Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
March-2018 Volume 15 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2018 Volume 15 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Cranial irradiation inhibits hippocampal neurogenesis via DNMT1 and DNMT3A

  • Authors:
    • Shengjun Ji
    • Xin Ding
    • Jiang Ji
    • Haohao Wu
    • Rui Sun
    • Xiaoyang Li
    • Liyuan Zhang
    • Ye Tian
  • View Affiliations / Copyright

    Affiliations: Cancer Center, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou, Jiangsu 215001, P.R. China, Department of Radiotherapy and Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, P.R. China
    Copyright: © Ji et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2899-2904
    |
    Published online on: December 19, 2017
       https://doi.org/10.3892/ol.2017.7643
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Impairment of neurogenesis in the hippocampus following whole‑brain irradiation is the most important mechanism of radiation‑induced cognitive dysfunction. However, the underlying mechanism remains obscure, meaning an ideal therapeutic target has not been identified. Evidence indicates that DNA methylation in neurons regulates synaptic plasticity and neuronal network activity. In the present study, the expression of DNA methyltransferases (DNMTs) in the hippocampus was analyzed to investigate their potential function in radiation‑induced neurogenesis impairment. Sprague‑Dawley rats were used throughout the present study, apportioned to the following groups: Control, radiation only, zebularine (a DNMT inhibitor) only, and radiation and zebularine together. Immunofluorescence staining revealed that radiation inhibited cellular proliferation and dendritic growth within new neurons of the hippocampus. In addition, western blot analysis demonstrated lower expression levels of DNMT1 and DNMT3A protein following radiation treatment compared with that in the non‑irradiated control. Furthermore, compared with the radiation‑only group, the radiation and zebularine group had significantly lower cell proliferative abilities, dendritic growth, and DNMT1 and DNMT3A protein levels. The results of the present study indicated that DNMT1 and DNMT3A may be involved in the pathogenesis of whole‑brain radiation‑induced neurogenesis impairment.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Cairncross G, Wang M, Shaw E, Jenkins R, Brachman D, Buckner J, Fink K, Souhami L, Laperriere N, Curran W and Mehta M: Phase III trial of chemoradiotherapy for anaplastic oligodendroglioma: Long-term results of RTOG 9402. J Clin Oncol. 31:337–343. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Xu T, Zhu G, He X, Ying H and Hu C: A phase III randomized study comparing neoadjuvant chemotherapy with concurrent chemotherapy combined with radiotherapy for locoregionally advanced nasopharyngeal carcinoma: Updated long-term survival outcomes. Oral Oncol. 50:71–76. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Davis MA, Tyrrell J, Slotman GJ, Sudhindra R, Sachdeva K, Fanelle J, Smith G, Wurzer JV, Cassir J and Nazha NT; Southern New Jersey Head and Neck Cancer Treatment Network, : Preoperative simultaneous fractionated cisplatin and radiation therapy in the treatment of advanced operable stage III and IV squamous cell carcinoma of the head and neck. Am J Surg. 209:575–579. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Douw L, Klein M, Fagel SS, van den Heuvel J, Taphoorn MJ, Aaronson NK, Postma TJ, Vandertop WP, Mooij JJ, Boerman RH, et al: Cognitive and radiological effects of radiotherapy in patients with low-grade glioma: Long-term follow-up. Lancet Neurol. 8:810–818. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Greene-Schloesser D, Moore E and Robbins ME: Molecular pathways: Radiation-induced cognitive impairment. Clin Cancer Res. 19:2294–2300. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Monje M and Dietrich J: Cognitive side effects of cancer therapy demonstrate a functional role for adult neurogenesis. Behav Brain Res. 227:376–379. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Ji S, Tian Y, Lu Y, Sun R, Ji J, Zhang L and Duan S: Irradiation-induced hippocampal neurogenesis impairment is associated with epigenetic regulation of bdnf gene transcription. Brain Res. 1577:77–88. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Bond AM, Ming GL and Song H: Adult mammalian neural stem cells and neurogenesis: Five decades later. Cell Stem Cell. 17:385–395. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Park H and Poo MM: Neurotrophin regulation of neural circuit development and function. Nature Rev Neurosci. 14:7–23. 2013. View Article : Google Scholar

10 

Cheng Z, Li YQ and Wong CS: Effects of aging on hippocampal neurogenesis after irradiation. Int J Radiat Oncol Biol Phys. 94:1181–1189. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Monje ML, Mizumatsu S, Fike JR and Palmer TD: Irradiation induces neural precursor-cell dysfunction. Nat Med. 8:955–962. 2002. View Article : Google Scholar : PubMed/NCBI

12 

Marty VN, Vlkolinsky R, Minassian N, Cohen T, Nelson GA and Spigelman I: Radiation-induced alterations in synaptic neurotransmission of dentate granule cells depend on the dose and species of charged particles. Radiat Res. 182:653–665. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Fischer A, Sananbenesi F, Wang X, Dobbin M and Tsai LH: Recovery of learning and memory is associated with chromatin remodelling. Nature. 447:178–182. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Zovkic IB, Guzman-Karlsson MC and Sweatt JD: Epigenetic regulation of memory formation and maintenance. Learn Mem. 20:61–74. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Hon GC, Rajagopal N, Shen Y, McCleary DF, Yue F, Dang MD and Ren B: Epigenetic memory at embryonic enhancers identified in DNA methylation maps from adult mouse tissues. Nat Genet. 45:1198–1206. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Miller CA, Gavin CF, White JA, Parrish RR, Honasoge A, Yancey CR, Rivera IM, Rubio MD, Rumbaugh G and Sweatt JD: Cortical DNA methylation maintains remote memory. Nature Neurosci. 13:664–666. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Feng J, Zhou Y, Campbell SL, Le T, Li E, Sweatt JD, Silva AJ and Fan G: Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons. Nat Neurosci. 13:423–430. 2010. View Article : Google Scholar : PubMed/NCBI

18 

LaPlant Q, Vialou V, Covington HE III, Dumitriu D, Feng J, Warren BL, Maze I, Dietz DM, Watts EL, Iñiguez SD, et al: Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens. Nat Neurosci. 13:1137–1143. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Tian Y, Shi Z, Yang S, Chen Y and Bao S: Changes in myelin basic protein and demyelination in the rat brain within 3 months of single 2-, 10-, or 30-Gy whole-brain radiation treatments. J Neurosurg. 109:881–888. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Pereira Dias G, Hollywood R, Bevilaqua MC, da Luz AC, Hindges R, Nardi AE and Thuret S: Consequences of cancer treatments on adult hippocampal neurogenesis: Implications for cognitive function and depressive symptoms. Neuro-oncol. 16:476–492. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Snyder JS, Soumier A, Brewer M, Pickel J and Cameron HA: Adult hippocampal neurogenesis buffers stress responses and depressive behaviour. Nature. 476:458–461. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Watanabe D, Uchiyama K and Hanaoka K: Transition of mouse de novo methyltransferases expression from Dnmt3b to Dnmt3a during neural progenitor cell development. Neurosci. 142:727–737. 2006. View Article : Google Scholar

23 

Maddox SA, Watts CS and Schafe GE: DNA methyltransferase activity is required for memory-related neural plasticity in the lateral amygdala. Neurobiol Learn Mem. 107:93–100. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Singh P and Thakur MK: Reduced recognition memory is correlated with decrease in DNA methyltransferase1 and increase in histone deacetylase2 protein expression in old male mice. Biogerontology. 15:339–346. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Hutnick LK, Golshani P, Namihira M, Xue Z, Matynia A, Yang XW, Silva AJ, Schweizer FE and Fan G: DNA hypomethylation restricted to the murine forebrain induces cortical degeneration and impairs postnatal neuronal maturation. Hum Mol Genet. 18:2875–2888. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Morris MJ, Adachi M, Na ES and Monteggia LM: Selective role for DNMT3a in learning and memory. Neurobiol Learn Mem. 115:30–37. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Simmons RK, Stringfellow SA, Glover ME, Wagle AA and Clinton SM: DNA methylation markers in the postnatal developing rat brain. Brain Res. 1533:26–36. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Hamidi T, Singh AK and Chen T: Genetic alterations of DNA methylation machinery in human diseases. Epigenomics. 7:247–265. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Lombardi LM, Baker SA and Zoghbi HY: MECP2 disorders: From the clinic to mice and back. J Clin Invest. 125:2914–2923. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Nelson ED, Kavalali ET and Monteggia LM: Activity-dependent suppression of miniature neurotransmission through the regulation of DNA methylation. J Neurosci. 28:395–406. 2008. View Article : Google Scholar : PubMed/NCBI

31 

Wang H, Meyer K and Korz V: Stress induced hippocampal mineralocorticoid and estrogen receptor β gene expression and long-term potentiation in male adult rats is sensitive to early-life stress experience. Psychoneuroendocrinology. 38:250–262. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Zhao Z, Fan L and Frick KM: Epigenetic alterations regulate estradiol-induced enhancement of memory consolidation. Proc Natl Acad Sci USA. 107:pp. 5605–5610. 2010; View Article : Google Scholar : PubMed/NCBI

33 

Tsai HW, Grant PA and Rissman EF: Sex differences in histone modifications in the neonatal mouse brain. Epigenetics. 4:47–53. 2009. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ji S, Ding X, Ji J, Wu H, Sun R, Li X, Zhang L and Tian Y: Cranial irradiation inhibits hippocampal neurogenesis via DNMT1 and DNMT3A. Oncol Lett 15: 2899-2904, 2018.
APA
Ji, S., Ding, X., Ji, J., Wu, H., Sun, R., Li, X. ... Tian, Y. (2018). Cranial irradiation inhibits hippocampal neurogenesis via DNMT1 and DNMT3A. Oncology Letters, 15, 2899-2904. https://doi.org/10.3892/ol.2017.7643
MLA
Ji, S., Ding, X., Ji, J., Wu, H., Sun, R., Li, X., Zhang, L., Tian, Y."Cranial irradiation inhibits hippocampal neurogenesis via DNMT1 and DNMT3A". Oncology Letters 15.3 (2018): 2899-2904.
Chicago
Ji, S., Ding, X., Ji, J., Wu, H., Sun, R., Li, X., Zhang, L., Tian, Y."Cranial irradiation inhibits hippocampal neurogenesis via DNMT1 and DNMT3A". Oncology Letters 15, no. 3 (2018): 2899-2904. https://doi.org/10.3892/ol.2017.7643
Copy and paste a formatted citation
x
Spandidos Publications style
Ji S, Ding X, Ji J, Wu H, Sun R, Li X, Zhang L and Tian Y: Cranial irradiation inhibits hippocampal neurogenesis via DNMT1 and DNMT3A. Oncol Lett 15: 2899-2904, 2018.
APA
Ji, S., Ding, X., Ji, J., Wu, H., Sun, R., Li, X. ... Tian, Y. (2018). Cranial irradiation inhibits hippocampal neurogenesis via DNMT1 and DNMT3A. Oncology Letters, 15, 2899-2904. https://doi.org/10.3892/ol.2017.7643
MLA
Ji, S., Ding, X., Ji, J., Wu, H., Sun, R., Li, X., Zhang, L., Tian, Y."Cranial irradiation inhibits hippocampal neurogenesis via DNMT1 and DNMT3A". Oncology Letters 15.3 (2018): 2899-2904.
Chicago
Ji, S., Ding, X., Ji, J., Wu, H., Sun, R., Li, X., Zhang, L., Tian, Y."Cranial irradiation inhibits hippocampal neurogenesis via DNMT1 and DNMT3A". Oncology Letters 15, no. 3 (2018): 2899-2904. https://doi.org/10.3892/ol.2017.7643
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team