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Article

Overexpression of flavin-containing monooxygenase 5 predicts poor prognosis in patients with colorectal cancer

  • Authors:
    • Tong Zhang
    • Ping Yang
    • Jianchang Wei
    • Wanglin Li
    • Junbin Zhong
    • Huacui Chen
    • Jie Cao
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, P.R. China
  • Pages: 3923-3927
    |
    Published online on: January 4, 2018
       https://doi.org/10.3892/ol.2018.7724
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Abstract

The present study investigated the expression and clinical significance of flavin‑containing monooxygenase 5 (FMO5) in colorectal cancer (CRC). The expression of FMO5 was detected by immunohistochemistry in 208 colon cancer tissues and 8 normal colon tissues. Then, the correlations of FMO5 expression with several clinicopathological features were evaluated. FMO5 mRNA expression from The Cancer Genome Atlas dataset was assessed for further validation. In addition, the association of the expression of FMO5 with prognosis was further evaluated by Kaplan‑Meier survival curves and Cox proportional hazards model. The FMO5 protein level in colon cancer tissues was significantly higher than that in normal colon tissues (P<0.001). Overexpression of FMO5 was associated with an advanced clinical stage of cancer (P=0.018) and lymph node metastasis (P=0.03). The TCGA dataset also demonstrated that FMO5 was upregulated in CRC with advanced clinical stage (P=0.047), lymph node metastasis (P=0.045) and distant metastasis (P=0.030). The Kaplan‑Meier survival curves showed that higher FMO5 mRNA indicated a shorter overall survival in patients with CRC compared with a low expression of FMO5 (P=0.029). Cox proportional hazards regression revealed that a high FMO5 mRNA level served as an independent prognostic factor for patients with CRC (hazard ratio, 2.865; 95% confidence interval, 1.116‑7.355; P=0.029). A high expression of FMO5 may serve roles in colorectal carcinogenesis and distant metastasis. FMO5 may be an independent predictive factor for the prognosis of CRC.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang T, Yang P, Wei J, Li W, Zhong J, Chen H and Cao J: Overexpression of flavin-containing monooxygenase 5 predicts poor prognosis in patients with colorectal cancer. Oncol Lett 15: 3923-3927, 2018.
APA
Zhang, T., Yang, P., Wei, J., Li, W., Zhong, J., Chen, H., & Cao, J. (2018). Overexpression of flavin-containing monooxygenase 5 predicts poor prognosis in patients with colorectal cancer. Oncology Letters, 15, 3923-3927. https://doi.org/10.3892/ol.2018.7724
MLA
Zhang, T., Yang, P., Wei, J., Li, W., Zhong, J., Chen, H., Cao, J."Overexpression of flavin-containing monooxygenase 5 predicts poor prognosis in patients with colorectal cancer". Oncology Letters 15.3 (2018): 3923-3927.
Chicago
Zhang, T., Yang, P., Wei, J., Li, W., Zhong, J., Chen, H., Cao, J."Overexpression of flavin-containing monooxygenase 5 predicts poor prognosis in patients with colorectal cancer". Oncology Letters 15, no. 3 (2018): 3923-3927. https://doi.org/10.3892/ol.2018.7724
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang T, Yang P, Wei J, Li W, Zhong J, Chen H and Cao J: Overexpression of flavin-containing monooxygenase 5 predicts poor prognosis in patients with colorectal cancer. Oncol Lett 15: 3923-3927, 2018.
APA
Zhang, T., Yang, P., Wei, J., Li, W., Zhong, J., Chen, H., & Cao, J. (2018). Overexpression of flavin-containing monooxygenase 5 predicts poor prognosis in patients with colorectal cancer. Oncology Letters, 15, 3923-3927. https://doi.org/10.3892/ol.2018.7724
MLA
Zhang, T., Yang, P., Wei, J., Li, W., Zhong, J., Chen, H., Cao, J."Overexpression of flavin-containing monooxygenase 5 predicts poor prognosis in patients with colorectal cancer". Oncology Letters 15.3 (2018): 3923-3927.
Chicago
Zhang, T., Yang, P., Wei, J., Li, W., Zhong, J., Chen, H., Cao, J."Overexpression of flavin-containing monooxygenase 5 predicts poor prognosis in patients with colorectal cancer". Oncology Letters 15, no. 3 (2018): 3923-3927. https://doi.org/10.3892/ol.2018.7724
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