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Article

Association between inflammation and cancer stem cell phenotype in breast cancer

  • Authors:
    • Young Ju Jeong
    • Hoon Kyu Oh
    • Sung Hwan Park
    • Jin Gu Bong
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, College of Medicine, Catholic University of Daegu, Nam, Daegu 42471, Republic of Korea, Department of Pathology, College of Medicine, Catholic University of Daegu, Nam, Daegu 42471, Republic of Korea, Department of Surgery, Raphael Hospital, Jung, Daegu 41968, Republic of Korea
  • Pages: 2380-2386
    |
    Published online on: December 13, 2017
       https://doi.org/10.3892/ol.2017.7607
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Abstract

Inflammation and cancer stem cells (CSCs) are becoming increasingly recognized as components of tumorigenesis in breast cancer. In the present study, the association between inflammation and BCSC phenotype was evaluated in human breast cancer tissue. Immunohistochemical staining for cluster of differentiation (CD)24, 44, 4, 8 and 68 was performed using tissue microarray blocks containing 47 consecutive cases of invasive breast carcinoma and 10 normal breast tissue samples. The levels of inflammatory modulators and cytokines, and intratumoral or peritumoral lymphocyte infiltration, were assessed. BCSCs were defined as CD44+/CD24‑ tumor cells. In total, 21.3% of samples exhibited the CD44+/CD24‑ phenotype. This phenotype was identified to be significantly inversely associated with lymph node metastasis. In addition, the CD44+/CD24‑ phenotype was significantly associated with the molecular subtype of breast cancer, and was particularly increased in the basal‑like subtype. Furthermore, the CD44+/CD24‑ phenotype was significantly associated with intratumoral inflammation and tumor‑infiltrating CD4+ T cell counts. Notably, tumor‑infiltrating CD4+ T cells were significantly increased in patients with the basal‑like molecular subtype of breast cancer. In conclusion, the present study identified a significant association between inflammation and the CD44+/CD24‑ phenotype in breast cancer. These results suggest that the interaction between inflammation and CSCs may affect the tumorigenesis and progression of breast cancer. Further studies are required to clarify the role of inflammation and CSCs in breast cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Jeong YJ, Oh HK, Park SH and Bong JG: Association between inflammation and cancer stem cell phenotype in breast cancer. Oncol Lett 15: 2380-2386, 2018.
APA
Jeong, Y.J., Oh, H.K., Park, S.H., & Bong, J.G. (2018). Association between inflammation and cancer stem cell phenotype in breast cancer. Oncology Letters, 15, 2380-2386. https://doi.org/10.3892/ol.2017.7607
MLA
Jeong, Y. J., Oh, H. K., Park, S. H., Bong, J. G."Association between inflammation and cancer stem cell phenotype in breast cancer". Oncology Letters 15.2 (2018): 2380-2386.
Chicago
Jeong, Y. J., Oh, H. K., Park, S. H., Bong, J. G."Association between inflammation and cancer stem cell phenotype in breast cancer". Oncology Letters 15, no. 2 (2018): 2380-2386. https://doi.org/10.3892/ol.2017.7607
Copy and paste a formatted citation
x
Spandidos Publications style
Jeong YJ, Oh HK, Park SH and Bong JG: Association between inflammation and cancer stem cell phenotype in breast cancer. Oncol Lett 15: 2380-2386, 2018.
APA
Jeong, Y.J., Oh, H.K., Park, S.H., & Bong, J.G. (2018). Association between inflammation and cancer stem cell phenotype in breast cancer. Oncology Letters, 15, 2380-2386. https://doi.org/10.3892/ol.2017.7607
MLA
Jeong, Y. J., Oh, H. K., Park, S. H., Bong, J. G."Association between inflammation and cancer stem cell phenotype in breast cancer". Oncology Letters 15.2 (2018): 2380-2386.
Chicago
Jeong, Y. J., Oh, H. K., Park, S. H., Bong, J. G."Association between inflammation and cancer stem cell phenotype in breast cancer". Oncology Letters 15, no. 2 (2018): 2380-2386. https://doi.org/10.3892/ol.2017.7607
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