysaccharide-induced acute lung injury in rat model". Oncology Letters 15.2 (2018): 2550-2554.
Chicago
Li, L., Zhang, Y., Tan, Y., Zhao, J., Zhang, H., Zhao, B."Tanshinone II is a potent candidate for treatment of lipopolysaccharide-induced acute lung injury in rat model". Oncology Letters 15, no. 2 (2018): 2550-2554. https://doi.org/10.3892/ol.2017.7581
Copy and paste a formatted citation
x
Spandidos Publications style
Li L, Zhang YG, Tan YF, Zhao JJ, Zhang HR and Zhao B: Tanshinone II is a potent candidate for treatment of lipopolysaccharide-induced acute lung injury in rat model. Oncol Lett 15: 2550-2554, 2018.
APA
Li, L., Zhang, Y., Tan, Y., Zhao, J., Zhang, H., & Zhao, B. (2018). Tanshinone II is a potent candidate for treatment of lipopolysaccharide-induced acute lung injury in rat model. Oncology Letters, 15, 2550-2554. https://doi.org/10.3892/ol.2017.7581
MLA
Li, L., Zhang, Y., Tan, Y., Zhao, J., Zhang, H., Zhao, B."Tanshinone II is a potent candidate for treatment of lipopolysaccharide-induced acute lung injury in rat model". Oncology Letters 15.2 (2018): 2550-2554.
Chicago
Li, L., Zhang, Y., Tan, Y., Zhao, J., Zhang, H., Zhao, B."Tanshinone II is a potent candidate for treatment of lipopolysaccharide-induced acute lung injury in rat model". Oncology Letters 15, no. 2 (2018): 2550-2554. https://doi.org/10.3892/ol.2017.7581
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