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Article Open Access

Long‑lasting memory of cellular immunity in a chronic myeloid leukemia patient maintains molecular response 5 after cessation of dasatinib

  • Authors:
    • Tatsuro Jo
    • Kazuhiro Noguchi
    • Shizuka Hayashi
    • Sadaharu Irie
    • Risa Hayase
    • Haruna Shioya
    • Youhei Kaneko
    • Kensuke Horio
    • Jun Taguchi
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Japanese Red Cross Nagasaki Genbaku Hospital, Nagasaki 852‑8511, Japan, Department of Clinical Laboratory, Japanese Red Cross Nagasaki Genbaku Hospital, Nagasaki 852‑8511, Japan, Department of Pharmacy, Japanese Red Cross Nagasaki Genbaku Hospital, Nagasaki 852‑8511, Japan
    Copyright: © Jo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2935-2938
    |
    Published online on: December 29, 2017
       https://doi.org/10.3892/ol.2017.7720
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Abstract

Tyrosine kinase inhibitors (TKIs), including imatinib, dasatinib and nilotinib are primarily used in the initial treatment of chronic phase (CP)‑chronic myeloid leukemia (CML), as CMLs harbor the BCR‑ABL fusion product. An increased number of lymphocytes and large granular lymphocytes (LGLs) have been observed in patients treated with dasatinib, but not other TKIs. The LGLs have been reported to be primarily natural killer (NK) cells and cytotoxic T lymphocytes (CTLs). In the present study, a CP‑CML patient who has maintained molecular response 5 for >2.4 years after stopping dasatinib was reported. Memory and effector CTLs and NK cells, were observed after 2.4 years of treatment‑free remission, despite the fact that lymphocyte counts are not elevated in the patient. These results suggest that dasatinib may induce cellular immunity, including NK cells and CTLs and this cellular immunity may be maintained for a long period following cessation of dasatinib. The results suggest that this cellular immunity may provide a long‑term cure without the need for continued TKI treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Jo T, Noguchi K, Hayashi S, Irie S, Hayase R, Shioya H, Kaneko Y, Horio K and Taguchi J: Long‑lasting memory of cellular immunity in a chronic myeloid leukemia patient maintains molecular response 5 after cessation of dasatinib. Oncol Lett 15: 2935-2938, 2018.
APA
Jo, T., Noguchi, K., Hayashi, S., Irie, S., Hayase, R., Shioya, H. ... Taguchi, J. (2018). Long‑lasting memory of cellular immunity in a chronic myeloid leukemia patient maintains molecular response 5 after cessation of dasatinib. Oncology Letters, 15, 2935-2938. https://doi.org/10.3892/ol.2017.7720
MLA
Jo, T., Noguchi, K., Hayashi, S., Irie, S., Hayase, R., Shioya, H., Kaneko, Y., Horio, K., Taguchi, J."Long‑lasting memory of cellular immunity in a chronic myeloid leukemia patient maintains molecular response 5 after cessation of dasatinib". Oncology Letters 15.3 (2018): 2935-2938.
Chicago
Jo, T., Noguchi, K., Hayashi, S., Irie, S., Hayase, R., Shioya, H., Kaneko, Y., Horio, K., Taguchi, J."Long‑lasting memory of cellular immunity in a chronic myeloid leukemia patient maintains molecular response 5 after cessation of dasatinib". Oncology Letters 15, no. 3 (2018): 2935-2938. https://doi.org/10.3892/ol.2017.7720
Copy and paste a formatted citation
x
Spandidos Publications style
Jo T, Noguchi K, Hayashi S, Irie S, Hayase R, Shioya H, Kaneko Y, Horio K and Taguchi J: Long‑lasting memory of cellular immunity in a chronic myeloid leukemia patient maintains molecular response 5 after cessation of dasatinib. Oncol Lett 15: 2935-2938, 2018.
APA
Jo, T., Noguchi, K., Hayashi, S., Irie, S., Hayase, R., Shioya, H. ... Taguchi, J. (2018). Long‑lasting memory of cellular immunity in a chronic myeloid leukemia patient maintains molecular response 5 after cessation of dasatinib. Oncology Letters, 15, 2935-2938. https://doi.org/10.3892/ol.2017.7720
MLA
Jo, T., Noguchi, K., Hayashi, S., Irie, S., Hayase, R., Shioya, H., Kaneko, Y., Horio, K., Taguchi, J."Long‑lasting memory of cellular immunity in a chronic myeloid leukemia patient maintains molecular response 5 after cessation of dasatinib". Oncology Letters 15.3 (2018): 2935-2938.
Chicago
Jo, T., Noguchi, K., Hayashi, S., Irie, S., Hayase, R., Shioya, H., Kaneko, Y., Horio, K., Taguchi, J."Long‑lasting memory of cellular immunity in a chronic myeloid leukemia patient maintains molecular response 5 after cessation of dasatinib". Oncology Letters 15, no. 3 (2018): 2935-2938. https://doi.org/10.3892/ol.2017.7720
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