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February-2018 Volume 15 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

A rare e14a3 BCR/ABL fusion transcript in acute lymphoblastic leukemia patient treated with CAR-modified T-cell therapy

  • Authors:
    • Haodong Cai
    • Li Yang
    • Kefeng Shen
    • Wei Zhang
    • Jie Xiong
    • Meilan Zhang
    • Xia Mao
    • Ying Wang
    • Min Xiao

  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China
  • Pages: 2491-2494
    |
    Published online on: December 13, 2017
       https://doi.org/10.3892/ol.2017.7611
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Abstract

E14a3 breakpoint cluster region (BCR)/ABL proto‑oncogene 1, non‑receptor tyrosine kinase (ABL) fusion transcript is rare in Philadelphia chromosome positive disease, particularly in acute lymphoblastic leukemia (ALL). Recently an e14a3 fusion transcript was detected by multiple laboratory examinations, and the patient was suffering from ALL. Except for the BCR/ABL fusion gene, in the present study the patient additionally had an IKAROS family zinc finger 1 deletion which, has been confirmed as a significant adverse prognosis factor. Following 2 rounds of chemotherapy, the patient presented cytological remission; however, the patient then relapsed 2 months later. They then received chimeric antigen receptor modified (CAR‑modified) T‑cell therapy and achieved complete remission. CAR‑modified T‑cell therapy is a powerful novel therapy which, exhibited great potential for treating refractory ALL, regardless of the existence and form of the BCR/ABL fusion transcript.
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Copy and paste a formatted citation
Spandidos Publications style
Cai H, Yang L, Shen K, Zhang W, Xiong J, Zhang M, Mao X, Wang Y and Xiao M: A rare e14a3 BCR/ABL fusion transcript in acute lymphoblastic leukemia patient treated with CAR-modified T-cell therapy. Oncol Lett 15: 2491-2494, 2018.
APA
Cai, H., Yang, L., Shen, K., Zhang, W., Xiong, J., Zhang, M. ... Xiao, M. (2018). A rare e14a3 BCR/ABL fusion transcript in acute lymphoblastic leukemia patient treated with CAR-modified T-cell therapy. Oncology Letters, 15, 2491-2494. https://doi.org/10.3892/ol.2017.7611
MLA
Cai, H., Yang, L., Shen, K., Zhang, W., Xiong, J., Zhang, M., Mao, X., Wang, Y., Xiao, M."A rare e14a3 BCR/ABL fusion transcript in acute lymphoblastic leukemia patient treated with CAR-modified T-cell therapy". Oncology Letters 15.2 (2018): 2491-2494.
Chicago
Cai, H., Yang, L., Shen, K., Zhang, W., Xiong, J., Zhang, M., Mao, X., Wang, Y., Xiao, M."A rare e14a3 BCR/ABL fusion transcript in acute lymphoblastic leukemia patient treated with CAR-modified T-cell therapy". Oncology Letters 15, no. 2 (2018): 2491-2494. https://doi.org/10.3892/ol.2017.7611
Copy and paste a formatted citation
x
Spandidos Publications style
Cai H, Yang L, Shen K, Zhang W, Xiong J, Zhang M, Mao X, Wang Y and Xiao M: A rare e14a3 BCR/ABL fusion transcript in acute lymphoblastic leukemia patient treated with CAR-modified T-cell therapy. Oncol Lett 15: 2491-2494, 2018.
APA
Cai, H., Yang, L., Shen, K., Zhang, W., Xiong, J., Zhang, M. ... Xiao, M. (2018). A rare e14a3 BCR/ABL fusion transcript in acute lymphoblastic leukemia patient treated with CAR-modified T-cell therapy. Oncology Letters, 15, 2491-2494. https://doi.org/10.3892/ol.2017.7611
MLA
Cai, H., Yang, L., Shen, K., Zhang, W., Xiong, J., Zhang, M., Mao, X., Wang, Y., Xiao, M."A rare e14a3 BCR/ABL fusion transcript in acute lymphoblastic leukemia patient treated with CAR-modified T-cell therapy". Oncology Letters 15.2 (2018): 2491-2494.
Chicago
Cai, H., Yang, L., Shen, K., Zhang, W., Xiong, J., Zhang, M., Mao, X., Wang, Y., Xiao, M."A rare e14a3 BCR/ABL fusion transcript in acute lymphoblastic leukemia patient treated with CAR-modified T-cell therapy". Oncology Letters 15, no. 2 (2018): 2491-2494. https://doi.org/10.3892/ol.2017.7611
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