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Article Open Access

PRL-3 promotes breast cancer progression by downregulating p14ARF-mediated p53 expression

  • Authors:
    • Hua Xie
    • Hao Wang
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Oncology, Sichuan Cancer Hospital, Chengdu, Sichuan 610041, P.R. China, Department of Breast Surgery, Sichuan Cancer Hospital, Chengdu, Sichuan 610041, P.R. China
    Copyright: © Xie et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2795-2800
    |
    Published online on: December 19, 2017
       https://doi.org/10.3892/ol.2017.7639
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Abstract

Prior studies have demonstrated that phosphatase of regenerating liver-3 (PRL-3) serves avital function in cell proliferation and metastasis in breast cancer. However, the molecular mechanisms underlying the function of PRL‑3 in breast cancer remain unknown. PRL‑3 expression was analyzed in 24 pairs of breast cancer and normal tissues using the reverse transcription‑quantitative polymerase chain reaction assay. The results of the present study identified that the expression of PLR‑3 in breast cancer tissues was increased 4.2‑fold, compared with normal tissues. Notably, overexpression of PRL‑3 significantly promoted the proliferation of cancer cells and inhibited endogenous p53 expression by downregulating the expression level of p14 alternate reading frame (p14ARF). In addition, decreased expression levels of PRL‑3 resulted in decreased breast cancer cell proliferation and increased expression level of p14ARF. These results suggested that PRL‑3 enhances cell proliferation by downregulating p14ARF expression, which results in decreased levels ofp53. The results of the present study demonstrated that PRL‑3 promotes tumor proliferation by affecting the p14ARF‑p53 axis, and that it may serve as a prognostic marker for patients with breast cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Xie H and Wang H: PRL-3 promotes breast cancer progression by downregulating p14ARF-mediated p53 expression. Oncol Lett 15: 2795-2800, 2018.
APA
Xie, H., & Wang, H. (2018). PRL-3 promotes breast cancer progression by downregulating p14ARF-mediated p53 expression. Oncology Letters, 15, 2795-2800. https://doi.org/10.3892/ol.2017.7639
MLA
Xie, H., Wang, H."PRL-3 promotes breast cancer progression by downregulating p14ARF-mediated p53 expression". Oncology Letters 15.3 (2018): 2795-2800.
Chicago
Xie, H., Wang, H."PRL-3 promotes breast cancer progression by downregulating p14ARF-mediated p53 expression". Oncology Letters 15, no. 3 (2018): 2795-2800. https://doi.org/10.3892/ol.2017.7639
Copy and paste a formatted citation
x
Spandidos Publications style
Xie H and Wang H: PRL-3 promotes breast cancer progression by downregulating p14ARF-mediated p53 expression. Oncol Lett 15: 2795-2800, 2018.
APA
Xie, H., & Wang, H. (2018). PRL-3 promotes breast cancer progression by downregulating p14ARF-mediated p53 expression. Oncology Letters, 15, 2795-2800. https://doi.org/10.3892/ol.2017.7639
MLA
Xie, H., Wang, H."PRL-3 promotes breast cancer progression by downregulating p14ARF-mediated p53 expression". Oncology Letters 15.3 (2018): 2795-2800.
Chicago
Xie, H., Wang, H."PRL-3 promotes breast cancer progression by downregulating p14ARF-mediated p53 expression". Oncology Letters 15, no. 3 (2018): 2795-2800. https://doi.org/10.3892/ol.2017.7639
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