|
1
|
The Lancet Oncology, . Pancreatic cancer
in the spotlight. Lancet Oncol. 15:2412014. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Blum R and Kloog Y: Metabolism addiction
in pancreatic cancer. Cell Death Dis. 5:e10652014. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Bian Y, Yu Y, Wang S and Li L:
Up-regulation of fatty acid synthase induced by EGFR/ERK activation
promotes tumor growth in pancreatic cancer. Biochem Biophys Res
Commun. 463:612–617. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Little JL and Kridel SJ: Fatty acid
synthase activity in tumor cells. Subcell Biochem. 49:169–194.
2008. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Menendez JA, Vazquez-Martin A, Ortega FJ
and Fernandez-Real JM: Fatty acid synthase: Association with
insulin resistance, type 2 diabetes, and cancer. Clin Chem.
55:425–438. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Kuhajda FP, Jenner K, Wood FD, Hennigar
RA, Jacobs LB, Dick JD and Pasternack GR: Fatty acid synthesis: A
potential selective target for antineoplastic therapy. Proc Natl
Acad Sci USA. 91:6379–6383. 1994. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Shurbaji MS, Kalbfleisch JH and Thurmond
TS: Immunohistochemical detection of a fatty acid synthase (OA-519)
as a predictor of progression of prostate cancer. Hum Pathol.
27:917–921. 1996. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Piyathilake CJ, Frost AR, Manne U, Bell
WC, Weiss H, Heimburger DC and Grizzle WE: The expression of fatty
acid synthase (FASE) is an early event in the development and
progression of squamous cell carcinoma of the lung. Hum Pathol.
31:1068–1073. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Alo PL, Amini M, Piro F, Pizzuti L,
Sebastiani V, Botti C, Murari R, Zotti G and Di Tondo U:
Immunohistochemical expression and prognostic significance of fatty
acid synthase in pancreatic carcinoma. Anticancer Res.
27:2523–2527. 2007.PubMed/NCBI
|
|
10
|
Yang Y, Liu H, Li Z, Zhao Z, Yip-Schneider
M, Fan Q, Schmidt CM, Chiorean EG, Xie J, Cheng L, et al: Role of
fatty acid synthase in gemcitabine and radiation resistance of
pancreatic cancers. Int J Biochem Mol Biol. 2:89–98.
2011.PubMed/NCBI
|
|
11
|
Kim DJ, Park YS, Kang MG, You YM, Jung Y,
Koo H, Kim JA, Kim MJ, Hong SM, Lee KB, et al: Pyruvate kinase
isoenzyme M2 is a therapeutic target of gemcitabine-resistant
pancreatic cancer cells. Exp Cell Res. 336:119–129. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.
View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Pei H, Li L, Fridley BL, Jenkins GD,
Kalari KR, Lingle W, Petersen G, Lou Z and Wang L: FKBP51 affects
cancer cell response to chemotherapy by negatively regulating Akt.
Cancer Cell. 16:259–266. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Rhodes DR, Yu J, Shanker K, Deshpande N,
Varambally R, Ghosh D, Barrette T, Pandey A and Chinnaiyan AM:
ONCOMINE: A cancer microarray database and integrated data-mining
platform. Neoplasia. 6:1–6. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Lai IL, Chou CC, Lai PT, Fang CS, Shirley
LA, Yan R, Mo X, Bloomston M, Kulp SK, Bekaii-Saab T and Chen CS:
Targeting the Warburg effect with a novel glucose transporter
inhibitor to overcome gemcitabine resistance in pancreatic cancer
cells. Carcinogenesis. 35:2203–2213. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Witkiewicz AK, Nguyen KH, Dasgupta A,
Kennedy EP, Yeo CJ, Lisanti MP and Brody JR: Co-expression of fatty
acid synthase and caveolin-1 in pancreatic ductal adenocarcinoma:
Implications for tumor progression and clinical outcome. Cell
Cycle. 7:3021–3025. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Zimmon DS and Ferstenberg R: Pancreatic
carcinoma. N Engl J Med. 326:17821992. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Hanahan D and Weinberg RA: Hallmarks of
cancer: The next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Wong N, Ojo D, Yan J and Tang D: PKM2
contributes to cancer metabolism. Cancer Lett. 356:184–191. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Li C, Zhao Z, Zhou Z and Liu R: PKM2
Promotes cell survival and invasion under metabolic stress by
enhancing warburg effect in pancreatic ductal adenocarcinoma. Dig
Dis Sci. 61:767–773. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Furuta E, Pai SK, Zhan R, Bandyopadhyay S,
Watabe M, Mo YY, Hirota S, Hosobe S, Tsukada T, Miura K, et al:
Fatty acid synthase gene is up-regulated by hypoxia via activation
of Akt and sterol regulatory element binding protein-1. Cancer Res.
68:1003–1011. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Legaspi A, Jeevanandam M, Starnes HF Jr
and Brennan MF: Whole body lipid and energy metabolism in the
cancer patient. Metabolism. 36:958–963. 1987. View Article : Google Scholar : PubMed/NCBI
|
