Functions of nuclear actin-binding proteins in human cancer (Review)
- Authors:
- Xinyi Yang
- Ying Lin
-
Affiliations: Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat‑sen Memorial Hospital, Sun Yat‑sen University, Guangzhou, Guangdong 510120, P.R. China - Published online on: December 19, 2017 https://doi.org/10.3892/ol.2017.7658
- Pages: 2743-2748
This article is mentioned in:
Abstract
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|
Pollard TD and Cooper JA: Actin and actin-binding proteins. A critical evaluation of mechanisms and functions. Annu Rev Biochem. 55:987–1035. 1986. View Article : Google Scholar : PubMed/NCBI | |
|
dos Remedios CG, Chhabra D, Kekic M, Dedova IV, Tsubakihara M, Berry DA and Nosworthy NJ: Actin binding proteins: Regulation of cytoskeletal microfilaments. Physiol Rev. 83:433–473. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Hartwig JH, Tyler J and Stossel TP: Actin-binding protein promotes the bipolar and perpendicular branching of actin filaments. J Cell Biol. 87:841–848. 1980. View Article : Google Scholar : PubMed/NCBI | |
|
Hall A: Rho GTPases and the actin cytoskeleton. Science. 279:509–514. 1998. View Article : Google Scholar : PubMed/NCBI | |
|
Amann KJ and Pollard TD: Cellular regulation of actin network assembly. Curr Biol. 10:R728–R730. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Vasioukhin V, Bauer C, Yin M and Fuchs E: Directed actin polymerization is the driving force for epithelial cell-cell adhesion. Cell. 100:209–219. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Winder SJ and Ayscough KR: Actin-binding proteins. J Cell Sci. 118:651–654. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Pollard TD and Cooper JA: Actin, a central player in cell shape and movement. Science. 326:1208–1212. View Article : Google Scholar : PubMed/NCBI | |
|
Weston L, Coutts AS and La Thangue NB: Actin nucleators in the nucleus: An emerging theme. J Cell Sci. 125:3519–3527. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Fairley EA, Kendrick-Jones J and Ellis JA: The Emery-Dreifuss muscular dystrophy phenotype arises from aberrant targeting and binding of emerin at the inner nuclear membrane. J Cell Sci. 112:2571–2582. 1999.PubMed/NCBI | |
|
Tse WT, Tang J, Jin O, Korsgren C, John KM, Kung AL, Gwynn B, Peters LL and Lux SE: A new spectrin, beta IV, has a major truncated isoform that associates with promyelocytic leukemia protein nuclear bodies and the nuclear matrix. J Biol Chem. 276:23974–23985. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Castano E, Philimonenko VV, Kahle M, Fukalová J, Kalendová A, Yildirim S, Dzijak R, Dingová-Krásna H and Hozák P: Actin complexes in the cell nucleus: New stones in an old field. Histochem Cell Biol. 133:607–626. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Kristo I, Bajusz I, Bajusz C, Borkuti P and Vilmos P: Actin, actin-binding proteins and actin-related proteins in the nucleus. Histochem Cell Biol. 145:373–388. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Hofmann WA: Cell and molecular biology of nuclear actin. Int Rev Cell Mol Biol. 273:219–263. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
de Lanerolle P and Serebryannyy L: Nuclear actin and myosins: Life without filaments. Nat Cell Biol. 13:1282–1288. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Gettemans J, Van Impe K, Delanote V, Hubert T, Vandekerckhove J and De Corte V: Nuclear actin-binding proteins as modulators of gene transcription. Traffic. 6:847–857. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Rando OJ, Zhao K and Crabtree GR: Searching for a function for nuclear actin. Trends Cell Biol. 10:92–97. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Bettinger BT, Gilbert DM and Amberg DC: Actin up in the nucleus. Nat Rev Mol Cell Biol. 5:410–415. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Blessing CA, Ugrinova GT and Goodson HV: Actin and ARPs: Action in the nucleus. Trends Cell Biol. 14:435–442. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Miralles F and Visa N: Actin in transcription and transcription regulation. Curr Opin Cell Biol. 18:261–266. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Zheng B, Han M, Bernier M and Wen JK: Nuclear actin and actin-binding proteins in the regulation of transcription and gene expression. FEBS J. 276:2669–2685. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Philimonenko VV, Zhao J, Iben S, Dingová H, Kyselá K, Kahle M, Zentgraf H, Hofmann WA, de Lanerolle P, Hozák P and Grummt I: Nuclear actin and myosin I are required for RNA polymerase I transcription. Nat Cell Biol. 6:1165–1172. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Hofmann WA, Stojiljkovic L, Fuchsova B, Vargas GM, Mavrommatis E, Philimonenko V, Kysela K, Goodrich JA, Lessard JL, Hope TJ, et al: Actin is part of pre-initiation complexes and is necessary for transcription by RNA polymerase II. Nat Cell Biol. 6:1094–1101. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Hu P, Wu S and Hernandez N: A role for beta-actin in RNA polymerase III transcription. Genes Dev. 18:3010–3015. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Miyamoto K and Gurdon JB: Transcriptional regulation and nuclear reprogramming: Roles of nuclear actin and actin-binding proteins. Cell Mol Life Sci. 70:3289–3302. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Ting HJ, Yeh S, Nishimura K and Chang C: Supervillin associates with androgen receptor and modulates its transcriptional activity. Proc Natl Acad Sci USA. 99:pp. 661–666. 2002; View Article : Google Scholar : PubMed/NCBI | |
|
Nishimura K, Ting HJ, Harada Y, Tokizane T, Nonomura N, Kang HY, Chang HC, Yeh S, Miyamoto H, Shin M, et al: Modulation of androgen receptor transactivation by gelsolin: A newly identified androgen receptor coregulator. Cancer Res. 63:4888–4894. 2003.PubMed/NCBI | |
|
Yang Z, Chang YJ, Miyamoto H, Ni J, Niu Y, Chen Z, Chen YL, Yao JL, di Sant'Agnese PA and Chang C: Transgelin functions as a suppressor via inhibition of ARA54-enhanced androgen receptor transactivation and prostate cancer cell growth. Mol Endocrinol. 21:343–358. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Baek SH, Ohgi KA, Nelson CA, Welsbie D, Chen C, Sawyers CL, Rose DW and Rosenfeld MG: Ligand-specific allosteric regulation of coactivator functions of androgen receptor in prostate cancer cells. Proc Natl Acad Sci USA. 103:pp. 3100–3105. 2006; View Article : Google Scholar : PubMed/NCBI | |
|
Wang F, Liu XQ, Li H, Liang KN, Miner JN, Hong M, Kallel EA, van Oeveren A, Zhi L and Jiang T: Structure of the ligand-binding domain (LBD) of human androgen receptor in complex with a selective modulator LGD2226. Acta Crystallogr Sect F Struct Biol Cryst Commun. 62:1067–1071. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Won Jeong K, Chodankar R, Purcell DJ, Bittencourt D and Stallcup MR: Gene-specific patterns of coregulator requirements by estrogen receptor-alpha in breast cancer cells. Mol Endocrinol. 26:955–966. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Jeong KW: Flightless I (Drosophila) homolog facilitates chromatin accessibility of the estrogen receptor α target genes in MCF-7 breast cancer cells. Biochem Biophys Res Commun. 446:608–613. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Khurana S: Structure and function of villinAspects of the Cytoskeleton. Khurana S: Elsevier; New York: pp. 89–1159. 2006, View Article : Google Scholar | |
|
Patnaik S, George SP, Pham E, Roy S, Singh K, Mariadason JM and Khurana S: By moonlighting in the nucleus, villin regulates epithelial plasticity. Mol Biol Cell. 27:535–548. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Shillingford NM, Calicchio ML, Teot LA, Boyd T, Kurek KC, Goldsmith JD, Bousvaros A, Perez-Atayde AR and Kozakewich HP: Villin immunohistochemistry is a reliable method for diagnosing microvillus inclusion disease. Am J Surg Pathol. 39:245–250. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Yang Z: The utility of villin and mammaglobin in the differential diagnosis between intrahepatic cholangiocarcinoma and breast cancer. Appl Immunohistochem Mol Morphol. 23:19–25. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Khurana S, Chakraborty S, Cheng X, Su YT and Kao HY: The actin-binding protein, actinin alpha 4 (ACTN4), is a nuclear receptor coactivator that promotes proliferation of MCF-7 breast cancer cells. J Biol Chem. 286:1850–1859. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Jasavala R, Martinez H, Thumar J, Andaya A, Gingras AC, Eng JK, Aebersold R, Han DK and Wright ME: Identification of putative androgen receptor interaction protein modules: Cytoskeleton and endosomes modulate androgen receptor signaling in prostate cancer cells. Mol Cell Proteomics. 6:252–271. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Zhao X, Hsu KS, Lim JH, Bruggeman LA and Kao HY: α-Actinin 4 potentiates nuclear factor κ-light-chain-enhancer of activated B-cell (NF-κB) activity in podocytes independent of its cytoplasmic actin binding function. J Biol Chem. 290:338–349. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Biswas DK, Shi Q, Baily S, Strickland I, Ghosh S, Pardee AB and Iglehart JD: NF-kappa B activation in human breast cancer specimens and its role in cell proliferation and apoptosis. Proc Natl Acad Sci USA. 101:pp. 10137–10142. 2004; View Article : Google Scholar : PubMed/NCBI | |
|
Chakraborty S, Reineke EL, Lam M, Li X, Liu Y, Gao C, Khurana S and Kao HY: Alpha-actinin 4 potentiates myocyte enhancer factor-2 transcription activity by antagonizing histone deacetylase 7. J Biol Chem. 281:35070–35080. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Hsu KS and Kao HY: Alpha-actinin 4 and tumorigenesis of breast cancer. Vitam Horm. 93:323–351. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Hara T, Honda K, Shitashige M, Ono M, Matsuyama H, Naito K, Hirohashi S and Yamada T: Mass spectrometry analysis of the native protein complex containing actinin-4 in prostate cancer cells. Mol Cell Proteomics. 6:479–491. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Yamamoto S, Tsuda H, Honda K, Kita T, Takano M, Tamai S, Inazawa J, Yamada T and Matsubara O: Actinin-4 expression in ovarian cancer: A novel prognostic indicator independent of clinical stage and histological type. Mod Pathol. 20:1278–1285. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Kikuchi S, Honda K, Tsuda H, Hiraoka N, Imoto I, Kosuge T, Umaki T, Onozato K, Shitashige M, Yamaguchi U, et al: Expression and gene amplification of actinin-4 in invasive ductal carcinoma of the pancreas. Clin Cancer Res. 14:5348–5356. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Honda K: The biological role of actinin-4 (ACTN4) in malignant phenotypes of cancer. Cell Biosci. 5:412015. View Article : Google Scholar : PubMed/NCBI | |
|
Savoy RM and Ghosh PM: The dual role of filamin A in cancer: Can't live with (too much of) it, can't live without it. Endocr Relat Cancer. 20:R341–R356. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Deng W, Lopez-Camacho C, Tang JY, Mendoza-Villanueva D, Maya-Mendoza A, Jackson DA and Shore P: Cytoskeletal protein filamin A is a nucleolar protein that suppresses ribosomal RNA gene transcription. Proc Natl Acad Sci USA. 109:pp. 1524–1529. 2012; View Article : Google Scholar : PubMed/NCBI | |
|
Loy CJ, Sim KS and Yong EL: Filamin-A fragment localizes to the nucleus to regulate androgen receptor and coactivator functions. Proc Natl Acad Sci USA. 100:pp. 4562–4567. 2003; View Article : Google Scholar : PubMed/NCBI | |
|
Lawson D, Harrison M and Shapland C: Fibroblast transgelin and smooth muscle SM22alpha are the same protein, the expression of which is down-regulated in many cell lines. Cell Motil Cytoskeleton. 38:250–257. 1997. View Article : Google Scholar : PubMed/NCBI | |
|
Shields JM, Rogers-Graham K and Der CJ: Loss of transgelin in breast and colon tumors and in RIE-1 cells by Ras deregulation of gene expression through Raf-independent pathways. J Biol Chem. 277:9790–9799. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Sitek B, Lüttges J, Marcus K, Klöppel G, Schmiegel W, Meyer HE, Hahn SA and Stühler K: Application of fluorescence difference gel electrophoresis saturation labelling for the analysis of microdissected precursor lesions of pancreatic ductal adenocarcinoma. Proteomics. 5:2665–2679. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Mikuriya K, Kuramitsu Y, Ryozawa S, Fujimoto M, Mori S, Oka M, Hamano K, Okita K, Sakaida I and Nakamura K: Expression of glycolytic enzymes is increased in pancreatic cancerous tissues as evidenced by proteomic profiling by two-dimensional electrophoresis and liquid chromatography-mass spectrometry/mass spectrometry. Int J Oncol. 30:849–855. 2007.PubMed/NCBI | |
|
Huang Q, Huang Q, Chen W, Wang L, Lin W, Lin J and Lin X: Identification of transgelin as a potential novel biomarker for gastric adenocarcinoma based on proteomics technology. J Cancer Res Clin Oncol. 134:1219–1227. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Sun X, Zhang H, Luo L, Zhong K, Ma Y, Fan L, Fu D and Wan L: Comparative proteomic profiling identifies potential prognostic factors for human clear cell renal cell carcinoma. Oncol Rep. 36:3131–3138. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Zhou H, Zhang Y, Chen Q and Lin Y: AKT and JNK signaling pathways increase the metastatic potential of colorectal cancer cells by altering transgelin expression. Dig Dis Sci. 61:1091–1097. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Lin Y, Buckhaults PJ, Lee JR, Xiong H, Farrell C, Podolsky RH, Schade RR and Dynan WS: Association of the actin-binding protein transgelin with lymph node metastasis in human colorectal cancer. Neoplasia. 11:864–873. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Zhou HM, Fang YY, Weinberger PM, Ding LL, Cowell JK, Hudson FZ, Ren M, Lee JR, Chen QK, Su H, et al: Transgelin increases metastatic potential of colorectal cancer cells in vivo and alters expression of genes involved in cell motility. BMC Cancer. 16:552016. View Article : Google Scholar : PubMed/NCBI | |
|
Yuan Y and Shen Z: Interaction with BRCA2 suggests a role for filamin-1 (hsFLNa) in DNA damage response. J Biol Chem. 276:48318–48324. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Yue J, Huhn S and Shen Z: Complex roles of filamin-A mediated cytoskeleton network in cancer progression. Cell Biosci. 3:72013. View Article : Google Scholar : PubMed/NCBI | |
|
Velkova A, Carvalho MA, Johnson JO, Tavtigian SV and Monteiro AN: Identification of Filamin A as a BRCA1-interacting protein required for efficient DNA repair. Cell cycle. 9:1421–1433. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Meng X, Yuan Y, Maestas A and Shen Z: Recovery from DNA damage-induced G2 arrest requires actin-binding protein filamin-A/actin-binding protein 280. J Biol Chem. 279:6098–6105. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Yue J, Wang Q, Lu H, Brenneman M, Fan F and Shen Z: The cytoskeleton protein filamin-A is required for an efficient recombinational DNA double strand break repair. Cancer Res. 69:7978–7985. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Sur I, Neumann S and Noegel AA: Nesprin-1 role in DNA damage response. Nucleus. 5:173–191. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Rashmi RN, Eckes B, Glöckner G, Groth M, Neumann S, Gloy J, Sellin L, Walz G, Schneider M, Karakesisoglou I, et al: The nuclear envelope protein Nesprin-2 has roles in cell proliferation and differentiation during wound healing. Nucleus. 3:172–186. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Kelkar P, Walter A, Papadopoulos S, Mroß C, Munck M, Peche VS and Noegel AA: Nesprin-2 mediated nuclear trafficking and its clinical implications. Nucleus. 6:479–489. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Matsumoto A, Hieda M, Yokoyama Y, Nishioka Y, Yoshidome K, Tsujimoto M and Matsuura N: Global loss of a nuclear lamina component, lamin A/C, and LINC complex components SUN1, SUN2 and nesprin-2 in breast cancer. Cancer Med. 4:1547–1557. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Neumann S and Noegel AA: Nesprins in cell stability and migration. Adv Exp Med Biol. 773:491–504. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Cartwright S and Karakesisoglou I: Nesprins in health and disease. Semin Cell Dev Biol. 29:169–179. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Sjöblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, et al: The consensus coding sequences of human breast and colorectal cancers. Science. 314:268–274. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Chittenden TW, Howe EA, Culhane AC, Sultana R, Taylor JM, Holmes C and Quackenbush J: Functional classification analysis of somatically mutated genes in human breast and colorectal cancers. Genomics. 91:508–511. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Stransky N, Egloff AM, Tward AD, Kostic AD, Cibulskis K, Sivachenko A, Kryukov GV, Lawrence MS, Sougnez C, McKenna A, et al: The mutational landscape of head and neck squamous cell carcinoma. Science. 333:1157–1160. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang P, Sridharan D and Lambert MW: Nuclear α spectrin differentially affects monoubiquitinated versus non-ubiquitinated FANCD2 function after DNA interstrand cross-link damage. J Cell Biochem. 117:671–683. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Almuzzaini B, Sarshad AA, Farrants AK and Percipalle P: Nuclear myosin 1 contributes to a chromatin landscape compatible with RNA polymerase II transcription activation. Bmc Biol. 13:352015. View Article : Google Scholar : PubMed/NCBI | |
|
Savoy RM, Chen L, Siddiqui S, Melgoza FU, Durbin-Johnson B, Drake C, Jathal MK, Bose S, Steele TM, Mooso BA, et al: Transcription of Nrdp1 by the androgen receptor is regulated by nuclear filamin A in prostate cancer. Endocr Relat Cancer. 22:369–386. 2015. View Article : Google Scholar : PubMed/NCBI |
