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Article

Acridone suppresses the proliferation of human breast cancer cells in vitro via ATP-binding cassette subfamily G member 2

  • Authors:
    • Licheng Xu
    • Shuyan Li
    • Zhi Liang
    • Haixia Lin
    • Rongzhan Fu
  • View Affiliations / Copyright

    Affiliations: Department of Breast Surgery, Yantaishan Hospital, Yantai, Shandong 264000, P.R. China, Department of Endocrinology, Yantai Yuhuangding Hospital, Yantai, Shandong 264000, P.R. China, Department of Breast Surgery, Qianfoshan Hospital Affiliated to Shandong University, Jinan, Shandong 250014, P.R. China
  • Pages: 2651-2654
    |
    Published online on: December 11, 2017
       https://doi.org/10.3892/ol.2017.7583
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Abstract

In the past decades, the tricyclic acridone ring system has become a focus of major research by medicinal chemists due to the biological significance of this moiety in drug design and discovery. Acridone has substantial bio‑potential since it performs crucial functions, including antibacterial, antimalarial, antiviral and anti‑neoplastic activities. However, the anticancer effect and the underlying mechanisms of acridone on breast cancer cells remains unclear. In the present study, the anti‑tumor function and the underlying mechanisms of acridone were evaluated in vitro. Firstly, an MTT assay was used to evaluate the inhibitory effect of acridone. Subsequently, reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) was performed to investigate whether ATP binding cassette subfamily G member 2 (ABCG2) was associated with the function of acridone. Finally, western blotting was used to confirm the results of RT‑qPCR. The present study demonstrated that acridone may decrease the proliferation of MDA‑MB‑231 cells dose‑dependently. Further experiments revealed that acridone may downregulate the mRNA and protein expression levels of ABCG2, supporting the potential application of acridone in breast cancer treatment. These findings suggested that acridone is a potential agent in the treatment of human breast cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Xu L, Li S, Liang Z, Lin H and Fu R: Acridone suppresses the proliferation of human breast cancer cells in vitro via ATP-binding cassette subfamily G member 2. Oncol Lett 15: 2651-2654, 2018.
APA
Xu, L., Li, S., Liang, Z., Lin, H., & Fu, R. (2018). Acridone suppresses the proliferation of human breast cancer cells in vitro via ATP-binding cassette subfamily G member 2. Oncology Letters, 15, 2651-2654. https://doi.org/10.3892/ol.2017.7583
MLA
Xu, L., Li, S., Liang, Z., Lin, H., Fu, R."Acridone suppresses the proliferation of human breast cancer cells in vitro via ATP-binding cassette subfamily G member 2". Oncology Letters 15.2 (2018): 2651-2654.
Chicago
Xu, L., Li, S., Liang, Z., Lin, H., Fu, R."Acridone suppresses the proliferation of human breast cancer cells in vitro via ATP-binding cassette subfamily G member 2". Oncology Letters 15, no. 2 (2018): 2651-2654. https://doi.org/10.3892/ol.2017.7583
Copy and paste a formatted citation
x
Spandidos Publications style
Xu L, Li S, Liang Z, Lin H and Fu R: Acridone suppresses the proliferation of human breast cancer cells in vitro via ATP-binding cassette subfamily G member 2. Oncol Lett 15: 2651-2654, 2018.
APA
Xu, L., Li, S., Liang, Z., Lin, H., & Fu, R. (2018). Acridone suppresses the proliferation of human breast cancer cells in vitro via ATP-binding cassette subfamily G member 2. Oncology Letters, 15, 2651-2654. https://doi.org/10.3892/ol.2017.7583
MLA
Xu, L., Li, S., Liang, Z., Lin, H., Fu, R."Acridone suppresses the proliferation of human breast cancer cells in vitro via ATP-binding cassette subfamily G member 2". Oncology Letters 15.2 (2018): 2651-2654.
Chicago
Xu, L., Li, S., Liang, Z., Lin, H., Fu, R."Acridone suppresses the proliferation of human breast cancer cells in vitro via ATP-binding cassette subfamily G member 2". Oncology Letters 15, no. 2 (2018): 2651-2654. https://doi.org/10.3892/ol.2017.7583
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