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Review

Functions of nuclear actin-binding proteins in human cancer (Review)

  • Authors:
    • Xinyi Yang
    • Ying Lin
  • View Affiliations / Copyright

    Affiliations: Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat‑sen Memorial Hospital, Sun Yat‑sen University, Guangzhou, Guangdong 510120, P.R. China
  • Pages: 2743-2748
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    Published online on: December 19, 2017
       https://doi.org/10.3892/ol.2017.7658
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Abstract

Nuclear actin-binding proteins (ABPs) perform distinguishable functions compared with their cytoplasmic counterparts in extensive activities of living cells. In addition to the ability to regulate actin cytoskeleton dynamics, nuclear ABPs are associated with multiple nuclear biological processes, including chromatin remodeling, gene transcriptional regulation, DNA damage response, nucleocytoplasmic trafficking and nuclear structure maintenance. The nuclear translocation of ABPs is affected by numerous intracellular or extracellular stimuli, which may lead to developmental malformation, tumor initiation, tumor progression and metastasis. Abnormal expression of certain ABPs have been reported in different types of cancer. This review focuses on the newly identified roles of nuclear ABPs in the pathological processes associated with cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Yang X and Lin Y: Functions of nuclear actin-binding proteins in human cancer (Review). Oncol Lett 15: 2743-2748, 2018.
APA
Yang, X., & Lin, Y. (2018). Functions of nuclear actin-binding proteins in human cancer (Review). Oncology Letters, 15, 2743-2748. https://doi.org/10.3892/ol.2017.7658
MLA
Yang, X., Lin, Y."Functions of nuclear actin-binding proteins in human cancer (Review)". Oncology Letters 15.3 (2018): 2743-2748.
Chicago
Yang, X., Lin, Y."Functions of nuclear actin-binding proteins in human cancer (Review)". Oncology Letters 15, no. 3 (2018): 2743-2748. https://doi.org/10.3892/ol.2017.7658
Copy and paste a formatted citation
x
Spandidos Publications style
Yang X and Lin Y: Functions of nuclear actin-binding proteins in human cancer (Review). Oncol Lett 15: 2743-2748, 2018.
APA
Yang, X., & Lin, Y. (2018). Functions of nuclear actin-binding proteins in human cancer (Review). Oncology Letters, 15, 2743-2748. https://doi.org/10.3892/ol.2017.7658
MLA
Yang, X., Lin, Y."Functions of nuclear actin-binding proteins in human cancer (Review)". Oncology Letters 15.3 (2018): 2743-2748.
Chicago
Yang, X., Lin, Y."Functions of nuclear actin-binding proteins in human cancer (Review)". Oncology Letters 15, no. 3 (2018): 2743-2748. https://doi.org/10.3892/ol.2017.7658
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