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Article

An obligatory anaerobic Salmonella typhimurium strain redirects M2 macrophages to the M1 phenotype

  • Authors:
    • Mei Yang
    • Juan Xu
    • Qi Wang
    • An‑Qin Zhang
    • Kun Wang
  • View Affiliations / Copyright

    Affiliations: Department of Breast Cancer, Cancer Center, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510080, P.R. China, Department of Breast Cancer, Guangdong Women and Children's Hospital, Guangzhou, Guangdong 511400, P.R. China
  • Pages: 3918-3922
    |
    Published online on: January 8, 2018
       https://doi.org/10.3892/ol.2018.7742
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Abstract

A genetically engineered Salmonella typhimurium strain that may be applied in the medically useful therapeutic strategy of using bacterial agents to target breast cancer in a tumor‑bearing nude mouse model has been previously reported. Furthermore, immune cell accumulation in breast tumor types has been observed, particularly distributed in regions surrounding the bacteria. M2 macrophages are associated with breast cancer aggressiveness, whereas M1 macrophages are prone to devouring bacteria and killing cancer cells. Therefore, this engineered tumor‑targeting salmonella strain was used in an attempt to reverse the phenotype of M2 macrophages into the M1 phenotype. Subsequent to the co‑culture of M2 macrophages with the bacteria for a short time, >50% of the M2 macrophages were invaded by bacteria. These M2 macrophages exhibited a decreased expression of mannose receptor (an M2 phenotypic marker) and increased expression of human leukocyte antigen‑antigen D related (an M1 phenotypic marker). The results of the present study indicated that differentiated M2 macrophages may be redirected into the M1 phenotype following exposure to the engineered bacteria stimulus. This effect may be a potential mechanism by which bacteria retard tumor growth. Thus, this engineered bacterium may be a useful candidate for targeting and redirecting M2 macrophages into the M1 phenotype.
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1 

Yazawa K, Fujimori M, Nakamura T, Sasaki T, Amano J, Kano Y and Taniguchi S: Bifidobacterium longum as a delivery system for gene therapy of chemically induced rat mammary tumors. Breast Cancer Res Treat. 66:165–170. 2001. View Article : Google Scholar : PubMed/NCBI

2 

Fujimori M: Anaerobic bacteria as a gene delivery system for breast cancer therapy. Nihon Rinsho. 66:1211–1218. 2008.(In Japanese). PubMed/NCBI

3 

Liu SC, Ahn GO, Kioi M, Dorie MJ, Patterson AV and Brown JM: Optimized clostridium-directed enzyme prodrug therapy improves the antitumor activity of the novel DNA cross-linking agent PR-104. Cancer Res. 68:7995–8003. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Zhao M, Yang M, Ma H, Li X, Tan X, Li S, Yang Z and Hoffman RM: Targeted therapy with a Salmonella typhimurium leucine-arginine auxotroph cures orthotopic human breast tumors in nude mice. Cancer Res. 66:7647–7652. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Low KB, Ittensohn M, Le T, Platt J, Sodi S, Amoss M, Ash O, Carmichael E, Chakraborty A, Fischer J, et al: Lipid A mutant Salmonella with suppressed virulence and TNFalpha induction retain tumor-targeting in vivo. Nat Biotechnol. 17:37–41. 1999. View Article : Google Scholar : PubMed/NCBI

6 

Felgner S, Kocijancic D, Frahm M, Curtiss R III, Erhardt M and Weiss S: Optimizing salmonella enterica serovar typhimurium for bacteria-mediated tumor therapy. Gut microbes. 7:171–177. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Frahm M, Felgner S, Kocijancic D, Rohde M, Hensel M, Curtiss R III, Erhardt M and Weiss S: Efficiency of conditionally attenuated Salmonella enterica serovar Typhimurium in bacterium-mediated tumor therapy. mBio. 6:pii: e00254–15. 2015. View Article : Google Scholar

8 

Yu B, Yang M, Shi L, Yao Y, Jiang Q, Li X, Tang LH, Zheng BJ, Yuen KY, Smith DK, et al: Explicit hypoxia targeting with tumor suppression by creating an ‘obligate’ anaerobic Salmonella Typhimurium strain. Sci Rep. 2:4362012. View Article : Google Scholar : PubMed/NCBI

9 

Tang X: Tumor-associated macrophages as potential diagnostic and prognostic biomarkers in breast cancer. Cancer Lett. 332:3–10. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Luo Y, Zhou H, Krueger J, Kaplan C, Lee SH, Dolman C, Markowitz D, Wu W, Liu C, Reisfeld RA and Xiang R: Targeting tumor-associated macrophages as a novel strategy against breast cancer. J Clin Invest. 116:2132–2141. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Leek RD, Lewis CE, Whitehouse R, Greenall M, Clarke J and Harris AL: Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma. Cancer Res. 56:4625–4629. 1996.PubMed/NCBI

12 

DeNardo DG, Barreto JB, Andreu P, Vasquez L, Tawfik D, Kolhatkar N and Coussens LM: CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages. Cancer cell. 16:91–102. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Zhang C, Gao L, Cai Y, Liu H, Gao D, Lai J, Jia B, Wang F and Liu Z: Inhibition of tumor growth and metastasis by photoimmunotherapy targeting tumor-associated macrophage in a sorafenib-resistant tumor model. Biomaterials. 84:1–12. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Khabbazi S, Goumon Y and Parat MO: Morphine modulates interleukin-4- or breast cancer cell-induced pro-metastatic activation of macrophages. Sci Rep. 5:113892015. View Article : Google Scholar : PubMed/NCBI

15 

Su S, Liu Q, Chen J, Chen J, Chen F, He C, Huang D, Wu W, Lin L, Huang W, et al: A positive feedback loop between mesenchymal-like cancer cells and macrophages is essential to breast cancer metastasis. Cancer cell. 25:605–620. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Dangaj D, Abbott KL, Mookerjee A, Zhao A, Kirby PS, Sandaltzopoulos R, Powell DJ Jr, Lamazière A, Siegel DL, Wolf C and Scholler N: Mannose receptor (MR) engagement by mesothelin GPI anchor polarizes tumor-associated macrophages and is blocked by anti-MR human recombinant antibody. PLoS One. 6:e283862011. View Article : Google Scholar : PubMed/NCBI

17 

Kuang DM, Wu Y, Chen N, Cheng J, Zhuang SM and Zheng L: Tumor-derived hyaluronan induces formation of immunosuppressive macrophages through transient early activation of monocytes. Blood. 110:587–595. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Yang M, Chen J, Su F, Yu B, Su F, Lin L, Liu Y, Huang JD and Song E: Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells. Mol cancer. 10:1172011. View Article : Google Scholar : PubMed/NCBI

19 

Chen J, Yao Y, Gong C, Yu F, Su S, Chen J, Liu B, Deng H, Wang F, Lin L, et al: CCL18 from tumor-associated macrophages promotes breast cancer metastasis via PITPNM3. Cancer Cell. 19:541–555. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Castoldi A, Naffah de Souza C, Câmara NO and Moraes-Vieira PM: The macrophage switch in obesity development. Front Immunol. 6:6372016. View Article : Google Scholar : PubMed/NCBI

21 

Hamaidia M, Staumont B, Duysinx B, Louis R and Willems L: Improvement of malignant pleural mesothelioma immunotherapy by epigenetic modulators. Curr Top Med Chem. 16:777–787. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Murray PJ and Wynn TA: Protective and pathogenic functions of macrophage subsets. Nat Rev Immunol. 11:723–737. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Hambleton J, Weinstein SL, Lem L and DeFranco AL: Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide-stimulated macrophages. Proc Natl Acad Sci USA. 93:pp. 2774–2778. 1996; View Article : Google Scholar : PubMed/NCBI

24 

Chimal-Ramírez GK, Espinoza-Sánchez NA, Chávez-Sánchez L, Arriaga-Pizano L and Fuentes-Pananá EM: Monocyte differentiation towards protumor activity does not correlate with M1 or M2 phenotypes. J Immunol Res. 2016:60314862016. View Article : Google Scholar : PubMed/NCBI

25 

Guo H, Liu Y, Gu J, Wang Y, Liu L, Zhang P and Li Y: Endostatin inhibits the growth and migration of 4T1 mouse breast cancer cells by skewing macrophage polarity toward the M1 phenotype. Cancer Immunol Immunother. 65:677–688. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Cameron DJ and Churchill WH: Cytotoxicity of human macrophages for tumor cells: Enhancement by bacterial lipopolysaccharides (LPS). J Immunol. 124:708–712. 1980.PubMed/NCBI

27 

Sinha P, Clements VK, Miller S and Ostrand-Rosenberg S: Tumor immunity: A balancing act between T cell activation, macrophage activation and tumor-induced immune suppression. Cancer Immunol Immunother. 54:1137–1142. 2005. View Article : Google Scholar : PubMed/NCBI

28 

Mills CD, Lenz LL and Harris RA: A breakthrough: Macrophage-directed cancer immunotherapy. Cancer Res. 76:513–516. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Mitra R, Singh S and Khar A: Antitumour immune responses. Expert Rev Mol Med. 5:1–19. 2003. View Article : Google Scholar : PubMed/NCBI

30 

Mantovani A, Sozzani S, Locati M, Allavena P and Sica A: Macrophage polarization: Tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol. 23:549–555. 2002. View Article : Google Scholar : PubMed/NCBI

31 

Wahl LM and Kleinman HK: Tumor-associated macrophages as targets for cancer therapy. J Natl Cancer Inst. 90:1583–1584. 1998. View Article : Google Scholar : PubMed/NCBI

32 

Ueno T, Toi M, Saji H, Muta M, Bando H, Kuroi K, Koike M, Inadera H and Matsushima K: Significance of macrophage chemoattractant protein-1 in macrophage recruitment, angiogenesis, and survival in human breast cancer. Clin Cancer Res. 6:3282–3289. 2000.PubMed/NCBI

33 

Leek RD and Harris AL: Tumor-associated macrophages in breast cancer. J Mammary Gland Biol Neoplasia. 7:177–189. 2002. View Article : Google Scholar : PubMed/NCBI

34 

Valković T, Dobrila F, Melato M, Sasso F, Rizzardi C and Jonjić N: Correlation between vascular endothelial growth factor, angiogenesis, and tumor-associated macrophages in invasive ductal breast carcinoma. Virchows Arch. 440:583–588. 2002. View Article : Google Scholar : PubMed/NCBI

35 

Deng R, Wang SM, Yin T, Ye TH, Shen GB, Li L, Zhao JY, Sang YX, Duan XG and Wei YQ: Inhibition of tumor growth and alteration of associated macrophage cell type by an HO-1 inhibitor in breast carcinoma-bearing mice. Oncol Res. 20:473–482. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yang M, Xu J, Wang Q, Zhang AQ and Wang K: An obligatory anaerobic Salmonella typhimurium strain redirects M2 macrophages to the M1 phenotype. Oncol Lett 15: 3918-3922, 2018.
APA
Yang, M., Xu, J., Wang, Q., Zhang, A., & Wang, K. (2018). An obligatory anaerobic Salmonella typhimurium strain redirects M2 macrophages to the M1 phenotype. Oncology Letters, 15, 3918-3922. https://doi.org/10.3892/ol.2018.7742
MLA
Yang, M., Xu, J., Wang, Q., Zhang, A., Wang, K."An obligatory anaerobic Salmonella typhimurium strain redirects M2 macrophages to the M1 phenotype". Oncology Letters 15.3 (2018): 3918-3922.
Chicago
Yang, M., Xu, J., Wang, Q., Zhang, A., Wang, K."An obligatory anaerobic Salmonella typhimurium strain redirects M2 macrophages to the M1 phenotype". Oncology Letters 15, no. 3 (2018): 3918-3922. https://doi.org/10.3892/ol.2018.7742
Copy and paste a formatted citation
x
Spandidos Publications style
Yang M, Xu J, Wang Q, Zhang AQ and Wang K: An obligatory anaerobic Salmonella typhimurium strain redirects M2 macrophages to the M1 phenotype. Oncol Lett 15: 3918-3922, 2018.
APA
Yang, M., Xu, J., Wang, Q., Zhang, A., & Wang, K. (2018). An obligatory anaerobic Salmonella typhimurium strain redirects M2 macrophages to the M1 phenotype. Oncology Letters, 15, 3918-3922. https://doi.org/10.3892/ol.2018.7742
MLA
Yang, M., Xu, J., Wang, Q., Zhang, A., Wang, K."An obligatory anaerobic Salmonella typhimurium strain redirects M2 macrophages to the M1 phenotype". Oncology Letters 15.3 (2018): 3918-3922.
Chicago
Yang, M., Xu, J., Wang, Q., Zhang, A., Wang, K."An obligatory anaerobic Salmonella typhimurium strain redirects M2 macrophages to the M1 phenotype". Oncology Letters 15, no. 3 (2018): 3918-3922. https://doi.org/10.3892/ol.2018.7742
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