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Upregulated HOXA9 expression is associated with lymph node metastasis in colorectal cancer

  • Authors:
    • Yohei Watanabe
    • Motonobu Saito
    • Katsuharu Saito
    • Yoshiko Matsumoto
    • Yasuyuki Kanke
    • Hisashi Onozawa
    • Suguru Hayase
    • Wataru Sakamoto
    • Teruhide Ishigame
    • Tomoyuki Momma
    • Shinji Ohki
    • Seiichi Takenoshita
  • View Affiliations / Copyright

    Affiliations: Department of Organ Regulatory Surgery, Fukushima Medical University School of Medicine, Fukushima 960‑1295, Japan
    Copyright: © Watanabe et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2756-2762
    |
    Published online on: December 19, 2017
       https://doi.org/10.3892/ol.2017.7650
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Abstract

Homeobox A (HOXA) cluster genes, members of the HOX family, perform an important role in normal organ development. It has previously been reported that HOXA gene expression in various types of cancer is associated with poor patient outcomes. However, the role of HOXA genes, as well as their expression, in colorectal cancers (CRC) remains unknown. Therefore, the present study investigated HOXA gene expression in patients with CRC and revealed that HOXA9 expression was significantly increased in tumor tissues compared with non‑tumor tissues. Additionally, the functional role of HOXA9 was assessed by knocking down the HOXA9 gene in CRC cells and by evaluating cell growth. Regarding gene expression, cases with positive HOXA9 expression (as detected by immunohistochemical staining) were significantly associated with higher TNM stage and positive lymph node metastasis, although no association was observed between increased HOXA9 levels and the rate of overall survival in the present cohort. Regarding the functional role, HOXA9 expression was demonstrated to be upregulated in patients with CRC and was associated with lymph node metastasis.
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Copy and paste a formatted citation
Spandidos Publications style
Watanabe Y, Saito M, Saito K, Matsumoto Y, Kanke Y, Onozawa H, Hayase S, Sakamoto W, Ishigame T, Momma T, Momma T, et al: Upregulated HOXA9 expression is associated with lymph node metastasis in colorectal cancer. Oncol Lett 15: 2756-2762, 2018.
APA
Watanabe, Y., Saito, M., Saito, K., Matsumoto, Y., Kanke, Y., Onozawa, H. ... Takenoshita, S. (2018). Upregulated HOXA9 expression is associated with lymph node metastasis in colorectal cancer. Oncology Letters, 15, 2756-2762. https://doi.org/10.3892/ol.2017.7650
MLA
Watanabe, Y., Saito, M., Saito, K., Matsumoto, Y., Kanke, Y., Onozawa, H., Hayase, S., Sakamoto, W., Ishigame, T., Momma, T., Ohki, S., Takenoshita, S."Upregulated HOXA9 expression is associated with lymph node metastasis in colorectal cancer". Oncology Letters 15.3 (2018): 2756-2762.
Chicago
Watanabe, Y., Saito, M., Saito, K., Matsumoto, Y., Kanke, Y., Onozawa, H., Hayase, S., Sakamoto, W., Ishigame, T., Momma, T., Ohki, S., Takenoshita, S."Upregulated HOXA9 expression is associated with lymph node metastasis in colorectal cancer". Oncology Letters 15, no. 3 (2018): 2756-2762. https://doi.org/10.3892/ol.2017.7650
Copy and paste a formatted citation
x
Spandidos Publications style
Watanabe Y, Saito M, Saito K, Matsumoto Y, Kanke Y, Onozawa H, Hayase S, Sakamoto W, Ishigame T, Momma T, Momma T, et al: Upregulated HOXA9 expression is associated with lymph node metastasis in colorectal cancer. Oncol Lett 15: 2756-2762, 2018.
APA
Watanabe, Y., Saito, M., Saito, K., Matsumoto, Y., Kanke, Y., Onozawa, H. ... Takenoshita, S. (2018). Upregulated HOXA9 expression is associated with lymph node metastasis in colorectal cancer. Oncology Letters, 15, 2756-2762. https://doi.org/10.3892/ol.2017.7650
MLA
Watanabe, Y., Saito, M., Saito, K., Matsumoto, Y., Kanke, Y., Onozawa, H., Hayase, S., Sakamoto, W., Ishigame, T., Momma, T., Ohki, S., Takenoshita, S."Upregulated HOXA9 expression is associated with lymph node metastasis in colorectal cancer". Oncology Letters 15.3 (2018): 2756-2762.
Chicago
Watanabe, Y., Saito, M., Saito, K., Matsumoto, Y., Kanke, Y., Onozawa, H., Hayase, S., Sakamoto, W., Ishigame, T., Momma, T., Ohki, S., Takenoshita, S."Upregulated HOXA9 expression is associated with lymph node metastasis in colorectal cancer". Oncology Letters 15, no. 3 (2018): 2756-2762. https://doi.org/10.3892/ol.2017.7650
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