Effects of thalidomide on growth and VEGF-A expression in SW480 colon cancer cells

  • Authors:
    • Xin Zhang
    • Hesheng Luo
  • View Affiliations

  • Published online on: December 19, 2017     https://doi.org/10.3892/ol.2017.7645
  • Pages: 3313-3320
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Abstract

Lymphatic and hematogenous spread are the most common ways for tumors to metastasize. Angiogenesis is essential for tumor growth and metastasis. Vascular endothelial growth factor (VEGF) particularly VEGF‑A is important in the process of angiogenesis. The current research has indicated that thalidomide (THD) may be able to inhibit angiogenesis, stimulate the activity of the immune system and inhibit the adherence of cancer cells to stromal cells. These changes may lead to suppression of tumor occurrence and development. To date, to the best of our knowledge, the effects of THD on colon cancer SW480 cells have not been reported. In the present study, the effects of THD and a combination of THD and oxaliplatin (L‑OHP) on the proliferation of SW480 cells have been investigated. Furthermore, the expression of VEGF‑A and hypoxia‑inducible factor 1 (HIF‑1) was analyzed using MTT assay, quantitative polymerase chain reaction and western blot analysis. The results indicated that THD was able to inhibit SW480 cells in dose‑and‑time dependent manner and inhibit the expression of VEGF‑A and HIF‑1α. Furthermore, treatment with THD and L‑OHP had synergistic inhibitory effect, which may provide a novel treatment strategy for advanced colorectal cancer.
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March-2018
Volume 15 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhang X and Zhang X: Effects of thalidomide on growth and VEGF-A expression in SW480 colon cancer cells. Oncol Lett 15: 3313-3320, 2018
APA
Zhang, X., & Zhang, X. (2018). Effects of thalidomide on growth and VEGF-A expression in SW480 colon cancer cells. Oncology Letters, 15, 3313-3320. https://doi.org/10.3892/ol.2017.7645
MLA
Zhang, X., Luo, H."Effects of thalidomide on growth and VEGF-A expression in SW480 colon cancer cells". Oncology Letters 15.3 (2018): 3313-3320.
Chicago
Zhang, X., Luo, H."Effects of thalidomide on growth and VEGF-A expression in SW480 colon cancer cells". Oncology Letters 15, no. 3 (2018): 3313-3320. https://doi.org/10.3892/ol.2017.7645