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Article

RKIP and peroxiredoxin 2 expression predicts the proliferative potential of gastric cancer stem cells

  • Authors:
    • Shao‑Feng Yang
    • Ran Ma
    • Li‑Li Pan
    • Jing Cao
    • Nan Sheng
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Jining First People's Hospital, Jining, Shandong 272011, P.R. China
  • Pages: 3173-3177
    |
    Published online on: December 28, 2017
       https://doi.org/10.3892/ol.2017.7700
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Abstract

Gastric cancer is associated with a high mortality rate, with the development of gastric cancer stem cells underlying this. Gastric cancer stem cells are responsible for tumor initiation, progression and recurrence. However, the link between gastric cancer and gastric cancer stem cells remains to be fully understood. Murine models mimic a human microenvironment more accurately than in vitro studies and are useful models for understanding the behavior of different markers. The present study compared the expression of cluster of differentiation 44 (CD44), a stem cell marker, with the expression of other cancer‑associated markers, including Raf kinase inhibitor protein (RKIP) and peroxiredoxin 2, in different pathological conditions of gastric cancer development using histological, immunohistological and western blot analyses. Initially, the murine model of gastric cancer was established using N‑methyl‑N‑nitrosourea, a chemical carcinogen. Following initiation of cancer, immunohistochemistry was used to compare the expression of CD44, RKIP and peroxiredoxin 2 at different stages of cancer development. The results suggested CD44 and peroxiredoxin 2 expression was upregulated as the tumor progressed. However, expression of RKIP, a metastasis suppressor, was elevated in the initial stage of gastric cancer and suppressed during the aggressive stages. In agreement with previous data suggesting higher expressions of RKIP in the initial stages of cancer and its downregulation in the advanced stage, the results of the present study revealed that RKIP exhibited a negative effect on initial tumor development, and that the downregulation of RKIP in the advanced stages of cancer facilitated CD44 and peroxiredoxin 2 overexpression.
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1 

Parkin DM, Bray F, Ferlay J and Pisani P: Global cancer statistics, 2002. CA Cancer J Clin. 55:74–108. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Ferlay J, Shin HR, Bray F, Forman D, Mathers C and Parkin DM: Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 127:2893–2917. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Siegel R, Ward E, Brawley O and Jemal A: Cancer statistic, 2011: The impact of eliminating socioeconomic and racial disparities on premature cancer deaths. Ca Cancer J Clin. 61:212–236. 2011. View Article : Google Scholar : PubMed/NCBI

4 

DeSantis CE, Lin CC, Mariotto AB, Siegel RL, Stein KD, Kramer JL, Alteri R, Robbins AS and Jemal A: Cancer treatment and survivorship statistics, 2014. CA Cancer J Clin. 64:252–271. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Singh SR: Gastric cancer stem cells: A novel therapeutic target. Cancer Lett. 338:110–119. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Zhao Y, Feng F and Zhou YN: Stem cells in gastric cancer. World J Gastroenterol. 21:112–123. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Roboz GJ and Guzman M: Acute myeloid leukemia stem cells: Seek and destroy. Expert Rev Hematol. 2:663–672. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Valent P: Targeting of leukemia-initiating cells to develop curative drug therapies: Straightforward but nontrivial concept. Current Cancer Drug Targets. 11:56–71. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Korkaya H and Wicha MS: Selective targeting of cancer stem cells. BioDrugs. 21:299–310. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Zhu L, Gibson P, Currle DS, Tong Y, Richardson RJ, Bayazitov IT, Poppleton H, Zakharenko S, Ellison DW and Gilbertson RJ: Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation. Nature. 457:603–607. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Barker N, Ridgway RA, Van Es JH, van de Wetering M, Begthel H, van den Born M, Danenberg E, Clarke AR, Sansom OJ and Clevers H: Crypt stem cells as the cells-of-origin of intestinal cancer. Nature. 457:608–611. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Cozzio A, Passegué E, Ayton PM, Karsunky H, Cleary ML and Weissman IL: Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors. Genes Dev. 17:3029–3035. 2003. View Article : Google Scholar : PubMed/NCBI

13 

Yeung K, Seitz T, Li S, Janosch P, McFerran B, Kaiser C, Fee F, Katsanakis KD, Rose DW, Mischak H, et al: Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP. nature. 401:173–177. 1999. View Article : Google Scholar : PubMed/NCBI

14 

Chatterjee D, Bai Y, Wang Z, Beach S, Mott S, Roy R, Braastad C, Sun Y, Mukhopadhyay A and Aggarwal BB: RKIP sensitizes prostate and breast cancer cells to drug-induced apoptosis. J Biol Chem. 279:17515–17523. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Al-Mulla F, Hagan S, Behbehani AI, Bitar MS, George SS, Going JJ, García JJ, Scott L, Fyfe N, Murray GI and Kolch W: Raf kinase inhibitor protein expression in a survival analysis of colorectal cancer patients. J Clin Oncol. 24:5672–5679. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Keller ET, Fu Z, Yeung K and Brennan M: Raf kinase inhibitor protein: A prostate cancer metastasis suppressor gene. Cancer Lett. 207:131–137. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Hagan S, Al-Mulla F, Mallon E, Oien K, Ferrier R, Gusterson B, García JJ and Kolch W: Reduction of Raf-1 kinase inhibitor protein expression correlates with breast cancer metastasis. Clin Cancer Res. 11:7392–7397. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Schuierer MM, Bataille F, Hagan S, Kolch W and Bosserhoff A-K: Reduction in Raf kinase inhibitor protein expression is associated with increased Ras-extracellular signal-regulated kinase signaling in melanoma cell lines. Cancer Res. 64:5186–5192. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Nyström T, Yang J and Molin M: Peroxiredoxins, gerontogenes linking aging to genome instability and cancer. Genes Dev. 26:2001–2008. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Szatrowski TP and Nathan CF: Production of large amounts of hydrogen peroxide by human tumor cells. Cancer Res. 51:794–798. 1991.PubMed/NCBI

21 

Yamamoto M, Furihata C, Ogiu T, Tsukamoto T, Inada Ki, Hirano K and Tatematsu M: Independent variation in susceptibilities of six different mouse strains to induction of pepsinogen-altered pyloric glands and gastric tumor intestinalization by N-methyl-N-nitrosourea. Cancer Lett. 179:121–132. 2002. View Article : Google Scholar : PubMed/NCBI

22 

Hayakawa Y, Fox JG, Gonda T, Worthley DL, Muthupalani S and Wang TC: Mouse models of gastric cancer. Cancers (Basel). 5:92–130. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Hamidouche Z, Haÿ E, Vaudin P, Charbord P, Schüle R, Marie PJ and Fromigué O: FHL2 mediates dexamethasone-induced mesenchymal cell differentiation into osteoblasts by activating Wnt/beta-catenin signaling-dependent Runx2 expression. FASEB J. 22:3813–3822. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Waterborg JH: The Lowry method for protein quantitation. protein Protoc Handb. 1–9. 2002.

25 

Abate-Shen C: Deregulated homeobox gene expression in cancer: Cause or consequence? Nat Re Cancer. 2:777–785. 2002. View Article : Google Scholar

26 

Yu S, Yang M and Nam KT: Mouse models of gastric carcinogenesis. J Gastric Cancer. 14:67–86. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Jang BI, Li Y, Graham DY and Cen P: The role of CD44 in the pathogenesis, diagnosis and therapy of gastric cancer. Gut Liver. 5:397–405. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Ghaffarzadehgan K, Jafarzadeh M, Raziee HR, Sima HR, Esmaili-Shandiz E, Hosseinnezhad H, Taghizadeh-Kermani A, Moaven O and Bahrani M: Expression of cell adhesion molecule CD44 in gastric adenocarcinoma and its prognostic importance. World J Gastroenterol. 14:6376–6381. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Nosrati A, Naghshvar F and Khanari S: Cancer stem cell markers CD44, CD133 in primary gastric adenocarcinoma. Int J Mol Cell Med. 3:279–286. 2014.PubMed/NCBI

30 

Li X, Wang J, Xu Z, Ahmad A, Li E, Wang Y, Qin S and Wang Q: Expression of sox2 and oct4 and their clinical significance in human non-small-cell lung cancer. Int J Mol Sci. 13:7663–7675. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Park YH, Kim SU, Lee BK, Kim HS, Song IS, Shin HJ, Han YH, Chang KT, Kim JM, Lee DS, et al: Prx I suppresses K-ras-driven lung tumorigenesis by opposing redox-sensitive ERK/cyclin D1 pathway. Antioxid Redox Signal. 19:482–496. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Diao S, Zhang Jf, Wang H, He ML, Lin MC, Chen Y and Kung HF: Proteomic identification of microRNA-122a target proteins in hepatocellular carcinoma. Proteomics. 10:3723–3731. 2010. View Article : Google Scholar : PubMed/NCBI

33 

Takaishi S, Okumura T, Tu S, Wang SS, Shibata W, Vigneshwaran R, Gordon SA, Shimada Y and Wang TC: Identification of gastric cancer stem cells using the cell surface marker CD44. Stem Cells. 27:1006–1020. 2009. View Article : Google Scholar : PubMed/NCBI

34 

Beshir AB, Ren G, Magpusao AN, Barone LM, Yeung KC and Fenteany G: Raf kinase inhibitor protein suppresses nuclear factor-κB-dependent cancer cell invasion through negative regulation of matrix metalloproteinase expression. Cancer Lett. 299:137–149. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Jin DZ, Jung HC, Kim JM, Kim JS, Song IS and Kim CY: Establishment of BALB/c mice model infected with Helicobacter pylori. Korean J Intern Med. 14:55–63. 1999. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yang SF, Ma R, Pan LL, Cao J and Sheng N: RKIP and peroxiredoxin 2 expression predicts the proliferative potential of gastric cancer stem cells. Oncol Lett 15: 3173-3177, 2018.
APA
Yang, S., Ma, R., Pan, L., Cao, J., & Sheng, N. (2018). RKIP and peroxiredoxin 2 expression predicts the proliferative potential of gastric cancer stem cells. Oncology Letters, 15, 3173-3177. https://doi.org/10.3892/ol.2017.7700
MLA
Yang, S., Ma, R., Pan, L., Cao, J., Sheng, N."RKIP and peroxiredoxin 2 expression predicts the proliferative potential of gastric cancer stem cells". Oncology Letters 15.3 (2018): 3173-3177.
Chicago
Yang, S., Ma, R., Pan, L., Cao, J., Sheng, N."RKIP and peroxiredoxin 2 expression predicts the proliferative potential of gastric cancer stem cells". Oncology Letters 15, no. 3 (2018): 3173-3177. https://doi.org/10.3892/ol.2017.7700
Copy and paste a formatted citation
x
Spandidos Publications style
Yang SF, Ma R, Pan LL, Cao J and Sheng N: RKIP and peroxiredoxin 2 expression predicts the proliferative potential of gastric cancer stem cells. Oncol Lett 15: 3173-3177, 2018.
APA
Yang, S., Ma, R., Pan, L., Cao, J., & Sheng, N. (2018). RKIP and peroxiredoxin 2 expression predicts the proliferative potential of gastric cancer stem cells. Oncology Letters, 15, 3173-3177. https://doi.org/10.3892/ol.2017.7700
MLA
Yang, S., Ma, R., Pan, L., Cao, J., Sheng, N."RKIP and peroxiredoxin 2 expression predicts the proliferative potential of gastric cancer stem cells". Oncology Letters 15.3 (2018): 3173-3177.
Chicago
Yang, S., Ma, R., Pan, L., Cao, J., Sheng, N."RKIP and peroxiredoxin 2 expression predicts the proliferative potential of gastric cancer stem cells". Oncology Letters 15, no. 3 (2018): 3173-3177. https://doi.org/10.3892/ol.2017.7700
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