Open Access

Dynamics of angiogenesis and cellularity in rabbit VX2 tumors using contrast-enhanced magnetic resonance imaging and diffusion-weighted imaging

  • Authors:
    • Haixia Li
    • Lijuan Yu
    • Wenzhi Wang
    • Lingling Wang
    • Xiulan Zheng
    • Shaochun Dai
    • Yanqin Sun
  • View Affiliations

  • Published online on: December 19, 2017     https://doi.org/10.3892/ol.2017.7657
  • Pages: 2978-2984
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

A number of studies have demonstrated that dynamic contrast‑enhanced magnetic resonance imaging (DCE‑MRI) may be used to evaluate microvessel density (MVD), and may quantitatively reflect tumor angiogenesis. To investigate the dynamics, including angiogenesis and tumor cellularity, of rabbit VX2 tumors during the 4 weeks following tumor implantation, the present study used DCE‑MRI combined with diffusion‑weighted imaging (DWI) to scan the tumors at 3 days, and then at 1, 2, 3 and 4‑week intervals, following tumor implantation. The dynamics, volume transfer coefficient (Ktrans) and apparent diffusion coefficient (ADC) of the tumor parenchyma were analyzed. Furthermore, the associations between Ktrans and MVD at 4 weeks after tumor implantation were analyzed. Tumor Ktrans was positively correlated with MVD at 4 weeks (r=0.674, P<0.001). Following tumor implantation, the tumor Ktrans level rose for 2 weeks and then began to decline, reaching its lowest point at 4 weeks (P<0.001). ADC values at 1 week were higher than at 3 days, but declined thereafter (P<0.001). Tumor necrosis appeared by 1 week after tumor implantation. The necrosis degree of tumor was gradually increased from the occurrence of necrosis within the 4‑week time span of the present study (1 vs. 2 weeks, P=0.008; 2 vs. 3 weeks, P<0.001; 3 vs. 4 weeks, P<0.001). The present study identified that tumor angiogenesis is a dynamic process that serves a function in tumor growth, and that DCE‑MRI may reflect tumor parenchymal MVD and be useful in evaluating angiogenesis.
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March-2018
Volume 15 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Li H, Yu L, Wang W, Wang L, Zheng X, Dai S and Sun Y: Dynamics of angiogenesis and cellularity in rabbit VX2 tumors using contrast-enhanced magnetic resonance imaging and diffusion-weighted imaging. Oncol Lett 15: 2978-2984, 2018
APA
Li, H., Yu, L., Wang, W., Wang, L., Zheng, X., Dai, S., & Sun, Y. (2018). Dynamics of angiogenesis and cellularity in rabbit VX2 tumors using contrast-enhanced magnetic resonance imaging and diffusion-weighted imaging. Oncology Letters, 15, 2978-2984. https://doi.org/10.3892/ol.2017.7657
MLA
Li, H., Yu, L., Wang, W., Wang, L., Zheng, X., Dai, S., Sun, Y."Dynamics of angiogenesis and cellularity in rabbit VX2 tumors using contrast-enhanced magnetic resonance imaging and diffusion-weighted imaging". Oncology Letters 15.3 (2018): 2978-2984.
Chicago
Li, H., Yu, L., Wang, W., Wang, L., Zheng, X., Dai, S., Sun, Y."Dynamics of angiogenesis and cellularity in rabbit VX2 tumors using contrast-enhanced magnetic resonance imaging and diffusion-weighted imaging". Oncology Letters 15, no. 3 (2018): 2978-2984. https://doi.org/10.3892/ol.2017.7657