Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
March-2018 Volume 15 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2018 Volume 15 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Angiogenesis for tumor vascular normalization of Endostar on hepatoma 22 tumor-bearing mice is involved in the immune response

  • Authors:
    • Qingyu Xu
    • Junfei Gu
    • You Lv
    • Jiarui Yuan
    • Nan Yang
    • Juan Chen
    • Chunfei Wang
    • Xuefeng Hou
    • Xiaobin Jia
    • Liang Feng
    • Guowen Yin
  • View Affiliations / Copyright

    Affiliations: Department of Intervention, Cancer Hospital of Jiangsu, Nanjing, Jiangsu 210009, P.R. China, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, P.R. China, Key Laboratory of Delivery Systems of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing, Jiangsu 210028, P.R. China
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3437-3446
    |
    Published online on: January 5, 2018
       https://doi.org/10.3892/ol.2018.7734
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Tumor vascular normalization involved in immune response is beneficial to the chemotherapy of tumors. Recombinant human endostatin (Endostar), an angiogenesis inhibitor, has been demonstrated to be effective in hepatocellular cancer (HCC). However, its vascular normalization in HCC and the role of the immune response in angiogenesis were unclear. In the present study, effects of Endostar on tumor vascular normalization were evaluated in hepatoma 22 (H22) tumor‑bearing mice. Endostar was able to inhibit the proliferation and infiltration of tumor cells and improve α‑fetoprotein, tumor necrosis factor‑α and cyclic adenosine 5'‑phosphate levels in the serum of H22‑bearing mice, as well as the protein expression levels of the immune factors interferon‑γ and cluster of differentiation (CD)86 in liver tissue. Endostar also exhibited more marked downregulation of the levels of vascular endothelial growth factor, CD31, matrix metalloproteinase (MMP)‑2, MMP‑9 and interleukin‑17 during day 3‑9 treatment, resulting in short‑term normalization of tumor blood vessels. The period of vascular normalization was 3‑9 days. The results of the present study demonstrated that Endostar was able to induce the period of vascular normalization, contributing to a more efficacious means of HCC treatment combined with other chemotherapy, and this effect was associated with the immune response. It may be concluded that Endostar inhibited immunity‑associated angiogenesis behaviors of vascular endothelial cells in response to HCC. The results of the present study provided more reasonable possibility for the combination therapy of Endostar for the treatment of HCC.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Llovet JM, Burroughs A and Bruix J: Hepatocellular carcinoma. Lancet. 362:1907–1917. 2003. View Article : Google Scholar : PubMed/NCBI

2 

Gish RG and Baron A: Hepatocellular carcinoma (HCC): Current and evolving therapies. IDrugs. 11:198–203. 2008.PubMed/NCBI

3 

Bruix J, Sala M and Llovet JM: Chemoembolization for hepatocellular carcinoma. Gastroenterology. 127:179–188. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Gacche RN: Compensatory angiogenesis and tumor refractoriness. Oncogenesis. 4:e1532015. View Article : Google Scholar : PubMed/NCBI

5 

Folkman J: Role of angiogenesis in tumor growth and metastasis. Semin Onco. l29(6 Suppl 16): S15–S18. 2002. View Article : Google Scholar

6 

Zhang C, Li K and Wang J: The effect of rh-endostatin on micrangium and angiogenic factors in tumor and myocardium tissue. Chin German J Clin Oncol. 11:43–48. 2012. View Article : Google Scholar

7 

Yan JC, Ding S, Liang Y, Liu PJ, Ren GQ, Zhu J, Ma GS, et al: Effect of CD_(40)-CD_(40) ligand interaction on proliferation and migration in cultured human umbilical vein endothelial cells. China J Modern Med. 2496–2499. 2007.(In Chinese).

8 

Murphy JF, Lennon F, Steele C, Kelleher D, Fitzgerald D and Long AC: Engagement of CD44 modulates cyclooxygenase induction, VEGF generation, and cell proliferation in human vascular endothelial cells. FASEB J. 19:446–448. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Ao JY, Chai ZT, Zhang YY, Zhu XD, Kong LQ, Zhang N, Ye BG, Cai H, Gao DM and Sun HC: Robo1 promotes angiogenesis in hepatocellular carcinoma through the Rho family of guanosine triphosphatases' signaling pathway. Tumour Biol. 36:8413–8424. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Ling Y, Yang Y, Lu N, You QD, Wang S, Gao Y, Chen Y and Guo QL: Endostar, a novel recombinant human endostatin, exerts antiangiogenic effect via blocking VEGF-induced tyrosine phosphorylation of KDR/Flk-1 of endothelial cells. Biochem Biophys Res Commun. 361:79–84. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Wang S, Lu XA, Liu P, Fu Y, Jia L, Zhan S and Luo Y: Endostatin has ATPase activity, which mediates its antiangiogenic and antitumor activities. Mol Cancer Ther. 14:1192–1201. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Liu F, Tan G, Li J, Dong X, Krissansen GW and Sun X: Gene transfer of endostatin enhances the efficacy of doxorubicin to suppress human hepatocellular carcinomas in mice. Cancer Sci. 98:1381–1387. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Lin K, Ye P, Liu J, He F and Xu W: Endostar inhibits hypoxia-induced cell proliferation and migration via the hypoxia-inducible factor-1α/vascular endothelial growth factor pathway in vitro. Mol Med Rep. 11:3780–3785. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Li N, Zheng D, Wei X, Jin Z, Zhang C and Li K: Effects of recombinant human endostatin and its synergy with cisplatin on circulating endothelial cells and tumor vascular normalization in A549 xenograft murine model. J Cancer Res Clin Oncol. 138:1131–1144. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Huang G and Chen L: Recombinant human endostatin improves anti-tumor efficacy of paclitaxel by normalizing tumor vasculature in Lewis lung carcinoma. J Cancer Res Clin Oncol. 136:1201–1211. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Zhao W, Zhang L, Yin Z, Su W, Ren G, Zhou C, You J, Fan J and Wang X: Activated hepatic stellate cells promote hepatocellular carcinoma development in immunocompetent mice. Int J Cancer. 129:2651–2661. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Khan MA, Assiri AM and Broering DC: Complement and macrophage crosstalk during process of angiogenesis in tumor progression. J Biomed Sci. 22:582015. View Article : Google Scholar : PubMed/NCBI

18 

Gomes FG, Nedel F, Alves AM, Nör JE and Tarquinio SB: Tumor angiogenesis and lymphangiogenesis: Tumor/endothelial crosstalk and cellular/microenvironmental signaling mechanisms. Life Sci. 92:101–107. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Tassi E and Wellstein A: Tumor angiogenesis: Initiation and targeting-therapeutic targeting of an FGF-binding protein, an angiogenic switch molecule, and indicator of early stages of gastrointestinal adenocarcinomas. Cancer Res Treat. 38:189–197. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Cutolo M, Montagna P, Soldano S, Contini P, Paolino S, Pizzorni C, Seriolo B, Sulli A and Brizzolara R: CTLA4-Ig/CD86 interactions in cultured human endothelial cells: Effects on VEGFR-2 and ICAM1 expression. Clin Exp Rheumatol. 33:250–254. 2015.PubMed/NCBI

21 

Fagiani E, Bill R, Pisarsky L, Ivanek R, Rüegg C and Christofori G: An immature B cell population from peripheral blood serves as surrogate marker for monitoring tumor angiogenesis and anti-angiogenic therapy in mouse models. Angiogenesis. 18:327–345. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Gao SR, Li LM, Xia HP, Wang GM, Xu HY and Wang AR: Clinical observation on recombinant human endostatin combined with chemotherapy for advanced gastrointestinal cancer. Asian Pac J Cancer Prev. 16:4037–4040. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Persad R, Liu C, Wu TT, Houlihan PS, Hamilton SR, Diehl AM and Rashid A: Overexpression of caspase-3 in hepatocellular carcinomas. Mod Pathol. 17:861–867. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Liu J, Wang S, Feng L, Ma D, Fu Q, Song Y, Jia X and Ma S: Hypoglycemic and antioxidant activities of paeonol and its beneficial effect on diabetic encephalopathy in streptozotocin-induced diabetic rats. J Med Food. 16:577–586. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Territo PR, Maluccio M, Riley AA, McCarthy BP, Fletcher J, Tann M, Saxena R and Skill NJ: Evaluation of 11C-acetate and 18 F-FDG PET/CT in mouse multidrug resistance gene-2 deficient mouse model of hepatocellular carcinoma. BMC Med Imaging. 15:152015. View Article : Google Scholar : PubMed/NCBI

27 

Fujii T, Nomoto S, Koshikawa K, Yatabe Y, Teshigawara O, Mori T, Inoue S, Takeda S and Nakao A: Overexpression of pituitary tumor transforming gene 1 in HCC is associated with angiogenesis and poor prognosis. Hepatology. 43:1267–1275. 2006. View Article : Google Scholar : PubMed/NCBI

28 

Roderburg C, Gautheron J and Luedde T: TNF-dependent signaling pathways in liver cancer: Promising targets for therapeutic strategies? Dig Dis. 30:500–507. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Dhanasekaran R, Limaye A and Cabrera R: Hepatocellular carcinoma: Current trends in worldwide epidemiology, risk factors, diagnosis, and therapeutics. Hepat Med. 4:19–37. 2012.PubMed/NCBI

30 

Zhu JY, Sun QK, Wang W and Jia WD: High-level expression of HOXB13 is closely associated with tumor angiogenesis and poor prognosis of hepatocellular carcinoma. Int J Clin Exp Pathol. 7:2925–2933. 2014.PubMed/NCBI

31 

Ye Q, Qin S, Liu Y, Feng J, Wu Q, Qu W and Yin X: Inhibitory effect of Endostar on specific angiogenesis induced by human hepatocellular carcinoma. Gastroenterol Res Pract. 2015:9575742015. View Article : Google Scholar : PubMed/NCBI

32 

Buachan P, Chularojmontri L and Wattanapitayakul SK: Selected activities of Citrus maxima Merr. Fruits on human endothelial cells: Enhancing cell migration and delaying cellular aging. Nutrients. 6:1618–1634. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Feng G, Lei Z, Wang D, Xu N, Wei Q, Li D and Liu J: The evaluation of anti-angiogenic effects of Endostar on rabbit VX2 portal vein tumor thrombus using perfusion MSCT. Cancer Imaging. 14:172014.PubMed/NCBI

34 

Bialecki ES and Di Bisceglie AM: Diagnosis of hepatocellular carcinoma. HPB (Oxford). 7:26–34. 2005. View Article : Google Scholar : PubMed/NCBI

35 

Bayati N, Silverman AL and Gordon SC: Serum alpha-fetoprotein levels and liver histology in patients with chronic hepatitis C. Am J Gastroenterol. 93:2452–2456. 1998. View Article : Google Scholar : PubMed/NCBI

36 

Riaz A, Ryu RK, Kulik LM, Mulcahy MF, Lewandowski RJ, Minocha J, Ibrahim SM, Sato KT, Baker T, Miller FH, et al: Alpha-fetoprotein response after locoregional therapy for hepatocellular carcinoma: Oncologic marker of radiologic response, progression, and survival. J Clin Oncol. 27:5734–5742. 2009. View Article : Google Scholar : PubMed/NCBI

37 

Skill NJ, Jianmin W, Yan X, Zhao Z, Tector AJ and Maluccio MA: Lysophospholipid variants in hepatocellular carcinoma. J Surg Res. 182:241–249. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Rancoule C, Pradère JP, Gonzalez J, Klein J, Valet P, Bascands JL, Schanstra JP and Saulnier-Blache JS: Lysophosphatidic acid-1-receptor targeting agents for fibrosis. Expert Opin Investig Drugs. 20:657–667. 2011. View Article : Google Scholar : PubMed/NCBI

39 

Jongsma M, Matas-Rico E, Rzadkowski A, Jalink K and Moolenaar WH: LPA Is a chemorepellent for B16 melanoma cells: Action through the cAMP-Elevating LPA5 receptor. PLoS One. 6:e292602011. View Article : Google Scholar : PubMed/NCBI

40 

Zhao C, Sardella A, Chun J, Poubelle PE, Fernandes MJ and Bourgoin SG: TNF-alpha promotes LPA1-and LPA3-mediated recruitment of leukocytes in vivo through CXCR2 ligand chemokines. J Lipid Res. 52:1307–1318. 2011. View Article : Google Scholar : PubMed/NCBI

41 

Betof AS, Lascola CD, Weitzel D, Landon C, Scarbrough PM, Devi GR, Palmer G, Jones LW and Dewhirst MW: Modulation of murine breast tumor vascularity, hypoxia and chemotherapeutic response by exercise. J Natl Cancer Inst. 107:pii: djv0402015. View Article : Google Scholar

42 

Zhang J, Liu Q, Hu X, Fang Z, Huang F, Tang L and Zhou S: Apelin/APJ signaling promotes hypoxia-induced proliferation of endothelial progenitor cells via phosphoinositide-3 kinase/Akt signaling. Mol Med Rep. 12:3829–3834. 2015. View Article : Google Scholar : PubMed/NCBI

43 

Wang J and Hao J: Role of HIF-1α in hypoxic microenvironment of tumor and the targeted therapy. Chin J Clin Oncol. 1–1075. 2013. View Article : Google Scholar

44 

Monteiro LS, Delgado ML, Ricardo S, Garcez F, do Amaral B, Pacheco JJ, Lopes C and Bousbaa H: EMMPRIN expression in oral squamous cell carcinomas: Correlation with tumor proliferation and patient survival. Biomed Res Int. 2014:9056802014. View Article : Google Scholar : PubMed/NCBI

45 

Kowshik J, Mishra R, Sophia J, Rautray S, Anbarasu K, Reddy GD, Dixit M, Mahalingam S and Nagini S: Nimbolide upregulates RECK by targeting miR-21 and HIF-1α in cell lines and in a hamster oral carcinogenesis model. Sci Rep. 7:20452017. View Article : Google Scholar : PubMed/NCBI

46 

Huang H, Song Y, Wu Y, Guo N, Ma Y and Qian L: Erbin loss promotes cancer cell proliferation through feedback activation of Akt-Skp2-p27 signaling. Biochem Biophys Res Commun. 463:370–376. 2015. View Article : Google Scholar : PubMed/NCBI

47 

Kazemi-Lomedasht F, Behdani M, Pooshang Bagheri K, Habibi Anbouhi M, Abolhassani M, Khanahmad H, Shahbazzadeh D and Mirzahoseini H: Expression and purification of functional human vascular endothelial growth factor-A121; the most important angiogenesis factor. Adv Pharm Bull. 4:323–328. 2014.PubMed/NCBI

48 

Huang TH, Chiu YH, Chan YL, Chiu YH, Wang H, Huang KC, Li TL, Hsu KH and Wu CJ: Prophylactic administration of fucoidan represses cancer metastasis by inhibiting vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs) in Lewis tumor-bearing mice. Mar Drugs. 13:1882–1900. 2015. View Article : Google Scholar : PubMed/NCBI

49 

Lopez-Avila V and Spencer J: Methods for detection of matrix metalloproteinases as biomarkers in cardiovascular disease. Clin Med Insights Cardiol. 2:75–87. 2008.

50 

Alexius-Lindgren M, Andersson E, Lindstedt I and Engström W: The RECK gene and biological malignancy-its significance in angiogenesis and inhibition of matrix metalloproteinases. Anticancer Res. 34:3867–3873. 2014.PubMed/NCBI

51 

Emingil G, Tervahartiala T, Mãntylã P, Määttä M, Sorsa T and Atilla G: Gingival crevicular fluid matrix metalloproteinase (MMP)-7, extracellular MMP inducer, and tissue inhibitor of MMP-1 levels in periodontal disease. J Periodontol. 77:2040–2050. 2006. View Article : Google Scholar : PubMed/NCBI

52 

Monteiro-Amado F, Castro-Silva II, Lima CJ, Soares FA, Kowalski LP and Granjeiro JM: Immunohistochemical evaluation of MMP-2, MMP-9 and CD31/microvascular density in squamous cell carcinomas of the floor of the mouth. Braz Dent J. 24:3–9. 2013. View Article : Google Scholar : PubMed/NCBI

53 

Griffioen AW: Anti-angiogenesis: Making the tumor vulnerable to the immune system. Cancer Immunol Immunother. 57:1553–1558. 2008. View Article : Google Scholar : PubMed/NCBI

54 

Sabnani MK, Rajan R, Rowland B, Mavinkurve V, Wood LM, Gabizon AA and La-Beck NM: Liposome promotion of tumor growth is associated with angiogenesis and inhibition of antitumor immune responses. Nanomedicine. 11:259–262. 2015. View Article : Google Scholar : PubMed/NCBI

55 

Mu X, Sang Y, Fang C, Shao B, Yang L, Yao K, Zhao X, Gou J, Wei Y, Yi T, et al: Immunotherapy of tumors with human telomerase reverse transcriptase immortalized human umbilical vein endothelial cells. Int J Oncol. 47:1901–1911. 2015. View Article : Google Scholar : PubMed/NCBI

56 

Zhu J, Wang Y, Yang F, Sang L, Zhai J, Li S, Li Y, Wang D, Lu C and Sun X: IL-33 alleviates DSS-induced chronic colitis in C57BL/6 mice colon lamina propria by suppressing Th17 cell response as well as Th1 cell response. Int Immunopharmacol. 29:846–853. 2015. View Article : Google Scholar : PubMed/NCBI

57 

Gagliani N, Amezcua Vesely MC, Iseppon A, Brockmann L, Xu H, Palm NW, de Zoete MR, Licona-Limón P, Paiva RS, Ching T, et al: Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation. Nature. 523:221–225. 2015. View Article : Google Scholar : PubMed/NCBI

58 

Wang H, Zhang L, Zhang S and Li Y: Inhibition of vascular endothelial growth factor by small interfering RNA upregulates differentiation, maturation and function of dendritic cells. Exp Ther Med. 9:120–124. 2015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Xu Q, Gu J, Lv Y, Yuan J, Yang N, Chen J, Wang C, Hou X, Jia X, Feng L, Feng L, et al: Angiogenesis for tumor vascular normalization of Endostar on hepatoma 22 tumor-bearing mice is involved in the immune response. Oncol Lett 15: 3437-3446, 2018.
APA
Xu, Q., Gu, J., Lv, Y., Yuan, J., Yang, N., Chen, J. ... Yin, G. (2018). Angiogenesis for tumor vascular normalization of Endostar on hepatoma 22 tumor-bearing mice is involved in the immune response. Oncology Letters, 15, 3437-3446. https://doi.org/10.3892/ol.2018.7734
MLA
Xu, Q., Gu, J., Lv, Y., Yuan, J., Yang, N., Chen, J., Wang, C., Hou, X., Jia, X., Feng, L., Yin, G."Angiogenesis for tumor vascular normalization of Endostar on hepatoma 22 tumor-bearing mice is involved in the immune response". Oncology Letters 15.3 (2018): 3437-3446.
Chicago
Xu, Q., Gu, J., Lv, Y., Yuan, J., Yang, N., Chen, J., Wang, C., Hou, X., Jia, X., Feng, L., Yin, G."Angiogenesis for tumor vascular normalization of Endostar on hepatoma 22 tumor-bearing mice is involved in the immune response". Oncology Letters 15, no. 3 (2018): 3437-3446. https://doi.org/10.3892/ol.2018.7734
Copy and paste a formatted citation
x
Spandidos Publications style
Xu Q, Gu J, Lv Y, Yuan J, Yang N, Chen J, Wang C, Hou X, Jia X, Feng L, Feng L, et al: Angiogenesis for tumor vascular normalization of Endostar on hepatoma 22 tumor-bearing mice is involved in the immune response. Oncol Lett 15: 3437-3446, 2018.
APA
Xu, Q., Gu, J., Lv, Y., Yuan, J., Yang, N., Chen, J. ... Yin, G. (2018). Angiogenesis for tumor vascular normalization of Endostar on hepatoma 22 tumor-bearing mice is involved in the immune response. Oncology Letters, 15, 3437-3446. https://doi.org/10.3892/ol.2018.7734
MLA
Xu, Q., Gu, J., Lv, Y., Yuan, J., Yang, N., Chen, J., Wang, C., Hou, X., Jia, X., Feng, L., Yin, G."Angiogenesis for tumor vascular normalization of Endostar on hepatoma 22 tumor-bearing mice is involved in the immune response". Oncology Letters 15.3 (2018): 3437-3446.
Chicago
Xu, Q., Gu, J., Lv, Y., Yuan, J., Yang, N., Chen, J., Wang, C., Hou, X., Jia, X., Feng, L., Yin, G."Angiogenesis for tumor vascular normalization of Endostar on hepatoma 22 tumor-bearing mice is involved in the immune response". Oncology Letters 15, no. 3 (2018): 3437-3446. https://doi.org/10.3892/ol.2018.7734
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team