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Article Open Access

Risk factors and coping strategies of severe community-acquired pneumonia in chemotherapy induction period of acute leukemia

  • Authors:
    • Ning Li
    • Qingcheng Duan
    • Weidan Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Dezhou People's Hospital, Dezhou, Shandong 253014, P.R. China, Department of Emergency, Dezhou People's Hospital, Dezhou, Shandong 253014, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3566-3571
    |
    Published online on: January 4, 2018
       https://doi.org/10.3892/ol.2018.7731
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Abstract

The risk factors and coping strategies of severe community-acquired pneumonia (SCAP) in chemotherapy induction period of acute leukemia were investigated. Eighty-six patients with CAP in chemotherapy induction period of acute leukemia in Dezhou Hospital from March 2014 to February 2017 were selected and divided into observation group (SCAP group, n=45) and control group (non-SCAP group, n=41) according to the acute physiology and chronic health evolution II (APACHE II) score. The blood, sputum, nasopharyngeal secretion and pleural effusion samples were collected from patients in both groups, and the samples were detected for pathogens, followed by the analysis of relevant factors. The dynamic changes in the sequential organ failure assessment (SOFA) score, procalcitonin (PCT), D-dimer (D-D) and C-reactive protein (CRP) levels in patients were observed before and after the corresponding treatment strategies were taken. The total distribution ratio of pathogens from high to low in the two groups was as follows: bacterium, virus, fungus, mycoplasma and chlamydia trachomatis; there was no significant difference between the two groups (P>0.05). Logistic regression analysis showed that the repeated infection (OR=3.315, P=0.005), multi-resistant bacterial infection (OR=1.915, P=0.008) and D-D (OR=1.936, P=0.009) were independent risk factors for SCAP (P<0.05). After different coping strategies were taken, the SOFA score, PCT, D-D and CRP levels in the two groups were significantly decreased, and they were obviously higher in observation group than those in control group (P<0.05). Repeated infection, D-D level and multi-resistant bacterial infection are the risk factors affecting the SCAP in chemotherapy induction period of acute leukemia. The coping strategies can effectively relieve the patient's condition, reduce the severity of disease and improve the survival rate of patients.
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Copy and paste a formatted citation
Spandidos Publications style
Li N, Duan Q and Zhang W: Risk factors and coping strategies of severe community-acquired pneumonia in chemotherapy induction period of acute leukemia. Oncol Lett 15: 3566-3571, 2018.
APA
Li, N., Duan, Q., & Zhang, W. (2018). Risk factors and coping strategies of severe community-acquired pneumonia in chemotherapy induction period of acute leukemia. Oncology Letters, 15, 3566-3571. https://doi.org/10.3892/ol.2018.7731
MLA
Li, N., Duan, Q., Zhang, W."Risk factors and coping strategies of severe community-acquired pneumonia in chemotherapy induction period of acute leukemia". Oncology Letters 15.3 (2018): 3566-3571.
Chicago
Li, N., Duan, Q., Zhang, W."Risk factors and coping strategies of severe community-acquired pneumonia in chemotherapy induction period of acute leukemia". Oncology Letters 15, no. 3 (2018): 3566-3571. https://doi.org/10.3892/ol.2018.7731
Copy and paste a formatted citation
x
Spandidos Publications style
Li N, Duan Q and Zhang W: Risk factors and coping strategies of severe community-acquired pneumonia in chemotherapy induction period of acute leukemia. Oncol Lett 15: 3566-3571, 2018.
APA
Li, N., Duan, Q., & Zhang, W. (2018). Risk factors and coping strategies of severe community-acquired pneumonia in chemotherapy induction period of acute leukemia. Oncology Letters, 15, 3566-3571. https://doi.org/10.3892/ol.2018.7731
MLA
Li, N., Duan, Q., Zhang, W."Risk factors and coping strategies of severe community-acquired pneumonia in chemotherapy induction period of acute leukemia". Oncology Letters 15.3 (2018): 3566-3571.
Chicago
Li, N., Duan, Q., Zhang, W."Risk factors and coping strategies of severe community-acquired pneumonia in chemotherapy induction period of acute leukemia". Oncology Letters 15, no. 3 (2018): 3566-3571. https://doi.org/10.3892/ol.2018.7731
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