Open Access

Therapeutic targeting of noncoding RNAs in hepatocellular carcinoma: Recent progress and future prospects (Review)

  • Authors:
    • Zhangang Xiao
    • Jing Shen
    • Lin Zhang
    • Mingxing Li
    • Wei Hu
    • Chihin Cho
  • View Affiliations

  • Published online on: January 9, 2018     https://doi.org/10.3892/ol.2018.7758
  • Pages: 3395-3402
  • Copyright: © Xiao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Due to the high mortality rate and unsatisfactory treatment options available, hepatocellular carcinoma (HCC) remains one of the most common malignancies and a leading cause of cancer‑associated mortality. Novel therapeutic targets for HCC are urgently required. Advanced RNA sequencing technology enables the identification of considerable amounts of noncoding RNAs (ncRNAs), including small noncoding RNAs and long noncoding RNAs, which exhibit no protein‑coding activities. In this respect, ncRNAs and their regulatory processes are important factors in liver tumorigenesis. The present review focuses on the characteristics and biological roles of ncRNAs in HCC. Potential therapeutic applications of ncRNAs in HCC are also evaluated.
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March-2018
Volume 15 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Xiao Z, Shen J, Zhang L, Li M, Hu W and Cho C: Therapeutic targeting of noncoding RNAs in hepatocellular carcinoma: Recent progress and future prospects (Review). Oncol Lett 15: 3395-3402, 2018
APA
Xiao, Z., Shen, J., Zhang, L., Li, M., Hu, W., & Cho, C. (2018). Therapeutic targeting of noncoding RNAs in hepatocellular carcinoma: Recent progress and future prospects (Review). Oncology Letters, 15, 3395-3402. https://doi.org/10.3892/ol.2018.7758
MLA
Xiao, Z., Shen, J., Zhang, L., Li, M., Hu, W., Cho, C."Therapeutic targeting of noncoding RNAs in hepatocellular carcinoma: Recent progress and future prospects (Review)". Oncology Letters 15.3 (2018): 3395-3402.
Chicago
Xiao, Z., Shen, J., Zhang, L., Li, M., Hu, W., Cho, C."Therapeutic targeting of noncoding RNAs in hepatocellular carcinoma: Recent progress and future prospects (Review)". Oncology Letters 15, no. 3 (2018): 3395-3402. https://doi.org/10.3892/ol.2018.7758