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Article

Common module analysis reveals prospective targets and mechanisms of pediatric adrenocortical adenoma and carcinoma

  • Authors:
    • Anurag Kulshrestha
    • Shikha Suman
  • View Affiliations / Copyright

    Affiliations: Bioinformatics Division, National Bureau of Animal Genetic Resources, Karnal, Haryana 132001, India, Department of Applied Sciences, Indian Institute of Information Technology, Allahabad, Uttar Pradesh 211012, India
  • Pages: 3267-3272
    |
    Published online on: December 19, 2017
       https://doi.org/10.3892/ol.2017.7646
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Abstract

Pediatric adrenocortical carcinoma and adrenocortical adenoma are two rare diseases affecting children. Molecular analyses were performed to identify commona­lities in gene expression between the diseases. Differentially expressed genes were identified for the pediatric adrenocortical adenoma and carcinoma tissues, as compared with normal tissues, using the expression dataset. Protein‑protein interaction (PPI) networks were constructed for adenoma and carcinoma disease models, and common modules among the diseases were identified. A total of two common modules with 14 nodes and 20 nodes were revealed among the adenoma and carcinoma networks, respectively. Genes of the common modules were also identified to be the common hub genes of the disease models. Enrichment of the genes of the common modules suggested associations with steroid biosynthesis, the proteasome, cell cycle and metabolic pathways. Modularity, topological and functional analysis of the PPI networks revealed common modules among pediatric adenoma and carcinoma disease models, which provided insight into the underlying disease mechanisms and suggesting prospective targets for future study.
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Copy and paste a formatted citation
Spandidos Publications style
Kulshrestha A and Suman S: Common module analysis reveals prospective targets and mechanisms of pediatric adrenocortical adenoma and carcinoma. Oncol Lett 15: 3267-3272, 2018.
APA
Kulshrestha, A., & Suman, S. (2018). Common module analysis reveals prospective targets and mechanisms of pediatric adrenocortical adenoma and carcinoma. Oncology Letters, 15, 3267-3272. https://doi.org/10.3892/ol.2017.7646
MLA
Kulshrestha, A., Suman, S."Common module analysis reveals prospective targets and mechanisms of pediatric adrenocortical adenoma and carcinoma". Oncology Letters 15.3 (2018): 3267-3272.
Chicago
Kulshrestha, A., Suman, S."Common module analysis reveals prospective targets and mechanisms of pediatric adrenocortical adenoma and carcinoma". Oncology Letters 15, no. 3 (2018): 3267-3272. https://doi.org/10.3892/ol.2017.7646
Copy and paste a formatted citation
x
Spandidos Publications style
Kulshrestha A and Suman S: Common module analysis reveals prospective targets and mechanisms of pediatric adrenocortical adenoma and carcinoma. Oncol Lett 15: 3267-3272, 2018.
APA
Kulshrestha, A., & Suman, S. (2018). Common module analysis reveals prospective targets and mechanisms of pediatric adrenocortical adenoma and carcinoma. Oncology Letters, 15, 3267-3272. https://doi.org/10.3892/ol.2017.7646
MLA
Kulshrestha, A., Suman, S."Common module analysis reveals prospective targets and mechanisms of pediatric adrenocortical adenoma and carcinoma". Oncology Letters 15.3 (2018): 3267-3272.
Chicago
Kulshrestha, A., Suman, S."Common module analysis reveals prospective targets and mechanisms of pediatric adrenocortical adenoma and carcinoma". Oncology Letters 15, no. 3 (2018): 3267-3272. https://doi.org/10.3892/ol.2017.7646
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