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Article Open Access

Long-term outcomes of patients with soft tissue sarcoma of the chest wall: Analysis of the prognostic significance of microscopic margins

  • Authors:
    • Kamran Harati
    • Jonas Kolbenschlag
    • Jens Bohm
    • Hiltrud Niggemann
    • Hamid Joneidi‑Jafari
    • Ingo Stricker
    • Marcus Lehnhardt
    • Adrien Daigeler
  • View Affiliations / Copyright

    Affiliations: Department of Plastic Surgery, BG‑University Hospital Bergmannsheil, D‑44789 Bochum, Germany, Statistical Consulting & Data Analysis, D‑07751 Jena, Germany, Institute of Pathology, Ruhr‑University Bochum, D‑44789 Bochum, Germany
    Copyright: © Harati et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2179-2187
    |
    Published online on: December 14, 2017
       https://doi.org/10.3892/ol.2017.7624
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Abstract

Data on prognostic factors and treatment outcomes for chest wall soft tissue sarcomas (STS) are sparse. Wide resections with negative margins are the mainstay of therapy, but the prognostic impact of surgical margins remains controversial. The purpose of the present study was to determine the significance of microscopic margins through a long‑term follow‑up. The associations between local recurrence‑free survival (LRFS), overall survival (OS) and potential prognostic factors were retrospectively assessed in a consecutive series of 110 patients who were suitable for surgical treatment with curative intent. Potential prognostic factors were assessed using univariate and multivariate analyses. The median follow‑up time following primary diagnosis was 9.6 years [95% confidence interval (CI), 7.2‑10.5]. In the entire cohort, the 5‑year estimates of the OS and LRFS rates were 66.0% (95% CI, 55.9‑74.3) and 60.6% (95% CI, 50.3‑69.4), respectively. A total of 27 patients (24.5%) developed distant metastases with a median survival time of 0.9 years following the diagnosis of metastasis. Surgical margins attained at the initial resection and eventual re‑excisions significantly influenced OS in univariate analysis (5‑year OS, R0 69.9% vs. R1/R2 38.5%; P=0.046), but this failed to reach statistical significance in the multivariate analysis. In the multivariate analysis, significant adverse prognostic features of LRFS included angiosarcoma subtype, G2 and G3 histology. For OS, the only independent significant predictors were age >50 years, tumor size >5 cm, angiosarcoma subtype and G3 histology. The results of the present study suggest that tumor biology, as reflected by the histological grade, influences the final outcome in patients with chest wall STS. Surgical margins failed to reach statistical significance in multivariate analysis as they demonstrated a dependency towards the independent predictors of OS. Subsequently, a positive margin status may be a result rather than a cause of biological aggressiveness, and it may not influence the outcome directly.
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1 

Jemal A, Siegel R, Ward E, Murray T, Xu J and Thun MJ: Cancer statistics, 2007. CA Cancer J Clin. 57:43–66. 2007. View Article : Google Scholar : PubMed/NCBI

2 

Kachroo P, Pak PS, Sandha HS, Lee C, Elashoff D, Nelson SD, Chmielowski B, Selch MT, Cameron RB, Holmes EC, et al: Single-institution, multidisciplinary experience with surgical resection of primary chest wall sarcomas. J Thorac Oncol. 7:552–558. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Gross JL, Younes RN, Haddad FJ, Deheinzelin D, Pinto CA and Costa ML: Soft-tissue sarcomas of the chest wall: Prognostic factors. Chest. 127:902–908. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Oksuz DC, Ozdemir S, Kaydihan N, Dervisoglu S, Hiz M, Tuzun H, Mandel NM, Koca S and Dincbas FO: Long-term treatment results in soft tissue sarcomas of the thoracic wall treated with pre-or-postoperative radiotherapy-a single institution experience. Asian Pac J Cancer Prev. 15:9949–9953. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Tsukushi S, Nishida Y, Sugiura H, Nakashima H and Ishiguro N: Soft tissue sarcomas of the chest wall. J Thorac Oncol. 4:834–837. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Salas S, Bui B, Stoeckle E, Terrier P, Ranchere-Vince D, Collin F, Leroux A, Guillou L, Michels JJ, Trassard M, et al: Soft tissue sarcomas of the trunk wall (STS-TW): A study of 343 patients from the French Sarcoma Group (FSG) database. Ann Oncol. 20:1127–1135. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Maretty-Nielsen K, Aggerholm-Pedersen N, Safwat A, Jørgensen PH, Hansen BH, Baerentzen S, Pedersen AB and Keller J: Prognostic factors for local recurrence and mortality in adult soft tissue sarcoma of the extremities and trunk wall: A cohort study of 922 consecutive patients. Acta Orthop. 85:323–332. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Stojadinovic A, Leung DH, Hoos A, Jaques DP, Lewis JJ and Brennan MF: Analysis of the prognostic significance of microscopic margins in 2,084 localized primary adult soft tissue sarcomas. Ann Surg. 235:424–434. 2002. View Article : Google Scholar : PubMed/NCBI

9 

van Geel AN, Wouters MW, Lans TE, Schmitz PI and Verhoef C: Chest wall resection for adult soft tissue sarcomas and chondrosarcomas: Analysis of prognostic factors. World J Surg. 35:63–69. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Wouters MW, van Geel AN, Nieuwenhuis L, van Tinteren H, Verhoef C, van Coevorden F and Klomp HM: Outcome after surgical resections of recurrent chest wall sarcomas. J Clin Oncol. 26:5113–5118. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Walsh GL, Davis BM, Swisher SG, Vaporciyan AA, Smythe WR, Willis-Merriman K, Roth JA and Putnam JB Jr: A single-institutional, multidisciplinary approach to primary sarcomas involving the chest wall requiring full-thickness resections. J Thorac Cardiovasc Surg. 121:48–60. 2001. View Article : Google Scholar : PubMed/NCBI

12 

Smith GM, Johnson GD, Grimer RJ and Wilson S: Trends in presentation of bone and soft tissue sarcomas over 25 years: Little evidence of earlier diagnosis. Ann R Coll Surg Engl. 93:542–547. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Gordon MS, Hajdu SI, Bains MS and Burt ME: Soft tissue sarcomas of the chest wall. Results of surgical resection. J Thorac Cardiovasc Surg. 101:843–854. 1991.PubMed/NCBI

14 

Coindre JM: Grading of soft tissue sarcomas: Review and update. Arch Pathol Lab Med. 130:1448–1453. 2006.PubMed/NCBI

15 

Fletcher CD: The evolving classification of soft tissue tumours-an update based on the new 2013 WHO classification. Histopathology. 64:2–11. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Schemper M and Smith TL: A note on quantifying follow-up in studies of failure time. Control Clin Trials. 17:343–346. 1996. View Article : Google Scholar : PubMed/NCBI

17 

Clark TG, Bradburn MJ, Love SB and Altman DG: Survival analysis part I: Basic concepts and first analyses. Br J Cancer. 89:232–238. 2003. View Article : Google Scholar : PubMed/NCBI

18 

Coindre JM, Terrier P, Guillou L, Le Doussal V, Collin F, Ranchère D, Sastre X, Vilain MO, Bonichon F and Bui N'Guyen B: Predictive value of grade for metastasis development in the main histologic types of adult soft tissue sarcomas: A study of 1240 patients from the French Federation of cancer centers sarcoma group. Cancer. 91:1914–1926. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Mery CM, George S, Bertagnolli MM and Raut CP: Secondary sarcomas after radiotherapy for breast cancer: Sustained risk and poor survival. Cancer. 115:4055–4063. 2009. View Article : Google Scholar : PubMed/NCBI

20 

McMillan RR, Sima CS, Moraco NH, Rusch VW and Huang J: Recurrence patterns after resection of soft tissue sarcomas of the chest wall. Ann Thorac Surg. 96:1223–1228. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Marulli G, Duranti L, Cardillo G, Luzzi L, Carbone L, Gotti G, Perissinotto E, Rea F and Pastorino U: Primary chest wall chondrosarcomas: Results of surgical resection and analysis of prognostic factors. Eur J Cardiothorac Surg. 45:e194–e201. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Widhe B and Bauer HC: Scandinavian Sarcoma Group: Surgical treatment is decisive for outcome in chondrosarcoma of the chest wall: A population-based Scandinavian Sarcoma Group study of 106 patients. J Thorac Cardiovasc Surg. 137:610–614. 2009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Harati K, Kolbenschlag J, Bohm J, Niggemann H, Joneidi‑Jafari H, Stricker I, Lehnhardt M and Daigeler A: Long-term outcomes of patients with soft tissue sarcoma of the chest wall: Analysis of the prognostic significance of microscopic margins. Oncol Lett 15: 2179-2187, 2018.
APA
Harati, K., Kolbenschlag, J., Bohm, J., Niggemann, H., Joneidi‑Jafari, H., Stricker, I. ... Daigeler, A. (2018). Long-term outcomes of patients with soft tissue sarcoma of the chest wall: Analysis of the prognostic significance of microscopic margins. Oncology Letters, 15, 2179-2187. https://doi.org/10.3892/ol.2017.7624
MLA
Harati, K., Kolbenschlag, J., Bohm, J., Niggemann, H., Joneidi‑Jafari, H., Stricker, I., Lehnhardt, M., Daigeler, A."Long-term outcomes of patients with soft tissue sarcoma of the chest wall: Analysis of the prognostic significance of microscopic margins". Oncology Letters 15.2 (2018): 2179-2187.
Chicago
Harati, K., Kolbenschlag, J., Bohm, J., Niggemann, H., Joneidi‑Jafari, H., Stricker, I., Lehnhardt, M., Daigeler, A."Long-term outcomes of patients with soft tissue sarcoma of the chest wall: Analysis of the prognostic significance of microscopic margins". Oncology Letters 15, no. 2 (2018): 2179-2187. https://doi.org/10.3892/ol.2017.7624
Copy and paste a formatted citation
x
Spandidos Publications style
Harati K, Kolbenschlag J, Bohm J, Niggemann H, Joneidi‑Jafari H, Stricker I, Lehnhardt M and Daigeler A: Long-term outcomes of patients with soft tissue sarcoma of the chest wall: Analysis of the prognostic significance of microscopic margins. Oncol Lett 15: 2179-2187, 2018.
APA
Harati, K., Kolbenschlag, J., Bohm, J., Niggemann, H., Joneidi‑Jafari, H., Stricker, I. ... Daigeler, A. (2018). Long-term outcomes of patients with soft tissue sarcoma of the chest wall: Analysis of the prognostic significance of microscopic margins. Oncology Letters, 15, 2179-2187. https://doi.org/10.3892/ol.2017.7624
MLA
Harati, K., Kolbenschlag, J., Bohm, J., Niggemann, H., Joneidi‑Jafari, H., Stricker, I., Lehnhardt, M., Daigeler, A."Long-term outcomes of patients with soft tissue sarcoma of the chest wall: Analysis of the prognostic significance of microscopic margins". Oncology Letters 15.2 (2018): 2179-2187.
Chicago
Harati, K., Kolbenschlag, J., Bohm, J., Niggemann, H., Joneidi‑Jafari, H., Stricker, I., Lehnhardt, M., Daigeler, A."Long-term outcomes of patients with soft tissue sarcoma of the chest wall: Analysis of the prognostic significance of microscopic margins". Oncology Letters 15, no. 2 (2018): 2179-2187. https://doi.org/10.3892/ol.2017.7624
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